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The map label for this gene is nth [H]

Identifier: 170079050

GI number: 170079050

Start: 2551708

End: 2552370

Strand: Reverse

Name: nth [H]

Synonym: SYNPCC7002_A2455

Alternate gene names: 170079050

Gene position: 2552370-2551708 (Counterclockwise)

Preceding gene: 170079055

Following gene: 170079048

Centisome position: 84.85

GC content: 50.68

Gene sequence:

>663_bases
ATGGCAATTCATTACCCGCGTAGTAAGAAAAAACGGGCGATCGCCGTTCTCGAAAAACTCCACGAACTCTATCCCGATGC
CACCTGTAGTTTGGACTATGAAACCCCCGTGCAACTCATGGTGGCAACCATTCTTTCAGCCCAATGTACCGACGAGCGAG
TAAATAAAGTTACACCGGCGCTCTTTGCCCGATTTCCTGATGCGGCGGCCTTTGCCGGGGCAAATGTGGCAGACATTGAA
CAGCTAGTGCGCTCAACGGGATTTTATCGAAATAAAGCGAAAAATATTCAGGGAGCTTGCCAGCGGATTATGGCGGTTTT
CAATGGGAAAGTGCCGCAAACCATGGAAGAGCTTCTGACCTTGCCCGGTGTGGCCCGGAAAACGGCCAATGTTGTTCTGG
CCCATGCTTTTGGGATTTGTGCGGGGGTGACGGTGGATACCCATGTCAAGCGTTTGAGTAATCGTTTGCGCCTCACAAAA
TCTGAGAATCCGGTACAAATTGAACGGGATTTGATGAAATTAATTCCCCAGCCGGAGTGGGAAAACTGGTCGATCCGTCT
GATTTACCATGGTCGCGCCGTCTGTAATGCCAGAAAACCTCAATGTGAGGTCTGTGCGATCGCCAATCTTTGTCCCTCAG
CCCCCAAACCCCAGCCAGTTTAA

Upstream 100 bases:

>100_bases
CTGTACCAACTTCAATGAGGTAGGTTGCCATGGGAAACGAAATCAGGTCAATAATGAATCTTGATTAGTTTACCGTGAAG
CCACAGGAAAAATAGTGCCC

Downstream 100 bases:

>100_bases
GGGTCTTGTCAAAAGATAAAGCGACTGGGCACAAGCTGAATCCGGCCCGCATCCATTTCTGCCATCAAAAGTTCGAGGGC
TTCATAATCCGCATCGGAAA

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MAIHYPRSKKKRAIAVLEKLHELYPDATCSLDYETPVQLMVATILSAQCTDERVNKVTPALFARFPDAAAFAGANVADIE
QLVRSTGFYRNKAKNIQGACQRIMAVFNGKVPQTMEELLTLPGVARKTANVVLAHAFGICAGVTVDTHVKRLSNRLRLTK
SENPVQIERDLMKLIPQPEWENWSIRLIYHGRAVCNARKPQCEVCAIANLCPSAPKPQPV

Sequences:

>Translated_220_residues
MAIHYPRSKKKRAIAVLEKLHELYPDATCSLDYETPVQLMVATILSAQCTDERVNKVTPALFARFPDAAAFAGANVADIE
QLVRSTGFYRNKAKNIQGACQRIMAVFNGKVPQTMEELLTLPGVARKTANVVLAHAFGICAGVTVDTHVKRLSNRLRLTK
SENPVQIERDLMKLIPQPEWENWSIRLIYHGRAVCNARKPQCEVCAIANLCPSAPKPQPV
>Mature_219_residues
AIHYPRSKKKRAIAVLEKLHELYPDATCSLDYETPVQLMVATILSAQCTDERVNKVTPALFARFPDAAAFAGANVADIEQ
LVRSTGFYRNKAKNIQGACQRIMAVFNGKVPQTMEELLTLPGVARKTANVVLAHAFGICAGVTVDTHVKRLSNRLRLTKS
ENPVQIERDLMKLIPQPEWENWSIRLIYHGRAVCNARKPQCEVCAIANLCPSAPKPQPV

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=179, Percent_Identity=31.2849162011173, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1787920, Length=210, Percent_Identity=38.5714285714286, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789331, Length=186, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554540, Length=181, Percent_Identity=35.3591160220994, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324530, Length=187, Percent_Identity=27.807486631016, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319304, Length=179, Percent_Identity=29.0502793296089, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550361, Length=179, Percent_Identity=30.7262569832402, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 24419; Mature: 24288

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHYPRSKKKRAIAVLEKLHELYPDATCSLDYETPVQLMVATILSAQCTDERVNKVTPA
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHHH
LFARFPDAAAFAGANVADIEQLVRSTGFYRNKAKNIQGACQRIMAVFNGKVPQTMEELLT
HHHHCCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LPGVARKTANVVLAHAFGICAGVTVDTHVKRLSNRLRLTKSENPVQIERDLMKLIPQPEW
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
ENWSIRLIYHGRAVCNARKPQCEVCAIANLCPSAPKPQPV
CCEEEEEEECCCHHHCCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AIHYPRSKKKRAIAVLEKLHELYPDATCSLDYETPVQLMVATILSAQCTDERVNKVTPA
CCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHHH
LFARFPDAAAFAGANVADIEQLVRSTGFYRNKAKNIQGACQRIMAVFNGKVPQTMEELLT
HHHHCCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LPGVARKTANVVLAHAFGICAGVTVDTHVKRLSNRLRLTKSENPVQIERDLMKLIPQPEW
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCC
ENWSIRLIYHGRAVCNARKPQCEVCAIANLCPSAPKPQPV
CCEEEEEEECCCHHHCCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]