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The map label for this gene is serS

Identifier: 170078923

GI number: 170078923

Start: 2405856

End: 2407139

Strand: Direct

Name: serS

Synonym: SYNPCC7002_A2328

Alternate gene names: 170078923

Gene position: 2405856-2407139 (Clockwise)

Preceding gene: 170078921

Following gene: 170078924

Centisome position: 79.98

GC content: 50.93

Gene sequence:

>1284_bases
GTGCTAGACATTAAACTCCTCCGCGAAAATCCAACCCTTGTCCAAGAACGCCTCGATGCCCGTAAAGCGGGAGAATACGC
TATTCAACCGATTCTTGATCTAGATATTCAACAACGCACCCTCGAAGGCGATCGCAGCCAACTCCAGGCCCGCAGCAATG
AGATCGGTAAACTCATCGGCCAAAAGATTAAAGGCGGTGCCGATCCCAAAGGCGAAGAAATTGCCACCCTCAAAGCGGAG
GGGAATGAAATCAAACAAAAGCTCGCCGACCTCGAACCCCAGGAAAAAGAACTCAAAGCCCAAATTTACAATCTGCTGTT
AGCGCTGCCGAATCTGCCGGATCAAAGCACCCCCGTGGGCACCAATGAAACTGAAAATGTCGAAGTGCGCCGCTGGGGAG
AAGCACATAAGCCCACCAATGAGAACATCTTGCCCCACTGGGAAATTGGTGAACAGCTCGGTATTCTCGAATTTGCCCGG
TCAGTAAAGGTCGCCCAAAGTCGCTTTGTGAGCCTCGTCGGTGCGGGAGCAGCCCTAGAACGAGCTTTGATCAACTTCAT
GTTGGATCAGCAAATTGCGGCAGGCTATGTGGAAGTAATGCCCCCGGTGTTGATCAATAGTGATTCCCTTACTGGAACAG
GACAACTGCCAAAATTTGCCGAGGAAAGTTTCCGCTGTGCCGACGATGATCTCTGGCTAACTCCCACTGCTGAAGTGCCC
GTCACAAATCTCTACCGTTATGAAATCCTCGAAGCGGAAAATTTGCCCATTTACCATTGTGCCTACACCCCTTGTTTTCG
GCGGGAAGCAGGTAGTTATGGCAAAGACACCCGTGGGCTAATTCGGCTGCATCAGTTTAATAAAGTCGAACTTGTAAAAT
TTGTCCATCCTGAAACCTCGGCGGCAGAACACGAAAAACTCGTTGCTAATGCCGAGGCGATTCTCCAAGCCCTCAAGTTG
CCCTATCGCGTTCTCGAACTCTGTAGTGGTGACTTGGGTTTCAGCGCCGGGAAATGCTATGACCTGGAAGTGTGGCTCCC
CTCCGCAGACACCTACCGGGAAATTTCTAGTTGTTCTAATTTTTATGATTTCCAAGCGCGACGGGCGGGGATTCGCTTTA
AAGAAGCAGGAAAAAAAGGCACCCAGTTTGTCCATACCCTCAATGGTTCTGGGTTGGCGATCGGTCGCACCATGGCGGCA
ATCCTCGAAAATTATCAACAGCCGAACGGAACGGTAGCTGTGCCAGAGGTGCTGCGGCCCTACCTTAAGCGTGATTTTCT
CTAG

Upstream 100 bases:

>100_bases
GAGGGGTGTCCCTAGAGACAGTACCAAGCAGGATTCGATTGATTATTACTAGCCCATCATGAATAATGTTGGGTGATTCA
ACCGCAGCAAAGCAAAGTCC

Downstream 100 bases:

>100_bases
TCCATCCGAGGTCACTGGTGCAACAACTCATTCTCTGGCAACTGATTAATTCAAACTTTCCCCTTGGAGCCTATAACTAT
TCGGAGGGTTTGGAATATTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDIKLLRENPTLVQERLDARKAGEYAIQPILDLDIQQRTLEGDRSQLQARSNEIGKLIGQKIKGGADPKGEEIATLKAE
GNEIKQKLADLEPQEKELKAQIYNLLLALPNLPDQSTPVGTNETENVEVRRWGEAHKPTNENILPHWEIGEQLGILEFAR
SVKVAQSRFVSLVGAGAALERALINFMLDQQIAAGYVEVMPPVLINSDSLTGTGQLPKFAEESFRCADDDLWLTPTAEVP
VTNLYRYEILEAENLPIYHCAYTPCFRREAGSYGKDTRGLIRLHQFNKVELVKFVHPETSAAEHEKLVANAEAILQALKL
PYRVLELCSGDLGFSAGKCYDLEVWLPSADTYREISSCSNFYDFQARRAGIRFKEAGKKGTQFVHTLNGSGLAIGRTMAA
ILENYQQPNGTVAVPEVLRPYLKRDFL

Sequences:

>Translated_427_residues
MLDIKLLRENPTLVQERLDARKAGEYAIQPILDLDIQQRTLEGDRSQLQARSNEIGKLIGQKIKGGADPKGEEIATLKAE
GNEIKQKLADLEPQEKELKAQIYNLLLALPNLPDQSTPVGTNETENVEVRRWGEAHKPTNENILPHWEIGEQLGILEFAR
SVKVAQSRFVSLVGAGAALERALINFMLDQQIAAGYVEVMPPVLINSDSLTGTGQLPKFAEESFRCADDDLWLTPTAEVP
VTNLYRYEILEAENLPIYHCAYTPCFRREAGSYGKDTRGLIRLHQFNKVELVKFVHPETSAAEHEKLVANAEAILQALKL
PYRVLELCSGDLGFSAGKCYDLEVWLPSADTYREISSCSNFYDFQARRAGIRFKEAGKKGTQFVHTLNGSGLAIGRTMAA
ILENYQQPNGTVAVPEVLRPYLKRDFL
>Mature_427_residues
MLDIKLLRENPTLVQERLDARKAGEYAIQPILDLDIQQRTLEGDRSQLQARSNEIGKLIGQKIKGGADPKGEEIATLKAE
GNEIKQKLADLEPQEKELKAQIYNLLLALPNLPDQSTPVGTNETENVEVRRWGEAHKPTNENILPHWEIGEQLGILEFAR
SVKVAQSRFVSLVGAGAALERALINFMLDQQIAAGYVEVMPPVLINSDSLTGTGQLPKFAEESFRCADDDLWLTPTAEVP
VTNLYRYEILEAENLPIYHCAYTPCFRREAGSYGKDTRGLIRLHQFNKVELVKFVHPETSAAEHEKLVANAEAILQALKL
PYRVLELCSGDLGFSAGKCYDLEVWLPSADTYREISSCSNFYDFQARRAGIRFKEAGKKGTQFVHTLNGSGLAIGRTMAA
ILENYQQPNGTVAVPEVLRPYLKRDFL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=466, Percent_Identity=30.68669527897, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI8923421, Length=408, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI225579074, Length=340, Percent_Identity=34.1176470588235, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=48.8372093023256, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17539260, Length=472, Percent_Identity=28.3898305084746, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17542084, Length=340, Percent_Identity=29.7058823529412, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=443, Percent_Identity=35.4401805869075, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321799, Length=378, Percent_Identity=32.2751322751323, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24581334, Length=471, Percent_Identity=31.8471337579618, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17737985, Length=251, Percent_Identity=32.2709163346614, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_SYNP2 (B1XJM0)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735561.1
- ProteinModelPortal:   B1XJM0
- SMR:   B1XJM0
- GeneID:   6057634
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A2328
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47692; Mature: 47692

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 290-290 BINDING 390-390

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKLLRENPTLVQERLDARKAGEYAIQPILDLDIQQRTLEGDRSQLQARSNEIGKLIG
CCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHH
QKIKGGADPKGEEIATLKAEGNEIKQKLADLEPQEKELKAQIYNLLLALPNLPDQSTPVG
HHHCCCCCCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
TNETENVEVRRWGEAHKPTNENILPHWEIGEQLGILEFARSVKVAQSRFVSLVGAGAALE
CCCCCCEEHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RALINFMLDQQIAAGYVEVMPPVLINSDSLTGTGQLPKFAEESFRCADDDLWLTPTAEVP
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCC
VTNLYRYEILEAENLPIYHCAYTPCFRREAGSYGKDTRGLIRLHQFNKVELVKFVHPETS
CHHHHEEEEEECCCCCEEEECCCCHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCC
AAEHEKLVANAEAILQALKLPYRVLELCSGDLGFSAGKCYDLEVWLPSADTYREISSCSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHH
FYDFQARRAGIRFKEAGKKGTQFVHTLNGSGLAIGRTMAAILENYQQPNGTVAVPEVLRP
HHHHHHHHCCCCHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHH
YLKRDFL
HHHHCCC
>Mature Secondary Structure
MLDIKLLRENPTLVQERLDARKAGEYAIQPILDLDIQQRTLEGDRSQLQARSNEIGKLIG
CCEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHH
QKIKGGADPKGEEIATLKAEGNEIKQKLADLEPQEKELKAQIYNLLLALPNLPDQSTPVG
HHHCCCCCCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
TNETENVEVRRWGEAHKPTNENILPHWEIGEQLGILEFARSVKVAQSRFVSLVGAGAALE
CCCCCCEEHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RALINFMLDQQIAAGYVEVMPPVLINSDSLTGTGQLPKFAEESFRCADDDLWLTPTAEVP
HHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHCCCCCCCEEECCCCCCC
VTNLYRYEILEAENLPIYHCAYTPCFRREAGSYGKDTRGLIRLHQFNKVELVKFVHPETS
CHHHHEEEEEECCCCCEEEECCCCHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCCC
AAEHEKLVANAEAILQALKLPYRVLELCSGDLGFSAGKCYDLEVWLPSADTYREISSCSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHH
FYDFQARRAGIRFKEAGKKGTQFVHTLNGSGLAIGRTMAAILENYQQPNGTVAVPEVLRP
HHHHHHHHCCCCHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHH
YLKRDFL
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA