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The map label for this gene is macA [H]

Identifier: 170077216

GI number: 170077216

Start: 620161

End: 621498

Strand: Reverse

Name: macA [H]

Synonym: SYNPCC7002_A0591

Alternate gene names: 170077216

Gene position: 621498-620161 (Counterclockwise)

Preceding gene: 170077225

Following gene: 170077215

Centisome position: 20.66

GC content: 56.13

Gene sequence:

>1338_bases
ATGTTAGAATCAGCGGCGACAAAACCTTTAAGAAACATTAAGTTTTTTGCCTGCTATTCCCCTCCTTGGTGCTCTCCTAT
GGCTCAGCAATTTCATCTCCCCATCGGTGCCTGTTTATCCCTAACCCTGGCCTTTGTTTCGACGGGATGCGCCCTCGAAC
AAAATAGCAATGCCCAACCAGCGGGCCGCCTAGAACAGTCAGACCAACCGCCCCTAGTCGAGGTGGCGATCGCCACTGGG
ACAGAAACAGCCCCCACCGCCAGCTATACCGGCACCACCATGGCCCTGAAACAAGTGGTAGTCCGCTCCCGGGTCGAAGG
ACAATTGCTTACCCTCAATGCAGATGTGGGAGATTTTATTCGCCAAGGTCAACTGCTCGCCGCCGTGGAACAGGACTTAC
CCCGCACCGATGTCAGTGAAGCCCAAGCTGAACTGGCCGCCCGGCAATTTGAAGTGAAAGAAGCAGAATCTGTTCTTGCC
GAAGCTAAAGCCCAGGTGGAACGGAACCGGGCCGAACTCAAACAAGCCGAAGCCGATGCCCGCCGTCTCCAACAGTTAGC
CGAAGCGGGAGCGATCACCGCCCAACAAGCTGAAGTCGCCCAAACCCAGCAAGCCACTGCCGCCCAGGTACTAAAAGCCA
GCCAAGAACAAGTCATTACCCGTCAACAGGCGATCGCCGCCACCAAGCAACGGGTGACGGCCCAACAAGCGATCCTCGCC
CAGGCCCAAGAACGCCTTACCTATACCCAAATCACAGCGCCCCAAAGTGGCATTCTCCTCAGTAAGCAAGCCGAAGCTGG
CGATACGATTCAAGGGGGGCAAACCCTCGTCGAAATTGGCGATCTGAGCGCCATTAAGGTTGAAATCCAAATCTCTGACC
GGGATCTGAGCCAATTTGCCCAAGGTCAACGGGTTAATGTGGCCCTCGATGCCTTCCCTGGGGAAACCTTTCCCGGCGAA
GTCACCCGCATTTCTCCTGTGGCCGATGCCGCTGCCCGTTTAATTCCCATTGAAGTGACCATTCCTAATCCCGCAGGAAA
AATTGCCACGGGGTTATTGGCGCGGGTCAGCCTTACAGATCCCAACCTCACCACGGCTGTCATGATTCCCGCATCCGCCC
TCACCACGGGGAATAATGGCAACCAGACGACGGTATTTGTGCCCGTTACCCAGGGGGACACAACAACTGTGCAAGCGCGT
CCGGTGCAGGTCGGCCCCGAAGATAATGGCATGGTCGCCATCTTGAGTGGCCTCAGTGCCGGGGAACGATATGTTGTCCA
AGGCGATCGCCCCCTGGAAACTGGACAAACAGTCCGCTTAAGTTTGCTGTCCGAATAA

Upstream 100 bases:

>100_bases
TCTTGATGTTGTAGTGATTTTTTATGTTCTAGCTATTGTAGGCGATCGCCATCGGAGTTATGGGAGAAAGACCTGGGTGA
GCGGCAGCCTCAAAATTGAG

Downstream 100 bases:

>100_bases
CCATAAAGCATCAATTATTTTTGATTTAATGTCCCTCACCCAAGACCTATCCCTAATTTTGCAGGGCTTCAAAGCCTTAG
GAGATCCCATTCGTTTGGAG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLESAATKPLRNIKFFACYSPPWCSPMAQQFHLPIGACLSLTLAFVSTGCALEQNSNAQPAGRLEQSDQPPLVEVAIATG
TETAPTASYTGTTMALKQVVVRSRVEGQLLTLNADVGDFIRQGQLLAAVEQDLPRTDVSEAQAELAARQFEVKEAESVLA
EAKAQVERNRAELKQAEADARRLQQLAEAGAITAQQAEVAQTQQATAAQVLKASQEQVITRQQAIAATKQRVTAQQAILA
QAQERLTYTQITAPQSGILLSKQAEAGDTIQGGQTLVEIGDLSAIKVEIQISDRDLSQFAQGQRVNVALDAFPGETFPGE
VTRISPVADAAARLIPIEVTIPNPAGKIATGLLARVSLTDPNLTTAVMIPASALTTGNNGNQTTVFVPVTQGDTTTVQAR
PVQVGPEDNGMVAILSGLSAGERYVVQGDRPLETGQTVRLSLLSE

Sequences:

>Translated_445_residues
MLESAATKPLRNIKFFACYSPPWCSPMAQQFHLPIGACLSLTLAFVSTGCALEQNSNAQPAGRLEQSDQPPLVEVAIATG
TETAPTASYTGTTMALKQVVVRSRVEGQLLTLNADVGDFIRQGQLLAAVEQDLPRTDVSEAQAELAARQFEVKEAESVLA
EAKAQVERNRAELKQAEADARRLQQLAEAGAITAQQAEVAQTQQATAAQVLKASQEQVITRQQAIAATKQRVTAQQAILA
QAQERLTYTQITAPQSGILLSKQAEAGDTIQGGQTLVEIGDLSAIKVEIQISDRDLSQFAQGQRVNVALDAFPGETFPGE
VTRISPVADAAARLIPIEVTIPNPAGKIATGLLARVSLTDPNLTTAVMIPASALTTGNNGNQTTVFVPVTQGDTTTVQAR
PVQVGPEDNGMVAILSGLSAGERYVVQGDRPLETGQTVRLSLLSE
>Mature_445_residues
MLESAATKPLRNIKFFACYSPPWCSPMAQQFHLPIGACLSLTLAFVSTGCALEQNSNAQPAGRLEQSDQPPLVEVAIATG
TETAPTASYTGTTMALKQVVVRSRVEGQLLTLNADVGDFIRQGQLLAAVEQDLPRTDVSEAQAELAARQFEVKEAESVLA
EAKAQVERNRAELKQAEADARRLQQLAEAGAITAQQAEVAQTQQATAAQVLKASQEQVITRQQAIAATKQRVTAQQAILA
QAQERLTYTQITAPQSGILLSKQAEAGDTIQGGQTLVEIGDLSAIKVEIQISDRDLSQFAQGQRVNVALDAFPGETFPGE
VTRISPVADAAARLIPIEVTIPNPAGKIATGLLARVSLTDPNLTTAVMIPASALTTGNNGNQTTVFVPVTQGDTTTVQAR
PVQVGPEDNGMVAILSGLSAGERYVVQGDRPLETGQTVRLSLLSE

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=349, Percent_Identity=28.6532951289398, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87082036, Length=391, Percent_Identity=27.6214833759591, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 47111; Mature: 47111

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESAATKPLRNIKFFACYSPPWCSPMAQQFHLPIGACLSLTLAFVSTGCALEQNSNAQP
CCCCHHCCCHHCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
AGRLEQSDQPPLVEVAIATGTETAPTASYTGTTMALKQVVVRSRVEGQLLTLNADVGDFI
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHH
RQGQLLAAVEQDLPRTDVSEAQAELAARQFEVKEAESVLAEAKAQVERNRAELKQAEADA
HCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLQQLAEAGAITAQQAEVAQTQQATAAQVLKASQEQVITRQQAIAATKQRVTAQQAILA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAQERLTYTQITAPQSGILLSKQAEAGDTIQGGQTLVEIGDLSAIKVEIQISDRDLSQFA
HHHHCCEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEECCCEEEEEEEEECCCCHHHHH
QGQRVNVALDAFPGETFPGEVTRISPVADAAARLIPIEVTIPNPAGKIATGLLARVSLTD
CCCEEEEEEECCCCCCCCCCCEEECHHHHCCCEEEEEEEEECCCCHHHHHHHEEEEEECC
PNLTTAVMIPASALTTGNNGNQTTVFVPVTQGDTTTVQARPVQVGPEDNGMVAILSGLSA
CCCEEEEEECCHHEECCCCCCEEEEEEEEECCCCEEEEEEEEEECCCCCCEEEEEECCCC
GERYVVQGDRPLETGQTVRLSLLSE
CCEEEEECCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MLESAATKPLRNIKFFACYSPPWCSPMAQQFHLPIGACLSLTLAFVSTGCALEQNSNAQP
CCCCHHCCCHHCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
AGRLEQSDQPPLVEVAIATGTETAPTASYTGTTMALKQVVVRSRVEGQLLTLNADVGDFI
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHH
RQGQLLAAVEQDLPRTDVSEAQAELAARQFEVKEAESVLAEAKAQVERNRAELKQAEADA
HCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLQQLAEAGAITAQQAEVAQTQQATAAQVLKASQEQVITRQQAIAATKQRVTAQQAILA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAQERLTYTQITAPQSGILLSKQAEAGDTIQGGQTLVEIGDLSAIKVEIQISDRDLSQFA
HHHHCCEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEECCCEEEEEEEEECCCCHHHHH
QGQRVNVALDAFPGETFPGEVTRISPVADAAARLIPIEVTIPNPAGKIATGLLARVSLTD
CCCEEEEEEECCCCCCCCCCCEEECHHHHCCCEEEEEEEEECCCCHHHHHHHEEEEEECC
PNLTTAVMIPASALTTGNNGNQTTVFVPVTQGDTTTVQARPVQVGPEDNGMVAILSGLSA
CCCEEEEEECCHHEECCCCCCEEEEEEEEECCCCEEEEEEEEEECCCCCCEEEEEECCCC
GERYVVQGDRPLETGQTVRLSLLSE
CCEEEEECCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]