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The map label for this gene is murC

Identifier: 170748773

GI number: 170748773

Start: 2491286

End: 2492692

Strand: Reverse

Name: murC

Synonym: Mrad2831_2355

Alternate gene names: 170748773

Gene position: 2492692-2491286 (Counterclockwise)

Preceding gene: 170748774

Following gene: 170748772

Centisome position: 41.01

GC content: 69.01

Gene sequence:

>1407_bases
ATGAAGCTGCCCGACAAGCTCGGCCCCATCCACTTCATCGGCATCGGCGGCATCGGCATGTCCGGCATCGCCGAGGTGAT
GCACAACCTCGGCTACACGGTGCAGGGCTCGGACGCGTCCGACAACGCCAATGTCCGCCGTCTCGCCGAGAAGGGCATGC
GCACCTTCGTGGGCCACGACGCCAAGAACGTCGAGGAGGCCGCCCTCGTCGTCGTCTCGACCGCGATCCGGCGCGACAAC
CCCGAGTTGCAGGCCGCCCGCGAGCGACGCCTGCCCGTGGTGCGACGGGCCGAGATGCTGGCCGAGCTGATGCGCTTCAA
GTCCTGCGTGGCGATCGCCGGCACGCACGGGAAGACCACGACCACGTCGCTCGTCGCCACCCTGCTCGACGCCGGCAACC
TCGACCCGACCGTGATCAACGGCGGCATCATCAACGCCTACGGCACCAACGCCCGCATGGGCGCGGGCGAGTGGATGGTG
GTGGAGGCCGACGAGTCCGACGGCACCTTCCTGAAGCTGCCGGCCGACGTCGCGATCGTCACCAACATCGACCCCGAGCA
CCTCGACCATTTCGGCTCGTTCGACGCGATCAAGGACGCGTTCCGGCGCTTCATCGACAACATCCCGTTCTACGGCTTCG
CGGTGATGTGCATCGACCACCCGGTGGTGCAGGATCTCGTCGGCCATATCGAGGACCGGCGGATCATCACCTACGGTGAG
AACCCGCAGGCCGATGTGCGCCTCATCGACGTGGACCTGCGCGGCGGCCAGAGCCGCTTCCGGGTGATGATCCGCGACCG
TCGCCCCGGCTACCGGATGGAGATGGAGGATCTCGTCCTGCCGATGCCCGGCAAGCACAACGCGCTCAACGCCACCGCGG
CGCTCGCCGTCGCGCACGAGCTCGGCGTGAAGCCGGACGCGATCCGCCAGGCACTCGCGGGCTTCGGCGGCGTGAAGCGG
CGCTTCACCCGCACCGGCGAGTGGAACGGCGCGACGATCTTCGACGATTACGGACACCACCCGGTGGAGATCAAGGCGGT
GCTCAAGGCCGCCCGTGCCTCGACCGAGCACGGCGTCATCGCGGTGGTGCAGCCGCACCGCTACACCCGGCTGCAGTCGC
TGTTCGACGATTTCTGCACCTGCTTCAACGATGCCGACACGGTCATCGTCGCGCCGGTCTACGCGGCCGGCGAGCAGCCG
ATCGAGGGTTTCGACCGCGACAGCCTCGTGGCCGGCCTGCGCTCCCGCGGCCATCGGGACGCCCGGGCCCTGGAGCGGCC
GGAGGAACTGGCCGGGATCATCGCGGACCTCGCCAAGCCCGGCGATTACGTGGTCTGCCTCGGCGCCGGCACGATCACGC
AGTGGGCCTACGCCCTGCCGGACGAACTCACCGCGCGGGGACGGTAG

Upstream 100 bases:

>100_bases
GCCGCCGAGCGGCTGGCCGAGGTCGTCGTCGAGACGGCCGCCCGCACCTGATCCTCAAGGGATTCCGCACCGGCGGTCCC
GCCACCAGACGGTTCGACCC

Downstream 100 bases:

>100_bases
GCGCGATGCGTGAGCCCGCCCCGGGAGGCGTCTCGGGTCGGCCACGCCGTCGGCCGTCCACACTGGGCTGCGCTCTGAGG
ATGAACCCGGCGGTGACTCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKLPDKLGPIHFIGIGGIGMSGIAEVMHNLGYTVQGSDASDNANVRRLAEKGMRTFVGHDAKNVEEAALVVVSTAIRRDN
PELQAARERRLPVVRRAEMLAELMRFKSCVAIAGTHGKTTTTSLVATLLDAGNLDPTVINGGIINAYGTNARMGAGEWMV
VEADESDGTFLKLPADVAIVTNIDPEHLDHFGSFDAIKDAFRRFIDNIPFYGFAVMCIDHPVVQDLVGHIEDRRIITYGE
NPQADVRLIDVDLRGGQSRFRVMIRDRRPGYRMEMEDLVLPMPGKHNALNATAALAVAHELGVKPDAIRQALAGFGGVKR
RFTRTGEWNGATIFDDYGHHPVEIKAVLKAARASTEHGVIAVVQPHRYTRLQSLFDDFCTCFNDADTVIVAPVYAAGEQP
IEGFDRDSLVAGLRSRGHRDARALERPEELAGIIADLAKPGDYVVCLGAGTITQWAYALPDELTARGR

Sequences:

>Translated_468_residues
MKLPDKLGPIHFIGIGGIGMSGIAEVMHNLGYTVQGSDASDNANVRRLAEKGMRTFVGHDAKNVEEAALVVVSTAIRRDN
PELQAARERRLPVVRRAEMLAELMRFKSCVAIAGTHGKTTTTSLVATLLDAGNLDPTVINGGIINAYGTNARMGAGEWMV
VEADESDGTFLKLPADVAIVTNIDPEHLDHFGSFDAIKDAFRRFIDNIPFYGFAVMCIDHPVVQDLVGHIEDRRIITYGE
NPQADVRLIDVDLRGGQSRFRVMIRDRRPGYRMEMEDLVLPMPGKHNALNATAALAVAHELGVKPDAIRQALAGFGGVKR
RFTRTGEWNGATIFDDYGHHPVEIKAVLKAARASTEHGVIAVVQPHRYTRLQSLFDDFCTCFNDADTVIVAPVYAAGEQP
IEGFDRDSLVAGLRSRGHRDARALERPEELAGIIADLAKPGDYVVCLGAGTITQWAYALPDELTARGR
>Mature_468_residues
MKLPDKLGPIHFIGIGGIGMSGIAEVMHNLGYTVQGSDASDNANVRRLAEKGMRTFVGHDAKNVEEAALVVVSTAIRRDN
PELQAARERRLPVVRRAEMLAELMRFKSCVAIAGTHGKTTTTSLVATLLDAGNLDPTVINGGIINAYGTNARMGAGEWMV
VEADESDGTFLKLPADVAIVTNIDPEHLDHFGSFDAIKDAFRRFIDNIPFYGFAVMCIDHPVVQDLVGHIEDRRIITYGE
NPQADVRLIDVDLRGGQSRFRVMIRDRRPGYRMEMEDLVLPMPGKHNALNATAALAVAHELGVKPDAIRQALAGFGGVKR
RFTRTGEWNGATIFDDYGHHPVEIKAVLKAARASTEHGVIAVVQPHRYTRLQSLFDDFCTCFNDADTVIVAPVYAAGEQP
IEGFDRDSLVAGLRSRGHRDARALERPEELAGIIADLAKPGDYVVCLGAGTITQWAYALPDELTARGR

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=45.9869848156182, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI1790680, Length=457, Percent_Identity=27.3522975929978, Blast_Score=162, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_METRJ (B1LXZ3)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001755033.1
- ProteinModelPortal:   B1LXZ3
- SMR:   B1LXZ3
- GeneID:   6138387
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_2355
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51083; Mature: 51083

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPDKLGPIHFIGIGGIGMSGIAEVMHNLGYTVQGSDASDNANVRRLAEKGMRTFVGHD
CCCCCHHCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCC
AKNVEEAALVVVSTAIRRDNPELQAARERRLPVVRRAEMLAELMRFKSCVAIAGTHGKTT
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCH
TTSLVATLLDAGNLDPTVINGGIINAYGTNARMGAGEWMVVEADESDGTFLKLPADVAIV
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHFGSFDAIKDAFRRFIDNIPFYGFAVMCIDHPVVQDLVGHIEDRRIITYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHCCCCEEEEECC
NPQADVRLIDVDLRGGQSRFRVMIRDRRPGYRMEMEDLVLPMPGKHNALNATAALAVAHE
CCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCHHHEEECCCCCCCCCHHHHHHHHHHH
LGVKPDAIRQALAGFGGVKRRFTRTGEWNGATIFDDYGHHPVEIKAVLKAARASTEHGVI
HCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEE
AVVQPHRYTRLQSLFDDFCTCFNDADTVIVAPVYAAGEQPIEGFDRDSLVAGLRSRGHRD
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCH
ARALERPEELAGIIADLAKPGDYVVCLGAGTITQWAYALPDELTARGR
HHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure
MKLPDKLGPIHFIGIGGIGMSGIAEVMHNLGYTVQGSDASDNANVRRLAEKGMRTFVGHD
CCCCCHHCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCC
AKNVEEAALVVVSTAIRRDNPELQAARERRLPVVRRAEMLAELMRFKSCVAIAGTHGKTT
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCH
TTSLVATLLDAGNLDPTVINGGIINAYGTNARMGAGEWMVVEADESDGTFLKLPADVAIV
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCEEEE
TNIDPEHLDHFGSFDAIKDAFRRFIDNIPFYGFAVMCIDHPVVQDLVGHIEDRRIITYGE
ECCCHHHHHHCCCHHHHHHHHHHHHHCCCHHHEEEEECCCHHHHHHHHHCCCCEEEEECC
NPQADVRLIDVDLRGGQSRFRVMIRDRRPGYRMEMEDLVLPMPGKHNALNATAALAVAHE
CCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCHHHEEECCCCCCCCCHHHHHHHHHHH
LGVKPDAIRQALAGFGGVKRRFTRTGEWNGATIFDDYGHHPVEIKAVLKAARASTEHGVI
HCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCEE
AVVQPHRYTRLQSLFDDFCTCFNDADTVIVAPVYAAGEQPIEGFDRDSLVAGLRSRGHRD
EEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCH
ARALERPEELAGIIADLAKPGDYVVCLGAGTITQWAYALPDELTARGR
HHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA