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The map label for this gene is penA [H]

Identifier: 170748781

GI number: 170748781

Start: 2502445

End: 2504337

Strand: Reverse

Name: penA [H]

Synonym: Mrad2831_2363

Alternate gene names: 170748781

Gene position: 2504337-2502445 (Counterclockwise)

Preceding gene: 170748782

Following gene: 170748780

Centisome position: 41.2

GC content: 68.62

Gene sequence:

>1893_bases
GTGTCCGATGACGCCGACCAGACCCTAGACCCGGCGGTCGAGCCCGCCGTGTCGGACCACGAGGCGGGGCTGCTCGAAGC
CGCCGCGCTGGCGCATGCCGCCGGCGCGCCACGCCCCCTGGAAGAGGAGGCGCGCGTGCCCGAGCCGCGCGCCGAGCGCG
CCAAGGCGCTCCTGCGCAGCATGTTCCGGCTGGCGATCGAGCGCTCGCACATGCGCGTCGCGATGGTCGGGCTGGTCTTC
GTCGGCGTGTTCGGGACGATCTCGGCCAAACTCCTGATGATGGCGATCTTCGGGGAGCCGCCCAGCCAGGAGCACCGGGT
CGCGGCGGCGTCCTCGACCGCCTTCCGGCCCGACATCATCGACCGCAACGGCGAGATCCTGGCCACCGACATCCGTACGG
TCTCGGTCTTCGCCGAGCCGGGCAACATCTACGACAAGGACGAGGCGGTCGAGCTGCTCACCGCCGTCCTGCCGGAACTC
AACGCGTCCGAGCTGCGCGCGAAGCTGACGCAACGCAAGGACAAGAAGGGCGCGGGCTTCGTCTGGGTGAAGCGCGAGCT
CACGCCGAAGCAGCAGGCCGAGGTTCACCGGCTCGGCATCCCGGGTATCGGCTTCCTGCCCGACCACAAGCGGGTCTACC
CGAACGGCGTCGCCGCCGCCCACATCCTGGGCGCGACGAACCTCGACGGCGTCGGCATCGCCGGCATGGAGAAGTACATC
GACTCCACCGGCCTGCAGGCCCTCAACAGCTTCGGGCTGATCAACAAGCAGGCCGACCTGAAGCCGGTGCAGCTGTCGAT
CGACCTGCGGGCGCAGTTCGCCGTGCGCGACGAGCTGGCCTGGGGCATCGACCACTTCAAGGCCAAGGCCGGCGCCTCGA
TGATCCTCGACGTGAAGACCGGCGAAGTCATCGCCCTCGTCTCCATGCCGGATTTCGACCCGAACGATCCGAAGGACGCG
CTCTCGCCCGACCGGATCAACCGGATGAATGTCGGCGTCTACGAGATGGGCTCGACCTTCAAGGCGATGACCCTCGCCAT
GGCGCTCGATTCGGGCAAGTACAACGTCAACTCGACCTTCGACACCCGGGGCGGCGTGCTGAACTGGGGCCGGCAGAAGA
TCCACGAGTACCACGGCACCAACCGCGTCATCACCATGCCGGAGGTCTTCACGCACTCCTCCAACATCGGCTCCGCCAAG
ATGGCGCTCGGCGTCGGCGTGCCCGGCCACAAGGCCTTCCTGAAGAAGATGGGCCTGCTCGACCGGCTGCGCACCGAGCT
GCCCGAGAGCGCGGCGCCGATCGTCCCGTCGCGCTGGACCGAGATCAACACCATCACCATCGCGTTCGGCCACGGCATCG
CGGTGGCGCCGATCCAGGCGGCGGCCGCGGTGGCGGCCATCGCCAACGGCGGCGACCTGATGACGCCGACCTTCCTCAAG
ACGACGCCCGAGGCGGCGAAGGCCCGCGCCGCGCACGTGCTCTCCGGCCAGACCTCCGAGGCGATGCGCTACATCATGCG
GCTCAACGCCTCCGAGGGGTCGGCCAAGAAGGCGGCGATCCCGTACTACTTCGTCGGCGGCAAGACCGGCACCGCCGAGA
AGGTCATCGGCGGCCGCTACATCCACAACCGCCTGTTCACGACCTTCATGGCGGCCGCGCCGATGAACGATCCGAAGTAC
CTGTTCGTCACGATCATGGACGAGCCGCAGGGCCTGCCGGAATCGGGCGGCTACGCCACGGCGGCCTGGAATTCCGGCGT
GGTGACCGGCAAGGTGATCGAGCGCGTGGCGCCGATCCTCGGCCTGCCGCCGCAATTCGAGCCGCCGGTGAGGCCGTTCC
CGCAGATGGTCAAGCTCAATGCCTACCACGTCAACCAGCTCGGCGGCCCGTGA

Upstream 100 bases:

>100_bases
GCCCAAGGACAAGGGTGCGATCGAGCCGCGCACGACCGGTTCGATCACCCGCACCGTCACCACGACCCGCACCCCGACGA
CGGCTTCGAGGTAAATCCCC

Downstream 100 bases:

>100_bases
GATTGGATCGATGAGGGTGGATCGATGAGCGCGCGGCTCGCCGACCTCTTCCCCGAGGCCGCCGGCCCCGCCGCGGACCT
GACCGTCTCGGACCTCACGG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MSDDADQTLDPAVEPAVSDHEAGLLEAAALAHAAGAPRPLEEEARVPEPRAERAKALLRSMFRLAIERSHMRVAMVGLVF
VGVFGTISAKLLMMAIFGEPPSQEHRVAAASSTAFRPDIIDRNGEILATDIRTVSVFAEPGNIYDKDEAVELLTAVLPEL
NASELRAKLTQRKDKKGAGFVWVKRELTPKQQAEVHRLGIPGIGFLPDHKRVYPNGVAAAHILGATNLDGVGIAGMEKYI
DSTGLQALNSFGLINKQADLKPVQLSIDLRAQFAVRDELAWGIDHFKAKAGASMILDVKTGEVIALVSMPDFDPNDPKDA
LSPDRINRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTFDTRGGVLNWGRQKIHEYHGTNRVITMPEVFTHSSNIGSAK
MALGVGVPGHKAFLKKMGLLDRLRTELPESAAPIVPSRWTEINTITIAFGHGIAVAPIQAAAAVAAIANGGDLMTPTFLK
TTPEAAKARAAHVLSGQTSEAMRYIMRLNASEGSAKKAAIPYYFVGGKTGTAEKVIGGRYIHNRLFTTFMAAAPMNDPKY
LFVTIMDEPQGLPESGGYATAAWNSGVVTGKVIERVAPILGLPPQFEPPVRPFPQMVKLNAYHVNQLGGP

Sequences:

>Translated_630_residues
MSDDADQTLDPAVEPAVSDHEAGLLEAAALAHAAGAPRPLEEEARVPEPRAERAKALLRSMFRLAIERSHMRVAMVGLVF
VGVFGTISAKLLMMAIFGEPPSQEHRVAAASSTAFRPDIIDRNGEILATDIRTVSVFAEPGNIYDKDEAVELLTAVLPEL
NASELRAKLTQRKDKKGAGFVWVKRELTPKQQAEVHRLGIPGIGFLPDHKRVYPNGVAAAHILGATNLDGVGIAGMEKYI
DSTGLQALNSFGLINKQADLKPVQLSIDLRAQFAVRDELAWGIDHFKAKAGASMILDVKTGEVIALVSMPDFDPNDPKDA
LSPDRINRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTFDTRGGVLNWGRQKIHEYHGTNRVITMPEVFTHSSNIGSAK
MALGVGVPGHKAFLKKMGLLDRLRTELPESAAPIVPSRWTEINTITIAFGHGIAVAPIQAAAAVAAIANGGDLMTPTFLK
TTPEAAKARAAHVLSGQTSEAMRYIMRLNASEGSAKKAAIPYYFVGGKTGTAEKVIGGRYIHNRLFTTFMAAAPMNDPKY
LFVTIMDEPQGLPESGGYATAAWNSGVVTGKVIERVAPILGLPPQFEPPVRPFPQMVKLNAYHVNQLGGP
>Mature_629_residues
SDDADQTLDPAVEPAVSDHEAGLLEAAALAHAAGAPRPLEEEARVPEPRAERAKALLRSMFRLAIERSHMRVAMVGLVFV
GVFGTISAKLLMMAIFGEPPSQEHRVAAASSTAFRPDIIDRNGEILATDIRTVSVFAEPGNIYDKDEAVELLTAVLPELN
ASELRAKLTQRKDKKGAGFVWVKRELTPKQQAEVHRLGIPGIGFLPDHKRVYPNGVAAAHILGATNLDGVGIAGMEKYID
STGLQALNSFGLINKQADLKPVQLSIDLRAQFAVRDELAWGIDHFKAKAGASMILDVKTGEVIALVSMPDFDPNDPKDAL
SPDRINRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTFDTRGGVLNWGRQKIHEYHGTNRVITMPEVFTHSSNIGSAKM
ALGVGVPGHKAFLKKMGLLDRLRTELPESAAPIVPSRWTEINTITIAFGHGIAVAPIQAAAAVAAIANGGDLMTPTFLKT
TPEAAKARAAHVLSGQTSEAMRYIMRLNASEGSAKKAAIPYYFVGGKTGTAEKVIGGRYIHNRLFTTFMAAAPMNDPKYL
FVTIMDEPQGLPESGGYATAAWNSGVVTGKVIERVAPILGLPPQFEPPVRPFPQMVKLNAYHVNQLGGP

