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The map label for this gene is deoA [H]

Identifier: 170025841

GI number: 170025841

Start: 4001297

End: 4002619

Strand: Reverse

Name: deoA [H]

Synonym: YPK_3626

Alternate gene names: 170025841

Gene position: 4002619-4001297 (Counterclockwise)

Preceding gene: 170025842

Following gene: 170025840

Centisome position: 85.35

GC content: 54.42

Gene sequence:

>1323_bases
TTGTTTCTGGCACAAGAAATTATCCGTAAAAAACGCGACGGTCAGCCATTGAGCGAAGAAGAGATTCGTTTTTTTATCAA
TGGGATCCGCGATAACGTTGTTTCTGAAGGGCAAATTGCCGCTTTAGCGATGACCATTTATTTCCACGATATGAGTATGC
CTGAGCGCGTTGCGCTGACCATGGCGATGCGTGATTCCGGTACTGTGCTGAATTGGAAGAGCCTGAATCTGAATGGCCCG
CTGGTCGATAAGCACTCCACTGGTGGCGTGGGTGATGTGACGTCACTGATGCTTGGCCCGATGGTGGCAGCTTGCGGCGG
CTATGTGCCGATGATCTCTGGCCGTGGTCTTGGTCATACCGGCGGCACACTGGATAAACTGGAGGCGATCCCCGGTTTTG
ATATTTTCCCGGATGATAATGCGTTCCGCAAAATTATTCAGAATGTTGGTGTGGCGATTATCGGCCAAACCAGCTCGCTG
GCCCCTGCCGATAAGCGTTTTTACGCGACCCGCGATATTACGGCAACAGTAGATTCTATTCCATTGATTACGGCCTCTAT
CCTGGCCAAAAAATTGGCGGAAGGGCTGGATGCATTGGTCATGGACGTGAAGGTCGGCTCCGGTGCCTTTATGCCAACCT
ACTCGTTGTCGGCTGATTTGGCGCAGGCGATTGTTGGTGTGGCAAACGGGGCGGGTTGCAAAACCACGGCGCTCCTGACG
GACATGAACCAAGTCCTGGCATCCAGCGCCGGTAATGGGGTCGAAGTCCGCGAAGCTGTGCGTTTCCTGACGGGCGAATA
TCGCAACCCACGTTTGCTGGAAGTGACTATGGCGCTGTGTGTTGAAATGTTGCTGTCAGGCGGTTTAGCGCACGATGAAG
CCGATGCCCGTGCCAAGCTGCAAGCCGTTTTGGATAACGGCAAAGCGGCAGAAGTCTTTGGCCGCATGGTGGCCGCGCAA
AAAGGCCCGGTAGACTTTGTTGAACGCTATGACAGCTACCTGCCCGTTGCTACCCTAAGCAAACCGGTATTTGCTGAACA
GACGGGAATCATTACTGCAATGGATACCCGCGCCTTGGGTATGGCGGTGGTCGCCCTCGGCGGGGGACGCCGTCGGGCAA
CGGATCCCATTGATTATAGTGTAGGGCTGACGGAAATGGCCCGCTTGGGTACCCGTGTTGACGGGCAGCAGCCACTTGCG
GTGATCCATGCCAATAACGAAGATGACTGGCAACAGGCGGCAGAGGCTGTGCGTGCGGCCATCACCTTAGGGAATAACGC
GCCAGAAGAAACGCCAGTGATTTATCGCCGTATCACTGAATAA

Upstream 100 bases:

>100_bases
TGAATTGATGCACTGTAGGCTGAAGGCCTGCCGTGTCGCTATTTCCGAAAGCGCTTGTGGGCGGCTTTCATCCCATATTC
AGGTCAAGCAGGGGGATGCC

Downstream 100 bases:

>100_bases
ACGTCATACTTTTGTTATCGACAGCCCGTGTTACAGCGCCCAAACGGATCGGCAATTAATTATGAATGTGGGGTGGTGGA
GCGAATGAATATTCGCCGCC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MFLAQEIIRKKRDGQPLSEEEIRFFINGIRDNVVSEGQIAALAMTIYFHDMSMPERVALTMAMRDSGTVLNWKSLNLNGP
LVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNAFRKIIQNVGVAIIGQTSSL
APADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYSLSADLAQAIVGVANGAGCKTTALLT
DMNQVLASSAGNGVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAHDEADARAKLQAVLDNGKAAEVFGRMVAAQ
KGPVDFVERYDSYLPVATLSKPVFAEQTGIITAMDTRALGMAVVALGGGRRRATDPIDYSVGLTEMARLGTRVDGQQPLA
VIHANNEDDWQQAAEAVRAAITLGNNAPEETPVIYRRITE

Sequences:

>Translated_440_residues
MFLAQEIIRKKRDGQPLSEEEIRFFINGIRDNVVSEGQIAALAMTIYFHDMSMPERVALTMAMRDSGTVLNWKSLNLNGP
LVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNAFRKIIQNVGVAIIGQTSSL
APADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYSLSADLAQAIVGVANGAGCKTTALLT
DMNQVLASSAGNGVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAHDEADARAKLQAVLDNGKAAEVFGRMVAAQ
KGPVDFVERYDSYLPVATLSKPVFAEQTGIITAMDTRALGMAVVALGGGRRRATDPIDYSVGLTEMARLGTRVDGQQPLA
VIHANNEDDWQQAAEAVRAAITLGNNAPEETPVIYRRITE
>Mature_440_residues
MFLAQEIIRKKRDGQPLSEEEIRFFINGIRDNVVSEGQIAALAMTIYFHDMSMPERVALTMAMRDSGTVLNWKSLNLNGP
LVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNAFRKIIQNVGVAIIGQTSSL
APADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYSLSADLAQAIVGVANGAGCKTTALLT
DMNQVLASSAGNGVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAHDEADARAKLQAVLDNGKAAEVFGRMVAAQ
KGPVDFVERYDSYLPVATLSKPVFAEQTGIITAMDTRALGMAVVALGGGRRRATDPIDYSVGLTEMARLGTRVDGQQPLA
VIHANNEDDWQQAAEAVRAAITLGNNAPEETPVIYRRITE

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=441, Percent_Identity=40.1360544217687, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI4503445, Length=441, Percent_Identity=40.1360544217687, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI166158922, Length=441, Percent_Identity=40.1360544217687, Blast_Score=276, Evalue=4e-74,
Organism=Escherichia coli, GI1790842, Length=440, Percent_Identity=83.6363636363636, Blast_Score=749, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 46887; Mature: 46887

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLAQEIIRKKRDGQPLSEEEIRFFINGIRDNVVSEGQIAALAMTIYFHDMSMPERVALT
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEEEEECCCCCHHHEEE
MAMRDSGTVLNWKSLNLNGPLVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
GGTLDKLEAIPGFDIFPDDNAFRKIIQNVGVAIIGQTSSLAPADKRFYATRDITATVDSI
CCCHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCHHEEEECCCCCHHHCC
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYSLSADLAQAIVGVANGAGCKTTALLT
HHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
DMNQVLASSAGNGVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAHDEADARAKL
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QAVLDNGKAAEVFGRMVAAQKGPVDFVERYDSYLPVATLSKPVFAEQTGIITAMDTRALG
HHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCCCHHHCCCCEEEECHHHHC
MAVVALGGGRRRATDPIDYSVGLTEMARLGTRVDGQQPLAVIHANNEDDWQQAAEAVRAA
EEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
ITLGNNAPEETPVIYRRITE
HHCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MFLAQEIIRKKRDGQPLSEEEIRFFINGIRDNVVSEGQIAALAMTIYFHDMSMPERVALT
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEEEEECCCCCHHHEEE
MAMRDSGTVLNWKSLNLNGPLVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHT
EEECCCCCEEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
GGTLDKLEAIPGFDIFPDDNAFRKIIQNVGVAIIGQTSSLAPADKRFYATRDITATVDSI
CCCHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCHHEEEECCCCCHHHCC
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYSLSADLAQAIVGVANGAGCKTTALLT
HHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
DMNQVLASSAGNGVEVREAVRFLTGEYRNPRLLEVTMALCVEMLLSGGLAHDEADARAKL
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QAVLDNGKAAEVFGRMVAAQKGPVDFVERYDSYLPVATLSKPVFAEQTGIITAMDTRALG
HHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCCCHHHCCCCEEEECHHHHC
MAVVALGGGRRRATDPIDYSVGLTEMARLGTRVDGQQPLAVIHANNEDDWQQAAEAVRAA
EEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
ITLGNNAPEETPVIYRRITE
HHCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA