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The map label for this gene is glmU

Identifier: 170079227

GI number: 170079227

Start: 2766821

End: 2768170

Strand: Direct

Name: glmU

Synonym: SYNPCC7002_A2633

Alternate gene names: 170079227

Gene position: 2766821-2768170 (Clockwise)

Preceding gene: 170079224

Following gene: 170079229

Centisome position: 91.98

GC content: 51.33

Gene sequence:

>1350_bases
ATGGTAGCGGTAGCAATTTTGGCAGCAGGCAAAGGTACACGGATGAAGTCGGATCTCCCAAAAGTCCTTCATCCCCTCGG
CGGGCGATCGCTCGTGGAACGGGTGATTGAAAGTTGTGCTCTCATTAAACCAGAACGAATTTGCACCATTGTCGGTTACC
GCGCGGCTGAGGTAAAAATGGCCCTGGCCCATTTGCCTCACCTAGAATTTGTTGAACAAACGGAACAACTCGGCACCGGT
CACGCTGTCCAACAGCTCCTCGAACCTCTCAAAGATTTTGTGGGCGATGTCGTGATTCTCAACGGCGATGTGCCTCTCCT
GCGCCCTGAAACCATTGCAGATCTCGTGAGTACCCACCAGAAAAATAATAATGACGCAACTCTATTAACGGCCCAACTGC
CAAATCCCACGGGTTATGGTCGTGTGTTTTGCGATGGTGACAACCTAGTCACCCAAATCGTCGAACATCGCGACTGCAAC
GATGCCCAACGTAAGAATAATCGGATCAATGCGGGTGTCTACTGTTTCAAGTGGGGGGTGTTGGCCGAGGCGCTACCCAA
ATTAACCACCAACAACGATCAACAGGAATATTACCTCACGGACGTTATTCTCCATTGCGATAAAGTGATGGCGATGGATG
TGGCGGATTTCCAGGAAATTAGCGGTATTAATGACCGTTTTCAGCTTTCGGCAGCCTACGAAATTTTGCAAGACCGCATC
AAGGAAAAATGGATGAAGGCCGGGGTCATGATCCACCAGCCCGATACAGTTACCATTGACGACACCGTGCAGCTCGAACC
AGATGTGATGATCGAACCCCAAACCCATCTGCGGGGCAATAGTTTGATCAAGACTGGTTGCCGCCTAGGGCCGGGCAGCT
TGATTGAAAATAGCGTCATTGAAGCCAATACAACAATTCTCTACAGCGTGGTGAGTGATAGCCAGGTGGGAGAAAATGCC
CAAATTGGCCCCTATACGCACATTCGCGGCCAGGCTAAGGTTGGGGAGCAATGCCGGATCGGGAATTTCGTGGAGGTCAA
AAAATCGACCATCGGCAACAATACCAACATGGCCCACCTCTCCTATATCGGCGATGCCACCCTAGGAGCAAAGGTGAATA
TCGGCGCTGGGACGATCACAGCGAACTATGACGGTGTGAATAAGCATCAAACAGTGATTGGCGATCGCAGTAAAACCGGA
GCCAATAGCGTCCTGGTTGCGCCCATCACCATCGGCGAAGATGTGACCATTGCGGCAGGCTCAACAATCACCAAGGATGT
GGATAATGATTGCCTCGTTGTCGCCCGGGCTCGCCAGAAGGAGATTAAAGGGTGGCGCTTACAGTCTTGA

Upstream 100 bases:

>100_bases
TGTAAACAAGAATCTTCTCCGGCACCGATGCCGGAAGTCCCAAACAATACGATATACTCCACACTGAAACGATGTCAGTC
AATCGAACACAGCAAAGGCA

Downstream 100 bases:

>100_bases
ACGGGGAAGCAGGCGTAATGGGGAATCAAACCTGATTAAAATTGCCGTCGACTGAAAATAAAGATGGCGATCGCCTGGAG
CAAAATCACGTAGACAAGGC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MVAVAILAAGKGTRMKSDLPKVLHPLGGRSLVERVIESCALIKPERICTIVGYRAAEVKMALAHLPHLEFVEQTEQLGTG
HAVQQLLEPLKDFVGDVVILNGDVPLLRPETIADLVSTHQKNNNDATLLTAQLPNPTGYGRVFCDGDNLVTQIVEHRDCN
DAQRKNNRINAGVYCFKWGVLAEALPKLTTNNDQQEYYLTDVILHCDKVMAMDVADFQEISGINDRFQLSAAYEILQDRI
KEKWMKAGVMIHQPDTVTIDDTVQLEPDVMIEPQTHLRGNSLIKTGCRLGPGSLIENSVIEANTTILYSVVSDSQVGENA
QIGPYTHIRGQAKVGEQCRIGNFVEVKKSTIGNNTNMAHLSYIGDATLGAKVNIGAGTITANYDGVNKHQTVIGDRSKTG
ANSVLVAPITIGEDVTIAAGSTITKDVDNDCLVVARARQKEIKGWRLQS

Sequences:

>Translated_449_residues
MVAVAILAAGKGTRMKSDLPKVLHPLGGRSLVERVIESCALIKPERICTIVGYRAAEVKMALAHLPHLEFVEQTEQLGTG
HAVQQLLEPLKDFVGDVVILNGDVPLLRPETIADLVSTHQKNNNDATLLTAQLPNPTGYGRVFCDGDNLVTQIVEHRDCN
DAQRKNNRINAGVYCFKWGVLAEALPKLTTNNDQQEYYLTDVILHCDKVMAMDVADFQEISGINDRFQLSAAYEILQDRI
KEKWMKAGVMIHQPDTVTIDDTVQLEPDVMIEPQTHLRGNSLIKTGCRLGPGSLIENSVIEANTTILYSVVSDSQVGENA
QIGPYTHIRGQAKVGEQCRIGNFVEVKKSTIGNNTNMAHLSYIGDATLGAKVNIGAGTITANYDGVNKHQTVIGDRSKTG
ANSVLVAPITIGEDVTIAAGSTITKDVDNDCLVVARARQKEIKGWRLQS
>Mature_449_residues
MVAVAILAAGKGTRMKSDLPKVLHPLGGRSLVERVIESCALIKPERICTIVGYRAAEVKMALAHLPHLEFVEQTEQLGTG
HAVQQLLEPLKDFVGDVVILNGDVPLLRPETIADLVSTHQKNNNDATLLTAQLPNPTGYGRVFCDGDNLVTQIVEHRDCN
DAQRKNNRINAGVYCFKWGVLAEALPKLTTNNDQQEYYLTDVILHCDKVMAMDVADFQEISGINDRFQLSAAYEILQDRI
KEKWMKAGVMIHQPDTVTIDDTVQLEPDVMIEPQTHLRGNSLIKTGCRLGPGSLIENSVIEANTTILYSVVSDSQVGENA
QIGPYTHIRGQAKVGEQCRIGNFVEVKKSTIGNNTNMAHLSYIGDATLGAKVNIGAGTITANYDGVNKHQTVIGDRSKTG
ANSVLVAPITIGEDVTIAAGSTITKDVDNDCLVVARARQKEIKGWRLQS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=450, Percent_Identity=40.8888888888889, Blast_Score=321, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6320148, Length=353, Percent_Identity=24.929178470255, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_SYNP2 (B1XLT6)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735865.1
- ProteinModelPortal:   B1XLT6
- SMR:   B1XLT6
- GeneID:   6056342
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2633
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14360
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 48938; Mature: 48938

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 359-359 BINDING 73-73 BINDING 140-140 BINDING 155-155 BINDING 170-170 BINDING 383-383 BINDING 419-419 BINDING 436-436

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVAILAAGKGTRMKSDLPKVLHPLGGRSLVERVIESCALIKPERICTIVGYRAAEVKM
CEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHEEEEECCCHHHHHH
ALAHLPHLEFVEQTEQLGTGHAVQQLLEPLKDFVGDVVILNGDVPLLRPETIADLVSTHQ
HHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHC
KNNNDATLLTAQLPNPTGYGRVFCDGDNLVTQIVEHRDCNDAQRKNNRINAGVYCFKWGV
CCCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEHHH
LAEALPKLTTNNDQQEYYLTDVILHCDKVMAMDVADFQEISGINDRFQLSAAYEILQDRI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHH
KEKWMKAGVMIHQPDTVTIDDTVQLEPDVMIEPQTHLRGNSLIKTGCRLGPGSLIENSVI
HHHHHHCCEEEECCCEEEECCEEEECCCEEECCCCCCCCCCHHHCCCCCCCCHHHHCCEE
EANTTILYSVVSDSQVGENAQIGPYTHIRGQAKVGEQCRIGNFVEVKKSTIGNNTNMAHL
ECCCEEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEEHHHHCCCCCCEEEE
SYIGDATLGAKVNIGAGTITANYDGVNKHQTVIGDRSKTGANSVLVAPITIGEDVTIAAG
EEECCCCCCCEEECCCEEEEECCCCCCCCCEEECCCCCCCCCCEEEEEEEECCCEEEECC
STITKDVDNDCLVVARARQKEIKGWRLQS
CEEECCCCCCEEEEEECHHHHCCCCCCCC
>Mature Secondary Structure
MVAVAILAAGKGTRMKSDLPKVLHPLGGRSLVERVIESCALIKPERICTIVGYRAAEVKM
CEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHEEEEECCCHHHHHH
ALAHLPHLEFVEQTEQLGTGHAVQQLLEPLKDFVGDVVILNGDVPLLRPETIADLVSTHQ
HHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHC
KNNNDATLLTAQLPNPTGYGRVFCDGDNLVTQIVEHRDCNDAQRKNNRINAGVYCFKWGV
CCCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEHHH
LAEALPKLTTNNDQQEYYLTDVILHCDKVMAMDVADFQEISGINDRFQLSAAYEILQDRI
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHH
KEKWMKAGVMIHQPDTVTIDDTVQLEPDVMIEPQTHLRGNSLIKTGCRLGPGSLIENSVI
HHHHHHCCEEEECCCEEEECCEEEECCCEEECCCCCCCCCCHHHCCCCCCCCHHHHCCEE
EANTTILYSVVSDSQVGENAQIGPYTHIRGQAKVGEQCRIGNFVEVKKSTIGNNTNMAHL
ECCCEEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEEEHHHHCCCCCCEEEE
SYIGDATLGAKVNIGAGTITANYDGVNKHQTVIGDRSKTGANSVLVAPITIGEDVTIAAG
EEECCCCCCCEEECCCEEEEECCCCCCCCCEEECCCCCCCCCCEEEEEEEECCCEEEECC
STITKDVDNDCLVVARARQKEIKGWRLQS
CEEECCCCCCEEEEEECHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA