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The map label for this gene is mutL [H]

Identifier: 170077272

GI number: 170077272

Start: 679147

End: 680844

Strand: Reverse

Name: mutL [H]

Synonym: SYNPCC7002_A0649

Alternate gene names: 170077272

Gene position: 680844-679147 (Counterclockwise)

Preceding gene: 170077273

Following gene: 170077271

Centisome position: 22.63

GC content: 47.23

Gene sequence:

>1698_bases
ATGGCCAATATCAAACAACTCCCTAATGATGTCATCCAGTTAATTGCGGCTGGTGAAGTGATTGATTCCCTGGCAGCGGT
GGTACGGGAGTTGGCAGAAAATGCCATTGATGCCGGGGCGACACGCATTAACATCGATATTCAGCCCCAACGTTGGCAAA
TTCGCGTTGTAGATAATGGTCAGGGAATGGATCTGGAGGATTTGCAACAGTGCGCCCTCCCCCACCGGACAAGTAAGATT
GGCGATCGCCAAGATTTAGCCCACATCAAAAGCCTCGGATTCCGGGGGGAAGCCCTCCACAGCATTGCTCAGGTGGCGAA
ACTTACCATCGCCAGTTGTCAAGATGGACAACCCGGTTATCAACTCACAGTGCAGCAAAATCATGTTTCGGAACCACTCC
TCAAGCCAATGGCCGTGGGAACGATGGTGACGGTGACAGACATTTTTCAGAATTTTCCGGTGCGACGCCATGCCTTACCG
GCGATCGCCCAGCAGCTCAAAACCGCCCAGCAGATGATTTATCATTTGGCCCTAGGTCAGCCACAAATTACCTGGCAAGT
CAACCAAAATAATCAGCCCTGGTTTGTCATTAGTGCAGGAAAAAATGCCCAGGAGATTTTGCCGCAACTGCTAAGATCAA
TTAGTATTCAAGACTTGATTTTTCAACGCTATCAAGCCACAGATTTTTTGACAGAAAATAATTCTGATTATGCAACAAGT
TATTTGGAAGTAGTCCTCGGTTTACCAGACCGTTGTCACCGCCACCAGGCCGATTGGTTAAAGTTGGCAATTAACGGCAG
AATTGTTAAATTTTCGGCTTTAGAACAGGCGATCATGAAAGGATTTAGTCGTACTCTTCCCCGCGATCGCCACCCCATCT
GTTTTGTCCATCTCCATGTCCCACCAGAACACATCGACTGGAATCGTCATCCCGCAAAAAGCGAAATTTATCTACAACAT
CAAACCCTCTGGCAAGAGATTATTCCGCAGGCGATCGCCAAAGGTTTAAGCTTCAGCGAGGCTAATCTACCACGCTTAGA
AAATCAGCGGGTTTTAAGTCTTATTCAAGCAGCAGAAAAAAAAGAGAACTATTCTATTGAGCCTCCCTCTGAACATTCAA
CGACAAGCGCATCAAATCCACACAAAAAAGTCTTAAAAGTCATTGGCCAAGCCCGCAATACTTATATCATTACGGAACAT
CCCGATGGCATCTGGCTAGTAGAGCAGCACATTGCCGACGAACGGGCAATTTATGAAGACTTATGCAAAAATTGGCAGCT
TATTTCTCCGATTCAACCCGTGCTGCTAAATGACTTATCACCAAAACAAATAGAGCAACTAACAGACCAACTGGGTTTGG
ATCTCGAAATTTTTGGGGAAAATGTTTGGCGAGTCAATACGATTCCTCGGGCTTTGCAAGGCCATTCTGATCTAGAAGCT
GCTTTACTAGAATTGAGTCGGGGGGGAGATCTTGAGGCCGCCCAAGTGGCGATCGCCTGCCGGACTGCTGTCCGTAATGG
CACACCGCTAGATTTCCCGACCATGCAAACAATCATTGATCGCTGGCAACAGTGCGAAAACCCAAGTACCTGTCCCCACG
GTCGACCCATTTATCTGGCCCTAGAAGAAACATCCCTTTATCGTTTTTTCCGTCGCCATTGGGTTTTGGGCAAGAGCCAT
GGCATTACCGAAAAATGA

Upstream 100 bases:

>100_bases
TTCATCAAAAGTGAGTGCTAAGTTATTAAAGCCTGGTCTTAAATTACTGAGATCTTAGTCATAACTTGATCGTCAAAAAT
AAATAATTACTCAGCACTAA

Downstream 100 bases:

>100_bases
GTATTTTAAAAGTTAATTGACCCTTTACCGTTATCTAGAGAAAAATGCTTGAGCTTGACCAGATTTTTGTCACTGCTGCC
CAAATGCAGCACCTTGAAAC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MANIKQLPNDVIQLIAAGEVIDSLAAVVRELAENAIDAGATRINIDIQPQRWQIRVVDNGQGMDLEDLQQCALPHRTSKI
GDRQDLAHIKSLGFRGEALHSIAQVAKLTIASCQDGQPGYQLTVQQNHVSEPLLKPMAVGTMVTVTDIFQNFPVRRHALP
AIAQQLKTAQQMIYHLALGQPQITWQVNQNNQPWFVISAGKNAQEILPQLLRSISIQDLIFQRYQATDFLTENNSDYATS
YLEVVLGLPDRCHRHQADWLKLAINGRIVKFSALEQAIMKGFSRTLPRDRHPICFVHLHVPPEHIDWNRHPAKSEIYLQH
QTLWQEIIPQAIAKGLSFSEANLPRLENQRVLSLIQAAEKKENYSIEPPSEHSTTSASNPHKKVLKVIGQARNTYIITEH
PDGIWLVEQHIADERAIYEDLCKNWQLISPIQPVLLNDLSPKQIEQLTDQLGLDLEIFGENVWRVNTIPRALQGHSDLEA
ALLELSRGGDLEAAQVAIACRTAVRNGTPLDFPTMQTIIDRWQQCENPSTCPHGRPIYLALEETSLYRFFRRHWVLGKSH
GITEK

Sequences:

>Translated_565_residues
MANIKQLPNDVIQLIAAGEVIDSLAAVVRELAENAIDAGATRINIDIQPQRWQIRVVDNGQGMDLEDLQQCALPHRTSKI
GDRQDLAHIKSLGFRGEALHSIAQVAKLTIASCQDGQPGYQLTVQQNHVSEPLLKPMAVGTMVTVTDIFQNFPVRRHALP
AIAQQLKTAQQMIYHLALGQPQITWQVNQNNQPWFVISAGKNAQEILPQLLRSISIQDLIFQRYQATDFLTENNSDYATS
YLEVVLGLPDRCHRHQADWLKLAINGRIVKFSALEQAIMKGFSRTLPRDRHPICFVHLHVPPEHIDWNRHPAKSEIYLQH
QTLWQEIIPQAIAKGLSFSEANLPRLENQRVLSLIQAAEKKENYSIEPPSEHSTTSASNPHKKVLKVIGQARNTYIITEH
PDGIWLVEQHIADERAIYEDLCKNWQLISPIQPVLLNDLSPKQIEQLTDQLGLDLEIFGENVWRVNTIPRALQGHSDLEA
ALLELSRGGDLEAAQVAIACRTAVRNGTPLDFPTMQTIIDRWQQCENPSTCPHGRPIYLALEETSLYRFFRRHWVLGKSH
GITEK
>Mature_564_residues
ANIKQLPNDVIQLIAAGEVIDSLAAVVRELAENAIDAGATRINIDIQPQRWQIRVVDNGQGMDLEDLQQCALPHRTSKIG
DRQDLAHIKSLGFRGEALHSIAQVAKLTIASCQDGQPGYQLTVQQNHVSEPLLKPMAVGTMVTVTDIFQNFPVRRHALPA
IAQQLKTAQQMIYHLALGQPQITWQVNQNNQPWFVISAGKNAQEILPQLLRSISIQDLIFQRYQATDFLTENNSDYATSY
LEVVLGLPDRCHRHQADWLKLAINGRIVKFSALEQAIMKGFSRTLPRDRHPICFVHLHVPPEHIDWNRHPAKSEIYLQHQ
TLWQEIIPQAIAKGLSFSEANLPRLENQRVLSLIQAAEKKENYSIEPPSEHSTTSASNPHKKVLKVIGQARNTYIITEHP
DGIWLVEQHIADERAIYEDLCKNWQLISPIQPVLLNDLSPKQIEQLTDQLGLDLEIFGENVWRVNTIPRALQGHSDLEAA
LLELSRGGDLEAAQVAIACRTAVRNGTPLDFPTMQTIIDRWQQCENPSTCPHGRPIYLALEETSLYRFFRRHWVLGKSHG
ITEK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=347, Percent_Identity=28.5302593659942, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI189458898, Length=338, Percent_Identity=26.0355029585799, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI4505911, Length=338, Percent_Identity=26.0355029585799, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI189458896, Length=328, Percent_Identity=27.7439024390244, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4505913, Length=370, Percent_Identity=26.7567567567568, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI310128478, Length=370, Percent_Identity=26.7567567567568, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI91992160, Length=195, Percent_Identity=32.3076923076923, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI91992162, Length=195, Percent_Identity=32.3076923076923, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI310128480, Length=317, Percent_Identity=24.9211356466877, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790612, Length=340, Percent_Identity=30.5882352941176, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71991825, Length=321, Percent_Identity=29.595015576324, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17562796, Length=372, Percent_Identity=23.6559139784946, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=28.3185840707965, Blast_Score=120, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6324247, Length=369, Percent_Identity=26.5582655826558, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6325093, Length=378, Percent_Identity=25.1322751322751, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136968, Length=354, Percent_Identity=28.5310734463277, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17136970, Length=160, Percent_Identity=36.875, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 63853; Mature: 63722

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIKQLPNDVIQLIAAGEVIDSLAAVVRELAENAIDAGATRINIDIQPQRWQIRVVDNG
CCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEEECC
QGMDLEDLQQCALPHRTSKIGDRQDLAHIKSLGFRGEALHSIAQVAKLTIASCQDGQPGY
CCCCHHHHHHHCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCE
QLTVQQNHVSEPLLKPMAVGTMVTVTDIFQNFPVRRHALPAIAQQLKTAQQMIYHLALGQ
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PQITWQVNQNNQPWFVISAGKNAQEILPQLLRSISIQDLIFQRYQATDFLTENNSDYATS
CEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHH
YLEVVLGLPDRCHRHQADWLKLAINGRIVKFSALEQAIMKGFSRTLPRDRHPICFVHLHV
HHHHHHCCCHHHHHCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
PPEHIDWNRHPAKSEIYLQHQTLWQEIIPQAIAKGLSFSEANLPRLENQRVLSLIQAAEK
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
KENYSIEPPSEHSTTSASNPHKKVLKVIGQARNTYIITEHPDGIWLVEQHIADERAIYED
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHHHHHHH
LCKNWQLISPIQPVLLNDLSPKQIEQLTDQLGLDLEIFGENVWRVNTIPRALQGHSDLEA
HHCCCEECCCCHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCEEECCCHHHHCCCCHHHH
ALLELSRGGDLEAAQVAIACRTAVRNGTPLDFPTMQTIIDRWQQCENPSTCPHGRPIYLA
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEE
LEETSLYRFFRRHWVLGKSHGITEK
ECHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ANIKQLPNDVIQLIAAGEVIDSLAAVVRELAENAIDAGATRINIDIQPQRWQIRVVDNG
CCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEEECC
QGMDLEDLQQCALPHRTSKIGDRQDLAHIKSLGFRGEALHSIAQVAKLTIASCQDGQPGY
CCCCHHHHHHHCCCCHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCE
QLTVQQNHVSEPLLKPMAVGTMVTVTDIFQNFPVRRHALPAIAQQLKTAQQMIYHLALGQ
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PQITWQVNQNNQPWFVISAGKNAQEILPQLLRSISIQDLIFQRYQATDFLTENNSDYATS
CEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHH
YLEVVLGLPDRCHRHQADWLKLAINGRIVKFSALEQAIMKGFSRTLPRDRHPICFVHLHV
HHHHHHCCCHHHHHCCCCEEEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
PPEHIDWNRHPAKSEIYLQHQTLWQEIIPQAIAKGLSFSEANLPRLENQRVLSLIQAAEK
CCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
KENYSIEPPSEHSTTSASNPHKKVLKVIGQARNTYIITEHPDGIWLVEQHIADERAIYED
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEHHHHHHHHHHHHH
LCKNWQLISPIQPVLLNDLSPKQIEQLTDQLGLDLEIFGENVWRVNTIPRALQGHSDLEA
HHCCCEECCCCHHHHHCCCCHHHHHHHHHHHCCEEEEECCCCEEECCCHHHHCCCCHHHH
ALLELSRGGDLEAAQVAIACRTAVRNGTPLDFPTMQTIIDRWQQCENPSTCPHGRPIYLA
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEE
LEETSLYRFFRRHWVLGKSHGITEK
ECHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA