| Definition | Methylobacterium radiotolerans JCM 2831 chromosome, complete genome. |
|---|---|
| Accession | NC_010505 |
| Length | 6,077,833 |
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The map label for this gene is slt [H]
Identifier: 170748307
GI number: 170748307
Start: 2014992
End: 2017358
Strand: Reverse
Name: slt [H]
Synonym: Mrad2831_1889
Alternate gene names: 170748307
Gene position: 2017358-2014992 (Counterclockwise)
Preceding gene: 170748311
Following gene: 170748306
Centisome position: 33.19
GC content: 76.09
Gene sequence:
>2367_bases GTGATCCGACCCGCGGCCTCGTCTCCGGCCTCGAAGCGCACGTCCCTCACCGCCGCCGCGCTCGTCGCCACCGTCGGCGT CGCGCTGGCCGGTCAGGTCGGCACGGACGCGCCGACCGCGGCGGCCCTGGCGGCGCCCGCGTCGCAGCCGAGCTCGCAGC CCGCCTCGCAGCCGACCCCGCCGGCGAGCGACGCCGCCCTCTCGACCGCCCAGGTCCGGGGCGCCCAGGCCGCGAAGGCC GCCGACCCGGTCGCGGCCGACGCCCTGAAGCTCGACCCGGTCCACGCCTCCGGCGGCGACGACAAGGGCGAGGAGCCCGC CCGGACGCTGCCCGCCGCGGCCTCGGCCTACGCCTCCGCCGACCCCGACGCCCCGGTGGCCTTCCCGCTGCCCGACGCCG CCGTCACCCCGGCGGCCCCGGTGCCCGAGGTGCCGGACCCGGCGCGGCCCAAGATCTCCGGCGACACCGACCCGACGCTG CTGCGCGGCGCCATCGACCTCTACCGCAAGGGCCGGGTCGCCGACGGCGACCGGATGCGCGACGGCTTCACCGACCCGGC CGCGCGGGCGCTGCTCGAATGGGTGGCGATCCGCGCGGGCGCCGGGATCGGCTTCAACCGCACCGTCGCGTTCGTCCGGG CCAACCCGGACTGGCCGGCGGGCCCGCTGCTGCGCCGCCGGGCCGAGGAGGCGCTGCTCTCCGAGCGGAAATCCCCCGCG GTCGTCCGGGCCTACTTCGCCACGGCGAAGCCGTCGAGCGCGCCGGGCAAGTTCGCCCTGGCGCTGGCCCTGCGCGCCGA CGGCTGCGAGGCCGACGCCGCCGAGATGGTCCGCGACCTCTGGCGCACCGAGAGCTTCGGCCGCAGCCTCGAGGCCAAGG TGCTCGACGCCTTCCCGGACGCGCTGACCCGTGTCGACCACCGCTACCGGATGGAGCGGGCGCTCCTGAAGGACGACTGG GAGAGCGCCGGCCGGGCGGCCGGCTACGCGGGCGGCGGCTACGCCAGCCTCGTGCGCGCCCGCCGGGCCGTGGAGGACAA GTCCTCCGGCGCCGCGGCCGCGCTCGCCGCCGTGCCGCCGTCGCTGCGCGGGGACGCCTCCTACATCTTCTCCCGGGCGC AGTATCTCCGCCGGGCCGACAAGCCCGAGGCCGCCGCCGCCGTGCTCGCCACGGCGCCGAGCAACCCGGACGTGCTGGTC GACGGCGACGAGTGGTGGATCGAGCGCCGGATCGTGGCGCGCAAGCTCCTCGACCTCGGCGATGCCAAGACCGCCTACGC GGTGGCGAGCCAGCCGGCGGCGCGCTCGCCCGAGAAGCGCATCGAGGCCGAGTTCCACGCCGGCTGGATCGCGCTCCGCT TCGCCGGCGATCCCGCCGCCGCCGCGCAGCATTTCGCGCAGGTGGCGGCGATCGCCGAGAGCCCGATCTCGGTGGCGCGG GCCGCCTACTGGCAGGGACGGGCGGCCGAGGCGCTCGGCCAGTCGGAGGAGGCGAAGCGCTTCTACGAGCGCGCCGCCCT GCAGCCGATCGCCTATTACGGCCAGGTGGCCCGGGCCCGGCTCGGCCAGACCAGCCTGCCCCTGCGGGCGCCGGCCGACC TCGAGGGCGCGGAGCGCCAGGCCTTCGACGGGCGGCTCTCCATCCGCGCCCTGCGCCTGCTCGGCGAGGCCGGGATCAAG GAGCTGGCCCTCCCGCTCTACATCGACGCCGCCCGGGACCTCTCGGACCCGCGCGAGCTCCAGGCGCTCGGCGACCTCGC CACCGACATGAAGGACGCCCGCGCCCTGGTGGCGATCGGCAAGCTCGCGGTCCAGCGCGGCCTGCCGCTCGACGCCCACG CCTACCCGACGATCGGCATTCCCAGCTACGAGACCTTCACGGCGGTGCCGCAGGTCGAGCGGGCCATGGTCTACGCCATC GCCCGCCAGGAGAGCCAGTTCGACCCGCGGGCGCAGTCGGGCGTCGGCGCCCGGGGGCTGATGCAGATGATGCCGGCCAC CGCCCAGCGCACCGCCCGCCGGGTCTCGACGGCGTTCGACGTCGACCGGCTGACCAGCGACCCCGCCTACTGCGCCAAGC TCGGCCAGGCCCATCTCGGCGAGCTGATGGAGGATTGGCGCGGCTCCTACGTGCTCGCCTTCGCGTCCTACAACGCGGGC GGCGGCAACGTGAAGAAGTGGATCGACGCCTACGGCGACCCGCGCAAGGGCGACGTCGACGTGATCGACTGGGTGGAGCG CATCCCGTTCACGGAGACGCGCAACTACGTGCAGCGGGTCATGGAGAACCTGCAGGTCTACCGCTCGCGGCTCGACAGCC GCAGCGCCCTGCTGATCGAGGGCGACCTCCACCGCGGCGCGCGGTAG
Upstream 100 bases:
>100_bases TCACGGCGCGCAAACAGATCGTGGCGACGGTTAACGCGATCTTAATGGTCACAGCCCGATCCTCGACCTTTCCCGCTCCG GTGATCAGTAGGGGGGAATC
Downstream 100 bases:
>100_bases GTCCTGGGCACGAGGCGCCGGCCCCTCGCGCGCGCGGCAGAGGTGGCGCGCGCGGCAGCGGCGGCGCGACAGAGGGCGCG CGGGGAGCCTCGCGGCGCGC
Product: lytic transglycosylase
Products: 1,6-Anhydrobond [C]
Alternate protein names: Exomuramidase; Peptidoglycan lytic exotransglycosylase; Slt70 [H]
Number of amino acids: Translated: 788; Mature: 788
Protein sequence:
>788_residues MIRPAASSPASKRTSLTAAALVATVGVALAGQVGTDAPTAAALAAPASQPSSQPASQPTPPASDAALSTAQVRGAQAAKA ADPVAADALKLDPVHASGGDDKGEEPARTLPAAASAYASADPDAPVAFPLPDAAVTPAAPVPEVPDPARPKISGDTDPTL LRGAIDLYRKGRVADGDRMRDGFTDPAARALLEWVAIRAGAGIGFNRTVAFVRANPDWPAGPLLRRRAEEALLSERKSPA VVRAYFATAKPSSAPGKFALALALRADGCEADAAEMVRDLWRTESFGRSLEAKVLDAFPDALTRVDHRYRMERALLKDDW ESAGRAAGYAGGGYASLVRARRAVEDKSSGAAAALAAVPPSLRGDASYIFSRAQYLRRADKPEAAAAVLATAPSNPDVLV DGDEWWIERRIVARKLLDLGDAKTAYAVASQPAARSPEKRIEAEFHAGWIALRFAGDPAAAAQHFAQVAAIAESPISVAR AAYWQGRAAEALGQSEEAKRFYERAALQPIAYYGQVARARLGQTSLPLRAPADLEGAERQAFDGRLSIRALRLLGEAGIK ELALPLYIDAARDLSDPRELQALGDLATDMKDARALVAIGKLAVQRGLPLDAHAYPTIGIPSYETFTAVPQVERAMVYAI ARQESQFDPRAQSGVGARGLMQMMPATAQRTARRVSTAFDVDRLTSDPAYCAKLGQAHLGELMEDWRGSYVLAFASYNAG GGNVKKWIDAYGDPRKGDVDVIDWVERIPFTETRNYVQRVMENLQVYRSRLDSRSALLIEGDLHRGAR
Sequences:
>Translated_788_residues MIRPAASSPASKRTSLTAAALVATVGVALAGQVGTDAPTAAALAAPASQPSSQPASQPTPPASDAALSTAQVRGAQAAKA ADPVAADALKLDPVHASGGDDKGEEPARTLPAAASAYASADPDAPVAFPLPDAAVTPAAPVPEVPDPARPKISGDTDPTL LRGAIDLYRKGRVADGDRMRDGFTDPAARALLEWVAIRAGAGIGFNRTVAFVRANPDWPAGPLLRRRAEEALLSERKSPA VVRAYFATAKPSSAPGKFALALALRADGCEADAAEMVRDLWRTESFGRSLEAKVLDAFPDALTRVDHRYRMERALLKDDW ESAGRAAGYAGGGYASLVRARRAVEDKSSGAAAALAAVPPSLRGDASYIFSRAQYLRRADKPEAAAAVLATAPSNPDVLV DGDEWWIERRIVARKLLDLGDAKTAYAVASQPAARSPEKRIEAEFHAGWIALRFAGDPAAAAQHFAQVAAIAESPISVAR AAYWQGRAAEALGQSEEAKRFYERAALQPIAYYGQVARARLGQTSLPLRAPADLEGAERQAFDGRLSIRALRLLGEAGIK ELALPLYIDAARDLSDPRELQALGDLATDMKDARALVAIGKLAVQRGLPLDAHAYPTIGIPSYETFTAVPQVERAMVYAI ARQESQFDPRAQSGVGARGLMQMMPATAQRTARRVSTAFDVDRLTSDPAYCAKLGQAHLGELMEDWRGSYVLAFASYNAG GGNVKKWIDAYGDPRKGDVDVIDWVERIPFTETRNYVQRVMENLQVYRSRLDSRSALLIEGDLHRGAR >Mature_788_residues MIRPAASSPASKRTSLTAAALVATVGVALAGQVGTDAPTAAALAAPASQPSSQPASQPTPPASDAALSTAQVRGAQAAKA