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The map label for this gene is iclR [H]

Identifier: 170747487

GI number: 170747487

Start: 1111784

End: 1112629

Strand: Reverse

Name: iclR [H]

Synonym: Mrad2831_1055

Alternate gene names: 170747487

Gene position: 1112629-1111784 (Counterclockwise)

Preceding gene: 170747488

Following gene: 170747486

Centisome position: 18.31

GC content: 74.47

Gene sequence:

>846_bases
ATGGAGGCGGATGCGGGCCTGCGCACCGGATCCGACGGCGCCGAGCCCGACGCTGGCGGGTCCGACGCAGGCGGGTCCGG
CGCGAAGGAGGACCGGCACTTCGTCACGGCGCTCGCCCGGGGACTGTCGGTGCTCGCCTGCTTCGGCCCGGGGCGCACGA
GCCTCGCCAACCACGACATCGCGGAGGCCTGCGGGCTGCCGCGCTCCACCGTGTCGCGGCTGACCTACACGCTGACCAAG
CTCGGCTACCTGCAGCACATGCCCGAGCTCGGCCGGTACCGCCTCGGCACCGCCACCATCGCGCTGAGCTCGGCCGCCCT
GGGCGGTCTCGACGTCCGCGCCATCGCCCGGCCGGTGCTGCGCGCGGTCGCGGAGGCGGCCAACGCCTCGGTGGGGCTCG
GGGTGCGCGACCGGCTCAGCATGCGCTACGTCGAGTGCCAGCGCGGCCCAGCGGCGATCTCGCTCAACCTTGACACCGGC
TCGCGCATCTCGCTCGCCCGCAGCGCCATGGGCCGCGCCTACGTGGCGGTCTGCCCGGACCGGGAGCGCGCGGGCATCTA
CGAGGACCTGAAGGCGCTCGATCCCGTGGCCTGGCCGGCGCTGCGCGCCGGCCTCGACCGGGCGGTGGAGGAGCACCGGG
ACCTCGGCTGCTGCACCTCGTTCGGCGAGTGGCAGGAGACGGTCTGCGCCATCGCGGTGGGGTTCCATCCCGGCGGCGGC
CTGCCGCCCATGGCGGTCAATTGCGGTGCCCCCACCGTCATCACCGACGCGCGCTTCCTCCTGGAGGTGGCGCGCCCGAA
ACTGATCGACGCCGTGCGCAGTCTCGACGGCGTCATGGGAGCCTGA

Upstream 100 bases:

>100_bases
CCCGCGCCCTCGACGCGGAGGCGGAGGTCTTCCACGCCCTCCGCCGCGGTCCGGCGGCGCAGGCGGCCTTCGCGGCGTTC
CTGCGCCGATGAGCGGGCCG

Downstream 100 bases:

>100_bases
GGACTTTCGCGATGGATGCCGTTGCCGACCTGCCGCTCGCCGGAATCCGCGTCCTCGACCTGTCCCGGGTCCTGGCCGGA
CCCTGGTGCGCGCAGGTGCT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MEADAGLRTGSDGAEPDAGGSDAGGSGAKEDRHFVTALARGLSVLACFGPGRTSLANHDIAEACGLPRSTVSRLTYTLTK
LGYLQHMPELGRYRLGTATIALSSAALGGLDVRAIARPVLRAVAEAANASVGLGVRDRLSMRYVECQRGPAAISLNLDTG
SRISLARSAMGRAYVAVCPDRERAGIYEDLKALDPVAWPALRAGLDRAVEEHRDLGCCTSFGEWQETVCAIAVGFHPGGG
LPPMAVNCGAPTVITDARFLLEVARPKLIDAVRSLDGVMGA

Sequences:

>Translated_281_residues
MEADAGLRTGSDGAEPDAGGSDAGGSGAKEDRHFVTALARGLSVLACFGPGRTSLANHDIAEACGLPRSTVSRLTYTLTK
LGYLQHMPELGRYRLGTATIALSSAALGGLDVRAIARPVLRAVAEAANASVGLGVRDRLSMRYVECQRGPAAISLNLDTG
SRISLARSAMGRAYVAVCPDRERAGIYEDLKALDPVAWPALRAGLDRAVEEHRDLGCCTSFGEWQETVCAIAVGFHPGGG
LPPMAVNCGAPTVITDARFLLEVARPKLIDAVRSLDGVMGA
>Mature_281_residues
MEADAGLRTGSDGAEPDAGGSDAGGSGAKEDRHFVTALARGLSVLACFGPGRTSLANHDIAEACGLPRSTVSRLTYTLTK
LGYLQHMPELGRYRLGTATIALSSAALGGLDVRAIARPVLRAVAEAANASVGLGVRDRLSMRYVECQRGPAAISLNLDTG
SRISLARSAMGRAYVAVCPDRERAGIYEDLKALDPVAWPALRAGLDRAVEEHRDLGCCTSFGEWQETVCAIAVGFHPGGG
LPPMAVNCGAPTVITDARFLLEVARPKLIDAVRSLDGVMGA

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=221, Percent_Identity=25.7918552036199, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786468, Length=202, Percent_Identity=27.2277227722772, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29286; Mature: 29286

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEADAGLRTGSDGAEPDAGGSDAGGSGAKEDRHFVTALARGLSVLACFGPGRTSLANHDI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCH
AEACGLPRSTVSRLTYTLTKLGYLQHMPELGRYRLGTATIALSSAALGGLDVRAIARPVL
HHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHCEECCHHHHHHHHHHCCCCHHHHHHHHHH
RAVAEAANASVGLGVRDRLSMRYVECQRGPAAISLNLDTGSRISLARSAMGRAYVAVCPD
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCC
RERAGIYEDLKALDPVAWPALRAGLDRAVEEHRDLGCCTSFGEWQETVCAIAVGFHPGGG
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHEEEECCCCC
LPPMAVNCGAPTVITDARFLLEVARPKLIDAVRSLDGVMGA
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEADAGLRTGSDGAEPDAGGSDAGGSGAKEDRHFVTALARGLSVLACFGPGRTSLANHDI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCH
AEACGLPRSTVSRLTYTLTKLGYLQHMPELGRYRLGTATIALSSAALGGLDVRAIARPVL
HHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHCEECCHHHHHHHHHHCCCCHHHHHHHHHH
RAVAEAANASVGLGVRDRLSMRYVECQRGPAAISLNLDTGSRISLARSAMGRAYVAVCPD
HHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCC
RERAGIYEDLKALDPVAWPALRAGLDRAVEEHRDLGCCTSFGEWQETVCAIAVGFHPGGG
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHEEEECCCCC
LPPMAVNCGAPTVITDARFLLEVARPKLIDAVRSLDGVMGA
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]