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The map label for this gene is srrB [H]

Identifier: 170747691

GI number: 170747691

Start: 1327376

End: 1328116

Strand: Reverse

Name: srrB [H]

Synonym: Mrad2831_1266

Alternate gene names: 170747691

Gene position: 1328116-1327376 (Counterclockwise)

Preceding gene: 170747692

Following gene: 170747690

Centisome position: 21.85

GC content: 75.71

Gene sequence:

>741_bases
ATGGGACTGACGATGGCGAGCCGGAGCGGTGCGGGGTCGGACGAGGCCGTGCTGCGCGCGGAGACCGCCCGCAGCGCCAT
GGCCCGGCTCCTCGCCGTCGCCGGACACGATCTCAAGCAGCCCCTGCAGGTGGCCCTCATGGCCATCGACCGCGCGGTCT
CGGACGGCGTCGGTCCCCGGGCCGCGGCCCGGCTCGGCCTCGCCAGCGACGCGCTGGTGCGGCTGGGCCGCGAACTCGAC
GACTTGGCCCGCTCCTCCCAGACCGGCGCCGTGCCGCCCCGGCTCGGTCCCGTCGCCCTCGTCCCGCTCCTGGAGGCGGT
GGCGGCCGAGTGGCAGCCCTACGCCGACGCGGTCGGAGTGCGGGTGCAGGTCTGCGCCACGGCGCTGACGGTCCAGAGCG
AGGCCGCCATGCTGACGACCATCCTGCGCAACCTCGTCGGGAACGCCGTGAAGTATGCGGGCCCGGGCGGCCGCGTCGTC
GTCGGATGCCGCCGCCGGCAGGGGCGGGTCACGATCGAGGTACACGATGACGGTCCCGGCATCGCGCCCGAACGGCTGGC
GGGCATCTTCGACGCCTTCGACCGCGCCGGGCGCCGGGACGGGGCCGGTCTCGGGCTCGGCCTGCACATCGTCCGGCAGA
CCGCCGCGGCGCTCGATCACCCGATCACCGTGCGATCCCGGCGCGACCGGGGCTCCGTCTTCGGCGTGACCGCGCCCCGT
CACTGTCCGGCATCCGCGTAG

Upstream 100 bases:

>100_bases
AACCTCCGTATGATTCCGGCGCGAACGGCCACGGTGCAAGGTCGCGCCATGGAAGGGGCGCCGCACGCGCGCCGCACGCG
GGCCGGACGAGGAGGCGGGG

Downstream 100 bases:

>100_bases
ATTTCCCGGGTCGATCCCGACGGCGCTGCCGCCGCGGAGCAGGTCCGCCGTCCCGGCACTGGAAGCCGCGAAACGCCCGG
ACCGCGTGCGCAGCCCACCG

Product: histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MGLTMASRSGAGSDEAVLRAETARSAMARLLAVAGHDLKQPLQVALMAIDRAVSDGVGPRAAARLGLASDALVRLGRELD
DLARSSQTGAVPPRLGPVALVPLLEAVAAEWQPYADAVGVRVQVCATALTVQSEAAMLTTILRNLVGNAVKYAGPGGRVV
VGCRRRQGRVTIEVHDDGPGIAPERLAGIFDAFDRAGRRDGAGLGLGLHIVRQTAAALDHPITVRSRRDRGSVFGVTAPR
HCPASA

Sequences:

>Translated_246_residues
MGLTMASRSGAGSDEAVLRAETARSAMARLLAVAGHDLKQPLQVALMAIDRAVSDGVGPRAAARLGLASDALVRLGRELD
DLARSSQTGAVPPRLGPVALVPLLEAVAAEWQPYADAVGVRVQVCATALTVQSEAAMLTTILRNLVGNAVKYAGPGGRVV
VGCRRRQGRVTIEVHDDGPGIAPERLAGIFDAFDRAGRRDGAGLGLGLHIVRQTAAALDHPITVRSRRDRGSVFGVTAPR
HCPASA
>Mature_245_residues
GLTMASRSGAGSDEAVLRAETARSAMARLLAVAGHDLKQPLQVALMAIDRAVSDGVGPRAAARLGLASDALVRLGRELDD
LARSSQTGAVPPRLGPVALVPLLEAVAAEWQPYADAVGVRVQVCATALTVQSEAAMLTTILRNLVGNAVKYAGPGGRVVV
GCRRRQGRVTIEVHDDGPGIAPERLAGIFDAFDRAGRRDGAGLGLGLHIVRQTAAALDHPITVRSRRDRGSVFGVTAPRH
CPASA

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=27.1255060728745, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788393, Length=188, Percent_Identity=28.7234042553192, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=26.0683760683761, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790567, Length=110, Percent_Identity=37.2727272727273, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=25.6302521008403, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 25523; Mature: 25391

Theoretical pI: Translated: 10.74; Mature: 10.74

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLTMASRSGAGSDEAVLRAETARSAMARLLAVAGHDLKQPLQVALMAIDRAVSDGVGPR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
AAARLGLASDALVRLGRELDDLARSSQTGAVPPRLGPVALVPLLEAVAAEWQPYADAVGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
RVQVCATALTVQSEAAMLTTILRNLVGNAVKYAGPGGRVVVGCRRRQGRVTIEVHDDGPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCEEEEEEECCCCC
IAPERLAGIFDAFDRAGRRDGAGLGLGLHIVRQTAAALDHPITVRSRRDRGSVFGVTAPR
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCC
HCPASA
CCCCCC
>Mature Secondary Structure 
GLTMASRSGAGSDEAVLRAETARSAMARLLAVAGHDLKQPLQVALMAIDRAVSDGVGPR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHH
AAARLGLASDALVRLGRELDDLARSSQTGAVPPRLGPVALVPLLEAVAAEWQPYADAVGV
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
RVQVCATALTVQSEAAMLTTILRNLVGNAVKYAGPGGRVVVGCRRRQGRVTIEVHDDGPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCEEEEEEECCCCC
IAPERLAGIFDAFDRAGRRDGAGLGLGLHIVRQTAAALDHPITVRSRRDRGSVFGVTAPR
CCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCC
HCPASA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA