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The map label for this gene is merA1 [H]

Identifier: 170077910

GI number: 170077910

Start: 1345683

End: 1347119

Strand: Reverse

Name: merA1 [H]

Synonym: SYNPCC7002_A1295

Alternate gene names: 170077910

Gene position: 1347119-1345683 (Counterclockwise)

Preceding gene: 170077911

Following gene: 170077907

Centisome position: 44.78

GC content: 52.61

Gene sequence:

>1437_bases
GTGGCTGTGGATTACGATATTGTCATCATCGGCGGTGGTTCTGGAGGCCTCGTGGTGGCCAGTGCAGCGGCCCAGTTAAA
GGCAAAGGTGGCCCTGGTCGAAAAGGATCGCCTTGGGGGAGATTGCCTCTGGTATGGTTGCGTTCCCAGTAAATCTTTTC
TCCATGCGGCAAAAGTTGCCCACCAAGTGCGCCACGCAGGACGGGTCGGCGTTCATACAAAAGCGCCAGAAATTAATTTT
TCAGAAGCAATGGGCCATGTACAAAAGGCGATCGCCACCATTGAACCCCATGATTCTCCAGAGCGATTTGAGGGGCTTGG
GGTCGAGGTGATTTTTGGGGATGGTCAGTTTCTCGACGGCAAAACTTTTCTCGTCAATGGTCGCAAGCTAACGGCCCGCG
CTTTTGTGATTGCCACCGGATCACGGCCTGCTGTTCCCCCCGTCGAAGGGCTCCAGGAAGCGGGTTTTATTACCAATGAA
CAGGTGTTTTCCCTCACAGAGCAGCCAGAATCCCTCGCGGTGATTGGGTCGGGGCCGATTGGTTGTGAGTTGGGGCAAGC
CTTCCACCGTTTGGGGACGGAAGTGACTCTGTTTGCGAGCCGCGATCGCCTTTTGCCCAAAGAAGACCCCGACGCCGCCG
CTGTCCTGGAGCAACAATTTAACCAAGAAGGAATCACCATTCTGAAAAATGCCCGGTTAAAACGGGTAGCAGTGGTCAAG
GGCAAAAAACACCTCTACACTGAGGATGATTCCCAGGTGGCGGCGATCGCCGATGAAATTCTCCTGGCCACGGGCCGCAC
TCCCAATATCAAGTCCCTCAACCTAGAAGCCGCTGGAGTGGACTACGACAGTCAAGGCATCCATGTAAACGACAAACTCC
AAACGACCAATGGTCGGATCTATGCTTGCGGCGATGTGATTGGGGGCTATCAGTTTACCCATGTGGCGGGTTACGAAGCC
GTTGTGGTACTCCAAAATGCCCTGAATCCACTGCAATTATTTCTCAAAAGCGTCAATTATCGGGTGATTCCCTGGGCAAC
CTTTACCGATCCGGAGGTGGCACGGGTTGGCATGACCGAGGAACAAGCCCGTAAACGTTACGGTGATGTGCTGATTTTGA
AAGTGCCTTTCGCGTCAGTGGATCGGGCCCAGGCGGAGGATTCTACCGTGGGCTTTAATAAGTTGATTGTGCGTCATAAC
GGCGAAATCCTAGGGGCGCATCTGGTAGGGCCAATGGCAGGGGAGCTGATCCATGAAATTGTTCTGGCGATGACCTATCG
CTTACCGGTTTCGGCCTTAACGGGGATTCATGTTTACCCGACCCTGAGCGAAATTAATAGTAAAACGGCGCTGTTACTCT
CCAAGAAAAAATACGCCGATAACGAAAAACTCCAAAATTTCTTGACCGAATTCTTTAAGTTTCTGCGCTCTTTGTAG

Upstream 100 bases:

>100_bases
AGAGTTAAAAATTTCCTGAAAATCCCAACGTTAGCGATACAAAGGGGAAATTTTCGCGCAAAATAAAATCACTTGACTGC
ACCAATGGAGAAACTTAACT

Downstream 100 bases:

>100_bases
GCCGCCAAATCGCATCGGCAATTTTCGCCACATCGATCATTTCTGGGCCATCATGCACCCGGAGGATATCGGCCCCGAAG
GCGATCGCCCCGGCACAGGC

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MAVDYDIVIIGGGSGGLVVASAAAQLKAKVALVEKDRLGGDCLWYGCVPSKSFLHAAKVAHQVRHAGRVGVHTKAPEINF
SEAMGHVQKAIATIEPHDSPERFEGLGVEVIFGDGQFLDGKTFLVNGRKLTARAFVIATGSRPAVPPVEGLQEAGFITNE
QVFSLTEQPESLAVIGSGPIGCELGQAFHRLGTEVTLFASRDRLLPKEDPDAAAVLEQQFNQEGITILKNARLKRVAVVK
GKKHLYTEDDSQVAAIADEILLATGRTPNIKSLNLEAAGVDYDSQGIHVNDKLQTTNGRIYACGDVIGGYQFTHVAGYEA
VVVLQNALNPLQLFLKSVNYRVIPWATFTDPEVARVGMTEEQARKRYGDVLILKVPFASVDRAQAEDSTVGFNKLIVRHN
GEILGAHLVGPMAGELIHEIVLAMTYRLPVSALTGIHVYPTLSEINSKTALLLSKKKYADNEKLQNFLTEFFKFLRSL

Sequences:

>Translated_478_residues
MAVDYDIVIIGGGSGGLVVASAAAQLKAKVALVEKDRLGGDCLWYGCVPSKSFLHAAKVAHQVRHAGRVGVHTKAPEINF
SEAMGHVQKAIATIEPHDSPERFEGLGVEVIFGDGQFLDGKTFLVNGRKLTARAFVIATGSRPAVPPVEGLQEAGFITNE
QVFSLTEQPESLAVIGSGPIGCELGQAFHRLGTEVTLFASRDRLLPKEDPDAAAVLEQQFNQEGITILKNARLKRVAVVK
GKKHLYTEDDSQVAAIADEILLATGRTPNIKSLNLEAAGVDYDSQGIHVNDKLQTTNGRIYACGDVIGGYQFTHVAGYEA
VVVLQNALNPLQLFLKSVNYRVIPWATFTDPEVARVGMTEEQARKRYGDVLILKVPFASVDRAQAEDSTVGFNKLIVRHN
GEILGAHLVGPMAGELIHEIVLAMTYRLPVSALTGIHVYPTLSEINSKTALLLSKKKYADNEKLQNFLTEFFKFLRSL
>Mature_477_residues
AVDYDIVIIGGGSGGLVVASAAAQLKAKVALVEKDRLGGDCLWYGCVPSKSFLHAAKVAHQVRHAGRVGVHTKAPEINFS
EAMGHVQKAIATIEPHDSPERFEGLGVEVIFGDGQFLDGKTFLVNGRKLTARAFVIATGSRPAVPPVEGLQEAGFITNEQ
VFSLTEQPESLAVIGSGPIGCELGQAFHRLGTEVTLFASRDRLLPKEDPDAAAVLEQQFNQEGITILKNARLKRVAVVKG
KKHLYTEDDSQVAAIADEILLATGRTPNIKSLNLEAAGVDYDSQGIHVNDKLQTTNGRIYACGDVIGGYQFTHVAGYEAV
VVLQNALNPLQLFLKSVNYRVIPWATFTDPEVARVGMTEEQARKRYGDVLILKVPFASVDRAQAEDSTVGFNKLIVRHNG
EILGAHLVGPMAGELIHEIVLAMTYRLPVSALTGIHVYPTLSEINSKTALLLSKKKYADNEKLQNFLTEFFKFLRSL

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=31.3978494623656, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=29.3103448275862, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI22035672, Length=489, Percent_Identity=29.038854805726, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI291045266, Length=495, Percent_Identity=26.8686868686869, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI148277065, Length=494, Percent_Identity=25.7085020242915, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI33519430, Length=491, Percent_Identity=25.6619144602851, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33519428, Length=491, Percent_Identity=25.6619144602851, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33519426, Length=491, Percent_Identity=25.6619144602851, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI148277071, Length=480, Percent_Identity=25.625, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI291045268, Length=489, Percent_Identity=25.7668711656442, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=30.5494505494506, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=30.7522123893805, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87082354, Length=425, Percent_Identity=29.4117647058824, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=34.338747099768, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI32565766, Length=463, Percent_Identity=31.317494600432, Blast_Score=181, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17557007, Length=471, Percent_Identity=26.963906581741, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=363, Percent_Identity=27.5482093663912, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=363, Percent_Identity=27.5482093663912, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=503, Percent_Identity=28.0318091451292, Blast_Score=105, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=31.7427385892116, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=436, Percent_Identity=28.6697247706422, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6325240, Length=464, Percent_Identity=24.3534482758621, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358499, Length=470, Percent_Identity=31.4893617021277, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24640549, Length=477, Percent_Identity=29.3501048218029, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24640553, Length=477, Percent_Identity=29.3501048218029, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24640551, Length=479, Percent_Identity=29.2275574112735, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI17737741, Length=488, Percent_Identity=28.2786885245902, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 51818; Mature: 51687

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVDYDIVIIGGGSGGLVVASAAAQLKAKVALVEKDRLGGDCLWYGCVPSKSFLHAAKVA
CCEEEEEEEEECCCCCEEEEEHHHHHEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHH
HQVRHAGRVGVHTKAPEINFSEAMGHVQKAIATIEPHDSPERFEGLGVEVIFGDGQFLDG
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCEEECC
KTFLVNGRKLTARAFVIATGSRPAVPPVEGLQEAGFITNEQVFSLTEQPESLAVIGSGPI
CEEEEECCEEEEEEEEEEECCCCCCCCHHHHHHCCCCCCHHHEEECCCCCEEEEEECCCC
GCELGQAFHRLGTEVTLFASRDRLLPKEDPDAAAVLEQQFNQEGITILKNARLKRVAVVK
CHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEEEE
GKKHLYTEDDSQVAAIADEILLATGRTPNIKSLNLEAAGVDYDSQGIHVNDKLQTTNGRI
CCCEEECCCCCHHHHHHHHHHEECCCCCCCEEEEEEEECCCCCCCCEEECCCEEECCCEE
YACGDVIGGYQFTHVAGYEAVVVLQNALNPLQLFLKSVNYRVIPWATFTDPEVARVGMTE
EEECCCCCCEEEEEECCCEEEEEEHHCCCHHHHHHHHCCEEEEEEEECCCCHHHCCCCCH
EQARKRYGDVLILKVPFASVDRAQAEDSTVGFNKLIVRHNGEILGAHLVGPMAGELIHEI
HHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEHHCHHHHHHHHHH
VLAMTYRLPVSALTGIHVYPTLSEINSKTALLLSKKKYADNEKLQNFLTEFFKFLRSL
HHHHHHCCCHHHHCCEEEEEEHHHCCCCEEEEEECHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVDYDIVIIGGGSGGLVVASAAAQLKAKVALVEKDRLGGDCLWYGCVPSKSFLHAAKVA
CEEEEEEEEECCCCCEEEEEHHHHHEEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHH
HQVRHAGRVGVHTKAPEINFSEAMGHVQKAIATIEPHDSPERFEGLGVEVIFGDGQFLDG
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCEEECC
KTFLVNGRKLTARAFVIATGSRPAVPPVEGLQEAGFITNEQVFSLTEQPESLAVIGSGPI
CEEEEECCEEEEEEEEEEECCCCCCCCHHHHHHCCCCCCHHHEEECCCCCEEEEEECCCC
GCELGQAFHRLGTEVTLFASRDRLLPKEDPDAAAVLEQQFNQEGITILKNARLKRVAVVK
CHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEEEEEE
GKKHLYTEDDSQVAAIADEILLATGRTPNIKSLNLEAAGVDYDSQGIHVNDKLQTTNGRI
CCCEEECCCCCHHHHHHHHHHEECCCCCCCEEEEEEEECCCCCCCCEEECCCEEECCCEE
YACGDVIGGYQFTHVAGYEAVVVLQNALNPLQLFLKSVNYRVIPWATFTDPEVARVGMTE
EEECCCCCCEEEEEECCCEEEEEEHHCCCHHHHHHHHCCEEEEEEEECCCCHHHCCCCCH
EQARKRYGDVLILKVPFASVDRAQAEDSTVGFNKLIVRHNGEILGAHLVGPMAGELIHEI
HHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEHHCHHHHHHHHHH
VLAMTYRLPVSALTGIHVYPTLSEINSKTALLLSKKKYADNEKLQNFLTEFFKFLRSL
HHHHHHCCCHHHHCCEEEEEEHHHCCCCEEEEEECHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]