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The map label for this gene is hemH

Identifier: 170079183

GI number: 170079183

Start: 2709800

End: 2710960

Strand: Direct

Name: hemH

Synonym: SYNPCC7002_A2589

Alternate gene names: 170079183

Gene position: 2709800-2710960 (Clockwise)

Preceding gene: 170079181

Following gene: 170079187

Centisome position: 90.09

GC content: 50.65

Gene sequence:

>1161_bases
ATGGGTCGTGTTGGGGTCTTATTACTTAACCTAGGTGGGCCAGACAAATTAGAGGATGTCCGTCCTTTTTTATTTAATTT
GTTTGCTGACCCCGAAATTATTCGTTTACCCGCGCCATGGATGCAAAAGCCGCTTGCTTGGCTCATTTCCACGCTCCGGG
CCGGCAAATCCCAAGAAAACTATAAAGAAATTGGCGGTGGTTCGCCCCTCCGACAAATCACCGAAGCCCAGGGGACAGCC
CTCGCCCAAAAGTTGGCGGAGTGGGGTCAAGAGGTCAAAGTTTATGTGGGGATGCGCTACTGGCACCCCTTCACCGAAGA
GGCGATCGCCGAAATCAAAAAAGACGACCTTGATCAGCTTGTGGTATTGCCACTCTATCCCCAGTTTTCCATCAGCACTA
GCGGGTCTAGCTTCCGGGTGCTCGAAGAAATGTGGCGCACCGACAAAGACCTCAATCAACTCGATTACACCCTCATTCCC
TCCTGGTATGACCATCCCCAATACATTGCTGCGATGGTCGATCTCATTCGCCAAGAGCTGGATCAATTTGATAACCCAGA
CCAGGCCCATATTTTCTTTAGTGCCCATGGCGTCCCCCAAAGCTATGTCGAAGAAGCAGGAGATCCCTACCAGCGAGAAA
TCGAAGAATGCACCAAATTAATCATGGAAGCCCTTGGTCGTCCCAATGACTACACCCTGGCCTACCAAAGTCGTGTTGGC
CCCGTAGAATGGCTCCAACCCTACACCGAAGATTCCCTCATTGCCCTGGGCGAAAAAGGCGTGAAGGATTTGGTGGTGAT
TCCCATTAGTTTCGTGTCTGAGCACATCGAAACCCTCCAGGAAATCGATATTGAGTATCGGGAAGTTGCCGAGGAAGCTG
GCATTGAAAATTTCCGCCGCGTTCCGGCTCTGAATACTCATCCATTGTTCATCGAATCCTTGGCGAACTTGGTCACCGAT
TCCCTCGAACAATGTCCTCGCACCTTTGGTCAGGTCACCCACCCCAAAGAAAATATGAAAATGTATCCCCAAGAATTGTC
CTGGGGCATGAATACCAGCGCCGAGGTCTTAAATGGCCGCCTCGCCATGATCGGCTTTTTGGCGTTGTTGTTGGAGTTGA
TTAGTGGCCAAGGCCCGCTCCATTTTGTTGGCATTATGTAA

Upstream 100 bases:

>100_bases
TCGACTTTCTTGTAGCCACCACGACAGGCACGCCGTCCCAAAGAGATATATTGTTACAATAACTTAAAGAAAATACCAGT
AAATTTAATTTGTATCAGCT

Downstream 100 bases:

>100_bases
ATAACATCCCCCTAGCTCCCCCTTCGGAAGTGACATCCCCCTAGCTCCCCCTTTCAAAGGGGGATTTTTGTTAAATGACG
CGCTCGTTGCCGCCATCAAG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MGRVGVLLLNLGGPDKLEDVRPFLFNLFADPEIIRLPAPWMQKPLAWLISTLRAGKSQENYKEIGGGSPLRQITEAQGTA
LAQKLAEWGQEVKVYVGMRYWHPFTEEAIAEIKKDDLDQLVVLPLYPQFSISTSGSSFRVLEEMWRTDKDLNQLDYTLIP
SWYDHPQYIAAMVDLIRQELDQFDNPDQAHIFFSAHGVPQSYVEEAGDPYQREIEECTKLIMEALGRPNDYTLAYQSRVG
PVEWLQPYTEDSLIALGEKGVKDLVVIPISFVSEHIETLQEIDIEYREVAEEAGIENFRRVPALNTHPLFIESLANLVTD
SLEQCPRTFGQVTHPKENMKMYPQELSWGMNTSAEVLNGRLAMIGFLALLLELISGQGPLHFVGIM

Sequences:

>Translated_386_residues
MGRVGVLLLNLGGPDKLEDVRPFLFNLFADPEIIRLPAPWMQKPLAWLISTLRAGKSQENYKEIGGGSPLRQITEAQGTA
LAQKLAEWGQEVKVYVGMRYWHPFTEEAIAEIKKDDLDQLVVLPLYPQFSISTSGSSFRVLEEMWRTDKDLNQLDYTLIP
SWYDHPQYIAAMVDLIRQELDQFDNPDQAHIFFSAHGVPQSYVEEAGDPYQREIEECTKLIMEALGRPNDYTLAYQSRVG
PVEWLQPYTEDSLIALGEKGVKDLVVIPISFVSEHIETLQEIDIEYREVAEEAGIENFRRVPALNTHPLFIESLANLVTD
SLEQCPRTFGQVTHPKENMKMYPQELSWGMNTSAEVLNGRLAMIGFLALLLELISGQGPLHFVGIM
>Mature_385_residues
GRVGVLLLNLGGPDKLEDVRPFLFNLFADPEIIRLPAPWMQKPLAWLISTLRAGKSQENYKEIGGGSPLRQITEAQGTAL
AQKLAEWGQEVKVYVGMRYWHPFTEEAIAEIKKDDLDQLVVLPLYPQFSISTSGSSFRVLEEMWRTDKDLNQLDYTLIPS
WYDHPQYIAAMVDLIRQELDQFDNPDQAHIFFSAHGVPQSYVEEAGDPYQREIEECTKLIMEALGRPNDYTLAYQSRVGP
VEWLQPYTEDSLIALGEKGVKDLVVIPISFVSEHIETLQEIDIEYREVAEEAGIENFRRVPALNTHPLFIESLANLVTDS
LEQCPRTFGQVTHPKENMKMYPQELSWGMNTSAEVLNGRLAMIGFLALLLELISGQGPLHFVGIM

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=327, Percent_Identity=41.2844036697248, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI60499025, Length=327, Percent_Identity=41.2844036697248, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=35.4037267080745, Blast_Score=158, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6324750, Length=328, Percent_Identity=37.8048780487805, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17864156, Length=327, Percent_Identity=40.0611620795107, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=37.5, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45552018, Length=193, Percent_Identity=39.8963730569948, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_SYNP2 (B1XL79)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735821.1
- ProteinModelPortal:   B1XL79
- SMR:   B1XL79
- GeneID:   6056609
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2589
- HOGENOM:   HBG697135
- OMA:   WLQKPLA
- ProtClustDB:   PRK00035
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 43796; Mature: 43664

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRVGVLLLNLGGPDKLEDVRPFLFNLFADPEIIRLPAPWMQKPLAWLISTLRAGKSQEN
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHH
YKEIGGGSPLRQITEAQGTALAQKLAEWGQEVKVYVGMRYWHPFTEEAIAEIKKDDLDQL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHEEEEEEEHHCCCCHHHHHHHHHHCCCCCE
VVLPLYPQFSISTSGSSFRVLEEMWRTDKDLNQLDYTLIPSWYDHPQYIAAMVDLIRQEL
EEEECCCCCEECCCCCHHHHHHHHHCCCCCHHHCCCEECCCCCCCHHHHHHHHHHHHHHH
DQFDNPDQAHIFFSAHGVPQSYVEEAGDPYQREIEECTKLIMEALGRPNDYTLAYQSRVG
HHCCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
PVEWLQPYTEDSLIALGEKGVKDLVVIPISFVSEHIETLQEIDIEYREVAEEAGIENFRR
CHHHHCCCCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHCHHHHHH
VPALNTHPLFIESLANLVTDSLEQCPRTFGQVTHPKENMKMYPQELSWGMNTSAEVLNGR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHCCCCCCHHHHHCCH
LAMIGFLALLLELISGQGPLHFVGIM
HHHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
GRVGVLLLNLGGPDKLEDVRPFLFNLFADPEIIRLPAPWMQKPLAWLISTLRAGKSQEN
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHH
YKEIGGGSPLRQITEAQGTALAQKLAEWGQEVKVYVGMRYWHPFTEEAIAEIKKDDLDQL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHCHHEEEEEEEHHCCCCHHHHHHHHHHCCCCCE
VVLPLYPQFSISTSGSSFRVLEEMWRTDKDLNQLDYTLIPSWYDHPQYIAAMVDLIRQEL
EEEECCCCCEECCCCCHHHHHHHHHCCCCCHHHCCCEECCCCCCCHHHHHHHHHHHHHHH
DQFDNPDQAHIFFSAHGVPQSYVEEAGDPYQREIEECTKLIMEALGRPNDYTLAYQSRVG
HHCCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
PVEWLQPYTEDSLIALGEKGVKDLVVIPISFVSEHIETLQEIDIEYREVAEEAGIENFRR
CHHHHCCCCCCCEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHCHHHHHH
VPALNTHPLFIESLANLVTDSLEQCPRTFGQVTHPKENMKMYPQELSWGMNTSAEVLNGR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCHHHHCCCCCCHHHHHCCH
LAMIGFLALLLELISGQGPLHFVGIM
HHHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA