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The map label for this gene is ilvB [H]

Identifier: 170079361

GI number: 170079361

Start: 2891967

End: 2893604

Strand: Reverse

Name: ilvB [H]

Synonym: SYNPCC7002_A2770

Alternate gene names: 170079361

Gene position: 2893604-2891967 (Counterclockwise)

Preceding gene: 170079362

Following gene: 170079357

Centisome position: 96.2

GC content: 52.14

Gene sequence:

>1638_bases
GTGAATACTGCAGAATTATTGATCCGATGTCTAGAAAATGAAGGGGTGGAGTATATTTTTGGGCTGCCGGGGGAAGAAAA
TCTCCATATCCTCGAAGCCCTTAAGGAGTCTCCCATCCGCTTTATCACCGTCCGCCATGAACAGGGTGCCGCTTTTATGG
CCGATGTGTATGGTCGTTTAACCGGGAAAGCAGGGGTTTGTCTGTCTACCCTGGGGCCTGGGGCTACCAATCTAATGACT
GGGGTTGCCGATGCGAACCTCGATGGGGCGCCCCTGATTGCGATTACAGGGCAGGTGGGTACCGACCGCATGCACATTGA
ATCCCACCAATATCTTGATCTGGTGGCGATGTTTGCCCCCGTCACCAAGTGGAATAAACAAATTGTCCGACCGAACACGA
CCCCGGAGGTGGTACGTCGTGCCTTTAAAATTGCCCAGCAGGAAAAACCAGGGGCAGTACACATCGATCTCCCTGAAAAT
ATTGCGGCGATGCCCGTAGAAGGTCAGCCCCTCCAGCGGGATGGTCGTGAAAAAATCTATGCTTCAAGCCGGAGTTTAAA
CCGGGCTGCCGAGGCGATCGCCCATGCCAAGAGTCCTTTAATTCTGGTGGGTAATGGCATTATTCGCGCCGATGCCGCCG
AAGCCCTCACCGATTTTGCCACCCAGTTGAATATTCCCGTAGTCAACACCTTTATGGGCAAAGGGGCAATTCCCTACACC
CATCCCCTGTCCCTGTGGACGGTAGGACTCCAACAGCGGGATTTTGTCACCTGTGCCTTTGAACAGAGCGATTTGGTGAT
TGCAGTGGGCTACGATCTGATCGAATATTCCCCCAAACGCTGGAACCCAGAGGGAACGACCCCAATTATCCACATTGGTG
AAGTGGCCGCCGAAATTGATAGTAGTTATATTCCCCTCACAGAAGTTGTCGGCGACATTGGCGATGCCTTAAATGAAATT
CGTAAACGCACAGACCGTGAGGGCAAAACCGCGCCAAAATTTCTCAATGTCCGGGCTGAGATTCGGGAGGACTATGAACG
CCACGGCACCGACGCTAGTTTTCCGGTCAAACCCCAAAAAATCATCTACGATCTCCGCCAAGTGATGGCCCCAGAGGACA
TCGTCATTTCTGATGTGGGGGCCCACAAAATGTGGATGGCCCGCCATTACCATTGCGATCGCCCCAATACTTGCCTGATT
TCCAATGGATTTGCGGCGATGGGCATTGCGATTCCCGGTGCTGTAGCAGCCAAATTAGTCTACCCAGAAAAAAATGTCGT
GGCTGTCACAGGGGACGGGGGATTTATGATGAACTGCCAGGAGCTCGAAACGGCCCTGCGCATTGGGGCGAACTTTGTCA
CCCTAATTTTCAATGATGGTGGCTATGGTTTGATCGGTTGGAAACAGATTAACCAGTTCGGTGCACCAGCCTTTGTGGAG
TTTGGCAATCCCGATTTTGTGCAGTTTGCCGAAAGTATGGGCCTCAAGGGTTATCGGATTACCGCCGCCGCCGACCTTGT
GCCGACCTTAAAAGAAGCCCTAGCCCAGGATGTACCAGCGGTGATCGATTGCCCCGTGGACTACAGTGAGAATGTGAAAT
TCTCCCAAAAATCAGGGGATTTAATCTGCCGTATGTAA

Upstream 100 bases:

>100_bases
CTCGCTGGGATTCGCACCTTTGTGAATGCCAAAACGGTGTGGCTGAAATAACCCCCCGACTTTATCCCAACGATTTTGGT
GCCTGAGGAGGCGATCGTCC

Downstream 100 bases:

>100_bases
CAGGGTGTCGTACTGGGGATGGAGTTCTACCACGCGACCCACAATGGCGATCGCCGGCGCAGAAAAGCCCGTTGTTTCGA
CTTTTTGGACAATGTCCCCA

Product: acetolactate synthase

Products: NA

Alternate protein names: ALS [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MNTAELLIRCLENEGVEYIFGLPGEENLHILEALKESPIRFITVRHEQGAAFMADVYGRLTGKAGVCLSTLGPGATNLMT
GVADANLDGAPLIAITGQVGTDRMHIESHQYLDLVAMFAPVTKWNKQIVRPNTTPEVVRRAFKIAQQEKPGAVHIDLPEN
IAAMPVEGQPLQRDGREKIYASSRSLNRAAEAIAHAKSPLILVGNGIIRADAAEALTDFATQLNIPVVNTFMGKGAIPYT
HPLSLWTVGLQQRDFVTCAFEQSDLVIAVGYDLIEYSPKRWNPEGTTPIIHIGEVAAEIDSSYIPLTEVVGDIGDALNEI
RKRTDREGKTAPKFLNVRAEIREDYERHGTDASFPVKPQKIIYDLRQVMAPEDIVISDVGAHKMWMARHYHCDRPNTCLI
SNGFAAMGIAIPGAVAAKLVYPEKNVVAVTGDGGFMMNCQELETALRIGANFVTLIFNDGGYGLIGWKQINQFGAPAFVE
FGNPDFVQFAESMGLKGYRITAAADLVPTLKEALAQDVPAVIDCPVDYSENVKFSQKSGDLICRM

Sequences:

>Translated_545_residues
MNTAELLIRCLENEGVEYIFGLPGEENLHILEALKESPIRFITVRHEQGAAFMADVYGRLTGKAGVCLSTLGPGATNLMT
GVADANLDGAPLIAITGQVGTDRMHIESHQYLDLVAMFAPVTKWNKQIVRPNTTPEVVRRAFKIAQQEKPGAVHIDLPEN
IAAMPVEGQPLQRDGREKIYASSRSLNRAAEAIAHAKSPLILVGNGIIRADAAEALTDFATQLNIPVVNTFMGKGAIPYT
HPLSLWTVGLQQRDFVTCAFEQSDLVIAVGYDLIEYSPKRWNPEGTTPIIHIGEVAAEIDSSYIPLTEVVGDIGDALNEI
RKRTDREGKTAPKFLNVRAEIREDYERHGTDASFPVKPQKIIYDLRQVMAPEDIVISDVGAHKMWMARHYHCDRPNTCLI
SNGFAAMGIAIPGAVAAKLVYPEKNVVAVTGDGGFMMNCQELETALRIGANFVTLIFNDGGYGLIGWKQINQFGAPAFVE
FGNPDFVQFAESMGLKGYRITAAADLVPTLKEALAQDVPAVIDCPVDYSENVKFSQKSGDLICRM
>Mature_545_residues
MNTAELLIRCLENEGVEYIFGLPGEENLHILEALKESPIRFITVRHEQGAAFMADVYGRLTGKAGVCLSTLGPGATNLMT
GVADANLDGAPLIAITGQVGTDRMHIESHQYLDLVAMFAPVTKWNKQIVRPNTTPEVVRRAFKIAQQEKPGAVHIDLPEN
IAAMPVEGQPLQRDGREKIYASSRSLNRAAEAIAHAKSPLILVGNGIIRADAAEALTDFATQLNIPVVNTFMGKGAIPYT
HPLSLWTVGLQQRDFVTCAFEQSDLVIAVGYDLIEYSPKRWNPEGTTPIIHIGEVAAEIDSSYIPLTEVVGDIGDALNEI
RKRTDREGKTAPKFLNVRAEIREDYERHGTDASFPVKPQKIIYDLRQVMAPEDIVISDVGAHKMWMARHYHCDRPNTCLI
SNGFAAMGIAIPGAVAAKLVYPEKNVVAVTGDGGFMMNCQELETALRIGANFVTLIFNDGGYGLIGWKQINQFGAPAFVE
FGNPDFVQFAESMGLKGYRITAAADLVPTLKEALAQDVPAVIDCPVDYSENVKFSQKSGDLICRM

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=554, Percent_Identity=25.2707581227437, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI21361361, Length=541, Percent_Identity=24.3992606284658, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1790104, Length=537, Percent_Identity=31.4711359404097, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87081685, Length=565, Percent_Identity=32.212389380531, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1786717, Length=574, Percent_Identity=28.397212543554, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI1788716, Length=543, Percent_Identity=25.9668508287293, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787096, Length=551, Percent_Identity=24.1379310344828, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17531299, Length=483, Percent_Identity=27.536231884058, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17531301, Length=483, Percent_Identity=27.536231884058, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17542570, Length=565, Percent_Identity=23.5398230088496, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323755, Length=555, Percent_Identity=30.4504504504505, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6320816, Length=481, Percent_Identity=26.1954261954262, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321524, Length=483, Percent_Identity=23.3954451345756, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323163, Length=484, Percent_Identity=23.5537190082645, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323073, Length=483, Percent_Identity=22.9813664596273, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320123, Length=491, Percent_Identity=21.7922606924644, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922626, Length=559, Percent_Identity=27.1914132379249, Blast_Score=163, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012782
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59535; Mature: 59535

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAELLIRCLENEGVEYIFGLPGEENLHILEALKESPIRFITVRHEQGAAFMADVYGRL
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHH
TGKAGVCLSTLGPGATNLMTGVADANLDGAPLIAITGQVGTDRMHIESHQYLDLVAMFAP
CCCCCEEEECCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHHHHH
VTKWNKQIVRPNTTPEVVRRAFKIAQQEKPGAVHIDLPENIAAMPVEGQPLQRDGREKIY
HHHHCCEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEECCCCCCCCCCCCCHHHH
ASSRSLNRAAEAIAHAKSPLILVGNGIIRADAAEALTDFATQLNIPVVNTFMGKGAIPYT
HHHHHHHHHHHHHHHCCCCEEEEECCEEECCHHHHHHHHHHHCCCCEEEHHHCCCCCCCC
HPLSLWTVGLQQRDFVTCAFEQSDLVIAVGYDLIEYSPKRWNPEGTTPIIHIGEVAAEID
CCCHHEEECCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCCCCCCCEEEHHHHHHHHC
SSYIPLTEVVGDIGDALNEIRKRTDREGKTAPKFLNVRAEIREDYERHGTDASFPVKPQK
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
IIYDLRQVMAPEDIVISDVGAHKMWMARHYHCDRPNTCLISNGFAAMGIAIPGAVAAKLV
HHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCEEEEECCCEEEEEECCCHHEEEEE
YPEKNVVAVTGDGGFMMNCQELETALRIGANFVTLIFNDGGYGLIGWKQINQFGAPAFVE
CCCCCEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEEECCCCEEEEHHHHHHCCCCEEEE
FGNPDFVQFAESMGLKGYRITAAADLVPTLKEALAQDVPAVIDCPVDYSENVKFSQKSGD
CCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCC
LICRM
EEEEC
>Mature Secondary Structure
MNTAELLIRCLENEGVEYIFGLPGEENLHILEALKESPIRFITVRHEQGAAFMADVYGRL
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHH
TGKAGVCLSTLGPGATNLMTGVADANLDGAPLIAITGQVGTDRMHIESHQYLDLVAMFAP
CCCCCEEEECCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHHHHH
VTKWNKQIVRPNTTPEVVRRAFKIAQQEKPGAVHIDLPENIAAMPVEGQPLQRDGREKIY
HHHHCCEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEECCCCCCCCCCCCCHHHH
ASSRSLNRAAEAIAHAKSPLILVGNGIIRADAAEALTDFATQLNIPVVNTFMGKGAIPYT
HHHHHHHHHHHHHHHCCCCEEEEECCEEECCHHHHHHHHHHHCCCCEEEHHHCCCCCCCC
HPLSLWTVGLQQRDFVTCAFEQSDLVIAVGYDLIEYSPKRWNPEGTTPIIHIGEVAAEID
CCCHHEEECCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCCCCCCCEEEHHHHHHHHC
SSYIPLTEVVGDIGDALNEIRKRTDREGKTAPKFLNVRAEIREDYERHGTDASFPVKPQK
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
IIYDLRQVMAPEDIVISDVGAHKMWMARHYHCDRPNTCLISNGFAAMGIAIPGAVAAKLV
HHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCCEEEEECCCEEEEEECCCHHEEEEE
YPEKNVVAVTGDGGFMMNCQELETALRIGANFVTLIFNDGGYGLIGWKQINQFGAPAFVE
CCCCCEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEEECCCCEEEEHHHHHHCCCCEEEE
FGNPDFVQFAESMGLKGYRITAAADLVPTLKEALAQDVPAVIDCPVDYSENVKFSQKSGD
CCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEECCCCC
LICRM
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644303 [H]