Click here to switch to the map view.

The map label for this gene is hexR [H]

Identifier: 170683767

GI number: 170683767

Start: 1322584

End: 1323453

Strand: Reverse

Name: hexR [H]

Synonym: EcSMS35_1333

Alternate gene names: 170683767

Gene position: 1323453-1322584 (Counterclockwise)

Preceding gene: 170684011

Following gene: 170680822

Centisome position: 26.11

GC content: 49.66

Gene sequence:

>870_bases
ATGAATATGCTGGAAAAAATCCAGTCTCAGCTGGAACATTTGAGCAAATCAGAGCGCAAAGTTGCCGAGGTCATTCTGGC
TTCGCCCGATAACGCGATCCATTCGAGTATTGCTGCTCTGGCGCTGGAAGCCAATGTTAGCGAACCGACGGTGAATCGTT
TCTGTCGCAGCATGGACACGCGCGGTTTTCCTGATTTTAAACTTCATCTGGCACAAAGTCTGGCGAATGGCACTCCCTAT
GTTAATCGCAACGTCAATGAAGATGACAGCGTTGAATCATACACGGGGAAAATATTTGAGTCCGCAATGGCAACGCTCGA
TCATGTCCGTCATTCACTGGATAAATCTGCCATCAACCGCGCCGTCGACTTGCTCACTCAGGCAAAAAAAATCGCCTTTT
TCGGATTAGGCTCTTCAGCCGCCGTTGCCCACGATGCGATGAATAAGTTCTTTCGTTTTAATGTTCCGGTGGTGTACTCC
GATGATATTGTGCTGCAACGCATGAGTTGTATGAATTGTAGCGACGGAGACGTGGTGGTGCTGATTTCTCACACGGGAAG
AACAAAAAATCTGGTCGAGCTGGCGCAGCTGGCACGCGAAAACGACGCCATGGTGATTGCCCTCACCTCTGCGGGTACCC
CGCTCGCCCGGGAAGCAACGCTGGCTATTACCCTCGACGTACCGGAAGATACTGACATTTATATGCCCATGGTTTCTCGA
CTTGCACAGCTGACCGTGATAGATGTGCTGGCGACAGGATTTACTTTGCGGCGCGGTGCAAAATTCAGAGATAACTTGAA
GCGGGTCAAGGAAGCGCTGAAGGAATCGCGTTTTGATAAGCAGTTACTTAATTTAAGTGACGATCGCTAA

Upstream 100 bases:

>100_bases
TTTTGTCATTAACACAGCACACAGGCGTAATATCTGGCAAAACTGCATTTCGATTTCTTTCAGTGCGGAAATCGTCATTA
CCCGTGAGTCTCTTTACATC

Downstream 100 bases:

>100_bases
AAACGACTGTCACTGTCCTAATCTTATACGACATCCGAATGAGATTAATTTATCGCCATCGCGGCGTTATTTCATTCGGA
TTTCATGTTCAAGCAACACC

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTPY
VNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYS
DDIVLQRMSCMNCSDGDVVVLISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKQLLNLSDDR

Sequences:

>Translated_289_residues
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTPY
VNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYS
DDIVLQRMSCMNCSDGDVVVLISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKQLLNLSDDR
>Mature_289_residues
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDTRGFPDFKLHLAQSLANGTPY
VNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINRAVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYS
DDIVLQRMSCMNCSDGDVVVLISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKQLLNLSDDR

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=289, Percent_Identity=99.6539792387543, Blast_Score=591, Evalue=1e-170,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=24.5833333333333, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788767, Length=264, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI87082130, Length=195, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31958; Mature: 31958

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
RGFPDFKLHLAQSLANGTPYVNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYSDDIVLQRMSCMNCSDGDVVV
HHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKQLLNLSDDR
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNMLEKIQSQLEHLSKSERKVAEVILASPDNAIHSSIAALALEANVSEPTVNRFCRSMDT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
RGFPDFKLHLAQSLANGTPYVNRNVNEDDSVESYTGKIFESAMATLDHVRHSLDKSAINR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKIAFFGLGSSAAVAHDAMNKFFRFNVPVVYSDDIVLQRMSCMNCSDGDVVV
HHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKNLVELAQLARENDAMVIALTSAGTPLAREATLAITLDVPEDTDIYMPMVSR
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKQLLNLSDDR
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]