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The map label for this gene is mscS [H]

Identifier: 170078761

GI number: 170078761

Start: 2243989

End: 2244855

Strand: Reverse

Name: mscS [H]

Synonym: SYNPCC7002_A2163

Alternate gene names: 170078761

Gene position: 2244855-2243989 (Counterclockwise)

Preceding gene: 170078774

Following gene: 170078750

Centisome position: 74.63

GC content: 48.79

Gene sequence:

>867_bases
ATGTCAACCCTGTTCACCAGCATTGCCAATCGCCTCCAAAACGTTTTTAACCTAGAGGTTATCGGTGACCAAATTGCCCA
GGGCCTAATCAACCTCGTCGTTGCCCTCATTACCTTCGCGGTGTTCTACTGCCTTTGGAAGATTGTTGATGTGCCCCTCT
ATGCATCCTTCAAAAAATCAAAACTCGATAAAACCTCCGCCAGCTTCTTAAGAACCCTCGTTCGCTACGCCATTTTGACC
TTTGGCGCGATCCAAGCCCTCAACGCAGTTGGGATTAACATGGCCGCAATCGTCACCAGTTTGGGACTTGTGGGATTAAC
GGTCGGTTTTGCTGCCCGGGATGCCCTTTCTAACTTGATTTCTGGGCTGCTCATTTTTTGGGATCGGCCCTTTGTGATTG
ATGACCTCGTGGAAATTAATGGTCTCTATGGCCGCGTCGAAACAATCACCCTAAGGAGCACGCGCATTGTGACCGTTGAT
GGCCGGATGTTAGCGGTGCCTAATTCTGTCGTGATCAATTCAACGGTGATCTCTTACACTAATTTTCCACAGTTACGCCT
CGATATTGATGTCACCGTCGCTGTCCATGAAAATCTAGAGCGGGTACGACAGATCCTCTTGTCTTTGGTCGATGATCGCA
GCATATTTACCGACACACCGCCCGCTAAAGTGGTGGTGACGGCTCTCAATGACTATAACGTGGCACTCCAACTTCAGGTT
TGGTTACGCAATGAGCGCACCCATATTCCCGAACGCTTTGCCCTCCGAGAAAAAGTTTTTACCGCTTTAACCGCAGCAGG
GATTGATATGCCCTTTGAAACAATTCAGCTCACTCCCTTGGCTGTGCAATTGCAATCAGAAATCTAG

Upstream 100 bases:

>100_bases
ACAAGGCTTGCGGAAACTAAAGCTGCAAATAATCTTTTCTGTCCGTTTCTTGAGAGGCGATCGCCCCATTACACTAAAGT
CATTACCACCACGCAGCACC

Downstream 100 bases:

>100_bases
ACAAGACGCCTGAAGCTGCGAGAAAAAATCGATTGGTTTGTCCTGGTGGGGATGTTGAAACTTTAGGTAATAAGCATTAA
GAGAATAACCACAATCCCCT

Product: putative small-conductance mechanosensitive channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSTLFTSIANRLQNVFNLEVIGDQIAQGLINLVVALITFAVFYCLWKIVDVPLYASFKKSKLDKTSASFLRTLVRYAILT
FGAIQALNAVGINMAAIVTSLGLVGLTVGFAARDALSNLISGLLIFWDRPFVIDDLVEINGLYGRVETITLRSTRIVTVD
GRMLAVPNSVVINSTVISYTNFPQLRLDIDVTVAVHENLERVRQILLSLVDDRSIFTDTPPAKVVVTALNDYNVALQLQV
WLRNERTHIPERFALREKVFTALTAAGIDMPFETIQLTPLAVQLQSEI

Sequences:

>Translated_288_residues
MSTLFTSIANRLQNVFNLEVIGDQIAQGLINLVVALITFAVFYCLWKIVDVPLYASFKKSKLDKTSASFLRTLVRYAILT
FGAIQALNAVGINMAAIVTSLGLVGLTVGFAARDALSNLISGLLIFWDRPFVIDDLVEINGLYGRVETITLRSTRIVTVD
GRMLAVPNSVVINSTVISYTNFPQLRLDIDVTVAVHENLERVRQILLSLVDDRSIFTDTPPAKVVVTALNDYNVALQLQV
WLRNERTHIPERFALREKVFTALTAAGIDMPFETIQLTPLAVQLQSEI
>Mature_287_residues
STLFTSIANRLQNVFNLEVIGDQIAQGLINLVVALITFAVFYCLWKIVDVPLYASFKKSKLDKTSASFLRTLVRYAILTF
GAIQALNAVGINMAAIVTSLGLVGLTVGFAARDALSNLISGLLIFWDRPFVIDDLVEINGLYGRVETITLRSTRIVTVDG
RMLAVPNSVVINSTVISYTNFPQLRLDIDVTVAVHENLERVRQILLSLVDDRSIFTDTPPAKVVVTALNDYNVALQLQVW
LRNERTHIPERFALREKVFTALTAAGIDMPFETIQLTPLAVQLQSEI

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=248, Percent_Identity=30.241935483871, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI2367355, Length=207, Percent_Identity=26.5700483091787, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786670, Length=185, Percent_Identity=26.4864864864865, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787591, Length=120, Percent_Identity=34.1666666666667, Blast_Score=71, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 31925; Mature: 31794

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLFTSIANRLQNVFNLEVIGDQIAQGLINLVVALITFAVFYCLWKIVDVPLYASFKKS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KLDKTSASFLRTLVRYAILTFGAIQALNAVGINMAAIVTSLGLVGLTVGFAARDALSNLI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLLIFWDRPFVIDDLVEINGLYGRVETITLRSTRIVTVDGRMLAVPNSVVINSTVISYT
HHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECEEEEEECCEEEECCCCEEEECEEEEEC
NFPQLRLDIDVTVAVHENLERVRQILLSLVDDRSIFTDTPPAKVVVTALNDYNVALQLQV
CCCEEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
WLRNERTHIPERFALREKVFTALTAAGIDMPFETIQLTPLAVQLQSEI
EECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHEEECCEEEEEECCC
>Mature Secondary Structure 
STLFTSIANRLQNVFNLEVIGDQIAQGLINLVVALITFAVFYCLWKIVDVPLYASFKKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KLDKTSASFLRTLVRYAILTFGAIQALNAVGINMAAIVTSLGLVGLTVGFAARDALSNLI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGLLIFWDRPFVIDDLVEINGLYGRVETITLRSTRIVTVDGRMLAVPNSVVINSTVISYT
HHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECEEEEEECCEEEECCCCEEEECEEEEEC
NFPQLRLDIDVTVAVHENLERVRQILLSLVDDRSIFTDTPPAKVVVTALNDYNVALQLQV
CCCEEEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
WLRNERTHIPERFALREKVFTALTAAGIDMPFETIQLTPLAVQLQSEI
EECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHEEECCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]