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The map label for this gene is purC

Identifier: 170076945

GI number: 170076945

Start: 330570

End: 331322

Strand: Direct

Name: purC

Synonym: SYNPCC7002_A0317

Alternate gene names: 170076945

Gene position: 330570-331322 (Clockwise)

Preceding gene: 170076942

Following gene: 170076946

Centisome position: 10.99

GC content: 51.53

Gene sequence:

>753_bases
ATGAGCGAGCACCACCCGGAAAAAAGATACGAAGGTAAGGCAAAAATTCTCTACAGCACCGCCGACTCTGATGTTCTCCT
CACCTATTTTAAAGATGACGCCACCGCCTTTAATGCCCAGAAAAAAGGCACCATCCAGGGTAAAGGGGAAATGAACTGCA
CCATTGCCGCTGCCCTCCTCCAATGGCTGGAAACCCAGGGTATTCCGACCCACTTTATCGAACAAACGAAAGCCGATGAA
ATGCTCGTTAAAGCAGTTAAAATTCTGCCGGTAGAAGTGGTTGTGCGCAATATTGCGGCGGGTAGTCTTTGTAAACAAAC
GGGTTTGGCCCAGGGCACAGTTCTCCCCCAACCCCTCGTGGAGTTTTATCTCAAGGATGATAACCTCGGTGATCCGCTCT
TGACCCGCGATCGCCTTATGCTGCTTCAGATCGTCACCGCCGAGCAACTGGCCCAACTCCAGGACTATGCCCTGCGGATC
AATGGTCTGATGCAAGGCTTTTTTGCGCGCTGTCAGATTACCCTGGTGGATTTTAAAATCGAGTTTGGCACCGACAAAAC
AGGGACAATTCTTTTGGCCGACGAAATTAGTCCCGACACCTGCCGCCTGTGGGATCAAACCGAAACAGACCCCAACCTGC
GGGTGATGGATAAAGACCGCTTCCGTCAAGACCTCGGTAACATCGAAAACGCTTATCAAACTGTCCAGGCCAGGGTCTTG
GCCCAGGTGCAGCAATTGCAATCCCTCGCCTAA

Upstream 100 bases:

>100_bases
GGCTTTATTGTGACATATTGTTTCCCCAAGCCCCTAGGCAAACCCAGGGACATCAGCCCCTACAATGGAGAATGATTTTA
TCCACGATTTTAACCAGCTT

Downstream 100 bases:

>100_bases
ATTTTCCCGACCCAAGGCTAAATTACGGGGTCTAGACATGGAAACATAAGCAACGCTTCCCCGTCTTCGACTCTGGTACA
ATCCAGCAGAGTAAATTACT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSEHHPEKRYEGKAKILYSTADSDVLLTYFKDDATAFNAQKKGTIQGKGEMNCTIAAALLQWLETQGIPTHFIEQTKADE
MLVKAVKILPVEVVVRNIAAGSLCKQTGLAQGTVLPQPLVEFYLKDDNLGDPLLTRDRLMLLQIVTAEQLAQLQDYALRI
NGLMQGFFARCQITLVDFKIEFGTDKTGTILLADEISPDTCRLWDQTETDPNLRVMDKDRFRQDLGNIENAYQTVQARVL
AQVQQLQSLA

Sequences:

>Translated_250_residues
MSEHHPEKRYEGKAKILYSTADSDVLLTYFKDDATAFNAQKKGTIQGKGEMNCTIAAALLQWLETQGIPTHFIEQTKADE
MLVKAVKILPVEVVVRNIAAGSLCKQTGLAQGTVLPQPLVEFYLKDDNLGDPLLTRDRLMLLQIVTAEQLAQLQDYALRI
NGLMQGFFARCQITLVDFKIEFGTDKTGTILLADEISPDTCRLWDQTETDPNLRVMDKDRFRQDLGNIENAYQTVQARVL
AQVQQLQSLA
>Mature_249_residues
SEHHPEKRYEGKAKILYSTADSDVLLTYFKDDATAFNAQKKGTIQGKGEMNCTIAAALLQWLETQGIPTHFIEQTKADEM
LVKAVKILPVEVVVRNIAAGSLCKQTGLAQGTVLPQPLVEFYLKDDNLGDPLLTRDRLMLLQIVTAEQLAQLQDYALRIN
GLMQGFFARCQITLVDFKIEFGTDKTGTILLADEISPDTCRLWDQTETDPNLRVMDKDRFRQDLGNIENAYQTVQARVLA
QVQQLQSLA

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=207, Percent_Identity=33.8164251207729, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI5453539, Length=207, Percent_Identity=33.8164251207729, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI119220559, Length=214, Percent_Identity=32.2429906542056, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788820, Length=234, Percent_Identity=38.4615384615385, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17531275, Length=220, Percent_Identity=30.4545454545455, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24583917, Length=249, Percent_Identity=27.710843373494, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18860083, Length=248, Percent_Identity=26.2096774193548, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_SYNP2 (B1XNE9)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001733583.1
- ProteinModelPortal:   B1XNE9
- SMR:   B1XNE9
- GeneID:   6056704
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0317
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 28049; Mature: 27917

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHHPEKRYEGKAKILYSTADSDVLLTYFKDDATAFNAQKKGTIQGKGEMNCTIAAALL
CCCCCCCHHCCCCEEEEEEECCCCEEEEEECCCCHHCCCCCCCCCCCCCCCCHHHHHHHH
QWLETQGIPTHFIEQTKADEMLVKAVKILPVEVVVRNIAAGSLCKQTGLAQGTVLPQPLV
HHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
EFYLKDDNLGDPLLTRDRLMLLQIVTAEQLAQLQDYALRINGLMQGFFARCQITLVDFKI
HHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEE
EFGTDKTGTILLADEISPDTCRLWDQTETDPNLRVMDKDRFRQDLGNIENAYQTVQARVL
EECCCCCCEEEEEECCCCCCEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
AQVQQLQSLA
HHHHHHHHCC
>Mature Secondary Structure 
SEHHPEKRYEGKAKILYSTADSDVLLTYFKDDATAFNAQKKGTIQGKGEMNCTIAAALL
CCCCCCHHCCCCEEEEEEECCCCEEEEEECCCCHHCCCCCCCCCCCCCCCCHHHHHHHH
QWLETQGIPTHFIEQTKADEMLVKAVKILPVEVVVRNIAAGSLCKQTGLAQGTVLPQPLV
HHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
EFYLKDDNLGDPLLTRDRLMLLQIVTAEQLAQLQDYALRINGLMQGFFARCQITLVDFKI
HHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEE
EFGTDKTGTILLADEISPDTCRLWDQTETDPNLRVMDKDRFRQDLGNIENAYQTVQARVL
EECCCCCCEEEEEECCCCCCEECCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
AQVQQLQSLA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA