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The map label for this gene is lpxK [H]

Identifier: 170683237

GI number: 170683237

Start: 2217905

End: 2218891

Strand: Reverse

Name: lpxK [H]

Synonym: EcSMS35_2205

Alternate gene names: 170683237

Gene position: 2218891-2217905 (Counterclockwise)

Preceding gene: 170680104

Following gene: 170680727

Centisome position: 43.78

GC content: 54.91

Gene sequence:

>987_bases
ATGATCGAAAAAATCTGGTCTGGTGAATCCCCTTTGTGGCGGCTATTGCTGCCACTCTCCTGGTTGTATGGCCTGGTGAG
TGGCGCGATCCGTCTTTGCTATAAACTAAAACTGAAGCGCGCCTGGCGTGCCCCCGTACCGGTTGTCGTGGTTGGTAATC
TCACCGCAGGCGGCAACGGAAAAACCCCGGTCGTTGTCTGGCTGGTGGAACAGTTGCAACAGCGCGGTATTTGCGTGGGG
GTCGTATCGCGGGGATATGGTGGTAAGGCTGAATCTTATCCGCTGTTATTGTCGGCAGATACCACCACAGCACAGGCGGG
TGATGAACCTGTGTTGATTTATCAACGCACTGATGCGCCTGTTGCGGTTTCTCCCGTGCGTTCTGATGCGATAAAAGCCA
TTCTGGCGCAACACCCTGATGTGCAGATCATCGTAACCGACGACGGTTTACAGCATTACCGTCTGGCGCGTGATGTGGAA
ATTGTCGTTATTGATGGTGTGCGTCGCTTTGGCAATGGCTGGTGGTTGCCGGCGGGGCCAATGCGTGAGCGAGCGGGGCG
CTTAAAGTCGGTTGATGCGGTAATCGTCAACGGTGGTGTCCCCCGCAGCGGTGAAATCCCCATGCATCTGCTGCCGGGTC
AGGCGGTGAATTTACGTACCGGTACGCGTTGTGACGTTGCTCAGCTTGAACATGTGGTGGCGATGGCAGGGATTGGTCAT
CCGCCGCGCTTTTTTGCCACGCTGAAGATGTGTGGCGTACAACCGGAAAAATGTGTACCGCTGGCCGATCATCAGTCTTT
GAATCATGCGGATGTCAGCGCGTTGGTCAGCGCCGGGCAAACGCTGGTAATGACAGAAAAAGATGCGGTGAAATGCCGGG
CCTTTGCAGAAGAAAATTGGTGGTATTTGCCTGTAGACGCACAGCTTTCAGGTGATGAACCAGCGAAACTGCTTGCGCAA
CTAACCTCGCTGGCTTCTGGCAACTAG

Upstream 100 bases:

>100_bases
TGGTCGTCGAGGATGGTGTCATTGTGGAACGCGGTACGCATAACGATTTGCTTGAGCACCGTGGCGTTTACGCGCAACTT
CACAAAATGCAGTTTGGCCA

Downstream 100 bases:

>100_bases
TTACGCCGCGGCAGCGTTCGATTGATGGAGTCATGAATGTCGCTGCCGCACCTCTCTCTTGCTGATGCGCGTAATCTTCA
CCTCGCCGCGCAAGGCCTGT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGICVG
VVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTDAPVAVSPVRSDAIKAILAQHPDVQIIVTDDGLQHYRLARDVE
IVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAMAGIGH
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDEPAKLLAQ
LTSLASGN

Sequences:

>Translated_328_residues
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGICVG
VVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTDAPVAVSPVRSDAIKAILAQHPDVQIIVTDDGLQHYRLARDVE
IVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAMAGIGH
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDEPAKLLAQ
LTSLASGN
>Mature_328_residues
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGICVG
VVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTDAPVAVSPVRSDAIKAILAQHPDVQIIVTDDGLQHYRLARDVE
IVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAMAGIGH
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDEPAKLLAQ
LTSLASGN

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=328, Percent_Identity=98.780487804878, Blast_Score=655, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 35495; Mature: 35495

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEECCCCC
KTPVVVWLVEQLQQRGICVGVVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTDAP
CCCEEEEEHHHHHHCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCC
VAVSPVRSDAIKAILAQHPDVQIIVTDDGLQHYRLARDVEIVVIDGVRRFGNGWWLPAGP
EEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCEEEEEEECHHHHCCCCCCCCCH
MRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAMAGIGH
HHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCCEEECCCCCCCCHHHHHHHHHHHCCCC
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENW
CHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCHHEEEEEECCCC
WYLPVDAQLSGDEPAKLLAQLTSLASGN
EEEEECCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPVPVVVVGNLTAGGNG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEECCCCC
KTPVVVWLVEQLQQRGICVGVVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTDAP
CCCEEEEEHHHHHHCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCC
VAVSPVRSDAIKAILAQHPDVQIIVTDDGLQHYRLARDVEIVVIDGVRRFGNGWWLPAGP
EEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCEEEEEEECHHHHCCCCCCCCCH
MRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVAMAGIGH
HHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCCEEECCCCCCCCHHHHHHHHHHHCCCC
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENW
CHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCHHEEEEEECCCC
WYLPVDAQLSGDEPAKLLAQLTSLASGN
EEEEECCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA