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The map label for this gene is pdhC [H]

Identifier: 170076743

GI number: 170076743

Start: 110430

End: 111740

Strand: Direct

Name: pdhC [H]

Synonym: SYNPCC7002_A0110

Alternate gene names: 170076743

Gene position: 110430-111740 (Clockwise)

Preceding gene: 170076742

Following gene: 170076744

Centisome position: 3.67

GC content: 53.17

Gene sequence:

>1311_bases
ATGATTCACGATATTTTCATGCCCGCCCTCAGCTCTACGATGACCGAAGGTAAAATCGTTTCTTGGACTAAGTCCCCGGG
AGATAAAGTCGCTAAAGGTGAAACCGTTGTCGTGGTGGAATCTGACAAAGCCGATATGGACGTTGAGTCTTTTAACGAAG
GGTTTCTCGCGGCGATTATCGTTGATGCAGGGGAAGAGGCACCAGTGGGTTCGGCGATCGCCCTCATCGCTGAAACCGAA
GCAGAAATTCCAGAGGCCAAACAAAAAGCCGCGACTCTGAAAGGGGGTAGTAGTGCTCCTGCTGCTAATCCTGCGCCTGC
ACCCGCCCCTGCGGCACCTAGTCCAGAACCGGCTCCCGTTGTGGCAGCCCCGGCGCCTACACCTGCGGCACCGACTCCCG
CACCAGTGGTCAACGATGGCAGAATTATTGCTTCTCCGAGGGCGAAAAAACTCGCCAAAGAATTTGGTGTTGATCTTAAA
ACAGTGCCTGGTTCTGGCCCCCACGGTCGAATTGTCGCCGAAGATGTCGAAAAAGCCGCTGGTAAAGCACCTACTATTGC
CCCTGCTGCCGTATCAACTCCAGCGCCGACAACCAGTAAGCCTGCCGCCCCAGCGCCAGCTCCCGTCGCTGTCACTCCTG
GTGAAGTTGTCCCGCTGAATACGTTGCAACAGGCGGTTGTGCGGAATATGAATGCCAGCCTGAATGTACCCACCTTCCAT
GTGTCCTATGACATCACGACCGATGCCCTAGATGCCCTCTACAAGCAAATTAAGAGTAAGGGCGTCACCATGACAGGTCT
ATTGGCGAAGGCCGTGGCTGTGACCCTCCAGAAACATCCAGTAGTTAATGCCAGCTTTGGGGATAATGCGATCCAATACA
GCAGTGGTATTAATGTGGCGGTGGCCGTTGCGATGCCCGACGGCGGCCTGATTACCCCTGTGCTGCAAAATGCCGATCAA
ATGGATATCTATTCCCTTTCCCGCAAGTGGAAAGATTTGGTAGACCGGGCGCGCCTCAAGCAACTGCAGCCCGATGAGTA
CAGCACTGGCACCTTTACCCTCTCTAACCTAGGGATGTTTGGGGTCAGCAGTTTTGATGCGATTTTGCCCCCTGGTCAAG
GTTCTATTTTGGCGATTGGGGGTGCTCAACCTAAAGTCGTTGCGACGCCCGACGGTTTATTTGGTGTGAAAAAACAAATG
ACCGTCAATATCACCTGCGACCACCGCATTATTTATGGTGCCGATGCGGCAGCATTCCTTAAGGATTTAGCTGACTTGAT
TGAAAATAACACGCACAGTCTGACCCTTTAG

Upstream 100 bases:

>100_bases
CTCTGATGGCAAATTCCTCAGCCCAGCTTCCCCCGATGGGTTAAAATCGACAACGATTGTAAAGTTTGTCCACACCGTTG
TTTTAAAAGAAGATTCCTCC

Downstream 100 bases:

>100_bases
GTTCATCTCGTTGCTCCTTGGGATTTTCCTCAAATATGCAATAAATCATGATCTATGGCTCCCCGGTCTGGGGAGTTTTT
TGTGTCGAAACCGGAGGCGA

Product: branched-chain alpha-keto acid dehydrogenase subunit E2

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MIHDIFMPALSSTMTEGKIVSWTKSPGDKVAKGETVVVVESDKADMDVESFNEGFLAAIIVDAGEEAPVGSAIALIAETE
AEIPEAKQKAATLKGGSSAPAANPAPAPAPAAPSPEPAPVVAAPAPTPAAPTPAPVVNDGRIIASPRAKKLAKEFGVDLK
TVPGSGPHGRIVAEDVEKAAGKAPTIAPAAVSTPAPTTSKPAAPAPAPVAVTPGEVVPLNTLQQAVVRNMNASLNVPTFH
VSYDITTDALDALYKQIKSKGVTMTGLLAKAVAVTLQKHPVVNASFGDNAIQYSSGINVAVAVAMPDGGLITPVLQNADQ
MDIYSLSRKWKDLVDRARLKQLQPDEYSTGTFTLSNLGMFGVSSFDAILPPGQGSILAIGGAQPKVVATPDGLFGVKKQM
TVNITCDHRIIYGADAAAFLKDLADLIENNTHSLTL

Sequences:

>Translated_436_residues
MIHDIFMPALSSTMTEGKIVSWTKSPGDKVAKGETVVVVESDKADMDVESFNEGFLAAIIVDAGEEAPVGSAIALIAETE
AEIPEAKQKAATLKGGSSAPAANPAPAPAPAAPSPEPAPVVAAPAPTPAAPTPAPVVNDGRIIASPRAKKLAKEFGVDLK
TVPGSGPHGRIVAEDVEKAAGKAPTIAPAAVSTPAPTTSKPAAPAPAPVAVTPGEVVPLNTLQQAVVRNMNASLNVPTFH
VSYDITTDALDALYKQIKSKGVTMTGLLAKAVAVTLQKHPVVNASFGDNAIQYSSGINVAVAVAMPDGGLITPVLQNADQ
MDIYSLSRKWKDLVDRARLKQLQPDEYSTGTFTLSNLGMFGVSSFDAILPPGQGSILAIGGAQPKVVATPDGLFGVKKQM
TVNITCDHRIIYGADAAAFLKDLADLIENNTHSLTL
>Mature_436_residues
MIHDIFMPALSSTMTEGKIVSWTKSPGDKVAKGETVVVVESDKADMDVESFNEGFLAAIIVDAGEEAPVGSAIALIAETE
AEIPEAKQKAATLKGGSSAPAANPAPAPAPAAPSPEPAPVVAAPAPTPAAPTPAPVVNDGRIIASPRAKKLAKEFGVDLK
TVPGSGPHGRIVAEDVEKAAGKAPTIAPAAVSTPAPTTSKPAAPAPAPVAVTPGEVVPLNTLQQAVVRNMNASLNVPTFH
VSYDITTDALDALYKQIKSKGVTMTGLLAKAVAVTLQKHPVVNASFGDNAIQYSSGINVAVAVAMPDGGLITPVLQNADQ
MDIYSLSRKWKDLVDRARLKQLQPDEYSTGTFTLSNLGMFGVSSFDAILPPGQGSILAIGGAQPKVVATPDGLFGVKKQM
TVNITCDHRIIYGADAAAFLKDLADLIENNTHSLTL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=436, Percent_Identity=33.9449541284404, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI203098753, Length=462, Percent_Identity=29.8701298701299, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI203098816, Length=462, Percent_Identity=29.4372294372294, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI110671329, Length=433, Percent_Identity=25.635103926097, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI260898739, Length=168, Percent_Identity=36.3095238095238, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786946, Length=442, Percent_Identity=26.2443438914027, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786305, Length=425, Percent_Identity=31.0588235294118, Blast_Score=118, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17560088, Length=453, Percent_Identity=36.644591611479, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17537937, Length=436, Percent_Identity=26.3761467889908, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17538894, Length=296, Percent_Identity=31.4189189189189, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25146366, Length=436, Percent_Identity=28.6697247706422, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324258, Length=442, Percent_Identity=35.2941176470588, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6320352, Length=438, Percent_Identity=25.1141552511416, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321632, Length=186, Percent_Identity=32.258064516129, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24582497, Length=430, Percent_Identity=33.2558139534884, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129315, Length=299, Percent_Identity=33.1103678929766, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI18859875, Length=440, Percent_Identity=27.2727272727273, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24645909, Length=200, Percent_Identity=33.5, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR006257
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 44859; Mature: 44859

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHDIFMPALSSTMTEGKIVSWTKSPGDKVAKGETVVVVESDKADMDVESFNEGFLAAII
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHCCCCEEEEEE
VDAGEEAPVGSAIALIAETEAEIPEAKQKAATLKGGSSAPAANPAPAPAPAAPSPEPAPV
EECCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VAAPAPTPAAPTPAPVVNDGRIIASPRAKKLAKEFGVDLKTVPGSGPHGRIVAEDVEKAA
EECCCCCCCCCCCCCEECCCEEEECCHHHHHHHHHCCEEEECCCCCCCCCEEHHHHHHHC
GKAPTIAPAAVSTPAPTTSKPAAPAPAPVAVTPGEVVPLNTLQQAVVRNMNASLNVPTFH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEECHHHHHHHHHHCCCCCCCCCEEE
VSYDITTDALDALYKQIKSKGVTMTGLLAKAVAVTLQKHPVVNASFGDNAIQYSSGINVA
EEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCEE
VAVAMPDGGLITPVLQNADQMDIYSLSRKWKDLVDRARLKQLQPDEYSTGTFTLSNLGMF
EEEEECCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCC
GVSSFDAILPPGQGSILAIGGAQPKVVATPDGLFGVKKQMTVNITCDHRIIYGADAAAFL
CCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCEEEEEEEEECCEEEECCCHHHHH
KDLADLIENNTHSLTL
HHHHHHHCCCCCEECC
>Mature Secondary Structure
MIHDIFMPALSSTMTEGKIVSWTKSPGDKVAKGETVVVVESDKADMDVESFNEGFLAAII
CCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHCCCCEEEEEE
VDAGEEAPVGSAIALIAETEAEIPEAKQKAATLKGGSSAPAANPAPAPAPAAPSPEPAPV
EECCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCE
VAAPAPTPAAPTPAPVVNDGRIIASPRAKKLAKEFGVDLKTVPGSGPHGRIVAEDVEKAA
EECCCCCCCCCCCCCEECCCEEEECCHHHHHHHHHCCEEEECCCCCCCCCEEHHHHHHHC
GKAPTIAPAAVSTPAPTTSKPAAPAPAPVAVTPGEVVPLNTLQQAVVRNMNASLNVPTFH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCEECHHHHHHHHHHCCCCCCCCCEEE
VSYDITTDALDALYKQIKSKGVTMTGLLAKAVAVTLQKHPVVNASFGDNAIQYSSGINVA
EEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCEE
VAVAMPDGGLITPVLQNADQMDIYSLSRKWKDLVDRARLKQLQPDEYSTGTFTLSNLGMF
EEEEECCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCC
GVSSFDAILPPGQGSILAIGGAQPKVVATPDGLFGVKKQMTVNITCDHRIIYGADAAAFL
CCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCCEEEEEEEEECCEEEECCCHHHHH
KDLADLIENNTHSLTL
HHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA