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The map label for this gene is bioF [C]

Identifier: 170077896

GI number: 170077896

Start: 1330747

End: 1331934

Strand: Direct

Name: bioF [C]

Synonym: SYNPCC7002_A1281

Alternate gene names: 170077896

Gene position: 1330747-1331934 (Clockwise)

Preceding gene: 170077895

Following gene: 170077899

Centisome position: 44.24

GC content: 52.1

Gene sequence:

>1188_bases
ATGGCGAATTCTGATCCTATTTATGGCTGGCTAGAGACCGCTTTGGCCACTATCAAAAAAGCAAATTGGTATCGACAACC
GAAAACAATCACCAGTCAATCGGGGGCGACGGTCACCTTAAATGGTCAATCGGTGGTTAATTTTGCCAGCAATGACTATC
TGGGTTTAGCGGGCGATCGCCGCTTAATTGATGCTGCCATAGCGGCCACCGAGGCGCTGGGGACAGGGAGTACAGGCTCT
CGGCTCACCAGTGGCCACCGACAACTCCACCAGGATTTGGAGCAGGCGATCGCCAATCTCAAACAAACCGAAGATGCCCT
AGTATTTAGCTCCGGTTACCTAGCCAACTTCGGCACCATTAGCGCCATTACTAACAAAAAAGACCTGATTTTAGGAGATC
AATACAACCATTCGAGTTTAAAAAATGGGGCAAAATTAAGCGGCGCGACGGTGTTGGAATATGACCACAATGATTTAGAC
GCATTACGTCAGCTTCTCGAAACCCATCGGCAAAACTACCGCCGTTGCCTGATCACCACCGATAGCGTTTTTAGTATGGA
TGGCGATCTCTGTTTACTGCCCGAACTGTTGGCGATCGCCAAGGAATTTTCCACCATGCTACTCGTGGACGAAGCCCACG
GGACTGGGGTTTTGGGCCAAAAAGGTGCCGGAGTCGTGGAACATTTTCACTGTACCCAGCAACCGCTTATCCAAGTGGGC
ACCCTCAGCAAAGCCCTGGGCAGTCTCGGCGGCTATGTAGCGGGCAGCAAAGCCTTAATTGATTTTCTCCGTAACCGTGC
TTCGACTTGGATTTACACCACCGGACTCTCCCCAGCGGATACGGCGGCCGCCCTCGCCGCGATTCATATTTTGCAGGAGG
AACCCCAACGGCGGCAGCAACTCTGGGAAAACATTCGTCAGTTAAAAAGCGCCCTTGGGAACCATGAATTGGTGCCTTCT
GAGTCGGCGGTGCTTTGTTTTGGTCTCGCTAATCCGCAGCAAGCACTAGCCATGGGCGATCGCCTTTTGGCCACAGGTTT
CTTTGCCCCTGCCATTCGCCCGCCAACAGTTCCTACCAGCCGCATTCGCGTGTCGGTGATGGCGACCCATAGCCCCCAAC
AGATCCAAGGATTTATCGAAATATTCCAGCGGTGCTTTGCGGAATTTTCTGGGTCATCGAATCTTTAA

Upstream 100 bases:

>100_bases
GCTCTAAAATTAAAACCACAATGGAGCAAGCGGTACCTTTATCTATTCCTTTAGTGGTTGATATTCACTGCGGTAAAAAT
TGGCTCGATGCGAAGTAACA

Downstream 100 bases:

>100_bases
TTTTCCTCAATTTGGAAAGCCTCTTTTTCCGCCTCTAGGATCTCCGGCGGCACCTGAAAGCGGGGTCTGCCATTTTCATC
AATGCGAACAATGACTCCCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MANSDPIYGWLETALATIKKANWYRQPKTITSQSGATVTLNGQSVVNFASNDYLGLAGDRRLIDAAIAATEALGTGSTGS
RLTSGHRQLHQDLEQAIANLKQTEDALVFSSGYLANFGTISAITNKKDLILGDQYNHSSLKNGAKLSGATVLEYDHNDLD
ALRQLLETHRQNYRRCLITTDSVFSMDGDLCLLPELLAIAKEFSTMLLVDEAHGTGVLGQKGAGVVEHFHCTQQPLIQVG
TLSKALGSLGGYVAGSKALIDFLRNRASTWIYTTGLSPADTAAALAAIHILQEEPQRRQQLWENIRQLKSALGNHELVPS
ESAVLCFGLANPQQALAMGDRLLATGFFAPAIRPPTVPTSRIRVSVMATHSPQQIQGFIEIFQRCFAEFSGSSNL

Sequences:

>Translated_395_residues
MANSDPIYGWLETALATIKKANWYRQPKTITSQSGATVTLNGQSVVNFASNDYLGLAGDRRLIDAAIAATEALGTGSTGS
RLTSGHRQLHQDLEQAIANLKQTEDALVFSSGYLANFGTISAITNKKDLILGDQYNHSSLKNGAKLSGATVLEYDHNDLD
ALRQLLETHRQNYRRCLITTDSVFSMDGDLCLLPELLAIAKEFSTMLLVDEAHGTGVLGQKGAGVVEHFHCTQQPLIQVG
TLSKALGSLGGYVAGSKALIDFLRNRASTWIYTTGLSPADTAAALAAIHILQEEPQRRQQLWENIRQLKSALGNHELVPS
ESAVLCFGLANPQQALAMGDRLLATGFFAPAIRPPTVPTSRIRVSVMATHSPQQIQGFIEIFQRCFAEFSGSSNL
>Mature_394_residues
ANSDPIYGWLETALATIKKANWYRQPKTITSQSGATVTLNGQSVVNFASNDYLGLAGDRRLIDAAIAATEALGTGSTGSR
LTSGHRQLHQDLEQAIANLKQTEDALVFSSGYLANFGTISAITNKKDLILGDQYNHSSLKNGAKLSGATVLEYDHNDLDA
LRQLLETHRQNYRRCLITTDSVFSMDGDLCLLPELLAIAKEFSTMLLVDEAHGTGVLGQKGAGVVEHFHCTQQPLIQVGT
LSKALGSLGGYVAGSKALIDFLRNRASTWIYTTGLSPADTAAALAAIHILQEEPQRRQQLWENIRQLKSALGNHELVPSE
SAVLCFGLANPQQALAMGDRLLATGFFAPAIRPPTVPTSRIRVSVMATHSPQQIQGFIEIFQRCFAEFSGSSNL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=383, Percent_Identity=33.1592689295039, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI284448556, Length=416, Percent_Identity=30.5288461538462, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI83977444, Length=381, Percent_Identity=32.5459317585302, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI83977440, Length=381, Percent_Identity=32.5459317585302, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI83977442, Length=381, Percent_Identity=32.5459317585302, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4758668, Length=352, Percent_Identity=31.25, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI119220554, Length=362, Percent_Identity=30.1104972375691, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4502025, Length=390, Percent_Identity=31.025641025641, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI40316939, Length=390, Percent_Identity=31.025641025641, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI5454084, Length=284, Percent_Identity=29.2253521126761, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1790046, Length=385, Percent_Identity=32.2077922077922, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786993, Length=358, Percent_Identity=33.7988826815642, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=389, Percent_Identity=34.4473007712082, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17560914, Length=401, Percent_Identity=28.1795511221945, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17560912, Length=401, Percent_Identity=28.1795511221945, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=29.8630136986301, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=29.2682926829268, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=29.2682926829268, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320267, Length=351, Percent_Identity=30.1994301994302, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320438, Length=376, Percent_Identity=32.1808510638298, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=271, Percent_Identity=28.4132841328413, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662918, Length=382, Percent_Identity=31.413612565445, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17137420, Length=365, Percent_Identity=32.0547945205479, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24653280, Length=395, Percent_Identity=26.5822784810127, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24653276, Length=395, Percent_Identity=26.5822784810127, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24653278, Length=395, Percent_Identity=26.5822784810127, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17136286, Length=378, Percent_Identity=28.3068783068783, Blast_Score=148, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_SYNP2 (B1XL23)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001734534.1
- ProteinModelPortal:   B1XL23
- SMR:   B1XL23
- GeneID:   6057314
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A1281
- HOGENOM:   HBG649839
- OMA:   YDAWTLV
- ProtClustDB:   PRK05958
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 42696; Mature: 42565

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 25-25 BINDING 137-137 BINDING 185-185 BINDING 356-356

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSDPIYGWLETALATIKKANWYRQPKTITSQSGATVTLNGQSVVNFASNDYLGLAGDR
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECCCEEEEECCCCCEECCCCH
RLIDAAIAATEALGTGSTGSRLTSGHRQLHQDLEQAIANLKQTEDALVFSSGYLANFGTI
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEECCCCE
SAITNKKDLILGDQYNHSSLKNGAKLSGATVLEYDHNDLDALRQLLETHRQNYRRCLITT
EEECCCCCEEECCCCCCHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEE
DSVFSMDGDLCLLPELLAIAKEFSTMLLVDEAHGTGVLGQKGAGVVEHFHCTQQPLIQVG
CCCEECCCCEEHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHCCHHHHHHHH
TLSKALGSLGGYVAGSKALIDFLRNRASTWIYTTGLSPADTAAALAAIHILQEEPQRRQQ
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHH
LWENIRQLKSALGNHELVPSESAVLCFGLANPQQALAMGDRLLATGFFAPAIRPPTVPTS
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCC
RIRVSVMATHSPQQIQGFIEIFQRCFAEFSGSSNL
CEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ANSDPIYGWLETALATIKKANWYRQPKTITSQSGATVTLNGQSVVNFASNDYLGLAGDR
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECCCEEEEECCCCCEECCCCH
RLIDAAIAATEALGTGSTGSRLTSGHRQLHQDLEQAIANLKQTEDALVFSSGYLANFGTI
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEECCCCE
SAITNKKDLILGDQYNHSSLKNGAKLSGATVLEYDHNDLDALRQLLETHRQNYRRCLITT
EEECCCCCEEECCCCCCHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEE
DSVFSMDGDLCLLPELLAIAKEFSTMLLVDEAHGTGVLGQKGAGVVEHFHCTQQPLIQVG
CCCEECCCCEEHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCHHHHHHCCHHHHHHHH
TLSKALGSLGGYVAGSKALIDFLRNRASTWIYTTGLSPADTAAALAAIHILQEEPQRRQQ
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCHHHHHH
LWENIRQLKSALGNHELVPSESAVLCFGLANPQQALAMGDRLLATGFFAPAIRPPTVPTS
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCC
RIRVSVMATHSPQQIQGFIEIFQRCFAEFSGSSNL
CEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA