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The map label for this gene is adhI [H]

Identifier: 170077490

GI number: 170077490

Start: 897454

End: 898563

Strand: Direct

Name: adhI [H]

Synonym: SYNPCC7002_A0868

Alternate gene names: 170077490

Gene position: 897454-898563 (Clockwise)

Preceding gene: 170077489

Following gene: 170077491

Centisome position: 29.84

GC content: 52.34

Gene sequence:

>1110_bases
ATGGATGTGAAAGCGGCGATCGCCTATGCAGCAAAAGAACCCCTCAAGGTAGAAACCGTCCAACTCGAACCCCCCAAAGC
TGGAGAAGTGCTGGTAGAAATCAAGGCGACGGGGGTTTGTCATACCGATGCCTACACTTTATCTGGGGCCGATCCAGAGG
GGCTATTCCCGGCGATCCTAGGCCATGAGGGGGCTGGGGTTGTGGTTGAAGTGGGGCCGGATGTTAAAAGTCTGAAACCG
GGCGATCACGTTATTCCCCTCTATGTGCCAGAATGCCGCGAGTGCGAATATTGCCTCAGTTTTAAAACAAATCTCTGTCA
GGCAATCCGACTTACCCAAGGCCGGGGCGTGATGCCCGATGGTACCGGACGTTTTTCGATTAATGGTAAGCCGCTGTTTC
ACTACATGGGCACCTCCACCTTTGCTAACTACACCGTGGTGCCAGAAATTTCCCTGGCAAAAATCCGCGAAGATGCCCCC
TTTGATAAGGTCTGCTACATCGGCTGCGGTGTCACCACGGGGATCGGGGCGGTGATCAATACGGCGAAAGTTGAAGTGGG
GTCAAAGGTAATTGTCTTCGGCTTGGGGGGCATTGGCCTAAACGTGATCCAAGGCTGTCGCATGGTGGGGGCAGATATGA
TTGTCGGCGTCGATATTAACGACGATAAAAAGGCGATCGCCGAAAAATTTGGTATGACCCATTTCGTCAATCCCAAGGAA
GTTGAGGGTGATCTCGTGCCCTATTTAGTGGATTTAACAAAAGGCGGTGCGGACTACACCTTTGAATGTATTGGCAATGT
CAACGTGATGCGCCAAGCGCTGGAAAGTTGCCATAAGGGTTGGGGTGTTTCTACTATTGTTGGGGTAGCAGGCGCAGGTC
AAGAGATTAGTACCCGACCCTTCCAGTTGGTAACGGGTCGCGTCTGGAAAGGAACCGCCTTCGGGGGCGCGAGGGGCCGT
ACCGATGTGCCGAAAATTGTCGATTGGTACATGGAAGGCAAAATCAACATCGATGATCTGATTACCCACACCATGCCCAT
TGAGAAGATTAACGAAGCCTTCGATTTGATGCACGCCGGAGAATCTATCCGCAGCGTGGTCACCTTTTAG

Upstream 100 bases:

>100_bases
TGTGTTTGCCGATGAACCCCTAGATTTAGCAAAAATCTGTCCCCCCAGTATTTGTCTTTAGAATAGTAACGACTAAAACC
AAAATTTAAGGATTGACCCC

Downstream 100 bases:

>100_bases
ATCCTCAAAATTGGTAGGGGTTTACCATGGTAAGCCCCCATAGCACGATCAAATTAACGATGACAAACCTTGTTTTAACG
AAAGAAACCCTCTGTTTTGG

Product: alcohol dehydrogenase, zinc-binding dehydrogenase family protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MDVKAAIAYAAKEPLKVETVQLEPPKAGEVLVEIKATGVCHTDAYTLSGADPEGLFPAILGHEGAGVVVEVGPDVKSLKP
GDHVIPLYVPECRECEYCLSFKTNLCQAIRLTQGRGVMPDGTGRFSINGKPLFHYMGTSTFANYTVVPEISLAKIREDAP
FDKVCYIGCGVTTGIGAVINTAKVEVGSKVIVFGLGGIGLNVIQGCRMVGADMIVGVDINDDKKAIAEKFGMTHFVNPKE
VEGDLVPYLVDLTKGGADYTFECIGNVNVMRQALESCHKGWGVSTIVGVAGAGQEISTRPFQLVTGRVWKGTAFGGARGR
TDVPKIVDWYMEGKINIDDLITHTMPIEKINEAFDLMHAGESIRSVVTF

Sequences:

>Translated_369_residues
MDVKAAIAYAAKEPLKVETVQLEPPKAGEVLVEIKATGVCHTDAYTLSGADPEGLFPAILGHEGAGVVVEVGPDVKSLKP
GDHVIPLYVPECRECEYCLSFKTNLCQAIRLTQGRGVMPDGTGRFSINGKPLFHYMGTSTFANYTVVPEISLAKIREDAP
FDKVCYIGCGVTTGIGAVINTAKVEVGSKVIVFGLGGIGLNVIQGCRMVGADMIVGVDINDDKKAIAEKFGMTHFVNPKE
VEGDLVPYLVDLTKGGADYTFECIGNVNVMRQALESCHKGWGVSTIVGVAGAGQEISTRPFQLVTGRVWKGTAFGGARGR
TDVPKIVDWYMEGKINIDDLITHTMPIEKINEAFDLMHAGESIRSVVTF
>Mature_369_residues
MDVKAAIAYAAKEPLKVETVQLEPPKAGEVLVEIKATGVCHTDAYTLSGADPEGLFPAILGHEGAGVVVEVGPDVKSLKP
GDHVIPLYVPECRECEYCLSFKTNLCQAIRLTQGRGVMPDGTGRFSINGKPLFHYMGTSTFANYTVVPEISLAKIREDAP
FDKVCYIGCGVTTGIGAVINTAKVEVGSKVIVFGLGGIGLNVIQGCRMVGADMIVGVDINDDKKAIAEKFGMTHFVNPKE
VEGDLVPYLVDLTKGGADYTFECIGNVNVMRQALESCHKGWGVSTIVGVAGAGQEISTRPFQLVTGRVWKGTAFGGARGR
TDVPKIVDWYMEGKINIDDLITHTMPIEKINEAFDLMHAGESIRSVVTF

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=61.3079019073569, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=47.1544715447154, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=47.0588235294118, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI262073058, Length=366, Percent_Identity=46.9945355191257, Blast_Score=354, Evalue=6e-98,
Organism=Homo sapiens, GI71743840, Length=366, Percent_Identity=46.9945355191257, Blast_Score=354, Evalue=6e-98,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=46.070460704607, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=45.5284552845528, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI156523966, Length=364, Percent_Identity=45.3296703296703, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=45.5307262569832, Blast_Score=332, Evalue=3e-91,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=61.2466124661247, Blast_Score=453, Evalue=1e-129,
Organism=Escherichia coli, GI1788073, Length=350, Percent_Identity=28.2857142857143, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082125, Length=366, Percent_Identity=24.5901639344262, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790045, Length=378, Percent_Identity=26.4550264550265, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI226510992, Length=364, Percent_Identity=25, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787863, Length=344, Percent_Identity=24.4186046511628, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786825, Length=398, Percent_Identity=24.3718592964824, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=30.9090909090909, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786518, Length=368, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790718, Length=338, Percent_Identity=24.8520710059172, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788075, Length=363, Percent_Identity=24.7933884297521, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=60.3217158176944, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=60, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=60.0583090379009, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17562876, Length=373, Percent_Identity=27.6139410187668, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=366, Percent_Identity=27.3224043715847, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=361, Percent_Identity=27.1468144044321, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=242, Percent_Identity=28.099173553719, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=366, Percent_Identity=24.5901639344262, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=55.5858310626703, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319621, Length=372, Percent_Identity=29.8387096774194, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=360, Percent_Identity=30, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=360, Percent_Identity=30, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=389, Percent_Identity=28.5347043701799, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=27.3224043715847, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=373, Percent_Identity=27.0777479892761, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=27.5147928994083, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=377, Percent_Identity=25.4641909814324, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=27.1698113207547, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=64.1304347826087, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI17137530, Length=356, Percent_Identity=26.123595505618, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39513; Mature: 39513

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKAAIAYAAKEPLKVETVQLEPPKAGEVLVEIKATGVCHTDAYTLSGADPEGLFPAIL
CCCHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCHHHH
GHEGAGVVVEVGPDVKSLKPGDHVIPLYVPECRECEYCLSFKTNLCQAIRLTQGRGVMPD
CCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GTGRFSINGKPLFHYMGTSTFANYTVVPEISLAKIREDAPFDKVCYIGCGVTTGIGAVIN
CCCEEEECCCEEEEECCCCCCCCEEEECCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHE
TAKVEVGSKVIVFGLGGIGLNVIQGCRMVGADMIVGVDINDDKKAIAEKFGMTHFVNPKE
EEEEECCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCEECCCHHH
VEGDLVPYLVDLTKGGADYTFECIGNVNVMRQALESCHKGWGVSTIVGVAGAGQEISTRP
CCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHEEEECCCCCCCCCCC
FQLVTGRVWKGTAFGGARGRTDVPKIVDWYMEGKINIDDLITHTMPIEKINEAFDLMHAG
EEEEECCEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCC
ESIRSVVTF
HHHHHHHCC
>Mature Secondary Structure
MDVKAAIAYAAKEPLKVETVQLEPPKAGEVLVEIKATGVCHTDAYTLSGADPEGLFPAIL
CCCHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCEEECCCEEECCCCCCCCCHHHH
GHEGAGVVVEVGPDVKSLKPGDHVIPLYVPECRECEYCLSFKTNLCQAIRLTQGRGVMPD
CCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GTGRFSINGKPLFHYMGTSTFANYTVVPEISLAKIREDAPFDKVCYIGCGVTTGIGAVIN
CCCEEEECCCEEEEECCCCCCCCEEEECCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHE
TAKVEVGSKVIVFGLGGIGLNVIQGCRMVGADMIVGVDINDDKKAIAEKFGMTHFVNPKE
EEEEECCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCEECCCHHH
VEGDLVPYLVDLTKGGADYTFECIGNVNVMRQALESCHKGWGVSTIVGVAGAGQEISTRP
CCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCHHHEEEECCCCCCCCCCC
FQLVTGRVWKGTAFGGARGRTDVPKIVDWYMEGKINIDDLITHTMPIEKINEAFDLMHAG
EEEEECCEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCC
ESIRSVVTF
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]