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The map label for this gene is cat [H]

Identifier: 170747993

GI number: 170747993

Start: 1662054

End: 1662773

Strand: Reverse

Name: cat [H]

Synonym: Mrad2831_1575

Alternate gene names: 170747993

Gene position: 1662773-1662054 (Counterclockwise)

Preceding gene: 170747994

Following gene: 170747985

Centisome position: 27.36

GC content: 67.08

Gene sequence:

>720_bases
ATGATCTCCGTCAACGAGGACATGAAGCAGGAGATGCTGCGGCGCGGCATCTCGGTGCTGCACCCGGCCCCGTTCGGCCT
GCCGGAGGATTGCGTCTTCGAGCCGCCGTGCAGCATCAAGTGGATGGGCGTCGATTACTGCCTCACCATGGGGGCGTTCT
CGTACGCGGTGAGCGGCTACTATTTCGGCGCCGACATCGCCCGCTACTGCTCGATCGGCGAGAGCGTCCAGGTCGGGCGC
GGCAGCCACCCGGTCCAGTGCGGCTCGACCTCGCCGCTGTTCTACACGCACCACTCGGCCGTGTTCGACCGCCTCGACCC
GCGGGCGGAGGATTACGAGATCTGCGGACCGTATCTCTGGCCCAAGCGCGTGCGCATCGGCAACGACGTCTATATCGGCC
ACGGCGCCTTCCTGATGCCCGACATCACGATCGGCGACGGGGCGGTGATCGGCGCCATGGCGGTGGTGACCAAGGACGTG
CCGCCCTACGCGATCGTGGCCGGCAGCCCCGCCCGGATCGTGAAGATGCGCTTCCCCGACGCGCTGATCGAGCGCTACCT
GAAGGTGCAATGGTGGCGCTACGCCTTCTGGGACCTGCGCCAGTGCTCGATCACCGACCCGGAGAAGTTCATCGACGCCG
TCGAGGAGCGGATCGCCGGGGGCATGCAGGAATACCGCCCGGAGCGGATCCCGATCCAGTCGCTGATACCGGGCGCCTGA

Upstream 100 bases:

>100_bases
TGCCGATCCGGGCCGCCACCTACGGGGACCTGAGGCGCGACTATTACGGCCTGGACCCGGCGCCGGCCGGAACCCGACAC
CCCATCGACGAGGACGCCGC

Downstream 100 bases:

>100_bases
GGCCCGGGGCCCGCCGGAACGCGCCGCGGCGGGCGTCCGGGGCGGCGCGCTCAGCCCGCCAGCACCCGCACCGCCGCGTC
GCCGAGGGCCCGCACCCCGA

Product: hexapaptide repeat-containing transferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MISVNEDMKQEMLRRGISVLHPAPFGLPEDCVFEPPCSIKWMGVDYCLTMGAFSYAVSGYYFGADIARYCSIGESVQVGR
GSHPVQCGSTSPLFYTHHSAVFDRLDPRAEDYEICGPYLWPKRVRIGNDVYIGHGAFLMPDITIGDGAVIGAMAVVTKDV
PPYAIVAGSPARIVKMRFPDALIERYLKVQWWRYAFWDLRQCSITDPEKFIDAVEERIAGGMQEYRPERIPIQSLIPGA

Sequences:

>Translated_239_residues
MISVNEDMKQEMLRRGISVLHPAPFGLPEDCVFEPPCSIKWMGVDYCLTMGAFSYAVSGYYFGADIARYCSIGESVQVGR
GSHPVQCGSTSPLFYTHHSAVFDRLDPRAEDYEICGPYLWPKRVRIGNDVYIGHGAFLMPDITIGDGAVIGAMAVVTKDV
PPYAIVAGSPARIVKMRFPDALIERYLKVQWWRYAFWDLRQCSITDPEKFIDAVEERIAGGMQEYRPERIPIQSLIPGA
>Mature_239_residues
MISVNEDMKQEMLRRGISVLHPAPFGLPEDCVFEPPCSIKWMGVDYCLTMGAFSYAVSGYYFGADIARYCSIGESVQVGR
GSHPVQCGSTSPLFYTHHSAVFDRLDPRAEDYEICGPYLWPKRVRIGNDVYIGHGAFLMPDITIGDGAVIGAMAVVTKDV
PPYAIVAGSPARIVKMRFPDALIERYLKVQWWRYAFWDLRQCSITDPEKFIDAVEERIAGGMQEYRPERIPIQSLIPGA

Specific function: This enzyme is an effector of chloramphenicol resistance in bacteria [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786664, Length=54, Percent_Identity=55.5555555555556, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.28 [H]

Molecular weight: Translated: 26781; Mature: 26781

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVNEDMKQEMLRRGISVLHPAPFGLPEDCVFEPPCSIKWMGVDYCLTMGAFSYAVSGY
CCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCEECCCCCEEEECHHHHHHHHHHHHHHHCE
YFGADIARYCSIGESVQVGRGSHPVQCGSTSPLFYTHHSAVFDRLDPRAEDYEICGPYLW
EEHHHHHHHHCCCCCEECCCCCCCEECCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCC
PKRVRIGNDVYIGHGAFLMPDITIGDGAVIGAMAVVTKDVPPYAIVAGSPARIVKMRFPD
CCEEEECCEEEECCCCEEECCEEECCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCH
ALIERYLKVQWWRYAFWDLRQCSITDPEKFIDAVEERIAGGMQEYRPERIPIQSLIPGA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHCCCCC
>Mature Secondary Structure
MISVNEDMKQEMLRRGISVLHPAPFGLPEDCVFEPPCSIKWMGVDYCLTMGAFSYAVSGY
CCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCEECCCCCEEEECHHHHHHHHHHHHHHHCE
YFGADIARYCSIGESVQVGRGSHPVQCGSTSPLFYTHHSAVFDRLDPRAEDYEICGPYLW
EEHHHHHHHHCCCCCEECCCCCCCEECCCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCC
PKRVRIGNDVYIGHGAFLMPDITIGDGAVIGAMAVVTKDVPPYAIVAGSPARIVKMRFPD
CCEEEECCEEEECCCCEEECCEEECCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCH
ALIERYLKVQWWRYAFWDLRQCSITDPEKFIDAVEERIAGGMQEYRPERIPIQSLIPGA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2013403; 11743193; 11743194 [H]