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The map label for this gene is chaA [H]

Identifier: 170076843

GI number: 170076843

Start: 220861

End: 221964

Strand: Direct

Name: chaA [H]

Synonym: SYNPCC7002_A0212

Alternate gene names: 170076843

Gene position: 220861-221964 (Clockwise)

Preceding gene: 170076841

Following gene: 170076844

Centisome position: 7.34

GC content: 50.54

Gene sequence:

>1104_bases
ATGCTAAACAAAAACACTTTTTTCCTAGCCCTGCTAGTTTTTATCCCAATTTCCCTAGCTGGCCACTTCCTCGAATGGAG
TCCCGTTACTGTGTTTTGTACAGCGGCGATCGCCATTGTGCCCCTCGCCGCTTTCATGGGAGAAGCCACCGAAGAAATTG
CCGTTGTCGTCGGCCCCAACCTTGGCGGTCTGTTAAATGCCACCTTTGGTAATGCCACCGAATTAATTTTGGCTTTTATC
GCCCTCAAGTCCGGCTTAGTCGATGTCGTCAAGGCCACGATCACCGGATCAATCATTAGTAACCTGCTGCTGGTGATGGG
TTTTGCGATGCTCCTGGGTGGCCTCAAGTTCAAAGAACAAGACTTTCAGCCCACCGCTGCCCGCCTTAATGCTTCGTCCA
TGAACTTGGCGGTAATTGCGATCCTAATTCCCACCGCCGTAGAGTACACCTCCGCTGGTATCGGCCAAGCCACTCTCCAA
AATCTTTCCGTTGCCGTAGCCATTGTGCTCATTTTGGTCTATGGCCTCACTTTATTGTTCTCGATGAAAACCCACTCCTA
TTTATATGATGTGGGGGTCGCAGAAATCGAAGAAGAAGGGGAAACAGAAGAAGAAGCCAAGGCAAAAGTTAACCTTTGGC
TCTGGGTTGGGGTTCTACTGATTGTTACCCTCGCTGTTGCCATTGAGTCGGAACTCCTAGTCGGTTCCCTCGAAGCAGCC
ACCGAAAGCCTCGGCCTCAGTCCTCTCTTTACAGGGGTGATCCTCCTGCCCATCATCGGTAATGCCGCAGAACATGCCAC
CGCTGTTACCGTTGCCCTCAAAAATAAAATGGATCTGTCTGTGTCCGTTGCCGTTGGCTCTAGTTTACAAATTGCCCTCT
TTGTCGCCCCGGTCTTAGTGATTGCTGGTTGGGTCATTGGTCAACCGATGGATCTTGATTTTAATCCTTTTGAACTGGTG
GCCGTGGCCGTGGCTGTACTGATTGCCAACTCCATTAGTTCTGACGGCAACTCCAACTGGTTAGAAGGAAGCTTGTTGCT
AGCGACCTATACAGTGCTCGGATTGGCCTTTTTCTTCCATCCTGCCGTACCTGGATTGGCCTAG

Upstream 100 bases:

>100_bases
TCGCCACTTTGCAAGTTTTCATCAAGGAATCTCTGCCAAAAGGAGCGCGGATTCTTGGTTTCGCGTCTATATTGGACACT
AGCGCAACCCTTACGTCTTT

Downstream 100 bases:

>100_bases
GCCGAGATATTCAACACAATCAAGCTGCTAATTTTTTTGGGCGAACCTTGGTTCGTCTTTATTTTTAGCCACCATAAATA
ATGCTGATTTAATCGGGAAA

Product: calcium/proton exchanger

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MLNKNTFFLALLVFIPISLAGHFLEWSPVTVFCTAAIAIVPLAAFMGEATEEIAVVVGPNLGGLLNATFGNATELILAFI
ALKSGLVDVVKATITGSIISNLLLVMGFAMLLGGLKFKEQDFQPTAARLNASSMNLAVIAILIPTAVEYTSAGIGQATLQ
NLSVAVAIVLILVYGLTLLFSMKTHSYLYDVGVAEIEEEGETEEEAKAKVNLWLWVGVLLIVTLAVAIESELLVGSLEAA
TESLGLSPLFTGVILLPIIGNAAEHATAVTVALKNKMDLSVSVAVGSSLQIALFVAPVLVIAGWVIGQPMDLDFNPFELV
AVAVAVLIANSISSDGNSNWLEGSLLLATYTVLGLAFFFHPAVPGLA

Sequences:

>Translated_367_residues
MLNKNTFFLALLVFIPISLAGHFLEWSPVTVFCTAAIAIVPLAAFMGEATEEIAVVVGPNLGGLLNATFGNATELILAFI
ALKSGLVDVVKATITGSIISNLLLVMGFAMLLGGLKFKEQDFQPTAARLNASSMNLAVIAILIPTAVEYTSAGIGQATLQ
NLSVAVAIVLILVYGLTLLFSMKTHSYLYDVGVAEIEEEGETEEEAKAKVNLWLWVGVLLIVTLAVAIESELLVGSLEAA
TESLGLSPLFTGVILLPIIGNAAEHATAVTVALKNKMDLSVSVAVGSSLQIALFVAPVLVIAGWVIGQPMDLDFNPFELV
AVAVAVLIANSISSDGNSNWLEGSLLLATYTVLGLAFFFHPAVPGLA
>Mature_367_residues
MLNKNTFFLALLVFIPISLAGHFLEWSPVTVFCTAAIAIVPLAAFMGEATEEIAVVVGPNLGGLLNATFGNATELILAFI
ALKSGLVDVVKATITGSIISNLLLVMGFAMLLGGLKFKEQDFQPTAARLNASSMNLAVIAILIPTAVEYTSAGIGQATLQ
NLSVAVAIVLILVYGLTLLFSMKTHSYLYDVGVAEIEEEGETEEEAKAKVNLWLWVGVLLIVTLAVAIESELLVGSLEAA
TESLGLSPLFTGVILLPIIGNAAEHATAVTVALKNKMDLSVSVAVGSSLQIALFVAPVLVIAGWVIGQPMDLDFNPFELV
AVAVAVLIANSISSDGNSNWLEGSLLLATYTVLGLAFFFHPAVPGLA

Specific function: According To Ref.1 The Natural Activity Of This Protein Is As A Calcium/Proton Antiporter, But It Can Act As A Weak Sodium/Proton Antiporter. The Presence Of A Preferred Substrate And Normal Ph Cytoplasmic Values Might Prevent Significant Sodium/Proton An

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=248, Percent_Identity=26.2096774193548, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320075, Length=358, Percent_Identity=42.7374301675978, Blast_Score=246, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6324008, Length=389, Percent_Identity=24.4215938303342, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004798
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 38395; Mature: 38395

Theoretical pI: Translated: 4.10; Mature: 4.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKNTFFLALLVFIPISLAGHFLEWSPVTVFCTAAIAIVPLAAFMGEATEEIAVVVGPN
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
LGGLLNATFGNATELILAFIALKSGLVDVVKATITGSIISNLLLVMGFAMLLGGLKFKEQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFQPTAARLNASSMNLAVIAILIPTAVEYTSAGIGQATLQNLSVAVAIVLILVYGLTLLF
CCCCHHHHCCCCCCHHEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SMKTHSYLYDVGVAEIEEEGETEEEAKAKVNLWLWVGVLLIVTLAVAIESELLVGSLEAA
HHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TESLGLSPLFTGVILLPIIGNAAEHATAVTVALKNKMDLSVSVAVGSSLQIALFVAPVLV
HHHCCCCHHHHHHHHHHHHCCCHHHHHEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHH
IAGWVIGQPMDLDFNPFELVAVAVAVLIANSISSDGNSNWLEGSLLLATYTVLGLAFFFH
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
PAVPGLA
CCCCCCC
>Mature Secondary Structure
MLNKNTFFLALLVFIPISLAGHFLEWSPVTVFCTAAIAIVPLAAFMGEATEEIAVVVGPN
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
LGGLLNATFGNATELILAFIALKSGLVDVVKATITGSIISNLLLVMGFAMLLGGLKFKEQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFQPTAARLNASSMNLAVIAILIPTAVEYTSAGIGQATLQNLSVAVAIVLILVYGLTLLF
CCCCHHHHCCCCCCHHEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SMKTHSYLYDVGVAEIEEEGETEEEAKAKVNLWLWVGVLLIVTLAVAIESELLVGSLEAA
HHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TESLGLSPLFTGVILLPIIGNAAEHATAVTVALKNKMDLSVSVAVGSSLQIALFVAPVLV
HHHCCCCHHHHHHHHHHHHCCCHHHHHEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHH
IAGWVIGQPMDLDFNPFELVAVAVAVLIANSISSDGNSNWLEGSLLLATYTVLGLAFFFH
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
PAVPGLA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]