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The map label for this gene is srrA [H]

Identifier: 170077233

GI number: 170077233

Start: 637345

End: 638043

Strand: Direct

Name: srrA [H]

Synonym: SYNPCC7002_A0608

Alternate gene names: 170077233

Gene position: 637345-638043 (Clockwise)

Preceding gene: 170077231

Following gene: 170077234

Centisome position: 21.19

GC content: 50.36

Gene sequence:

>699_bases
ATGGATAAACGCTACAATATTTTGCTTGTCGATGATGAACCGGGCGTCCGGGAGGCGGTTCAAGCCTATTTAGAAGATGA
TGAAGCCCTAACCGTCACCACCGCTGAGAATGCCACAAAAGCCTGGGATGTTTTGCAAACGTTTACACCGGATTTGGTCA
TTTCTGATATTATGATGCCCCAGGTGGATGGCTATCAGTTTTTGGGGCAACTGCGCGAAGATCCGCGCTTTAAAACGCTT
CCGGTAATTTTTCTAACGGCCCGTGGCATGACTGGCGATCGCATCCAAGGCTACCAAGCAGGCTGTGATGCCTATTTACC
GAAACCCTTTGAACCCGAAGAACTCGAAGCCATTGTCAAAAATCTCCTCACCAGGGAGGCGGCGATCGCCGAACAACAAG
ACGGTGGTGGCAGCAATCTCGAAGGCATCGCCCAGGATCTCCGGGAGATTAAGCAATTCCTCGGCCAGCAAAATCAATTG
GTCACCACCCCACCGCCTTTAAAAATTGACCTGACCCCCAGGGAGCAAAGTGTCCTTGACCTCGTGGCCCAGGGACTGAT
GAATAAAGAAATTGCCAAGGAGCTCGAAACCAGCGTCCGCAATGTTGAAAAGTATGTTAGTCGCCTATTTAGCAAAACGG
GAACCAATAGTCGGACAGAATTGGTACGCTACGCCCTCAAGCACGGTTTAACGCAATAG

Upstream 100 bases:

>100_bases
GAGCATGGTGTGATTTCCGACAAAGAACAACAGAGGGCAAAACCGTGAAAAGCTATAATCAGGGGCAAGATCATGCGCTT
TCGTAAGGGGAAAATGGGCG

Downstream 100 bases:

>100_bases
TTGACGAAGTAATTCCTTCGGTCTTGCGCCATGATTTAGCTTTTTTTGTAGTTGTAGTTCTATACGCGACGATGCCCCAA
CAAGATCAAGTCCATCCCCA

Product: regulatory component

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MDKRYNILLVDDEPGVREAVQAYLEDDEALTVTTAENATKAWDVLQTFTPDLVISDIMMPQVDGYQFLGQLREDPRFKTL
PVIFLTARGMTGDRIQGYQAGCDAYLPKPFEPEELEAIVKNLLTREAAIAEQQDGGGSNLEGIAQDLREIKQFLGQQNQL
VTTPPPLKIDLTPREQSVLDLVAQGLMNKEIAKELETSVRNVEKYVSRLFSKTGTNSRTELVRYALKHGLTQ

Sequences:

>Translated_232_residues
MDKRYNILLVDDEPGVREAVQAYLEDDEALTVTTAENATKAWDVLQTFTPDLVISDIMMPQVDGYQFLGQLREDPRFKTL
PVIFLTARGMTGDRIQGYQAGCDAYLPKPFEPEELEAIVKNLLTREAAIAEQQDGGGSNLEGIAQDLREIKQFLGQQNQL
VTTPPPLKIDLTPREQSVLDLVAQGLMNKEIAKELETSVRNVEKYVSRLFSKTGTNSRTELVRYALKHGLTQ
>Mature_232_residues
MDKRYNILLVDDEPGVREAVQAYLEDDEALTVTTAENATKAWDVLQTFTPDLVISDIMMPQVDGYQFLGQLREDPRFKTL
PVIFLTARGMTGDRIQGYQAGCDAYLPKPFEPEELEAIVKNLLTREAAIAEQQDGGGSNLEGIAQDLREIKQFLGQQNQL
VTTPPPLKIDLTPREQSVLDLVAQGLMNKEIAKELETSVRNVEKYVSRLFSKTGTNSRTELVRYALKHGLTQ

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=127, Percent_Identity=37.007874015748, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789809, Length=218, Percent_Identity=30.2752293577982, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790299, Length=145, Percent_Identity=34.4827586206897, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786911, Length=123, Percent_Identity=37.3983739837398, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788521, Length=217, Percent_Identity=31.7972350230415, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786784, Length=123, Percent_Identity=36.5853658536585, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787375, Length=205, Percent_Identity=29.2682926829268, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790860, Length=123, Percent_Identity=34.9593495934959, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786747, Length=221, Percent_Identity=25.3393665158371, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788222, Length=230, Percent_Identity=27.3913043478261, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787229, Length=121, Percent_Identity=34.7107438016529, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI2367329, Length=220, Percent_Identity=33.6363636363636, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788394, Length=120, Percent_Identity=31.6666666666667, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790552, Length=122, Percent_Identity=37.7049180327869, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788191, Length=115, Percent_Identity=35.6521739130435, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1790863, Length=120, Percent_Identity=34.1666666666667, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082012, Length=96, Percent_Identity=37.5, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787473, Length=219, Percent_Identity=28.7671232876712, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26015; Mature: 26015

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRYNILLVDDEPGVREAVQAYLEDDEALTVTTAENATKAWDVLQTFTPDLVISDIMMP
CCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCHHHHHHHHHCC
QVDGYQFLGQLREDPRFKTLPVIFLTARGMTGDRIQGYQAGCDAYLPKPFEPEELEAIVK
CCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHH
NLLTREAAIAEQQDGGGSNLEGIAQDLREIKQFLGQQNQLVTTPPPLKIDLTPREQSVLD
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCHHHHHH
LVAQGLMNKEIAKELETSVRNVEKYVSRLFSKTGTNSRTELVRYALKHGLTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKRYNILLVDDEPGVREAVQAYLEDDEALTVTTAENATKAWDVLQTFTPDLVISDIMMP
CCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCHHHHHHHHHCC
QVDGYQFLGQLREDPRFKTLPVIFLTARGMTGDRIQGYQAGCDAYLPKPFEPEELEAIVK
CCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHH
NLLTREAAIAEQQDGGGSNLEGIAQDLREIKQFLGQQNQLVTTPPPLKIDLTPREQSVLD
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCHHHHHH
LVAQGLMNKEIAKELETSVRNVEKYVSRLFSKTGTNSRTELVRYALKHGLTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA