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The map label for this gene is argD [H]

Identifier: 170748736

GI number: 170748736

Start: 2455104

End: 2456294

Strand: Reverse

Name: argD [H]

Synonym: Mrad2831_2318

Alternate gene names: 170748736

Gene position: 2456294-2455104 (Counterclockwise)

Preceding gene: 170748744

Following gene: 170748735

Centisome position: 40.41

GC content: 73.47

Gene sequence:

>1191_bases
GTGACGTCAGCCCTTCTGCCGACCTACGTCCGCGCGCCGCTCGCCTTCGAGCGCGGCGAGGGCGCCTGGCTCGTGACGGA
GGGCGGGGAGCGATACCTCGACTTCGGCGCCGGCATCGCGGTGAACGGCCTCGGCCACGCGCACCCGCACCTCGTCGGCG
CGCTGACCGAGCAGGCGAGCAAGATCTGGCACACCTCGAACCTGTTCCAGATTCCGGGCGGCGAGCGCCTCGGGCAACGC
CTCGTCGACGCGACCTTCGCGGACGTGGTGTTCTTCTGCAACTCGGGCGCGGAGGCGAACGAGGCGGCGATCAAGATCGC
CCGCAAGTACCACGCGGCCGGTGGGCAGCCGGAGCGCTACCGGATCGTCACCTTCGCGGGCGCCTTCCACGGGCGGACGC
TGGCGACGCTCGCGGCCGGCGGCCAGCAGAAGTACATCGAGGGCTTCGGTCCGAAGGTCGAGGGCTTCGACCAGGTCCCG
GCCGGCGACTGGGCGGCGCTCGAGGCGGCGATCGGGCCGGAGACGGCGGCGCTGATGATCGAGCCGATCCAGGGCGAGGG
CGGCGTTCGGGAGATCCCCCACGCGGACCTGCGCCGGCTGCGCGAGATCTGCGACGCCAACGGCCTCCTGCTGATCATGG
ACGAGGTCCAGACCGGCGTCGGCCGCACGGGCCGGCTGTTCGCGCACGAATGGTCCGGCATCACCCCGGACATCATGAGC
GTCGCCAAGGGCATCGGCGGCGGCTTCCCGCTCGGCGCCTGCCTCGCGACCCGCGAGGCCGCCCGCGGCATGACCGCCGG
CACGCACGGGACCACCTTCGGCGGCAACCCGCTCGCCATGGCGGTGGGCAACGCCGTGCTGGACGTGGTGCTGGAGGAGG
GCTTCCTCGCGCGCGTCGCCCGGTCCGGCCTGCTGCTCAAGCAGAAGCTCGCGGCCCTGCGCGACCGCCACCCGCACGTC
ATCCAGGAGATCCGCGGCGAGGGGCTGATGCTCGGCCTCAAGCTCGGCGTGCCGAACACCGACTTCGCCGCCGCCGCGCG
GGACGCCCACCTGCTGGTCATCCCGGCGGGCGACAACATCGTCCGCCTGCTGCCGCCGCTGACCATCGGCGAGGCCGAGA
TCGACGAGGCGGTCCGCCGCCTGGACGCGGCGGCGTCCGGCTTCGAGGCCGTGCGCGGCGCGGCCGAGTAG

Upstream 100 bases:

>100_bases
ATAGTAATCGCGCGCGTGCCGCCCAGGACTGAGGCGGCACTTTCATTTGGAGCCGGTTAACGCTCGCTCCGGGATCCTGC
GTGAAACGGAGATGGGACCC

Downstream 100 bases:

>100_bases
GATCGATCCGCGCGATTGAGAACACCGCCCCCCGGATCCCGGAGGGCGGCCCGAAGCATTTCCGGGCGCGGTCGATCCCG
CCGCGCGTGACGGAGATGCC

Product: acetylornithine and succinylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTSALLPTYVRAPLAFERGEGAWLVTEGGERYLDFGAGIAVNGLGHAHPHLVGALTEQASKIWHTSNLFQIPGGERLGQR
LVDATFADVVFFCNSGAEANEAAIKIARKYHAAGGQPERYRIVTFAGAFHGRTLATLAAGGQQKYIEGFGPKVEGFDQVP
AGDWAALEAAIGPETAALMIEPIQGEGGVREIPHADLRRLREICDANGLLLIMDEVQTGVGRTGRLFAHEWSGITPDIMS
VAKGIGGGFPLGACLATREAARGMTAGTHGTTFGGNPLAMAVGNAVLDVVLEEGFLARVARSGLLLKQKLAALRDRHPHV
IQEIRGEGLMLGLKLGVPNTDFAAAARDAHLLVIPAGDNIVRLLPPLTIGEAEIDEAVRRLDAAASGFEAVRGAAE

Sequences:

>Translated_396_residues
MTSALLPTYVRAPLAFERGEGAWLVTEGGERYLDFGAGIAVNGLGHAHPHLVGALTEQASKIWHTSNLFQIPGGERLGQR
LVDATFADVVFFCNSGAEANEAAIKIARKYHAAGGQPERYRIVTFAGAFHGRTLATLAAGGQQKYIEGFGPKVEGFDQVP
AGDWAALEAAIGPETAALMIEPIQGEGGVREIPHADLRRLREICDANGLLLIMDEVQTGVGRTGRLFAHEWSGITPDIMS
VAKGIGGGFPLGACLATREAARGMTAGTHGTTFGGNPLAMAVGNAVLDVVLEEGFLARVARSGLLLKQKLAALRDRHPHV
IQEIRGEGLMLGLKLGVPNTDFAAAARDAHLLVIPAGDNIVRLLPPLTIGEAEIDEAVRRLDAAASGFEAVRGAAE
>Mature_395_residues
TSALLPTYVRAPLAFERGEGAWLVTEGGERYLDFGAGIAVNGLGHAHPHLVGALTEQASKIWHTSNLFQIPGGERLGQRL
VDATFADVVFFCNSGAEANEAAIKIARKYHAAGGQPERYRIVTFAGAFHGRTLATLAAGGQQKYIEGFGPKVEGFDQVPA
GDWAALEAAIGPETAALMIEPIQGEGGVREIPHADLRRLREICDANGLLLIMDEVQTGVGRTGRLFAHEWSGITPDIMSV
AKGIGGGFPLGACLATREAARGMTAGTHGTTFGGNPLAMAVGNAVLDVVLEEGFLARVARSGLLLKQKLAALRDRHPHVI
QEIRGEGLMLGLKLGVPNTDFAAAARDAHLLVIPAGDNIVRLLPPLTIGEAEIDEAVRRLDAAASGFEAVRGAAE

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=390, Percent_Identity=35.3846153846154, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=30.0904977375566, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI284507298, Length=304, Percent_Identity=37.171052631579, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI37574042, Length=432, Percent_Identity=27.3148148148148, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24119277, Length=418, Percent_Identity=28.4688995215311, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI226442705, Length=432, Percent_Identity=26.6203703703704, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=27.455919395466, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI188536080, Length=422, Percent_Identity=24.6445497630332, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI38679950, Length=422, Percent_Identity=24.6445497630332, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI38679946, Length=422, Percent_Identity=24.6445497630332, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=47.0588235294118, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1789759, Length=385, Percent_Identity=43.8961038961039, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI145693181, Length=390, Percent_Identity=35.6410256410256, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=35.678391959799, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=34.4059405940594, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1786991, Length=416, Percent_Identity=33.4134615384615, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786349, Length=301, Percent_Identity=31.2292358803987, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=393, Percent_Identity=34.0966921119593, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=33.3333333333333, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI25144274, Length=275, Percent_Identity=34.5454545454545, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI71992977, Length=422, Percent_Identity=27.9620853080569, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=457, Percent_Identity=25.8205689277899, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=34.1614906832298, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=401, Percent_Identity=40.1496259351621, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6323470, Length=401, Percent_Identity=32.6683291770574, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321456, Length=429, Percent_Identity=27.7389277389277, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324386, Length=303, Percent_Identity=26.4026402640264, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357415, Length=383, Percent_Identity=35.509138381201, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI161085790, Length=439, Percent_Identity=32.5740318906606, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI28574759, Length=441, Percent_Identity=33.1065759637188, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21356575, Length=414, Percent_Identity=30.4347826086957, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281366494, Length=380, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667139, Length=380, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667143, Length=380, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 41676; Mature: 41545

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSALLPTYVRAPLAFERGEGAWLVTEGGERYLDFGAGIAVNGLGHAHPHLVGALTEQAS
CCCCCCCHHHHCCCEEECCCCEEEEECCCCEEEECCCCEEECCCCCCCHHHHHHHHHHHH
KIWHTSNLFQIPGGERLGQRLVDATFADVVFFCNSGAEANEAAIKIARKYHAAGGQPERY
HHHCCCCEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCEE
RIVTFAGAFHGRTLATLAAGGQQKYIEGFGPKVEGFDQVPAGDWAALEAAIGPETAALMI
EEEEEECCCCCCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEE
EPIQGEGGVREIPHADLRRLREICDANGLLLIMDEVQTGVGRTGRLFAHEWSGITPDIMS
EEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCEEEECCCCCCHHHHH
VAKGIGGGFPLGACLATREAARGMTAGTHGTTFGGNPLAMAVGNAVLDVVLEEGFLARVA
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RSGLLLKQKLAALRDRHPHVIQEIRGEGLMLGLKLGVPNTDFAAAARDAHLLVIPAGDNI
HCCHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHCCCCEEEEEECCCCE
VRLLPPLTIGEAEIDEAVRRLDAAASGFEAVRGAAE
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSALLPTYVRAPLAFERGEGAWLVTEGGERYLDFGAGIAVNGLGHAHPHLVGALTEQAS
CCCCCCHHHHCCCEEECCCCEEEEECCCCEEEECCCCEEECCCCCCCHHHHHHHHHHHH
KIWHTSNLFQIPGGERLGQRLVDATFADVVFFCNSGAEANEAAIKIARKYHAAGGQPERY
HHHCCCCEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCEE
RIVTFAGAFHGRTLATLAAGGQQKYIEGFGPKVEGFDQVPAGDWAALEAAIGPETAALMI
EEEEEECCCCCCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEE
EPIQGEGGVREIPHADLRRLREICDANGLLLIMDEVQTGVGRTGRLFAHEWSGITPDIMS
EEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCEEEECCCCCCHHHHH
VAKGIGGGFPLGACLATREAARGMTAGTHGTTFGGNPLAMAVGNAVLDVVLEEGFLARVA
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RSGLLLKQKLAALRDRHPHVIQEIRGEGLMLGLKLGVPNTDFAAAARDAHLLVIPAGDNI
HCCHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHCCCCEEEEEECCCCE
VRLLPPLTIGEAEIDEAVRRLDAAASGFEAVRGAAE
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]