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The map label for this gene is hisA [H]

Identifier: 170747397

GI number: 170747397

Start: 1019859

End: 1020590

Strand: Reverse

Name: hisA [H]

Synonym: Mrad2831_0964

Alternate gene names: 170747397

Gene position: 1020590-1019859 (Counterclockwise)

Preceding gene: 170747402

Following gene: 170747396

Centisome position: 16.79

GC content: 78.42

Gene sequence:

>732_bases
ATGAGCGCCTCGATGGACCACAGGATCGGGCGCCCCGGCTTCGCGGTGATCCCGGTGCTCGATCTCCGGGGCGGCCGCGT
GGTGCGGGCGCGCCGGGGCGAGCGCTCCTCCTATGCCCCGATCGAGACGCCCTTGGCAAAGGGCTCGGCGCCCGACGCGG
TGGCCCGGGGGCTGCGCGACGCGTGGCCCGCCGCCATCCTCTACGTCGCCGATCTCGACGCGATCATCGATCGCGCCGCG
CCCGATCTCCGCGCCCTGGAGGCGATCGCCCGCGCCTGCCCGGGCGTCAGCCTGTGGGTCGATGCGGGCTTCGCCGAGCC
GGCGGCCGTCGACGCGTTCCTGGCCTCCGGCCTGGGCCGCCCGGTGATCGGCAGCGAGAGCCAGGCGGATGCCGACCTCG
TGACGCGGCTCGGCGACCGGGCGGTGTTCTCCCTCGACACGCGCGGCGCGGAGCGGCTCGGCCCGGCGGCCCTCCACGAC
GATCCCGCGCTCTGGCCGCCGGAGGTGATCGCCATGACGCTGGCGCAGGTCGGCGCCGGGGCCGGCCCGGACCTTGGGGC
CCTGGGAGCCCTGCGCGCGCGGGCGCCGGATCGCCGCCTCTACGCGGCGGGCGGCGTGCGCGGCCCGGACGACCTGCGGG
CGCTGCGGGCGGCCGGGATCGCCGGGGCGCTGGTCGCCTCGGCCCTCCACGACGGGACCCTGTCCCGGGCGACGGCGCCC
GACCTCGCCTGA

Upstream 100 bases:

>100_bases
CGGCCGCGACCCGGCCGTCCTCGACCAGGGCGACCTTGACGTGGACCCCGCCGAGGTCCCACCCGATCGTCGTTGGGTTT
GATGAGCGCATGGGACCGCG

Downstream 100 bases:

>100_bases
CGCTTCCGGCCCGGGCCGGCGGCTGCTAAACCGCCCGGCAGAGAGACCACCGACACGAGCCGTCAGACGATGGAAAAGTT
CACCACCCTGGAGGGCGTCG

Product: histidine biosynthesis protein

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSASMDHRIGRPGFAVIPVLDLRGGRVVRARRGERSSYAPIETPLAKGSAPDAVARGLRDAWPAAILYVADLDAIIDRAA
PDLRALEAIARACPGVSLWVDAGFAEPAAVDAFLASGLGRPVIGSESQADADLVTRLGDRAVFSLDTRGAERLGPAALHD
DPALWPPEVIAMTLAQVGAGAGPDLGALGALRARAPDRRLYAAGGVRGPDDLRALRAAGIAGALVASALHDGTLSRATAP
DLA

Sequences:

>Translated_243_residues
MSASMDHRIGRPGFAVIPVLDLRGGRVVRARRGERSSYAPIETPLAKGSAPDAVARGLRDAWPAAILYVADLDAIIDRAA
PDLRALEAIARACPGVSLWVDAGFAEPAAVDAFLASGLGRPVIGSESQADADLVTRLGDRAVFSLDTRGAERLGPAALHD
DPALWPPEVIAMTLAQVGAGAGPDLGALGALRARAPDRRLYAAGGVRGPDDLRALRAAGIAGALVASALHDGTLSRATAP
DLA
>Mature_242_residues
SASMDHRIGRPGFAVIPVLDLRGGRVVRARRGERSSYAPIETPLAKGSAPDAVARGLRDAWPAAILYVADLDAIIDRAAP
DLRALEAIARACPGVSLWVDAGFAEPAAVDAFLASGLGRPVIGSESQADADLVTRLGDRAVFSLDTRGAERLGPAALHDD
PALWPPEVIAMTLAQVGAGAGPDLGALGALRARAPDRRLYAAGGVRGPDDLRALRAAGIAGALVASALHDGTLSRATAPD
LA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG1411

COG function: function code R; Uncharacterized protein related to proFAR isomerase (HisA)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 24910; Mature: 24778

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASMDHRIGRPGFAVIPVLDLRGGRVVRARRGERSSYAPIETPLAKGSAPDAVARGLRD
CCCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AWPAAILYVADLDAIIDRAAPDLRALEAIARACPGVSLWVDAGFAEPAAVDAFLASGLGR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCC
PVIGSESQADADLVTRLGDRAVFSLDTRGAERLGPAALHDDPALWPPEVIAMTLAQVGAG
CCCCCCCCCHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCC
AGPDLGALGALRARAPDRRLYAAGGVRGPDDLRALRAAGIAGALVASALHDGTLSRATAP
CCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCC
DLA
CCC
>Mature Secondary Structure 
SASMDHRIGRPGFAVIPVLDLRGGRVVRARRGERSSYAPIETPLAKGSAPDAVARGLRD
CCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AWPAAILYVADLDAIIDRAAPDLRALEAIARACPGVSLWVDAGFAEPAAVDAFLASGLGR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCC
PVIGSESQADADLVTRLGDRAVFSLDTRGAERLGPAALHDDPALWPPEVIAMTLAQVGAG
CCCCCCCCCHHHHHHHHCCCEEEEECCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCC
AGPDLGALGALRARAPDRRLYAAGGVRGPDDLRALRAAGIAGALVASALHDGTLSRATAP
CCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCC
DLA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA