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The map label for this gene is folE [H]

Identifier: 170079039

GI number: 170079039

Start: 2537855

End: 2538574

Strand: Direct

Name: folE [H]

Synonym: SYNPCC7002_A2444

Alternate gene names: 170079039

Gene position: 2537855-2538574 (Clockwise)

Preceding gene: 170079038

Following gene: 170079043

Centisome position: 84.37

GC content: 50.56

Gene sequence:

>720_bases
ATGACAACATCTTCTTCAAGCGGCTTCAATGGTTCTACAAAAACCATGGCGACTGATGCTCTAGGTCGTGACCTCAATGA
TCTGGTGACTCGGCCAGACCGCAATAGCCACAATGGCAAAGCAGCAAGCATTCGCCCTGCCACAGAAGAAAGCCAGCAGA
AAATGGCAGAGGCTGTGCATACGATGCTAGAAGCCGTTGGCGAAGATCCTGACCGTGAAGGTCTCCTAAAGACGCCGCTG
CGGGTGGCAAAAGCCATGCAGTTTCTGACCCAAGGCTATAACCAGTCCCTTGAAGACATCGTCAATGGTGCAATTTTCGA
TGAAGGGCACAATGAAATGGTATTGGTGCGGGACATCGATTTCTTTAGCCTCTGCGAACACCACATGTTGCCCTTTATGG
GTCGGGCCCACGTGGCCTATATCCCGAATCAGAAAGTTGTGGGCCTCAGCAAATTAGCGCGGATCGTTGAAATGTATTCC
CGTCGTCTCCAGGTGCAAGAACGTCTGACCCGACAAATTGCAGAAGCGGTCCAAGAAATCCTTGACCCCCAAGGGGTTGC
GGTGGTGATGGAAGGGATTCACATGTGTATGTCCATGCGGGGTGTCCAAAAGCCCGGTTCTTGGACAGTTACCAGTGCCA
TGATTGGGTGCTTCCAGAAAGAACAAAAAACCCGTGAAGAGTTTCTCAACTTGATTCGTCACCAACCCAGCTTTATTTAA

Upstream 100 bases:

>100_bases
GACCATGATCTCTAAAGCAGGGAATCCAACAGTTTATTGTTAGCGAGGATCTACTCTCCCCTGCCCCAGTTCCTTTTACT
TCTTCATTCCATACCGAATT

Downstream 100 bases:

>100_bases
GGCAATTTGAGATTGTAGTGTCGCAATCTAAAACATAAAAAACATAAATAAGAGAAGGGCAGCCCTAGGGCTGCCCTTTT
TGCTAAATTGCCTATCAGCA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MTTSSSSGFNGSTKTMATDALGRDLNDLVTRPDRNSHNGKAASIRPATEESQQKMAEAVHTMLEAVGEDPDREGLLKTPL
RVAKAMQFLTQGYNQSLEDIVNGAIFDEGHNEMVLVRDIDFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYS
RRLQVQERLTRQIAEAVQEILDPQGVAVVMEGIHMCMSMRGVQKPGSWTVTSAMIGCFQKEQKTREEFLNLIRHQPSFI

Sequences:

>Translated_239_residues
MTTSSSSGFNGSTKTMATDALGRDLNDLVTRPDRNSHNGKAASIRPATEESQQKMAEAVHTMLEAVGEDPDREGLLKTPL
RVAKAMQFLTQGYNQSLEDIVNGAIFDEGHNEMVLVRDIDFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYS
RRLQVQERLTRQIAEAVQEILDPQGVAVVMEGIHMCMSMRGVQKPGSWTVTSAMIGCFQKEQKTREEFLNLIRHQPSFI
>Mature_238_residues
TTSSSSGFNGSTKTMATDALGRDLNDLVTRPDRNSHNGKAASIRPATEESQQKMAEAVHTMLEAVGEDPDREGLLKTPLR
VAKAMQFLTQGYNQSLEDIVNGAIFDEGHNEMVLVRDIDFFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSR
RLQVQERLTRQIAEAVQEILDPQGVAVVMEGIHMCMSMRGVQKPGSWTVTSAMIGCFQKEQKTREEFLNLIRHQPSFI

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=193, Percent_Identity=60.6217616580311, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI4503949, Length=193, Percent_Identity=60.6217616580311, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI66932970, Length=152, Percent_Identity=58.5526315789474, Blast_Score=200, Evalue=9e-52,
Organism=Homo sapiens, GI66932972, Length=152, Percent_Identity=58.5526315789474, Blast_Score=200, Evalue=1e-51,
Organism=Escherichia coli, GI1788476, Length=125, Percent_Identity=48, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560486, Length=184, Percent_Identity=60.8695652173913, Blast_Score=246, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6321706, Length=181, Percent_Identity=60.2209944751381, Blast_Score=235, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24656782, Length=189, Percent_Identity=60.8465608465608, Blast_Score=235, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24656791, Length=189, Percent_Identity=60.8465608465608, Blast_Score=235, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24656796, Length=189, Percent_Identity=60.8465608465608, Blast_Score=234, Evalue=3e-62,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 26749; Mature: 26618

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSSSSGFNGSTKTMATDALGRDLNDLVTRPDRNSHNGKAASIRPATEESQQKMAEAVH
CCCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
TMLEAVGEDPDREGLLKTPLRVAKAMQFLTQGYNQSLEDIVNGAIFDEGHNEMVLVRDID
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHCCCCCCEEEEECCC
FFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSRRLQVQERLTRQIAEAVQEI
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDPQGVAVVMEGIHMCMSMRGVQKPGSWTVTSAMIGCFQKEQKTREEFLNLIRHQPSFI
HCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTSSSSGFNGSTKTMATDALGRDLNDLVTRPDRNSHNGKAASIRPATEESQQKMAEAVH
CCCCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
TMLEAVGEDPDREGLLKTPLRVAKAMQFLTQGYNQSLEDIVNGAIFDEGHNEMVLVRDID
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHCCCCCCEEEEECCC
FFSLCEHHMLPFMGRAHVAYIPNQKVVGLSKLARIVEMYSRRLQVQERLTRQIAEAVQEI
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDPQGVAVVMEGIHMCMSMRGVQKPGSWTVTSAMIGCFQKEQKTREEFLNLIRHQPSFI
HCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]