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The map label for this gene is ndhD4 [H]

Identifier: 170078412

GI number: 170078412

Start: 1893039

End: 1894520

Strand: Direct

Name: ndhD4 [H]

Synonym: SYNPCC7002_A1806

Alternate gene names: 170078412

Gene position: 1893039-1894520 (Clockwise)

Preceding gene: 170078411

Following gene: 170078413

Centisome position: 62.93

GC content: 52.29

Gene sequence:

>1482_bases
ATGCTGAGTGCCTTAATTTGGCTGCCCTTGGCCGGAGCTCTGTTGGTGGCGATACTCCCCCAGGGAGAAAAAAATCAGTT
TTCCCGGACGATGGCCCTGGGAGCGGCTGCCCTCGTTTTTGTTTGGACAGCTTGGTTGGGGTTCCATTATGATGTGGCGA
TCGCCGGCCTCCAATTTGTCGAACATTATCTTTGGATTGAGTGGTTGGGTCTGAACTACGATCTCGGTGTTGATGGTCTA
TCGTTGCCCCTCCTTGCCCTCAATGCGTTGTTGACCCTAGTAGCCCTCTGGATTAGCCCCAAGGATCTGCACCGCCCTCG
CTTTTATTACGCCCTCTTTTTGCTCTTGCAGGCGAGTGTCAATGGGGCGTTTTTGGCCCAGGATGTGCTGCTCTTTTTTC
TGTTCTACGAAATTGAAATTATCCCCCTATATTTTCTCATTGCGATTTGGGGCGGCAAAAAACGAGGCTATGCCGCCATT
AAATTTTTGCTCTACACAGCCGTTTCCGGAATTTTAATTCTGGCTTCTTTCTTGGGTCTGGCCTTCCTCACAGAATCTAA
TACCTTTGCCTACAGTGCCCTCCACAGTGATTTGTTGCCCCTGACCACCCAATTAATTCTCCTCGGCGGCATTTTGGTGG
GCTTTGGGATCAAAATTCCGTTTTTGCCTTTCCATACTTGGCTCCCGGATGCCCACGTCGAAGCGTCTACCCCTGTATCG
GTGATTTTGGCGGGGGTACTCCTCAAAGTTGGTACCTACGGTCTACTGAAGTTTGGGATTGGCCTATTTCCCCTGGCTTG
GGCTGTCGTGGCCCCTTGGCTAGCGATCTGGGCGGCAATCAGTGCCTTGTATGGGGCTTCCTGTGCGATCGCCCAAAAAG
ACATGAAAAAAGTGGTGGCCTATTCCTCCATTGCCCACATGGCGTTTATTCTGCTGGCGGCGGCGGCGGCGACCCCCTTA
AGTTTGGCAGCGGCAGAAATCCAGATGGTCAGCCATGGTTTAATCTCTGGGCTGCTCTTTTTGTTGGTGGGCATTGTCTA
CAAAAAAACGGGCAGTCGGGATGTCGATTATCTACGGGGACTGCTCACCCCAGAACGGGGTCTGCCTTTGACGGGGAGTT
TGATGATCCTGGGGGTCATGGCCAGTGCGGGTTTGCCGGGGATGGCGGGCTTTATCGCTGAATTCCTCATTTTTCGGGGC
AGCTTTCCGGTGTATCCAGTGGCGACTCTCCTGTGTATGGTGGGGACAGGTCTCACGGCGGTGTATTTTCTGCTGATGAT
TAATAAGGTCTTTTTTGGCCGCTTGACCCCAGAACTCATTAATATGTCCCCGGTCAATTGGGCGGATCAGTTTCCGGCGG
TTATGTTAGTGATATTGCTGTTCGTCTTTGGGTTGCAGCCCCAGTGGCTGGTGCGCTGGAGTGAGATCGACACAGCGGCC
TTGGTGGCATCCCCGACGGCTATTGAAATTTCTTTAAAGTAA

Upstream 100 bases:

>100_bases
TCAATGGACGATGATTACGGATTTTTGGTCGAATCAGTTGGCCTAAGGAGTTTCCCCCTTTGTTGTTAAATCTGCTTTTT
TGTGAATTTTGGAGGAAAGA

Downstream 100 bases:

>100_bases
AAGTAAGCGTTTAAGAATTGTGGATATGAATATGGTCACTGCTGTTTTAGAGCCTTCGCGGCACCCCCTTGCCCCTTTCA
TTCATCGCCTTGAGCAAGGT

Product: NADH dehydrogenase subunit D4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1 [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MLSALIWLPLAGALLVAILPQGEKNQFSRTMALGAAALVFVWTAWLGFHYDVAIAGLQFVEHYLWIEWLGLNYDLGVDGL
SLPLLALNALLTLVALWISPKDLHRPRFYYALFLLLQASVNGAFLAQDVLLFFLFYEIEIIPLYFLIAIWGGKKRGYAAI
KFLLYTAVSGILILASFLGLAFLTESNTFAYSALHSDLLPLTTQLILLGGILVGFGIKIPFLPFHTWLPDAHVEASTPVS
VILAGVLLKVGTYGLLKFGIGLFPLAWAVVAPWLAIWAAISALYGASCAIAQKDMKKVVAYSSIAHMAFILLAAAAATPL
SLAAAEIQMVSHGLISGLLFLLVGIVYKKTGSRDVDYLRGLLTPERGLPLTGSLMILGVMASAGLPGMAGFIAEFLIFRG
SFPVYPVATLLCMVGTGLTAVYFLLMINKVFFGRLTPELINMSPVNWADQFPAVMLVILLFVFGLQPQWLVRWSEIDTAA
LVASPTAIEISLK

Sequences:

>Translated_493_residues
MLSALIWLPLAGALLVAILPQGEKNQFSRTMALGAAALVFVWTAWLGFHYDVAIAGLQFVEHYLWIEWLGLNYDLGVDGL
SLPLLALNALLTLVALWISPKDLHRPRFYYALFLLLQASVNGAFLAQDVLLFFLFYEIEIIPLYFLIAIWGGKKRGYAAI
KFLLYTAVSGILILASFLGLAFLTESNTFAYSALHSDLLPLTTQLILLGGILVGFGIKIPFLPFHTWLPDAHVEASTPVS
VILAGVLLKVGTYGLLKFGIGLFPLAWAVVAPWLAIWAAISALYGASCAIAQKDMKKVVAYSSIAHMAFILLAAAAATPL
SLAAAEIQMVSHGLISGLLFLLVGIVYKKTGSRDVDYLRGLLTPERGLPLTGSLMILGVMASAGLPGMAGFIAEFLIFRG
SFPVYPVATLLCMVGTGLTAVYFLLMINKVFFGRLTPELINMSPVNWADQFPAVMLVILLFVFGLQPQWLVRWSEIDTAA
LVASPTAIEISLK
>Mature_493_residues
MLSALIWLPLAGALLVAILPQGEKNQFSRTMALGAAALVFVWTAWLGFHYDVAIAGLQFVEHYLWIEWLGLNYDLGVDGL
SLPLLALNALLTLVALWISPKDLHRPRFYYALFLLLQASVNGAFLAQDVLLFFLFYEIEIIPLYFLIAIWGGKKRGYAAI
KFLLYTAVSGILILASFLGLAFLTESNTFAYSALHSDLLPLTTQLILLGGILVGFGIKIPFLPFHTWLPDAHVEASTPVS
VILAGVLLKVGTYGLLKFGIGLFPLAWAVVAPWLAIWAAISALYGASCAIAQKDMKKVVAYSSIAHMAFILLAAAAATPL
SLAAAEIQMVSHGLISGLLFLLVGIVYKKTGSRDVDYLRGLLTPERGLPLTGSLMILGVMASAGLPGMAGFIAEFLIFRG
SFPVYPVATLLCMVGTGLTAVYFLLMINKVFFGRLTPELINMSPVNWADQFPAVMLVILLFVFGLQPQWLVRWSEIDTAA
LVASPTAIEISLK

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=358, Percent_Identity=32.9608938547486, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI251831117, Length=330, Percent_Identity=28.1818181818182, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788613, Length=386, Percent_Identity=39.119170984456, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1788827, Length=387, Percent_Identity=26.6149870801034, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788831, Length=378, Percent_Identity=27.5132275132275, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788829, Length=384, Percent_Identity=27.34375, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI145693160, Length=417, Percent_Identity=26.8585131894484, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788614, Length=482, Percent_Identity=29.045643153527, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI2367154, Length=297, Percent_Identity=28.6195286195286, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 53514; Mature: 53514

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HEECCCEEEEEEC
>Mature Secondary Structure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HEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]