ADPVAADALKLDPVHASGGDDKGEEPARTLPAAASAYASADPDAPVAFPLPDAAVTPAAPVPEVPDPARPKISGDTDPTL LRGAIDLYRKGRVADGDRMRDGFTDPAARALLEWVAIRAGAGIGFNRTVAFVRANPDWPAGPLLRRRAEEALLSERKSPA VVRAYFATAKPSSAPGKFALALALRADGCEADAAEMVRDLWRTESFGRSLEAKVLDAFPDALTRVDHRYRMERALLKDDW ESAGRAAGYAGGGYASLVRARRAVEDKSSGAAAALAAVPPSLRGDASYIFSRAQYLRRADKPEAAAAVLATAPSNPDVLV DGDEWWIERRIVARKLLDLGDAKTAYAVASQPAARSPEKRIEAEFHAGWIALRFAGDPAAAAQHFAQVAAIAESPISVAR AAYWQGRAAEALGQSEEAKRFYERAALQPIAYYGQVARARLGQTSLPLRAPADLEGAERQAFDGRLSIRALRLLGEAGIK ELALPLYIDAARDLSDPRELQALGDLATDMKDARALVAIGKLAVQRGLPLDAHAYPTIGIPSYETFTAVPQVERAMVYAI ARQESQFDPRAQSGVGARGLMQMMPATAQRTARRVSTAFDVDRLTSDPAYCAKLGQAHLGELMEDWRGSYVLAFASYNAG GGNVKKWIDAYGDPRKGDVDVIDWVERIPFTETRNYVQRVMENLQVYRSRLDSRSALLIEGDLHRGAR
Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]
COG id: COG0741
COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)
Gene ontology:
Cell location: Periplasm. Note=Tightly associated with the murein sacculus (By similarity) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transglycosylase slt family [H]
Homologues:
Organism=Escherichia coli, GI87082441, Length=305, Percent_Identity=28.1967213114754, Blast_Score=94, Evalue=5e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016026 - InterPro: IPR008258 - InterPro: IPR012289 - InterPro: IPR008939 - InterPro: IPR000189 [H]
Pfam domain/function: PF01464 SLT [H]
EC number: 3.2.1.- [C]
Molecular weight: Translated: 83828; Mature: 83828
Theoretical pI: Translated: 8.48; Mature: 8.48
Prosite motif: PS00922 TRANSGLYCOSYLASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 1.6 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 1.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIRPAASSPASKRTSLTAAALVATVGVALAGQVGTDAPTAAALAAPASQPSSQPASQPTP CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCC PASDAALSTAQVRGAQAAKAADPVAADALKLDPVHASGGDDKGEEPARTLPAAASAYASA CCCHHHHHHHHHCCHHHHHHCCCHHHHHEEECCCCCCCCCCCCCCHHHHCCHHHHHHCCC DPDAPVAFPLPDAAVTPAAPVPEVPDPARPKISGDTDPTLLRGAIDLYRKGRVADGDRMR CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHH DGFTDPAARALLEWVAIRAGAGIGFNRTVAFVRANPDWPAGPLLRRRAEEALLSERKSPA CCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCH VVRAYFATAKPSSAPGKFALALALRADGCEADAAEMVRDLWRTESFGRSLEAKVLDAFPD HEEHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH ALTRVDHRYRMERALLKDDWESAGRAAGYAGGGYASLVRARRAVEDKSSGAAAALAAVPP HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCC SLRGDASYIFSRAQYLRRADKPEAAAAVLATAPSNPDVLVDGDEWWIERRIVARKLLDLG CCCCCHHHHHHHHHHHHHCCCCHHHHEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCC DAKTAYAVASQPAARSPEKRIEAEFHAGWIALRFAGDPAAAAQHFAQVAAIAESPISVAR CCCHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHHHH AAYWQGRAAEALGQSEEAKRFYERAALQPIAYYGQVARARLGQTSLPLRAPADLEGAERQ HHHHCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH AFDGRLSIRALRLLGEAGIKELALPLYIDAARDLSDPRELQALGDLATDMKDARALVAIG HCCCHHHHHHHHHHHHHCHHHHHHHHEEECHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH KLAVQRGLPLDAHAYPTIGIPSYETFTAVPQVERAMVYAIARQESQFDPRAQSGVGARGL HHHHHCCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHH MQMMPATAQRTARRVSTAFDVDRLTSDPAYCAKLGQAHLGELMEDWRGSYVLAFASYNAG HHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC GGNVKKWIDAYGDPRKGDVDVIDWVERIPFTETRNYVQRVMENLQVYRSRLDSRSALLIE CCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE GDLHRGAR CCCCCCCC >Mature Secondary Structure MIRPAASSPASKRTSLTAAALVATVGVALAGQVGTDAPTAAALAAPASQPSSQPASQPTP CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCC PASDAALSTAQVRGAQAAKAADPVAADALKLDPVHASGGDDKGEEPARTLPAAASAYASA CCCHHHHHHHHHCCHHHHHHCCCHHHHHEEECCCCCCCCCCCCCCHHHHCCHHHHHHCCC DPDAPVAFPLPDAAVTPAAPVPEVPDPARPKISGDTDPTLLRGAIDLYRKGRVADGDRMR CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHH DGFTDPAARALLEWVAIRAGAGIGFNRTVAFVRANPDWPAGPLLRRRAEEALLSERKSPA CCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCH VVRAYFATAKPSSAPGKFALALALRADGCEADAAEMVRDLWRTESFGRSLEAKVLDAFPD HEEHHHHHCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH ALTRVDHRYRMERALLKDDWESAGRAAGYAGGGYASLVRARRAVEDKSSGAAAALAAVPP HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCC SLRGDASYIFSRAQYLRRADKPEAAAAVLATAPSNPDVLVDGDEWWIERRIVARKLLDLG CCCCCHHHHHHHHHHHHHCCCCHHHHEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCC DAKTAYAVASQPAARSPEKRIEAEFHAGWIALRFAGDPAAAAQHFAQVAAIAESPISVAR CCCHHHHHHCCCCCCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHHHH AAYWQGRAAEALGQSEEAKRFYERAALQPIAYYGQVARARLGQTSLPLRAPADLEGAERQ HHHHCCHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH AFDGRLSIRALRLLGEAGIKELALPLYIDAARDLSDPRELQALGDLATDMKDARALVAIG HCCCHHHHHHHHHHHHHCHHHHHHHHEEECHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH KLAVQRGLPLDAHAYPTIGIPSYETFTAVPQVERAMVYAIARQESQFDPRAQSGVGARGL HHHHHCCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHH MQMMPATAQRTARRVSTAFDVDRLTSDPAYCAKLGQAHLGELMEDWRGSYVLAFASYNAG HHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC GGNVKKWIDAYGDPRKGDVDVIDWVERIPFTETRNYVQRVMENLQVYRSRLDSRSALLIE CCHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE GDLHRGAR CCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]
Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]
General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]