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The map label for this gene is cysM [H]

Identifier: 170077597

GI number: 170077597

Start: 1004056

End: 1005033

Strand: Direct

Name: cysM [H]

Synonym: SYNPCC7002_A0976

Alternate gene names: 170077597

Gene position: 1004056-1005033 (Clockwise)

Preceding gene: 170077595

Following gene: 170077598

Centisome position: 33.38

GC content: 51.02

Gene sequence:

>978_bases
ATGGATATCAAAGACGGTTTTGTTGGTGCAGTTGGCAACACCCCCCTCATTCGCCTAAACAGTTTTAGTGAAGCAACGGG
CTGTGAAATTTTAGGCAAAGCAGAATTTCTCAATCCCGGTGGTTCCGTCAAAGACCGGGCCGCCCTCTACATCATCAAAG
ACGCCGAAGAACGGGGCCTGCTCAAACCTGGTGGCACCGTTGTTGAAGGCACCGCAGGGAACACAGGCATTGGTCTGGTT
CATATCTGTAATGCTAAGGGTTACAAGTGCATCATTGTGATCCCCGAAACCCAGTCCCAAGAAAAAATTGACCTGCTCCG
CACTTTAGGGGCAGAAGTAATTACGGTTCCGGCGGTGCCCTATGCCGACCCTAACAATTATGTGAAATATTCCCAACGGC
TCGCCGCAGAAACAGAAAACGCGATCTGGGCGAATCAGTTTGATAATTTAGCCAACCGCCGCGCCCACTACGAGACCACT
GGCCCCGAAATTTGGGCTCAAACCGACGGCAAAATTGATGCTTGGACGGCTGCTACGGGAACTGGGGGCACCTATGCTGG
TACCGCCCTTTACCTCAAGGAAAAAAATCCTAACGTTAAATGTGTTGTGGCTGACCCCATGGGTAGTGTGCTCTATAGCT
ATGTAAAAACGGGCAAACTCGACCGGGAAGGCGGTTCGATCACGGAAGGCATTGGTCAAGGACGCATTACCGCCAATATG
GAAGGAGTGCCCATGGACGACGCCATTCGGGTTGATGACCAAGAGGCGGTGCAGGTTGTGTATCAACTCTTGAAAAAAGA
TGGTCTGTTTATGGGGGGCTCCGTAGGAATTAATGTCGGTGCTGCCTATGCCCTCGCGAAGGAAATGGGGCCAGGTCATA
CTATTGTGACGGTGTTGTGTGACAGTGGCGCTCGTTATCAATCTCGCCTATTTAACCCAGCATGGCTCGCCAGTAAAGGG
CTATCTATTCCTAATTAA

Upstream 100 bases:

>100_bases
CGATCGCCTCCATAATTCACCACAGGAATCGAACCAGCCCATGTCACAATAGGGGGATTGCAACCCACAGTGCAAAAGAC
AGAAGAAACAGAATCAACCT

Downstream 100 bases:

>100_bases
TATTTAAACTGTGTAAGGAGAATAAAGGTGAATAACCTTAGTCTGGAAGCCACCAAAGTTAGCCATATTTACACTTAGAG
GAATGATGAGGATATAGTCA

Product: cysteine synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MDIKDGFVGAVGNTPLIRLNSFSEATGCEILGKAEFLNPGGSVKDRAALYIIKDAEERGLLKPGGTVVEGTAGNTGIGLV
HICNAKGYKCIIVIPETQSQEKIDLLRTLGAEVITVPAVPYADPNNYVKYSQRLAAETENAIWANQFDNLANRRAHYETT
GPEIWAQTDGKIDAWTAATGTGGTYAGTALYLKEKNPNVKCVVADPMGSVLYSYVKTGKLDREGGSITEGIGQGRITANM
EGVPMDDAIRVDDQEAVQVVYQLLKKDGLFMGGSVGINVGAAYALAKEMGPGHTIVTVLCDSGARYQSRLFNPAWLASKG
LSIPN

Sequences:

>Translated_325_residues
MDIKDGFVGAVGNTPLIRLNSFSEATGCEILGKAEFLNPGGSVKDRAALYIIKDAEERGLLKPGGTVVEGTAGNTGIGLV
HICNAKGYKCIIVIPETQSQEKIDLLRTLGAEVITVPAVPYADPNNYVKYSQRLAAETENAIWANQFDNLANRRAHYETT
GPEIWAQTDGKIDAWTAATGTGGTYAGTALYLKEKNPNVKCVVADPMGSVLYSYVKTGKLDREGGSITEGIGQGRITANM
EGVPMDDAIRVDDQEAVQVVYQLLKKDGLFMGGSVGINVGAAYALAKEMGPGHTIVTVLCDSGARYQSRLFNPAWLASKG
LSIPN
>Mature_325_residues
MDIKDGFVGAVGNTPLIRLNSFSEATGCEILGKAEFLNPGGSVKDRAALYIIKDAEERGLLKPGGTVVEGTAGNTGIGLV
HICNAKGYKCIIVIPETQSQEKIDLLRTLGAEVITVPAVPYADPNNYVKYSQRLAAETENAIWANQFDNLANRRAHYETT
GPEIWAQTDGKIDAWTAATGTGGTYAGTALYLKEKNPNVKCVVADPMGSVLYSYVKTGKLDREGGSITEGIGQGRITANM
EGVPMDDAIRVDDQEAVQVVYQLLKKDGLFMGGSVGINVGAAYALAKEMGPGHTIVTVLCDSGARYQSRLFNPAWLASKG
LSIPN

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=314, Percent_Identity=40.4458598726115, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI295821200, Length=314, Percent_Identity=40.4458598726115, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI4557415, Length=314, Percent_Identity=40.4458598726115, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI2367138, Length=308, Percent_Identity=35.3896103896104, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1788754, Length=301, Percent_Identity=37.5415282392027, Blast_Score=167, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI32566674, Length=298, Percent_Identity=38.9261744966443, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=38.9261744966443, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17535051, Length=304, Percent_Identity=39.1447368421053, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=301, Percent_Identity=37.5415282392027, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534315, Length=331, Percent_Identity=34.441087613293, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=38.0327868852459, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147552, Length=328, Percent_Identity=33.2317073170732, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=34.5794392523364, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71996324, Length=322, Percent_Identity=25.4658385093168, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17539800, Length=349, Percent_Identity=23.2091690544413, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539640, Length=338, Percent_Identity=24.8520710059172, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321449, Length=334, Percent_Identity=44.0119760479042, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321594, Length=332, Percent_Identity=35.2409638554217, Blast_Score=189, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24643623, Length=325, Percent_Identity=38.4615384615385, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI20129101, Length=325, Percent_Identity=38.4615384615385, Blast_Score=211, Evalue=8e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 34577; Mature: 34577

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKDGFVGAVGNTPLIRLNSFSEATGCEILGKAEFLNPGGSVKDRAALYIIKDAEERGL
CCCCCCCEECCCCCCEEEECCCCCCCCCEEEECEEEECCCCCCCCCEEEEEEECCCCCCC
LKPGGTVVEGTAGNTGIGLVHICNAKGYKCIIVIPETQSQEKIDLLRTLGAEVITVPAVP
CCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCC
YADPNNYVKYSQRLAAETENAIWANQFDNLANRRAHYETTGPEIWAQTDGKIDAWTAATG
CCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECC
TGGTYAGTALYLKEKNPNVKCVVADPMGSVLYSYVKTGKLDREGGSITEGIGQGRITANM
CCCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEECC
EGVPMDDAIRVDDQEAVQVVYQLLKKDGLFMGGSVGINVGAAYALAKEMGPGHTIVTVLC
CCCCCCCCEECCCHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCCEEEEEEE
DSGARYQSRLFNPAWLASKGLSIPN
CCCCHHHHHCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MDIKDGFVGAVGNTPLIRLNSFSEATGCEILGKAEFLNPGGSVKDRAALYIIKDAEERGL
CCCCCCCEECCCCCCEEEECCCCCCCCCEEEECEEEECCCCCCCCCEEEEEEECCCCCCC
LKPGGTVVEGTAGNTGIGLVHICNAKGYKCIIVIPETQSQEKIDLLRTLGAEVITVPAVP
CCCCCEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCC
YADPNNYVKYSQRLAAETENAIWANQFDNLANRRAHYETTGPEIWAQTDGKIDAWTAATG
CCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECC
TGGTYAGTALYLKEKNPNVKCVVADPMGSVLYSYVKTGKLDREGGSITEGIGQGRITANM
CCCCCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCHHHCCCCCEEEECC
EGVPMDDAIRVDDQEAVQVVYQLLKKDGLFMGGSVGINVGAAYALAKEMGPGHTIVTVLC
CCCCCCCCEECCCHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHCCCCCEEEEEEE
DSGARYQSRLFNPAWLASKGLSIPN
CCCCHHHHHCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]