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The map label for this gene is hbd [H]

Identifier: 170749305

GI number: 170749305

Start: 3051181

End: 3052104

Strand: Reverse

Name: hbd [H]

Synonym: Mrad2831_2898

Alternate gene names: 170749305

Gene position: 3052104-3051181 (Counterclockwise)

Preceding gene: 170749306

Following gene: 170749304

Centisome position: 50.22

GC content: 72.08

Gene sequence:

>924_bases
ATGACCGAGAGCGTCGCGATCGTCGGCGCCGGCCTGATCGGCCGGGCCTGGGCGATGATCTTCGCCCGCGCCGGCTGGGA
CGTGCGCCTGTTCGATCCCGCGGAGGGCGTCGCCGAGGCCGCGATCCCGCTCTGCGCCGAGGGGCTGCGGACGCTCGCGG
CGCATGACCTCTGCGCCGACCCTGCGGCCGCCGCGGGGCGCATCCGCGCGGCCGGCACCCTCGCGGCCGCCCTCGACGGC
GTCGCCTTCGTGCAGGAGAACGGGCCAGAGCGGCTGGAGGTGAAGCGGAGCCTCTTCGCGGACCTCGACGCCGCGGCGCC
GCGGGAGGCCGTCATCGCCTCGTCCTCCTCGGCGATCCGCTGCTCCCTGTTCACCGAGGATCTGCCGGGTCGGGCGCGCT
GCCTGATCGGCCATCCGGTGAATCCGCCGCACCTGATCCCGCTGGTGGAGATCTCCGGCGCACCGTGGACGGCCCCCGAC
GCGCTGGACCGGGCCCGGCAGGTCTACGAGCAGATCGGGCAGGTGCCGATCACCGTGCTGAAGGAGATCGAGGGCTTCAT
CCTCAATCGCCTCCAGGGCGCGCTTCTCGCAGAGGCGTTCCGCCTCGCTTCGGAGGGCTACGTGACCCCGCAGGATCTCG
ATAAGACCGTCTCGGACGGGCTGGGCCTGCGCTGGAGCTTCATGGGGCCGTTCGAGACCATTGAGCTGAACGCGCCCGGC
GGGATCGCCGATTACTGCGCGCGCTATACCGGCTTCTACAAGAACCTCGCCGCCGATCCGGCACCGCCGAGCGTTTATGA
GGCGCCGGCCACCGAGGCGATCCTGGCGAACTGGCAGGCGCCCGCGGACCTGCCCGCCCGCATGAACCGCCGCGATGCGC
GGCTCGCGGCCCTGCGGGCCCACAAGGCTTCACAGAAGGACTGA

Upstream 100 bases:

>100_bases
CGGACCGGACGGTGGCCCTGGAGCGCGGCAGCGTGCAGTGGACGGGCGCGTCGCGTCTCCTGCGCGAGGATCAGGAGCTG
AGGCGGAAGGTGCTGTGGCT

Downstream 100 bases:

>100_bases
GCATGGCCTCACAGCGGAAAGTCATCATCACCTGCGCGGTGACGGGCGCGATCCATACGCCCAGCATGTCGCCGCATCTG
CCGGTGACGCCCGAGGAGAT

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTESVAIVGAGLIGRAWAMIFARAGWDVRLFDPAEGVAEAAIPLCAEGLRTLAAHDLCADPAAAAGRIRAAGTLAAALDG
VAFVQENGPERLEVKRSLFADLDAAAPREAVIASSSSAIRCSLFTEDLPGRARCLIGHPVNPPHLIPLVEISGAPWTAPD
ALDRARQVYEQIGQVPITVLKEIEGFILNRLQGALLAEAFRLASEGYVTPQDLDKTVSDGLGLRWSFMGPFETIELNAPG
GIADYCARYTGFYKNLAADPAPPSVYEAPATEAILANWQAPADLPARMNRRDARLAALRAHKASQKD

Sequences:

>Translated_307_residues
MTESVAIVGAGLIGRAWAMIFARAGWDVRLFDPAEGVAEAAIPLCAEGLRTLAAHDLCADPAAAAGRIRAAGTLAAALDG
VAFVQENGPERLEVKRSLFADLDAAAPREAVIASSSSAIRCSLFTEDLPGRARCLIGHPVNPPHLIPLVEISGAPWTAPD
ALDRARQVYEQIGQVPITVLKEIEGFILNRLQGALLAEAFRLASEGYVTPQDLDKTVSDGLGLRWSFMGPFETIELNAPG
GIADYCARYTGFYKNLAADPAPPSVYEAPATEAILANWQAPADLPARMNRRDARLAALRAHKASQKD
>Mature_306_residues
TESVAIVGAGLIGRAWAMIFARAGWDVRLFDPAEGVAEAAIPLCAEGLRTLAAHDLCADPAAAAGRIRAAGTLAAALDGV
AFVQENGPERLEVKRSLFADLDAAAPREAVIASSSSAIRCSLFTEDLPGRARCLIGHPVNPPHLIPLVEISGAPWTAPDA
LDRARQVYEQIGQVPITVLKEIEGFILNRLQGALLAEAFRLASEGYVTPQDLDKTVSDGLGLRWSFMGPFETIELNAPGG
IADYCARYTGFYKNLAADPAPPSVYEAPATEAILANWQAPADLPARMNRRDARLAALRAHKASQKD

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=312, Percent_Identity=36.5384615384615, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI296179429, Length=242, Percent_Identity=28.099173553719, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI296179427, Length=259, Percent_Identity=26.2548262548263, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1787661, Length=256, Percent_Identity=26.5625, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533614, Length=225, Percent_Identity=38.2222222222222, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI193203623, Length=225, Percent_Identity=38.2222222222222, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17549919, Length=237, Percent_Identity=27.4261603375527, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17553560, Length=235, Percent_Identity=23.4042553191489, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17563036, Length=238, Percent_Identity=24.7899159663866, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45549573, Length=307, Percent_Identity=39.7394136807818, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI20129993, Length=261, Percent_Identity=42.5287356321839, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI19921000, Length=220, Percent_Identity=29.5454545454545, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583077, Length=220, Percent_Identity=29.5454545454545, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583079, Length=220, Percent_Identity=29.5454545454545, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32645; Mature: 32514

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESVAIVGAGLIGRAWAMIFARAGWDVRLFDPAEGVAEAAIPLCAEGLRTLAAHDLCAD
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAAAAGRIRAAGTLAAALDGVAFVQENGPERLEVKRSLFADLDAAAPREAVIASSSSAIR
CHHHHCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCCCCHHEEECCCCCEE
CSLFTEDLPGRARCLIGHPVNPPHLIPLVEISGAPWTAPDALDRARQVYEQIGQVPITVL
EEEECCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHH
KEIEGFILNRLQGALLAEAFRLASEGYVTPQDLDKTVSDGLGLRWSFMGPFETIELNAPG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCC
GIADYCARYTGFYKNLAADPAPPSVYEAPATEAILANWQAPADLPARMNRRDARLAALRA
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHCCHHHHHHHHHHH
HKASQKD
HHCCCCC
>Mature Secondary Structure 
TESVAIVGAGLIGRAWAMIFARAGWDVRLFDPAEGVAEAAIPLCAEGLRTLAAHDLCAD
CCCEEEEECCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PAAAAGRIRAAGTLAAALDGVAFVQENGPERLEVKRSLFADLDAAAPREAVIASSSSAIR
CHHHHCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHCCCCCCCHHEEECCCCCEE
CSLFTEDLPGRARCLIGHPVNPPHLIPLVEISGAPWTAPDALDRARQVYEQIGQVPITVL
EEEECCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHH
KEIEGFILNRLQGALLAEAFRLASEGYVTPQDLDKTVSDGLGLRWSFMGPFETIELNAPG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCC
GIADYCARYTGFYKNLAADPAPPSVYEAPATEAILANWQAPADLPARMNRRDARLAALRA
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHCCHHHHHHHHHHH
HKASQKD
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]