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The map label for this gene is pepA

Identifier: 170079055

GI number: 170079055

Start: 2558107

End: 2559582

Strand: Reverse

Name: pepA

Synonym: SYNPCC7002_A2460

Alternate gene names: 170079055

Gene position: 2559582-2558107 (Counterclockwise)

Preceding gene: 170079056

Following gene: 170079050

Centisome position: 85.09

GC content: 53.66

Gene sequence:

>1476_bases
ATGGAAATTCGCGGTAGTTCGCAAACGGCAGCGGCTTGGGCGGGTGAGGCGATCGCCTTGGGTTTTTTTGAAAGTGAAAC
GGTACTCACGGTACCCGAAAATTTGACGGCCCTGGACGAACGCTTATCGGGGGTGATCGCGGAAGTAATCGCTGAAACGG
AATTTAAAGGTAAATCCGGCAAGCTATCGGTGACCCGTCTTGGGAGTGGTGCGCCAATTAAGAAATTACTCTTGGTGGGT
CTGGGCAATGCCGAGAAATGGAATAGTGCCGTCTTACGGAGTACCGCAGCGGCGATCGCCCGGGCTGTGAAAGGGGACAA
AGCCATCACAACTTTGGGTTTGCAGTTGCCAGTGGCCGAAACTGAGGCGATCACAGCGCAAATGGTCACAGAAGGGATGT
ATCTGGGCTTTTATGAAGATAATCGCTTCAAATCAGAACAAAAAGACCCCCCAGCCCTCGAAGCTGTTGAAATCCTTGGC
ATTGGCGACCAACCAGCGGCGATCGCCTTGGGCACAAGCCTCTGTGAAGGGGTGATCTATGCGCGGGAATTGGTTAACGC
TCCGGCTAACATTATTAATCCTGTGACCCTGGCCGCTTCCGTGGAAAGCCTCGCCAGCACCTATGGCCTGGAACTGAATA
TCCTCGAAGAAGCAGACTGCGAAGCAGCAGGAATGGGATCTTTCCTTGGGGTGGCGGCGGCCTCGGATTTACCCCCGAAA
TTTATCCACCTCGTTTATAAACCCCTAGGCACACCCCGGAAGAAAGTGGCGATTGTCGGTAAAGGGTTAACCTTTGATTC
TGGCGGTTACAACATTAAACCCTCCGGCCCCAGCATCGCGATGATGAAAATGGACATGGGGGGCGCAGCGGCAACTTTTG
GAGCGGCAAAGGCGATCGCCGAACTAAAACCCGATGTGGAAGTGCATTTCATTAGTGCGGCTACTGAAAATATGATCAGT
GGTCGGGGGATGCGTCCGGGGGATATTCTCACGGCCTCCAACGGTAAAACCATCGAAGTGAACAACACCGACGCCGAAGG
TCGCCTCACCCTCGCCGATGCCCTCGTTTATGCCGAAAAGCTAGGGGTCGAAGCGATTGTAGACATTGCCACCTTGACCG
GAGCCTGCGTCATTGCCCTGGGTGACGATATTTGTGGTCTGTGGAGTGACAATGATGATCTCGCCCAGGCGATCGCCACC
GCATCAGAGAAAGCGGGCGAAAAATTCTGGCAGATGCCCCTCGAAGAAAAATACTTTGAAGGCTTAAAATCTCCCATCGC
CGACATGAAAAACACTGGGCCACGGGAAGGCGGTTCGATTACGGCGGCGTTGTTCCTCAAGGAATTTGTCGAAAACACGC
CCTGGGCACACCTCGATATTGCTGGGCCAGCCTGGTCAGAAAAAGACGCCGATATTTACAGCAAAGGCGGTACAGGGTTC
CCGGTGCGTACCCTTGTGCATTGGGTACTGAGCTAA

Upstream 100 bases:

>100_bases
AGTTGCGGTCTTCCTCGTAATGTTGCTCTGGGCAATTTCTTGGACAGGGTTTGCCGGAAATGTCAGACTAAAGGACAGTA
ACAAGTTTTGAGGTTTAGTT

Downstream 100 bases:

>100_bases
TTTTTGCATCTAAAGTTTAATTAAAAACCCCCCTTGGCCAATCATTCCAGGGGGGCTGTTTTATGGAAATTATCTATTTC
AGTAGTCTGAGATTAAAGGG

Product: cytosol aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MEIRGSSQTAAAWAGEAIALGFFESETVLTVPENLTALDERLSGVIAEVIAETEFKGKSGKLSVTRLGSGAPIKKLLLVG
LGNAEKWNSAVLRSTAAAIARAVKGDKAITTLGLQLPVAETEAITAQMVTEGMYLGFYEDNRFKSEQKDPPALEAVEILG
IGDQPAAIALGTSLCEGVIYARELVNAPANIINPVTLAASVESLASTYGLELNILEEADCEAAGMGSFLGVAAASDLPPK
FIHLVYKPLGTPRKKVAIVGKGLTFDSGGYNIKPSGPSIAMMKMDMGGAAATFGAAKAIAELKPDVEVHFISAATENMIS
GRGMRPGDILTASNGKTIEVNNTDAEGRLTLADALVYAEKLGVEAIVDIATLTGACVIALGDDICGLWSDNDDLAQAIAT
ASEKAGEKFWQMPLEEKYFEGLKSPIADMKNTGPREGGSITAALFLKEFVENTPWAHLDIAGPAWSEKDADIYSKGGTGF
PVRTLVHWVLS

Sequences:

>Translated_491_residues
MEIRGSSQTAAAWAGEAIALGFFESETVLTVPENLTALDERLSGVIAEVIAETEFKGKSGKLSVTRLGSGAPIKKLLLVG
LGNAEKWNSAVLRSTAAAIARAVKGDKAITTLGLQLPVAETEAITAQMVTEGMYLGFYEDNRFKSEQKDPPALEAVEILG
IGDQPAAIALGTSLCEGVIYARELVNAPANIINPVTLAASVESLASTYGLELNILEEADCEAAGMGSFLGVAAASDLPPK
FIHLVYKPLGTPRKKVAIVGKGLTFDSGGYNIKPSGPSIAMMKMDMGGAAATFGAAKAIAELKPDVEVHFISAATENMIS
GRGMRPGDILTASNGKTIEVNNTDAEGRLTLADALVYAEKLGVEAIVDIATLTGACVIALGDDICGLWSDNDDLAQAIAT
ASEKAGEKFWQMPLEEKYFEGLKSPIADMKNTGPREGGSITAALFLKEFVENTPWAHLDIAGPAWSEKDADIYSKGGTGF
PVRTLVHWVLS
>Mature_491_residues
MEIRGSSQTAAAWAGEAIALGFFESETVLTVPENLTALDERLSGVIAEVIAETEFKGKSGKLSVTRLGSGAPIKKLLLVG
LGNAEKWNSAVLRSTAAAIARAVKGDKAITTLGLQLPVAETEAITAQMVTEGMYLGFYEDNRFKSEQKDPPALEAVEILG
IGDQPAAIALGTSLCEGVIYARELVNAPANIINPVTLAASVESLASTYGLELNILEEADCEAAGMGSFLGVAAASDLPPK
FIHLVYKPLGTPRKKVAIVGKGLTFDSGGYNIKPSGPSIAMMKMDMGGAAATFGAAKAIAELKPDVEVHFISAATENMIS
GRGMRPGDILTASNGKTIEVNNTDAEGRLTLADALVYAEKLGVEAIVDIATLTGACVIALGDDICGLWSDNDDLAQAIAT
ASEKAGEKFWQMPLEEKYFEGLKSPIADMKNTGPREGGSITAALFLKEFVENTPWAHLDIAGPAWSEKDADIYSKGGTGF
PVRTLVHWVLS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=506, Percent_Identity=36.7588932806324, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI47155554, Length=343, Percent_Identity=33.8192419825073, Blast_Score=150, Evalue=3e-36,
Organism=Escherichia coli, GI1790710, Length=508, Percent_Identity=35.0393700787402, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=37.9310344827586, Blast_Score=181, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=301, Percent_Identity=36.2126245847176, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=433, Percent_Identity=24.7113163972286, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24661038, Length=311, Percent_Identity=33.7620578778135, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21355725, Length=373, Percent_Identity=30.8310991957105, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20129969, Length=466, Percent_Identity=29.1845493562232, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI21355645, Length=490, Percent_Identity=27.5510204081633, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24662223, Length=490, Percent_Identity=27.5510204081633, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI19922386, Length=480, Percent_Identity=30, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI20129963, Length=471, Percent_Identity=27.1762208067941, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24662227, Length=460, Percent_Identity=26.0869565217391, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI161077148, Length=358, Percent_Identity=29.3296089385475, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20130057, Length=358, Percent_Identity=29.3296089385475, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21357381, Length=298, Percent_Identity=32.5503355704698, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221379063, Length=298, Percent_Identity=32.5503355704698, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221379062, Length=298, Percent_Identity=32.5503355704698, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24646701, Length=182, Percent_Identity=34.0659340659341, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24646703, Length=182, Percent_Identity=34.0659340659341, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21358201, Length=182, Percent_Identity=34.0659340659341, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_SYNP2 (B1XK83)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735693.1
- ProteinModelPortal:   B1XK83
- SMR:   B1XK83
- MEROPS:   M17.002
- GeneID:   6057643
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2460
- HOGENOM:   HBG742580
- OMA:   LGHHNSG
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 51522; Mature: 51522

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 273-273 ACT_SITE 348-348

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRGSSQTAAAWAGEAIALGFFESETVLTVPENLTALDERLSGVIAEVIAETEFKGKSG
CCCCCCCCCHHHHCCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
KLSVTRLGSGAPIKKLLLVGLGNAEKWNSAVLRSTAAAIARAVKGDKAITTLGLQLPVAE
CEEEEECCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCH
TEAITAQMVTEGMYLGFYEDNRFKSEQKDPPALEAVEILGIGDQPAAIALGTSLCEGVIY
HHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHH
ARELVNAPANIINPVTLAASVESLASTYGLELNILEEADCEAAGMGSFLGVAAASDLPPK
HHHHHCCCHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCHH
FIHLVYKPLGTPRKKVAIVGKGLTFDSGGYNIKPSGPSIAMMKMDMGGAAATFGAAKAIA
HHHHHHHCCCCCCCEEEEEECCEEECCCCCEECCCCCCEEEEEECCCCCHHHHHHHHHHH
ELKPDVEVHFISAATENMISGRGMRPGDILTASNGKTIEVNNTDAEGRLTLADALVYAEK
HCCCCCEEEEEEHHHHHHHCCCCCCCCCEEEECCCCEEEECCCCCCCEEEHHHHHHHHHH
LGVEAIVDIATLTGACVIALGDDICGLWSDNDDLAQAIATASEKAGEKFWQMPLEEKYFE
HCHHHHHHHHHHCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GLKSPIADMKNTGPREGGSITAALFLKEFVENTPWAHLDIAGPAWSEKDADIYSKGGTGF
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCC
PVRTLVHWVLS
CHHHHHHHHCC
>Mature Secondary Structure
MEIRGSSQTAAAWAGEAIALGFFESETVLTVPENLTALDERLSGVIAEVIAETEFKGKSG
CCCCCCCCCHHHHCCCEEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
KLSVTRLGSGAPIKKLLLVGLGNAEKWNSAVLRSTAAAIARAVKGDKAITTLGLQLPVAE
CEEEEECCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCH
TEAITAQMVTEGMYLGFYEDNRFKSEQKDPPALEAVEILGIGDQPAAIALGTSLCEGVIY
HHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHH
ARELVNAPANIINPVTLAASVESLASTYGLELNILEEADCEAAGMGSFLGVAAASDLPPK
HHHHHCCCHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHCCCCCHH
FIHLVYKPLGTPRKKVAIVGKGLTFDSGGYNIKPSGPSIAMMKMDMGGAAATFGAAKAIA
HHHHHHHCCCCCCCEEEEEECCEEECCCCCEECCCCCCEEEEEECCCCCHHHHHHHHHHH
ELKPDVEVHFISAATENMISGRGMRPGDILTASNGKTIEVNNTDAEGRLTLADALVYAEK
HCCCCCEEEEEEHHHHHHHCCCCCCCCCEEEECCCCEEEECCCCCCCEEEHHHHHHHHHH
LGVEAIVDIATLTGACVIALGDDICGLWSDNDDLAQAIATASEKAGEKFWQMPLEEKYFE
HCHHHHHHHHHHCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GLKSPIADMKNTGPREGGSITAALFLKEFVENTPWAHLDIAGPAWSEKDADIYSKGGTGF
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCC
PVRTLVHWVLS
CHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA