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The map label for this gene is purK [H]

Identifier: 170077231

GI number: 170077231

Start: 635698

End: 636840

Strand: Direct

Name: purK [H]

Synonym: SYNPCC7002_A0606

Alternate gene names: 170077231

Gene position: 635698-636840 (Clockwise)

Preceding gene: 170077230

Following gene: 170077233

Centisome position: 21.13

GC content: 52.06

Gene sequence:

>1143_bases
ATGAAACATAAAGTGGGTGTCATTGGCGGCGGACAACTCGCCTGGATGATGGGAGCAGAAGCCCGGAGCCTCGGCATGGA
ACTGTGGGTACAAACACCCAACGCCAGTGATCCGGCGGTTTCTAATGCTGATCAAGTGATCATTGGGGCGATCGACGATT
TAGAGTCCACGGCCAAGCTGGTGGAAAACTGCCATGTGGTCACCTTTGAAAATGAATTTGTTGATCTCGAAGCCCTCGAT
ACCCTCGTTAAACGGGGGGCAAAATTCTTCCCTTCTCTGCCTTTCCTCGCTGCCCTCTTGGATAAATATGATCAACGGCG
CTGTTGTCAACGGTTTGGTATTCCGGTGCCGACCTTTGTCCCTTGGCAACTGGGGGAACTGCTCCCCTCTGGTTGGGAAT
TTCCACTGGTCGTGAAGGCCCGTCGCCATGGTTATGACGGCAAAGGGACATTTATCGTGAAAGATGCTGCGGCGTTACAG
ACTTTACCAACGGATTTAGCTGATACTCCCTTACTTTTAGAAGCGTTTGTGCCCTTTGAGCAGGAATTGGCGGTGATGGT
AACGCGCAACCGCCGGGGAGAAATTCGCACCTTTCCGACGGTGGAAACCCAACAGATTGATCAAGTGTGTCGTTGGGTGC
TGGCCCCTGCGGCGATCGCTCAAGATGTAGTAAATCAGGTCGAAAAGATTGCCCGTACCTTAGCTGAAGGGTTAAATCTG
GTGGGCATTATGGGGATTGAGCTGTTTCTCACTCCCGAAGGACAAGTATTAGTCAATGAAATCGCGCCCCGCACCCACAA
TTCCGGCCATTTTAGTTTGGATGCTTGTCAGACTTCGCAGTTTGCAATGCAACTCCAGGCGATCGCCGATTTGCCTTTAG
GGAACCCCAAGATGATCACCCCTGGGGCGGTGATGGTGAATTTACTAGGGTTTGAGCACAGCACGGGGAACTATGCCCAC
AAACGGCAAATGCTGAGCCAATTTCCCCATAGCCATGTCCACTGGTACGACAAAACCAGCGCCAGTCCAGGCCGCAAGCT
GGGTCATGTCACAGTTTTAAGTGAGACGAATGACCGAGAAACATTGGTGGCGATCGCCCAGCAAATTGAAGCCATTTGGT
ATGGTGACTCTAGCCCCACCTAG

Upstream 100 bases:

>100_bases
TCAGGCTTAGGCTCGCGGATCTAGACAATTGACATCCGGCAGCCCTCCTAGGGTTTAATGGGGCACGGGCAATCCATATA
AAAACGGCAAAAACAAGAGC

Downstream 100 bases:

>100_bases
AAGTTCGAGAAGTTTTGGTTAGCCGTCCAGCGGGAACCAGAGAAAGGCGTCCCTCCCAGTTGGGCAACCTTTTCTGGGGT
CATCCCATAGACCCAAGCCT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKHKVGVIGGGQLAWMMGAEARSLGMELWVQTPNASDPAVSNADQVIIGAIDDLESTAKLVENCHVVTFENEFVDLEALD
TLVKRGAKFFPSLPFLAALLDKYDQRRCCQRFGIPVPTFVPWQLGELLPSGWEFPLVVKARRHGYDGKGTFIVKDAAALQ
TLPTDLADTPLLLEAFVPFEQELAVMVTRNRRGEIRTFPTVETQQIDQVCRWVLAPAAIAQDVVNQVEKIARTLAEGLNL
VGIMGIELFLTPEGQVLVNEIAPRTHNSGHFSLDACQTSQFAMQLQAIADLPLGNPKMITPGAVMVNLLGFEHSTGNYAH
KRQMLSQFPHSHVHWYDKTSASPGRKLGHVTVLSETNDRETLVAIAQQIEAIWYGDSSPT

Sequences:

>Translated_380_residues
MKHKVGVIGGGQLAWMMGAEARSLGMELWVQTPNASDPAVSNADQVIIGAIDDLESTAKLVENCHVVTFENEFVDLEALD
TLVKRGAKFFPSLPFLAALLDKYDQRRCCQRFGIPVPTFVPWQLGELLPSGWEFPLVVKARRHGYDGKGTFIVKDAAALQ
TLPTDLADTPLLLEAFVPFEQELAVMVTRNRRGEIRTFPTVETQQIDQVCRWVLAPAAIAQDVVNQVEKIARTLAEGLNL
VGIMGIELFLTPEGQVLVNEIAPRTHNSGHFSLDACQTSQFAMQLQAIADLPLGNPKMITPGAVMVNLLGFEHSTGNYAH
KRQMLSQFPHSHVHWYDKTSASPGRKLGHVTVLSETNDRETLVAIAQQIEAIWYGDSSPT
>Mature_380_residues
MKHKVGVIGGGQLAWMMGAEARSLGMELWVQTPNASDPAVSNADQVIIGAIDDLESTAKLVENCHVVTFENEFVDLEALD
TLVKRGAKFFPSLPFLAALLDKYDQRRCCQRFGIPVPTFVPWQLGELLPSGWEFPLVVKARRHGYDGKGTFIVKDAAALQ
TLPTDLADTPLLLEAFVPFEQELAVMVTRNRRGEIRTFPTVETQQIDQVCRWVLAPAAIAQDVVNQVEKIARTLAEGLNL
VGIMGIELFLTPEGQVLVNEIAPRTHNSGHFSLDACQTSQFAMQLQAIADLPLGNPKMITPGAVMVNLLGFEHSTGNYAH
KRQMLSQFPHSHVHWYDKTSASPGRKLGHVTVLSETNDRETLVAIAQQIEAIWYGDSSPT

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=367, Percent_Identity=30.5177111716621, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1788155, Length=317, Percent_Identity=22.7129337539432, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324702, Length=366, Percent_Identity=35.792349726776, Blast_Score=215, Evalue=9e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41862; Mature: 41862

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHKVGVIGGGQLAWMMGAEARSLGMELWVQTPNASDPAVSNADQVIIGAIDDLESTAKL
CCCEEEEEECCCEEEEECCHHHHCCEEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHH
VENCHVVTFENEFVDLEALDTLVKRGAKFFPSLPFLAALLDKYDQRRCCQRFGIPVPTFV
HHCCEEEEECCCEECHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PWQLGELLPSGWEFPLVVKARRHGYDGKGTFIVKDAAALQTLPTDLADTPLLLEAFVPFE
CHHHHHHCCCCCCCCEEEEEHHCCCCCCCEEEEECHHHHHHCCCCCCCCCHHHHHHCCCH
QELAVMVTRNRRGEIRTFPTVETQQIDQVCRWVLAPAAIAQDVVNQVEKIARTLAEGLNL
HCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VGIMGIELFLTPEGQVLVNEIAPRTHNSGHFSLDACQTSQFAMQLQAIADLPLGNPKMIT
EEEEEEEEEECCCCCEEHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEEC
PGAVMVNLLGFEHSTGNYAHKRQMLSQFPHSHVHWYDKTSASPGRKLGHVTVLSETNDRE
CHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEECCCCHH
TLVAIAQQIEAIWYGDSSPT
HHHHHHHHHHEEEECCCCCC
>Mature Secondary Structure
MKHKVGVIGGGQLAWMMGAEARSLGMELWVQTPNASDPAVSNADQVIIGAIDDLESTAKL
CCCEEEEEECCCEEEEECCHHHHCCEEEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHH
VENCHVVTFENEFVDLEALDTLVKRGAKFFPSLPFLAALLDKYDQRRCCQRFGIPVPTFV
HHCCEEEEECCCEECHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PWQLGELLPSGWEFPLVVKARRHGYDGKGTFIVKDAAALQTLPTDLADTPLLLEAFVPFE
CHHHHHHCCCCCCCCEEEEEHHCCCCCCCEEEEECHHHHHHCCCCCCCCCHHHHHHCCCH
QELAVMVTRNRRGEIRTFPTVETQQIDQVCRWVLAPAAIAQDVVNQVEKIARTLAEGLNL
HCEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VGIMGIELFLTPEGQVLVNEIAPRTHNSGHFSLDACQTSQFAMQLQAIADLPLGNPKMIT
EEEEEEEEEECCCCCEEHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEEC
PGAVMVNLLGFEHSTGNYAHKRQMLSQFPHSHVHWYDKTSASPGRKLGHVTVLSETNDRE
CHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEECCCCHH
TLVAIAQQIEAIWYGDSSPT
HHHHHHHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]