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The map label for this gene is hisA

Identifier: 170078495

GI number: 170078495

Start: 1974117

End: 1974887

Strand: Direct

Name: hisA

Synonym: SYNPCC7002_A1890

Alternate gene names: 170078495

Gene position: 1974117-1974887 (Clockwise)

Preceding gene: 170078493

Following gene: 170078496

Centisome position: 65.63

GC content: 54.73

Gene sequence:

>771_bases
ATGGAAGTTATTCCCGCTATTGATCTGCTCGGTGGCCAATGTGTGCGCCTCTATCAGGGTGATTATCAACAGGCGCAAGT
GTTTAATAATGACCCGGTTCAGGTGGCACGGACTTGGGCTGAGCAGGGGGCAACGCGGCTCCATGTGGTGGATTTAGACG
GGGCAAAACAGGGAGAGTCGGTCAATCTAGGGGCGATCGCCAAAATTGCAGCAGCGATTGATATTCCTGTACAGGTGGGC
GGTGGTCTCCGTACGGTAGAAAGTGTGGCGCAATTGTTTGATGTGGGTGTAGAGCGAGCCATTCTTGGGACGGCGGCGGT
AGATAATCCGGATCTCGTGACAGAACTCTGTGCCAAATATCCGGGCCGGATTGCGGTTGGGATTGATGCCCGCGATGGAA
AGGTAGCGACAAAGGGATGGTTGGAAACATCGGCGGTTTTAGCGACGGATTTGGCGAAACAGATGGCTACCCAGGGGGTC
GCTGCCATTATTTACACGGATATTCATCGAGATGGCACCATGGCTGGGCCTAATTTGGAGGCGCTGCGGGAATTGGCGGC
CACCATTGAGATTCCGGTGATTGCGTCGGGGGGCGTGAGTTCTTTGGCGGATCTGGTTAATCTTGTGGCCCTCGAAGGGA
TCGGAGTCACAGGAGCGATTGTGGGCCGGGCGATTTATACCGGAGATATTAATTTGGCTGAAGCGGTGAAGGCGGTTGGC
CCCCAACGTTTACAGGATGTGTTTCCGGATGATGGTACGGCGATCGCCTAA

Upstream 100 bases:

>100_bases
AGGTTTTGCAGACCTCTGCCTTACCACTTGGCTATACCACCGGGTCAACAGTTCGCTATTATAACAGGGCTTTTGTTCAC
ATCACAACATTTTTTTCGTT

Downstream 100 bases:

>100_bases
TTTTCGTGCTAGATTGAGTCGTGAAATTGTAATGGAACAAACCACATCAAAAGCGATTCTAGAGTAAAGCTATATAGTGA
TCGACTGCACCACTTTATGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MEVIPAIDLLGGQCVRLYQGDYQQAQVFNNDPVQVARTWAEQGATRLHVVDLDGAKQGESVNLGAIAKIAAAIDIPVQVG
GGLRTVESVAQLFDVGVERAILGTAAVDNPDLVTELCAKYPGRIAVGIDARDGKVATKGWLETSAVLATDLAKQMATQGV
AAIIYTDIHRDGTMAGPNLEALRELAATIEIPVIASGGVSSLADLVNLVALEGIGVTGAIVGRAIYTGDINLAEAVKAVG
PQRLQDVFPDDGTAIA

Sequences:

>Translated_256_residues
MEVIPAIDLLGGQCVRLYQGDYQQAQVFNNDPVQVARTWAEQGATRLHVVDLDGAKQGESVNLGAIAKIAAAIDIPVQVG
GGLRTVESVAQLFDVGVERAILGTAAVDNPDLVTELCAKYPGRIAVGIDARDGKVATKGWLETSAVLATDLAKQMATQGV
AAIIYTDIHRDGTMAGPNLEALRELAATIEIPVIASGGVSSLADLVNLVALEGIGVTGAIVGRAIYTGDINLAEAVKAVG
PQRLQDVFPDDGTAIA
>Mature_256_residues
MEVIPAIDLLGGQCVRLYQGDYQQAQVFNNDPVQVARTWAEQGATRLHVVDLDGAKQGESVNLGAIAKIAAAIDIPVQVG
GGLRTVESVAQLFDVGVERAILGTAAVDNPDLVTELCAKYPGRIAVGIDARDGKVATKGWLETSAVLATDLAKQMATQGV
AAIIYTDIHRDGTMAGPNLEALRELAATIEIPVIASGGVSSLADLVNLVALEGIGVTGAIVGRAIYTGDINLAEAVKAVG
PQRLQDVFPDDGTAIA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=240, Percent_Identity=37.5, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1788336, Length=243, Percent_Identity=27.5720164609054, Blast_Score=95, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_SYNP2 (B1XQI2)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001735133.1
- ProteinModelPortal:   B1XQI2
- SMR:   B1XQI2
- GeneID:   6056026
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1890
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26490; Mature: 26490

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVIPAIDLLGGQCVRLYQGDYQQAQVFNNDPVQVARTWAEQGATRLHVVDLDGAKQGES
CCCCCCHHHCCCCEEEECCCCCHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNLGAIAKIAAAIDIPVQVGGGLRTVESVAQLFDVGVERAILGTAAVDNPDLVTELCAKY
CCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PGRIAVGIDARDGKVATKGWLETSAVLATDLAKQMATQGVAAIIYTDIHRDGTMAGPNLE
CCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHH
ALRELAATIEIPVIASGGVSSLADLVNLVALEGIGVTGAIVGRAIYTGDINLAEAVKAVG
HHHHHHHHEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCEEEECCCCHHHHHHHCC
PQRLQDVFPDDGTAIA
HHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEVIPAIDLLGGQCVRLYQGDYQQAQVFNNDPVQVARTWAEQGATRLHVVDLDGAKQGES
CCCCCCHHHCCCCEEEECCCCCHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCC
VNLGAIAKIAAAIDIPVQVGGGLRTVESVAQLFDVGVERAILGTAAVDNPDLVTELCAKY
CCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PGRIAVGIDARDGKVATKGWLETSAVLATDLAKQMATQGVAAIIYTDIHRDGTMAGPNLE
CCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHH
ALRELAATIEIPVIASGGVSSLADLVNLVALEGIGVTGAIVGRAIYTGDINLAEAVKAVG
HHHHHHHHEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCEEEECCCCHHHHHHHCC
PQRLQDVFPDDGTAIA
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA