Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 170077862

GI number: 170077862

Start: 1285537

End: 1287114

Strand: Direct

Name: serA [H]

Synonym: SYNPCC7002_A1246

Alternate gene names: 170077862

Gene position: 1285537-1287114 (Clockwise)

Preceding gene: 170077861

Following gene: 170077863

Centisome position: 42.74

GC content: 53.11

Gene sequence:

>1578_bases
ATGGCTAAAGTTCTTGTTTCCGACTCTATCGACCAAGCCGGAATCGATATCCTCTCCCAGGTCGCCCAAGTAGACGTTAA
AGTCGGATTACCCCTCGAAGAACTCATCAGCATTATTCCCGAATACGATGCCCTGATGATTCGCTCCGGGACCAAAGTCA
CCAAAGAAGTGATCGAAGCCGGTAAAAACCTCAAAATCATTGGCCGTGCCGGAGTCGGTGTTGATAATGTCGATATTCCC
GCCGCCACCCGCCAAGGGATCATCGTCGTCAACTCCCCCGAAGGAAACACCATTGCTGCCGCCGAACATGCCCTCGCGAT
GATGTTGTCCCTCTCTCGCCACATCCCCGATGCCAACCAGTCCGTCAAAGCCAAAGAATGGAACCGGAAAAAATTCATCG
GCGCAGAAGTGTATAAAAAGACCCTCGGCGTTGTCGGTCTCGGCAAAATTGGTGCCCACGTAGCTAGCGTCGGTAAAGCC
CTAGGCATGAAGCTCCTCGCCTATGATCCGTTTATCTCCGAAGAACGGGCCGGACAATTGGGTTGTCGCCTCGTCGATCT
CGATTACCTGTTCCGGGAAGCCGACTACATTACCCTCCACGTCCCCAAAACCCCCGAAACTACCCATTTAATTGGCGAAG
AGTCCATCGCCAAAATGAAGCCCACCACCCGCATTGTGAACTGTGCTCGTGGTGGCGTTGTTGATGAAGCCGCCGTTGCT
AAAGCGATCCAAGAAGGTCGCCTTGGTGGGGCCGCTTTGGATGTTTTTGAAGAAGAGCCCCTGGGTGAATCTGAACTCCG
GGCCTTGGATAACGTCGTCCTTACCCCCCACTTGGGTGCTTCTACCGCTGAAGCCCAGGTAAATGTTGCCGTTGATGTTG
CCGAGCAAATTCGGGATGTCATTTTAGGGTTGCCAGCACGCTCTGCGGTGAATATTCCTGGCCTTAATGCCAACGTCATG
GAAAAACTGCGTCCCTATCTCCAATTGGCGGAGACCCTAGGGAACATGGTCGGTCAGTTAGCCGGAGGCCGCATCGAAAA
ATTAAATGTGACCCTCCAAGGGGATTTGGCCGAAAAAGAAGCCAAGCCTTTGGTTGTAGCTGCGCTCAAAGGTCTCCTTT
CTCCGGCATTGCGGGAACGGGTCAACTATGTGAACGCAGAAATCGAAGCGAAGGAACGGGGGATCCGGATCATTGAGACC
CGTGATGAATCGGTGCGTGATTACACCGGAGCCATTCACCTAGAAGCCACTGGCGCTGATGGAGAACACTCCGTCAATGG
GGCGCTGTTAAGTGACGGGGATATTCGCATTACTAGTATCAATGGTTTTCCGATTAATGTGCCGCCAACGGGCTACATGC
TCTTTACTCTCCACCGGGATGTTCCGGGGATTATCGGCAAGATCGGCTCTCTGCTGGGCAGCTTTAATGTGAATATCGCC
AGTATGCAGGTGGGCCGCAAAATTGTCCGGGGTGACGCCGTAATGGTTCTGAGCCTAGATGATCCGCTGCCGGAAGGTGT
CTTGAGTGAGATTACCAAGGTAACCGGAATCCGGGATGCCTACACGGTTAAGCTGTAA

Upstream 100 bases:

>100_bases
TAGCCCTCGTGCCCACGGGAACTTCCCCCAAACCCCGCCCCCGGCGACACGACCCGCAGTATCCGACCCAAACGAAACAT
TTATATTTAATCGAATTGTT

Downstream 100 bases:

>100_bases
GGTTGAGCCATGGGGGAAAGGTCTCTGGATTCTTTCCCCCGCCCAATGACAAGAGGAAAACAATGACAACAACTTGGTGG
GAATTACAGATCCTCTGCGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MAKVLVSDSIDQAGIDILSQVAQVDVKVGLPLEELISIIPEYDALMIRSGTKVTKEVIEAGKNLKIIGRAGVGVDNVDIP
AATRQGIIVVNSPEGNTIAAAEHALAMMLSLSRHIPDANQSVKAKEWNRKKFIGAEVYKKTLGVVGLGKIGAHVASVGKA
LGMKLLAYDPFISEERAGQLGCRLVDLDYLFREADYITLHVPKTPETTHLIGEESIAKMKPTTRIVNCARGGVVDEAAVA
KAIQEGRLGGAALDVFEEEPLGESELRALDNVVLTPHLGASTAEAQVNVAVDVAEQIRDVILGLPARSAVNIPGLNANVM
EKLRPYLQLAETLGNMVGQLAGGRIEKLNVTLQGDLAEKEAKPLVVAALKGLLSPALRERVNYVNAEIEAKERGIRIIET
RDESVRDYTGAIHLEATGADGEHSVNGALLSDGDIRITSINGFPINVPPTGYMLFTLHRDVPGIIGKIGSLLGSFNVNIA
SMQVGRKIVRGDAVMVLSLDDPLPEGVLSEITKVTGIRDAYTVKL

Sequences:

>Translated_525_residues
MAKVLVSDSIDQAGIDILSQVAQVDVKVGLPLEELISIIPEYDALMIRSGTKVTKEVIEAGKNLKIIGRAGVGVDNVDIP
AATRQGIIVVNSPEGNTIAAAEHALAMMLSLSRHIPDANQSVKAKEWNRKKFIGAEVYKKTLGVVGLGKIGAHVASVGKA
LGMKLLAYDPFISEERAGQLGCRLVDLDYLFREADYITLHVPKTPETTHLIGEESIAKMKPTTRIVNCARGGVVDEAAVA
KAIQEGRLGGAALDVFEEEPLGESELRALDNVVLTPHLGASTAEAQVNVAVDVAEQIRDVILGLPARSAVNIPGLNANVM
EKLRPYLQLAETLGNMVGQLAGGRIEKLNVTLQGDLAEKEAKPLVVAALKGLLSPALRERVNYVNAEIEAKERGIRIIET
RDESVRDYTGAIHLEATGADGEHSVNGALLSDGDIRITSINGFPINVPPTGYMLFTLHRDVPGIIGKIGSLLGSFNVNIA
SMQVGRKIVRGDAVMVLSLDDPLPEGVLSEITKVTGIRDAYTVKL
>Mature_524_residues
AKVLVSDSIDQAGIDILSQVAQVDVKVGLPLEELISIIPEYDALMIRSGTKVTKEVIEAGKNLKIIGRAGVGVDNVDIPA
ATRQGIIVVNSPEGNTIAAAEHALAMMLSLSRHIPDANQSVKAKEWNRKKFIGAEVYKKTLGVVGLGKIGAHVASVGKAL
GMKLLAYDPFISEERAGQLGCRLVDLDYLFREADYITLHVPKTPETTHLIGEESIAKMKPTTRIVNCARGGVVDEAAVAK
AIQEGRLGGAALDVFEEEPLGESELRALDNVVLTPHLGASTAEAQVNVAVDVAEQIRDVILGLPARSAVNIPGLNANVME
KLRPYLQLAETLGNMVGQLAGGRIEKLNVTLQGDLAEKEAKPLVVAALKGLLSPALRERVNYVNAEIEAKERGIRIIETR
DESVRDYTGAIHLEATGADGEHSVNGALLSDGDIRITSINGFPINVPPTGYMLFTLHRDVPGIIGKIGSLLGSFNVNIAS
MQVGRKIVRGDAVMVLSLDDPLPEGVLSEITKVTGIRDAYTVKL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=404, Percent_Identity=42.0792079207921, Blast_Score=315, Evalue=9e-86,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=38.0073800738007, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=38.0073800738007, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI145580578, Length=307, Percent_Identity=33.8762214983713, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI4557499, Length=307, Percent_Identity=33.8762214983713, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI145580575, Length=268, Percent_Identity=35.0746268656716, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI6912396, Length=325, Percent_Identity=28.6153846153846, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1789279, Length=319, Percent_Identity=34.1692789968652, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082289, Length=285, Percent_Identity=34.3859649122807, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1787645, Length=304, Percent_Identity=33.2236842105263, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788660, Length=304, Percent_Identity=30.9210526315789, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87081824, Length=238, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=317, Percent_Identity=45.7413249211356, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=31.5217391304348, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=36.8098159509202, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6322116, Length=325, Percent_Identity=34.7692307692308, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324055, Length=241, Percent_Identity=30.2904564315353, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=261, Percent_Identity=28.3524904214559, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=177, Percent_Identity=29.3785310734463, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=282, Percent_Identity=26.9503546099291, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=47, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24646446, Length=284, Percent_Identity=34.5070422535211, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24646448, Length=284, Percent_Identity=34.5070422535211, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24646452, Length=284, Percent_Identity=34.5070422535211, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24646450, Length=284, Percent_Identity=34.5070422535211, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI62472511, Length=284, Percent_Identity=34.5070422535211, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28571528, Length=304, Percent_Identity=31.9078947368421, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28574286, Length=313, Percent_Identity=27.7955271565495, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574284, Length=316, Percent_Identity=27.2151898734177, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585514, Length=316, Percent_Identity=27.2151898734177, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574282, Length=316, Percent_Identity=27.2151898734177, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551003, Length=316, Percent_Identity=27.2151898734177, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45552429, Length=316, Percent_Identity=27.2151898734177, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24585516, Length=278, Percent_Identity=25.8992805755396, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55963; Mature: 55832

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVLVSDSIDQAGIDILSQVAQVDVKVGLPLEELISIIPEYDALMIRSGTKVTKEVIEA
CCEEEECCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHCCCCCEEEEECCCHHHHHHHHC
GKNLKIIGRAGVGVDNVDIPAATRQGIIVVNSPEGNTIAAAEHALAMMLSLSRHIPDANQ
CCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCC
SVKAKEWNRKKFIGAEVYKKTLGVVGLGKIGAHVASVGKALGMKLLAYDPFISEERAGQL
CCCHHHCCCHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCC
GCRLVDLDYLFREADYITLHVPKTPETTHLIGEESIAKMKPTTRIVNCARGGVVDEAAVA
CCEEEEHHHHHCCCCEEEEECCCCCCCCEECCCHHHHHCCCHHHHHHHHCCCCCHHHHHH
KAIQEGRLGGAALDVFEEEPLGESELRALDNVVLTPHLGASTAEAQVNVAVDVAEQIRDV
HHHHHCCCCCHHHHHHCCCCCCHHHHHHHHCEEECCCCCCCCCCCEEEEEHHHHHHHHHH
ILGLPARSAVNIPGLNANVMEKLRPYLQLAETLGNMVGQLAGGRIEKLNVTLQGDLAEKE
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHC
AKPLVVAALKGLLSPALRERVNYVNAEIEAKERGIRIIETRDESVRDYTGAIHLEATGAD
CCCHHHHHHHHHHCHHHHHHHHHHCCEEEECCCCEEEEECCCCCHHHHCCEEEEEEECCC
GEHSVNGALLSDGDIRITSINGFPINVPPTGYMLFTLHRDVPGIIGKIGSLLGSFNVNIA
CCCCCCCEEEECCCEEEEEECCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEE
SMQVGRKIVRGDAVMVLSLDDPLPEGVLSEITKVTGIRDAYTVKL
HHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure 
AKVLVSDSIDQAGIDILSQVAQVDVKVGLPLEELISIIPEYDALMIRSGTKVTKEVIEA
CEEEECCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHCCCCCEEEEECCCHHHHHHHHC
GKNLKIIGRAGVGVDNVDIPAATRQGIIVVNSPEGNTIAAAEHALAMMLSLSRHIPDANQ
CCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCC
SVKAKEWNRKKFIGAEVYKKTLGVVGLGKIGAHVASVGKALGMKLLAYDPFISEERAGQL
CCCHHHCCCHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCC
GCRLVDLDYLFREADYITLHVPKTPETTHLIGEESIAKMKPTTRIVNCARGGVVDEAAVA
CCEEEEHHHHHCCCCEEEEECCCCCCCCEECCCHHHHHCCCHHHHHHHHCCCCCHHHHHH
KAIQEGRLGGAALDVFEEEPLGESELRALDNVVLTPHLGASTAEAQVNVAVDVAEQIRDV
HHHHHCCCCCHHHHHHCCCCCCHHHHHHHHCEEECCCCCCCCCCCEEEEEHHHHHHHHHH
ILGLPARSAVNIPGLNANVMEKLRPYLQLAETLGNMVGQLAGGRIEKLNVTLQGDLAEKE
HHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHC
AKPLVVAALKGLLSPALRERVNYVNAEIEAKERGIRIIETRDESVRDYTGAIHLEATGAD
CCCHHHHHHHHHHCHHHHHHHHHHCCEEEECCCCEEEEECCCCCHHHHCCEEEEEEECCC
GEHSVNGALLSDGDIRITSINGFPINVPPTGYMLFTLHRDVPGIIGKIGSLLGSFNVNIA
CCCCCCCEEEECCCEEEEEECCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEE
SMQVGRKIVRGDAVMVLSLDDPLPEGVLSEITKVTGIRDAYTVKL
HHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]