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The map label for this gene is dusA [H]

Identifier: 170077369

GI number: 170077369

Start: 775011

End: 776045

Strand: Direct

Name: dusA [H]

Synonym: SYNPCC7002_A0746

Alternate gene names: 170077369

Gene position: 775011-776045 (Clockwise)

Preceding gene: 170077365

Following gene: 170077370

Centisome position: 25.76

GC content: 52.27

Gene sequence:

>1035_bases
ATGTCGCAGAGGATCAATACCGTGGTTTGTCCCCATTTGTTAAGTGTAGCGCCGATGATGGATCGCACCGATCGCCATTT
TCGTTACTTGATGCGCCGGATTACCCGACGGACATTACTCTACACGGAGATGATTACCACCCAGGCGATTATCCATGGCG
ATCGCCCCAAGCTTTTAGACTTTGATGCCGCAGAACATCCCATTTCCCTCCAATTGGGGGGCGATAATCCCAAGGAATTA
GCCGAATGTGCCAAGGTGGGCGAAGACTGGGGTTACGACGAAATTAATCTCAATGTGGGCTGTCCCAGTCCGAGGGTGCA
ACAGGGCAATTTTGGGGCTTGTTTGATGACCCAGCCGGAGTTGGTGGCCGATTGTGTAGCGGCGATGCAGGGGGCCGTCA
ATATTCCCGTTACAGTGAAACATCGCATTGGCGTCGATGAACAAGATAGTTACGCAGACCTCTGCCGCTTTATCGAGATT
GTCTCGGCAACCGGATGCGATCGCTTTTCTGTCCATGCCCGCAAAGCCTGGCTACAGGGTTTAAGCCCAAAGGAAAATCG
CACGGTACCACCTTTACGTTATGCAGATGTTTATCGGTTAAAACAAGACTTTCCTCACCTCTGGATCGAGATCAATGGCG
GCATTACGACGCTAGAACACATTCAAACCCATTTAACCCAAGTGGATGCCGTAATGGTGGGGCGGGCAGCCTATGACAAC
CCCTATCTGTTTGCGACGGTGGACCGCGATATCTACGGGGAAGCGATTCAGCCCAAAAGCCGCCATGAAATTGTTGAAGA
GATGTTGCCCTACATTGAACGTGCCACAAAAGCCGGGGTGAAACTCCACAGCATTAGCCGTCACATGTTGTCGCTGTTTT
TAGGCCAGCCCGGCACCAAAGCCTGGAAACGGTTTATCACGGAGGAGGGTCGAGGAACGACGGTGGGACGAGAAATTATT
GAGCAAGCCTTGGCCCTAGTGTCCCAGACAAACGCGATCGCCGATCCGGTCTCCATGGTTTCTGGGAGAAAGTGA

Upstream 100 bases:

>100_bases
GCGTTGAGAATACATCGCATTGTAGCCTGTTGGCTGGTTTCTGTTTTGTTCTAGGATTGGCTGAAATTTCCGTTGAATAT
TTCTTCATCCGTTTTGGTTT

Downstream 100 bases:

>100_bases
CCATGACAGCAAAAATTATTGTGTTTGATGATGACCCGACGGGCTCCCAAACGGTGCATAGTTGTCCATTACTATTGCGT
TGGGATGTGGACACGTTGCG

Product: dihydrouridine synthase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSQRINTVVCPHLLSVAPMMDRTDRHFRYLMRRITRRTLLYTEMITTQAIIHGDRPKLLDFDAAEHPISLQLGGDNPKEL
AECAKVGEDWGYDEINLNVGCPSPRVQQGNFGACLMTQPELVADCVAAMQGAVNIPVTVKHRIGVDEQDSYADLCRFIEI
VSATGCDRFSVHARKAWLQGLSPKENRTVPPLRYADVYRLKQDFPHLWIEINGGITTLEHIQTHLTQVDAVMVGRAAYDN
PYLFATVDRDIYGEAIQPKSRHEIVEEMLPYIERATKAGVKLHSISRHMLSLFLGQPGTKAWKRFITEEGRGTTVGREII
EQALALVSQTNAIADPVSMVSGRK

Sequences:

>Translated_344_residues
MSQRINTVVCPHLLSVAPMMDRTDRHFRYLMRRITRRTLLYTEMITTQAIIHGDRPKLLDFDAAEHPISLQLGGDNPKEL
AECAKVGEDWGYDEINLNVGCPSPRVQQGNFGACLMTQPELVADCVAAMQGAVNIPVTVKHRIGVDEQDSYADLCRFIEI
VSATGCDRFSVHARKAWLQGLSPKENRTVPPLRYADVYRLKQDFPHLWIEINGGITTLEHIQTHLTQVDAVMVGRAAYDN
PYLFATVDRDIYGEAIQPKSRHEIVEEMLPYIERATKAGVKLHSISRHMLSLFLGQPGTKAWKRFITEEGRGTTVGREII
EQALALVSQTNAIADPVSMVSGRK
>Mature_343_residues
SQRINTVVCPHLLSVAPMMDRTDRHFRYLMRRITRRTLLYTEMITTQAIIHGDRPKLLDFDAAEHPISLQLGGDNPKELA
ECAKVGEDWGYDEINLNVGCPSPRVQQGNFGACLMTQPELVADCVAAMQGAVNIPVTVKHRIGVDEQDSYADLCRFIEIV
SATGCDRFSVHARKAWLQGLSPKENRTVPPLRYADVYRLKQDFPHLWIEINGGITTLEHIQTHLTQVDAVMVGRAAYDNP
YLFATVDRDIYGEAIQPKSRHEIVEEMLPYIERATKAGVKLHSISRHMLSLFLGQPGTKAWKRFITEEGRGTTVGREIIE
QALALVSQTNAIADPVSMVSGRK

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family [H]

Homologues:

Organism=Homo sapiens, GI31742496, Length=236, Percent_Identity=29.2372881355932, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI40807366, Length=239, Percent_Identity=26.3598326359833, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI145693211, Length=316, Percent_Identity=56.6455696202532, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1789660, Length=297, Percent_Identity=24.9158249158249, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788462, Length=286, Percent_Identity=26.2237762237762, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144369, Length=226, Percent_Identity=30.5309734513274, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323560, Length=285, Percent_Identity=23.5087719298246, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24580595, Length=259, Percent_Identity=27.027027027027, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920448, Length=259, Percent_Identity=27.027027027027, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004653
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: 1.-.-.-

Molecular weight: Translated: 38618; Mature: 38487

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQRINTVVCPHLLSVAPMMDRTDRHFRYLMRRITRRTLLYTEMITTQAIIHGDRPKLLD
CCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
FDAAEHPISLQLGGDNPKELAECAKVGEDWGYDEINLNVGCPSPRVQQGNFGACLMTQPE
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCHH
LVADCVAAMQGAVNIPVTVKHRIGVDEQDSYADLCRFIEIVSATGCDRFSVHARKAWLQG
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LSPKENRTVPPLRYADVYRLKQDFPHLWIEINGGITTLEHIQTHLTQVDAVMVGRAAYDN
CCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PYLFATVDRDIYGEAIQPKSRHEIVEEMLPYIERATKAGVKLHSISRHMLSLFLGQPGTK
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHH
AWKRFITEEGRGTTVGREIIEQALALVSQTNAIADPVSMVSGRK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQRINTVVCPHLLSVAPMMDRTDRHFRYLMRRITRRTLLYTEMITTQAIIHGDRPKLLD
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
FDAAEHPISLQLGGDNPKELAECAKVGEDWGYDEINLNVGCPSPRVQQGNFGACLMTQPE
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCHH
LVADCVAAMQGAVNIPVTVKHRIGVDEQDSYADLCRFIEIVSATGCDRFSVHARKAWLQG
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
LSPKENRTVPPLRYADVYRLKQDFPHLWIEINGGITTLEHIQTHLTQVDAVMVGRAAYDN
CCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PYLFATVDRDIYGEAIQPKSRHEIVEEMLPYIERATKAGVKLHSISRHMLSLFLGQPGTK
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHH
AWKRFITEEGRGTTVGREIIEQALALVSQTNAIADPVSMVSGRK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]