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=518, Percent_Identity=30.1158301158301, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1786854, Length=614, Percent_Identity=24.2671009771987, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67774; Mature: 67643

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDADQTLDPAVEPAVSDHEAGLLEAAALAHAAGAPRPLEEEARVPEPRAERAKALLRS
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHH
MFRLAIERSHMRVAMVGLVFVGVFGTISAKLLMMAIFGEPPSQEHRVAAASSTAFRPDII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCC
DRNGEILATDIRTVSVFAEPGNIYDKDEAVELLTAVLPELNASELRAKLTQRKDKKGAGF
CCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCE
VWVKRELTPKQQAEVHRLGIPGIGFLPDHKRVYPNGVAAAHILGATNLDGVGIAGMEKYI
EEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCHHHHHHH
DSTGLQALNSFGLINKQADLKPVQLSIDLRAQFAVRDELAWGIDHFKAKAGASMILDVKT
HHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEHHHHHHHHHHHHHHCCCEEEEEECC
GEVIALVSMPDFDPNDPKDALSPDRINRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTF
CCEEEEEECCCCCCCCCHHCCCCCCCCCCCCCCEECCCHHHHHHEEHEECCCCEECCCCC
DTRGGVLNWGRQKIHEYHGTNRVITMPEVFTHSSNIGSAKMALGVGVPGHKAFLKKMGLL
CCCCCCCHHHHHHHHHHCCCCCEEECCHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
DRLRTELPESAAPIVPSRWTEINTITIAFGHGIAVAPIQAAAAVAAIANGGDLMTPTFLK
HHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEEECHHHHHHHHHHHCCCCCCCCCHHHC
TTPEAAKARAAHVLSGQTSEAMRYIMRLNASEGSAKKAAIPYYFVGGKTGTAEKVIGGRY
CCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHCCHH
IHNRLFTTFMAAAPMNDPKYLFVTIMDEPQGLPESGGYATAAWNSGVVTGKVIERVAPIL
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHH
GLPPQFEPPVRPFPQMVKLNAYHVNQLGGP
CCCCCCCCCCCCCCHHEEECEEEECCCCCC
>Mature Secondary Structure 
SDDADQTLDPAVEPAVSDHEAGLLEAAALAHAAGAPRPLEEEARVPEPRAERAKALLRS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHH
MFRLAIERSHMRVAMVGLVFVGVFGTISAKLLMMAIFGEPPSQEHRVAAASSTAFRPDII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCC
DRNGEILATDIRTVSVFAEPGNIYDKDEAVELLTAVLPELNASELRAKLTQRKDKKGAGF
CCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCE
VWVKRELTPKQQAEVHRLGIPGIGFLPDHKRVYPNGVAAAHILGATNLDGVGIAGMEKYI
EEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCHHHHHHH
DSTGLQALNSFGLINKQADLKPVQLSIDLRAQFAVRDELAWGIDHFKAKAGASMILDVKT
HHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEHHHHHHHHHHHHHHCCCEEEEEECC
GEVIALVSMPDFDPNDPKDALSPDRINRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTF
CCEEEEEECCCCCCCCCHHCCCCCCCCCCCCCCEECCCHHHHHHEEHEECCCCEECCCCC
DTRGGVLNWGRQKIHEYHGTNRVITMPEVFTHSSNIGSAKMALGVGVPGHKAFLKKMGLL
CCCCCCCHHHHHHHHHHCCCCCEEECCHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
DRLRTELPESAAPIVPSRWTEINTITIAFGHGIAVAPIQAAAAVAAIANGGDLMTPTFLK
HHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEEECHHHHHHHHHHHCCCCCCCCCHHHC
TTPEAAKARAAHVLSGQTSEAMRYIMRLNASEGSAKKAAIPYYFVGGKTGTAEKVIGGRY
CCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHCCHH
IHNRLFTTFMAAAPMNDPKYLFVTIMDEPQGLPESGGYATAAWNSGVVTGKVIERVAPIL
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHH
GLPPQFEPPVRPFPQMVKLNAYHVNQLGGP
CCCCCCCCCCCCCCHHEEECEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]