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The map label for this gene is ykgC [H]

Identifier: 170747695

GI number: 170747695

Start: 1332534

End: 1333916

Strand: Reverse

Name: ykgC [H]

Synonym: Mrad2831_1270

Alternate gene names: 170747695

Gene position: 1333916-1332534 (Counterclockwise)

Preceding gene: 170747700

Following gene: 170747693

Centisome position: 21.95

GC content: 73.68

Gene sequence:

>1383_bases
ATGGACGACCACTACGATGCGCTCGTGATCGGCAGCGGCGAGGGTGGCAAGTTCCTGGCCTGGCACCTGGCCAAGGCCGG
GCAGCGGGTCGCGGTGGTCGAGCGCCGCTGGATCGGGGGCTCCTGCCCCAACACCAACTGCCTGCCGAGCAAGAACGAGA
TCTGGAGCGCCGAGATCGCCCATCTCGCCCGGCACGCCGACCGGTACGGCATCGAGACCGGCCCGGTCGCGGTGGACATG
GCCCGGGTGGTCGAGCGCAAGCGGGCGATGGTCCGCGGCCTCGTCGACATGCACCTCGACCGCTACCGCGACAGCGGCGC
GGAGCTCATCATGGGAACGGCCGCCTTCACGGGGCCCAGGGCGCTCACGGTCGCGCTGAACGCGGGCGGGTCCCGCGCGC
TGACGGCCGAGCGGATCTTCCTCAACCTCGGCACGCGCCCGACCATCCCCGACGTCCCGGGCCTGTGCGACGCGGAACCG
CTGACGAATATCGAGGCGCTCGAACTCGACGCCGTGCCCGCCCACCTCGTCGTCCTCGGAGGCGGCTACGTGGGCCTCGA
ACTGGCCCAGGCCTACCGCCGGTTCGGCAGCGCGGTGACGGTGATCGAGCACGGGGCGCAGATCGCGGGCCGCGAGGATC
CGGACGTGGCCTCCGCGCTCGCGCAGCTCCTCGAGGCCGAGGGGCTGGCCATCCGCACCGGCACGGAGGTCGTGCGCGTG
CGCGGCCGTTCGGGCGACGCCGTGGAGATCACGGTGCGCGACGGCGGCGGCGAGGCGGTCATCGCCGGAAGCCACATCCT
CGTCGCGGCGGGCCGCGCGCCGAATACCGGCGGGATCGGCCTCGACCGCGCGGGGGTGGACCTCACCGAGCGGGGCGTGA
TCAAGGTCGACGACCGTCTGCGGACGAGCGCGCCGGGCGTCTGGGCCATCGGCGAGTGCGCGGGCAGCCCGGCCTTCACC
CACGCCTCCGCGGACGATTTCCGCGTGATCCGCGACGATCTCGCGGGGATCCCGCGCTCGACCGCGGGGCGGCTGATGCC
CGCCTGCCTGTTCACGGACCCGCCGCTGGCGCGGGTCGGATCGACCGAGACCGAGGCGCGCGCCCGCGGCGATGCCGTCC
GGGTCGCCAAGCTGCCGATGGCGGCGGTGCTGCGCACGCGGACGACCGGGCAGACCGAGGGCTTCATGAAGGCCGTCATC
GGACCGGACGATCGGATCCTCGGCTTCACGATGCTCGGCGCGGAGGCCGGCGAGGTCATGGCCGCGGTCCAGGTCGCGAT
GCTCGCCGGCCTGCCCTACACGGCTTTGCGCGACGCGATCCTCGCCCACCCGACCACCGCGGAGGGGCTGAACAGCCTGT
TCTCGGCCGTGCCCGCCCCCTGA

Upstream 100 bases:

>100_bases
CCGGCCGGTCAGGGCCGGTCTATCATACCGACGCATGATATCCGGCCGATCGCGATGCCTTTACGTGTTTCCGAAATCTC
GGATCCGCGGAGGATGGACG

Downstream 100 bases:

>100_bases
CCACTCCCTGACCCGCTCTCCGCGGTTCAGGCGCTCGCCGCGGCGGGTTCCGCCGCGCGGCTCTCTCGGTCCGGCTCGGC
CGCCGGAAGATCGACCGCGA

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MDDHYDALVIGSGEGGKFLAWHLAKAGQRVAVVERRWIGGSCPNTNCLPSKNEIWSAEIAHLARHADRYGIETGPVAVDM
ARVVERKRAMVRGLVDMHLDRYRDSGAELIMGTAAFTGPRALTVALNAGGSRALTAERIFLNLGTRPTIPDVPGLCDAEP
LTNIEALELDAVPAHLVVLGGGYVGLELAQAYRRFGSAVTVIEHGAQIAGREDPDVASALAQLLEAEGLAIRTGTEVVRV
RGRSGDAVEITVRDGGGEAVIAGSHILVAAGRAPNTGGIGLDRAGVDLTERGVIKVDDRLRTSAPGVWAIGECAGSPAFT
HASADDFRVIRDDLAGIPRSTAGRLMPACLFTDPPLARVGSTETEARARGDAVRVAKLPMAAVLRTRTTGQTEGFMKAVI
GPDDRILGFTMLGAEAGEVMAAVQVAMLAGLPYTALRDAILAHPTTAEGLNSLFSAVPAP

Sequences:

>Translated_460_residues
MDDHYDALVIGSGEGGKFLAWHLAKAGQRVAVVERRWIGGSCPNTNCLPSKNEIWSAEIAHLARHADRYGIETGPVAVDM
ARVVERKRAMVRGLVDMHLDRYRDSGAELIMGTAAFTGPRALTVALNAGGSRALTAERIFLNLGTRPTIPDVPGLCDAEP
LTNIEALELDAVPAHLVVLGGGYVGLELAQAYRRFGSAVTVIEHGAQIAGREDPDVASALAQLLEAEGLAIRTGTEVVRV
RGRSGDAVEITVRDGGGEAVIAGSHILVAAGRAPNTGGIGLDRAGVDLTERGVIKVDDRLRTSAPGVWAIGECAGSPAFT
HASADDFRVIRDDLAGIPRSTAGRLMPACLFTDPPLARVGSTETEARARGDAVRVAKLPMAAVLRTRTTGQTEGFMKAVI
GPDDRILGFTMLGAEAGEVMAAVQVAMLAGLPYTALRDAILAHPTTAEGLNSLFSAVPAP
>Mature_460_residues
MDDHYDALVIGSGEGGKFLAWHLAKAGQRVAVVERRWIGGSCPNTNCLPSKNEIWSAEIAHLARHADRYGIETGPVAVDM
ARVVERKRAMVRGLVDMHLDRYRDSGAELIMGTAAFTGPRALTVALNAGGSRALTAERIFLNLGTRPTIPDVPGLCDAEP
LTNIEALELDAVPAHLVVLGGGYVGLELAQAYRRFGSAVTVIEHGAQIAGREDPDVASALAQLLEAEGLAIRTGTEVVRV
RGRSGDAVEITVRDGGGEAVIAGSHILVAAGRAPNTGGIGLDRAGVDLTERGVIKVDDRLRTSAPGVWAIGECAGSPAFT
HASADDFRVIRDDLAGIPRSTAGRLMPACLFTDPPLARVGSTETEARARGDAVRVAKLPMAAVLRTRTTGQTEGFMKAVI
GPDDRILGFTMLGAEAGEVMAAVQVAMLAGLPYTALRDAILAHPTTAEGLNSLFSAVPAP

Specific function: Unknown

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=455, Percent_Identity=28.7912087912088, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=26.8817204301075, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=27.8481012658228, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI148277065, Length=454, Percent_Identity=24.8898678414097, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI33519430, Length=454, Percent_Identity=24.8898678414097, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI33519428, Length=454, Percent_Identity=24.8898678414097, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI33519426, Length=454, Percent_Identity=24.8898678414097, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI148277071, Length=454, Percent_Identity=24.8898678414097, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI291045266, Length=433, Percent_Identity=24.0184757505774, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI291045268, Length=427, Percent_Identity=23.8875878220141, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87081717, Length=467, Percent_Identity=36.4025695931477, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1786307, Length=450, Percent_Identity=28.2222222222222, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI87082354, Length=480, Percent_Identity=27.5, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1789915, Length=465, Percent_Identity=26.6666666666667, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=456, Percent_Identity=29.3859649122807, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=27.6507276507277, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=441, Percent_Identity=26.530612244898, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=441, Percent_Identity=26.530612244898, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=24.223602484472, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=27.8617710583153, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=465, Percent_Identity=22.5806451612903, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=468, Percent_Identity=24.3589743589744, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21358499, Length=454, Percent_Identity=31.2775330396476, Blast_Score=212, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=25.9023354564756, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=25.9023354564756, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=25.9023354564756, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737741, Length=474, Percent_Identity=27.2151898734177, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: NA

Molecular weight: Translated: 48159; Mature: 48159

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDHYDALVIGSGEGGKFLAWHLAKAGQRVAVVERRWIGGSCPNTNCLPSKNEIWSAEIA
CCCCCCEEEEECCCCCCEEEEEEHHCCCEEEEEEEHHCCCCCCCCCCCCCCCCHHHHHHH
HLARHADRYGIETGPVAVDMARVVERKRAMVRGLVDMHLDRYRDSGAELIMGTAAFTGPR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCE
ALTVALNAGGSRALTAERIFLNLGTRPTIPDVPGLCDAEPLTNIEALELDAVPAHLVVLG
EEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEC
GGYVGLELAQAYRRFGSAVTVIEHGAQIAGREDPDVASALAQLLEAEGLAIRTGTEVVRV
CCHHHHHHHHHHHHHCCEEEEECCCCHHCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEE
RGRSGDAVEITVRDGGGEAVIAGSHILVAAGRAPNTGGIGLDRAGVDLTERGVIKVDDRL
ECCCCCEEEEEEECCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCHH
RTSAPGVWAIGECAGSPAFTHASADDFRVIRDDLAGIPRSTAGRLMPACLFTDPPLARVG
HCCCCCEEEEHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCHHHCCCCCCHHHCC
STETEARARGDAVRVAKLPMAAVLRTRTTGQTEGFMKAVIGPDDRILGFTMLGAEAGEVM
CCCHHHHHCCCEEEEHHCCHHHHHHHCCCCCCCHHHHEEECCCCCEEEEEEECCCHHHHH
AAVQVAMLAGLPYTALRDAILAHPTTAEGLNSLFSAVPAP
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MDDHYDALVIGSGEGGKFLAWHLAKAGQRVAVVERRWIGGSCPNTNCLPSKNEIWSAEIA
CCCCCCEEEEECCCCCCEEEEEEHHCCCEEEEEEEHHCCCCCCCCCCCCCCCCHHHHHHH
HLARHADRYGIETGPVAVDMARVVERKRAMVRGLVDMHLDRYRDSGAELIMGTAAFTGPR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCE
ALTVALNAGGSRALTAERIFLNLGTRPTIPDVPGLCDAEPLTNIEALELDAVPAHLVVLG
EEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEC
GGYVGLELAQAYRRFGSAVTVIEHGAQIAGREDPDVASALAQLLEAEGLAIRTGTEVVRV
CCHHHHHHHHHHHHHCCEEEEECCCCHHCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEE
RGRSGDAVEITVRDGGGEAVIAGSHILVAAGRAPNTGGIGLDRAGVDLTERGVIKVDDRL
ECCCCCEEEEEEECCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCHH
RTSAPGVWAIGECAGSPAFTHASADDFRVIRDDLAGIPRSTAGRLMPACLFTDPPLARVG
HCCCCCEEEEHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCHHHCCCCCCHHHCC
STETEARARGDAVRVAKLPMAAVLRTRTTGQTEGFMKAVIGPDDRILGFTMLGAEAGEVM
CCCHHHHHCCCEEEEHHCCHHHHHHHCCCCCCCHHHHEEECCCCCEEEEEEECCCHHHHH
AAVQVAMLAGLPYTALRDAILAHPTTAEGLNSLFSAVPAP
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]