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The map label for this gene is mraY

Identifier: 170748778

GI number: 170748778

Start: 2498341

End: 2499426

Strand: Reverse

Name: mraY

Synonym: Mrad2831_2360

Alternate gene names: 170748778

Gene position: 2499426-2498341 (Counterclockwise)

Preceding gene: 170748779

Following gene: 170748777

Centisome position: 41.12

GC content: 65.75

Gene sequence:

>1086_bases
ATGCTGTACCTTCTCTCGGACCTGAGCAGCAGCTTCACGCCGCTCAACGTGTTCCGCTACATCACCTTCCGCACCGGCGG
CGCGCTGTTCACGGCGGGCCTGTTCGTGTTCTGGTTCGGACCCTGGATCATCTCGCTGCTGCGGATCCGCCAGGGCAAGG
GCCAGCCGATCCGCGAGGACGGACCGCAGACCCATCTGCTGACCAAGCGCGGCACGCCGACCATGGGCGGCCTGATGATC
CTGGCCGGTGCCGTGGTGGCGATCCTGCTCTGGGCCAACCCGCGCAACCACTATGTCTGGGTGACGCTGACCGTCACCCT
CGGATTCGGCGCGATCGGCTTCTACGACGATTACCTCAAGGTCACGAAGCAGTCGCACAAGGGCTTCTCGGGCAAGTTCC
GCCTCGCCCTCGAGGCGGTGATCGCCATGGCGGCCTGCGTGACCATCGCGGTCTACTCGCCCGCCGCGCTCCAGAACCAG
CTCGCCTTCCCGGTATTCAAGGACGCGCTCCTCAATCTGGGCTGGTTCTACCCGCTGTTCGGCGCCTTCGTGATCGTCGG
GGCGGGCAATTCCGTGAATATGACCGACGGCCTCGACGGCCTCGCGATCGTGCCGGTGATGATCGCCTGCGGCACGTTCG
GCTTCATCGCCTACCTCGTCGGCAACTCGTTCACCGCCAGCTATCTGCAGGTGAACTACGTCCGCGACACGGGCGAGCTC
GCTGTGGTCTGCGGCGCGGTCATCGGCGCCGGGCTCGGCTTCCTCTGGTTCAACGCGCCGCCGGCCCAGATCTTCATGGG
CGACACCGGCTCGCTGGCGCTGGGCGGCCTGCTGGGCTCCATCGCGGTTGCGACGAAGCACGAGATCGTCCTGGCGATCG
TCGGCGGCCTGTTCGTGCTGGAGATGATGTCGGTGATCATCCAGGTCGCGTCGTTCAAGCTGACGGGCAAGCGCGTCTTC
CGCATGGCGCCGATCCACCACCATTTCGAGCAGAAGGGCTGGAAGGAGCCGCAGGTCGTGATCCGCTTCTGGATCATCGC
GGTGATCCTGGCGATGGCCGGTCTGGCGACGCTGAAGCTGCGCTGA

Upstream 100 bases:

>100_bases
ATCCGGCCCGGCGGACCCAGGCCGCCCCGTGACCGGCACGCCTGCGCGTTCGGCGCCGTCCCCCGAAACCTGAGCCTGAA
CAAGGGGGCCGAGCGCCCGG

Downstream 100 bases:

>100_bases
GAATCTGTGCTAGAGGGGCGACCTGAGAGGTCGATCCGACCCTCGCCCTCACCCTGAGGTGCGGCCGCGGAGCGCGGGCC
TCGAAGGAGGCTCCGGGCCG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MLYLLSDLSSSFTPLNVFRYITFRTGGALFTAGLFVFWFGPWIISLLRIRQGKGQPIREDGPQTHLLTKRGTPTMGGLMI
LAGAVVAILLWANPRNHYVWVTLTVTLGFGAIGFYDDYLKVTKQSHKGFSGKFRLALEAVIAMAACVTIAVYSPAALQNQ
LAFPVFKDALLNLGWFYPLFGAFVIVGAGNSVNMTDGLDGLAIVPVMIACGTFGFIAYLVGNSFTASYLQVNYVRDTGEL
AVVCGAVIGAGLGFLWFNAPPAQIFMGDTGSLALGGLLGSIAVATKHEIVLAIVGGLFVLEMMSVIIQVASFKLTGKRVF
RMAPIHHHFEQKGWKEPQVVIRFWIIAVILAMAGLATLKLR

Sequences:

>Translated_361_residues
MLYLLSDLSSSFTPLNVFRYITFRTGGALFTAGLFVFWFGPWIISLLRIRQGKGQPIREDGPQTHLLTKRGTPTMGGLMI
LAGAVVAILLWANPRNHYVWVTLTVTLGFGAIGFYDDYLKVTKQSHKGFSGKFRLALEAVIAMAACVTIAVYSPAALQNQ
LAFPVFKDALLNLGWFYPLFGAFVIVGAGNSVNMTDGLDGLAIVPVMIACGTFGFIAYLVGNSFTASYLQVNYVRDTGEL
AVVCGAVIGAGLGFLWFNAPPAQIFMGDTGSLALGGLLGSIAVATKHEIVLAIVGGLFVLEMMSVIIQVASFKLTGKRVF
RMAPIHHHFEQKGWKEPQVVIRFWIIAVILAMAGLATLKLR
>Mature_361_residues
MLYLLSDLSSSFTPLNVFRYITFRTGGALFTAGLFVFWFGPWIISLLRIRQGKGQPIREDGPQTHLLTKRGTPTMGGLMI
LAGAVVAILLWANPRNHYVWVTLTVTLGFGAIGFYDDYLKVTKQSHKGFSGKFRLALEAVIAMAACVTIAVYSPAALQNQ
LAFPVFKDALLNLGWFYPLFGAFVIVGAGNSVNMTDGLDGLAIVPVMIACGTFGFIAYLVGNSFTASYLQVNYVRDTGEL
AVVCGAVIGAGLGFLWFNAPPAQIFMGDTGSLALGGLLGSIAVATKHEIVLAIVGGLFVLEMMSVIIQVASFKLTGKRVF
RMAPIHHHFEQKGWKEPQVVIRFWIIAVILAMAGLATLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=361, Percent_Identity=51.8005540166205, Blast_Score=366, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_METRJ (B1LXZ8)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001755038.1
- GeneID:   6138392
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_2360
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- ProtClustDB:   PRK00108
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 39091; Mature: 39091

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x18a59f38)-; HASH(0x1a02357c)-; HASH(0x1913cf10)-; HASH(0x16e023cc)-; HASH(0x1617fef0)-; HASH(0x19cc18b0)-; HASH(0x18fb15a8)-; HASH(0x1a023618)-; HASH(0x162e945c)-; HASH(0x1946cfbc)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYLLSDLSSSFTPLNVFRYITFRTGGALFTAGLFVFWFGPWIISLLRIRQGKGQPIRED
CEEEEECCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GPQTHLLTKRGTPTMGGLMILAGAVVAILLWANPRNHYVWVTLTVTLGFGAIGFYDDYLK
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHH
VTKQSHKGFSGKFRLALEAVIAMAACVTIAVYSPAALQNQLAFPVFKDALLNLGWFYPLF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCHHHHHHH
GAFVIVGAGNSVNMTDGLDGLAIVPVMIACGTFGFIAYLVGNSFTASYLQVNYVRDTGEL
HHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCH
AVVCGAVIGAGLGFLWFNAPPAQIFMGDTGSLALGGLLGSIAVATKHEIVLAIVGGLFVL
HHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMMSVIIQVASFKLTGKRVFRMAPIHHHFEQKGWKEPQVVIRFWIIAVILAMAGLATLKL
HHHHHHHHHHHCEECCHHHHEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHEEC
R
H
>Mature Secondary Structure
MLYLLSDLSSSFTPLNVFRYITFRTGGALFTAGLFVFWFGPWIISLLRIRQGKGQPIRED
CEEEEECCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GPQTHLLTKRGTPTMGGLMILAGAVVAILLWANPRNHYVWVTLTVTLGFGAIGFYDDYLK
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHH
VTKQSHKGFSGKFRLALEAVIAMAACVTIAVYSPAALQNQLAFPVFKDALLNLGWFYPLF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCHHHHHHH
GAFVIVGAGNSVNMTDGLDGLAIVPVMIACGTFGFIAYLVGNSFTASYLQVNYVRDTGEL
HHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCH
AVVCGAVIGAGLGFLWFNAPPAQIFMGDTGSLALGGLLGSIAVATKHEIVLAIVGGLFVL
HHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMMSVIIQVASFKLTGKRVFRMAPIHHHFEQKGWKEPQVVIRFWIIAVILAMAGLATLKL
HHHHHHHHHHHCEECCHHHHEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHEEC
R
H

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA