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The map label for this gene is purU [H]

Identifier: 170077627

GI number: 170077627

Start: 1039092

End: 1039940

Strand: Direct

Name: purU [H]

Synonym: SYNPCC7002_A1006

Alternate gene names: 170077627

Gene position: 1039092-1039940 (Clockwise)

Preceding gene: 170077624

Following gene: 170077629

Centisome position: 34.54

GC content: 50.53

Gene sequence:

>849_bases
ATGCCCACTGCTACTCTGCTAGTGTCCTGTCCGGATCAACAAGGTCTGGTTGCGAAAATTGCCAACTTTATCTACGCCAA
TGGCGGCAATATTATCCACGCCGATCAACATACGGATCTCAGTGCTGGTTTATTTCTAACGCGCATCGAGTGGGAGCTAG
ACGGATTCAACCTGCCACGGGAAGTGATTGAACCCGCTTTTGGGGCGATCGCCAAACCGTTGGGGGCGACCTACAGCTTA
CATTTTTCTGATCAGGTTCCCCGGCTGGCCATTTGGGTCACCAAACAGGATCACTGTTTGCTGGATCTGCTCTGGCGACA
ACAGGCAAAAGAACTCAAAGCAGAGATTCCCCTAATCATCAGCAATCACCAGGAACTAGAGGCGATCGCCCAGCAATTTA
AGATTGATTTTCACCACATTCCGATCACCAAAGCCACAAAAGCAGAACAAGAAGCAAAACAATTGGCCCTGTTGCAAGAA
TACAACATCGATCTGGTGATCCTCGCCAAATATATGCAGGTGCTTAGTCCAGATTTTCTTGGCAAGTTTAACCAGGTGAT
CAATATCCACCATTCCTTTTTACCAGCCTTTGCAGGGGCGAAACCCTACCACCGCGCCTACGACCGGGGTGTAAAAATCA
TTGGTGCCACGGCCCACTACGTCACCCAGGATCTCGACGAAGGGCCGATTATCGAACAGGATGTGGTGCGGGTCAGCCAC
CGGGATGACGTGAAAGATCTAATTCGCAAAGGCAAAGATTTAGAACGTATCGTTTTATCCCGCGCCGTCCGCCTCCACCT
GCAACATCGCGTTTTAGTTTACGGCAACCGCACCGCCGTCTTCGCCTAA

Upstream 100 bases:

>100_bases
TGTGTCATTTTCCCGTGAGATTCTCGCTACACCGTTTATTTTCAAGGCGAAACCCGTACAATAGTGGAGTTTTGCGAACC
TTTAAGAATCTACAAAAGCA

Downstream 100 bases:

>100_bases
AATCCTCCCTTGAGGGAGGTGGCCGATAGGCCAGAGGGTGTATGTCCCTTAAGGGAGGTGGCGCAGCTTAAGATTTCCCC
TTGAGGGGAACTAAAGGGGT

Product: formyltetrahydrofolate deformylase

Products: NA

Alternate protein names: Formyl-FH(4) hydrolase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MPTATLLVSCPDQQGLVAKIANFIYANGGNIIHADQHTDLSAGLFLTRIEWELDGFNLPREVIEPAFGAIAKPLGATYSL
HFSDQVPRLAIWVTKQDHCLLDLLWRQQAKELKAEIPLIISNHQELEAIAQQFKIDFHHIPITKATKAEQEAKQLALLQE
YNIDLVILAKYMQVLSPDFLGKFNQVINIHHSFLPAFAGAKPYHRAYDRGVKIIGATAHYVTQDLDEGPIIEQDVVRVSH
RDDVKDLIRKGKDLERIVLSRAVRLHLQHRVLVYGNRTAVFA

Sequences:

>Translated_282_residues
MPTATLLVSCPDQQGLVAKIANFIYANGGNIIHADQHTDLSAGLFLTRIEWELDGFNLPREVIEPAFGAIAKPLGATYSL
HFSDQVPRLAIWVTKQDHCLLDLLWRQQAKELKAEIPLIISNHQELEAIAQQFKIDFHHIPITKATKAEQEAKQLALLQE
YNIDLVILAKYMQVLSPDFLGKFNQVINIHHSFLPAFAGAKPYHRAYDRGVKIIGATAHYVTQDLDEGPIIEQDVVRVSH
RDDVKDLIRKGKDLERIVLSRAVRLHLQHRVLVYGNRTAVFA
>Mature_281_residues
PTATLLVSCPDQQGLVAKIANFIYANGGNIIHADQHTDLSAGLFLTRIEWELDGFNLPREVIEPAFGAIAKPLGATYSLH
FSDQVPRLAIWVTKQDHCLLDLLWRQQAKELKAEIPLIISNHQELEAIAQQFKIDFHHIPITKATKAEQEAKQLALLQEY
NIDLVILAKYMQVLSPDFLGKFNQVINIHHSFLPAFAGAKPYHRAYDRGVKIIGATAHYVTQDLDEGPIIEQDVVRVSHR
DDVKDLIRKGKDLERIVLSRAVRLHLQHRVLVYGNRTAVFA

Specific function: Produces Formate From Formyl-Tetrahydrofolate. Provides The Major Source Of Formate For The Purt-Dependent Synthesis Of 5'-Phosphoribosyl-N-Formylglycinamide (Fgar) During Aerobic Growth. Has A Role In Regulating The One-Carbon Pool. [C]

COG id: COG0788

COG function: function code F; Formyltetrahydrofolate hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=205, Percent_Identity=30.2439024390244, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI209869995, Length=205, Percent_Identity=30.2439024390244, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI209869993, Length=205, Percent_Identity=30.2439024390244, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1787483, Length=273, Percent_Identity=45.0549450549451, Blast_Score=231, Evalue=3e-62,
Organism=Escherichia coli, GI1788846, Length=175, Percent_Identity=28, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17567511, Length=166, Percent_Identity=32.5301204819277, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24582400, Length=198, Percent_Identity=26.7676767676768, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR002376
- InterPro:   IPR004810 [H]

Pfam domain/function: PF01842 ACT; PF00551 Formyl_trans_N [H]

EC number: =3.5.1.10 [H]

Molecular weight: Translated: 31855; Mature: 31724

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTATLLVSCPDQQGLVAKIANFIYANGGNIIHADQHTDLSAGLFLTRIEWELDGFNLPR
CCCCEEEEECCCCCCHHHHHHHHHEECCCCEEECCCCCCCCCCEEEEEEEEEECCCCCCH
EVIEPAFGAIAKPLGATYSLHFSDQVPRLAIWVTKQDHCLLDLLWRQQAKELKAEIPLII
HHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEE
SNHQELEAIAQQFKIDFHHIPITKATKAEQEAKQLALLQEYNIDLVILAKYMQVLSPDFL
CCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCHHHH
GKFNQVINIHHSFLPAFAGAKPYHRAYDRGVKIIGATAHYVTQDLDEGPIIEQDVVRVSH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECHHHHHHHCCCCCCCCHHHHHHHCC
RDDVKDLIRKGKDLERIVLSRAVRLHLQHRVLVYGNRTAVFA
CCCHHHHHHCCCHHHHHHHHHHHHHHHHCEEEEEECCEEECC
>Mature Secondary Structure 
PTATLLVSCPDQQGLVAKIANFIYANGGNIIHADQHTDLSAGLFLTRIEWELDGFNLPR
CCCEEEEECCCCCCHHHHHHHHHEECCCCEEECCCCCCCCCCEEEEEEEEEECCCCCCH
EVIEPAFGAIAKPLGATYSLHFSDQVPRLAIWVTKQDHCLLDLLWRQQAKELKAEIPLII
HHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEE
SNHQELEAIAQQFKIDFHHIPITKATKAEQEAKQLALLQEYNIDLVILAKYMQVLSPDFL
CCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCHHHH
GKFNQVINIHHSFLPAFAGAKPYHRAYDRGVKIIGATAHYVTQDLDEGPIIEQDVVRVSH
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECHHHHHHHCCCCCCCCHHHHHHHCC
RDDVKDLIRKGKDLERIVLSRAVRLHLQHRVLVYGNRTAVFA
CCCHHHHHHCCCHHHHHHHHHHHHHHHHCEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]