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The map label for this gene is murC [H]

Identifier: 170025732

GI number: 170025732

Start: 3862589

End: 3864091

Strand: Reverse

Name: murC [H]

Synonym: YPK_3517

Alternate gene names: 170025732

Gene position: 3864091-3862589 (Counterclockwise)

Preceding gene: 170025733

Following gene: 170025731

Centisome position: 82.4

GC content: 51.56

Gene sequence:

>1503_bases
ATGACAGACAAAAAAGTGAAGAGAAACGTGAATACACAACAACTGGCGAAACTGCGTACTATCGTGCCCGAGATGCGACG
TGTCCGGCACATTCACTTTGTTGGCATCGGTGGTGCCGGCATGGGGGGTATCGCCGAAGTGTTGGCCAACGAAGGTTATC
AGATTAGTGGTTCAGATTTAGCACCCAACTCGGTAACTCAGCATTTGACTGCCCTGGGTGCACAGATTTATTTCCATCAT
CGCCCGGAAAACGTGCTGGATGCGAGCGTGGTCGTGGTTTCTACTGCAATCTCTGCGGATAACCCAGAGATTGTCGCGGC
CCGTGAGGCGAGAATACCGGTGATCCGCCGCGCAGAAATGTTGGCGGAATTGATGCGCTATCGCCATGGGATTGCCGTTG
CTGGCACCCACGGCAAAACCACCACAACGGCGATGTTATCCAGTATTTATGCCGAAGCAGGGTTAGATCCAACGTTCGTC
AATGGTGGGTTAGTCAAGGCCGCGGGTACACATGCTCGTTTGGGTTCCAGCCGTTACCTGATTGCAGAAGCCGATGAAAG
CGACGCGTCATTCCTGCATTTGCAACCGATGGTGGCGATTGTTACCAATATCGAAGCCGATCATATGGATACCTACCAAG
GCGACTTCGAAAATTTAAAACAGACATTCATTAACTTTTTGCACAATTTGCCCTTTTATGGCCGTGCGGTGATGTGTATC
GATGATCCCGTAGTGCGTGAATTATTGCCACGTGTTGGCCGTCACATCACAACCTATGGTTTCAGTGATGATGCTGATGT
GCAGATCGCCAGCTATCGGCAAGAAGGCCCACAAGGGCACTTCACGTTGCGCCGTCAGGATAAACCGTTGATAGAGGTGA
CCTTGAATGCACCAGGTCGCCACAATGCACTGAATGCGGCGGCAGCAGTCGCTGTCGCAACAGAAGAAGGCATTGAAGAC
GAAGATATCCTGCGTGCATTAGTGGGTTTCCAAGGGACGGGGCGCCGTTTTGATTTCCTCGGCAACTTCCCACTGGCCCC
GGTTAACGGTAAAGAAGGCAGTGCGATGCTGGTTGATGATTATGGTCATCACCCTACCGAAGTGGATGCCACCATTAAAG
CCGCACGTGCTGGTTGGCCGGATAAACGCATTGTCATGCTCTTTCAGCCACACCGCTATACCCGAACCCGCGATCTGTAT
GACGATTTCGCGAATGTGCTGTCACAGGTCGATGTTTTATTGATGCTGGATGTGTATGCCGCAGGTGAACCACCGATCCC
AGGGGCAGATAGCCGCGCGTTGTGCCGAACGATTCGTAATCGCGGTAAGTTGGACCCTATTTTAGTGCCAGACAGCGAAT
CAGCACCTGAAATGTTGGCGCAAATACTGAACGGGGAAGACCTGATCTTGGTTCAGGGCGCAGGTAACATTGGTAAAATT
GCCCGTAAATTGGCTGAGCATAAATTGCAGCCACAGTTAAAAGACGAGGAACATCATGGCTGA

Upstream 100 bases:

>100_bases
ACTTTGAAATAGCTACAATTTTAAATGGTTACGGTTTTGAAATAGCGATGACCTTGAAATAAACAGTGATCAGTGGGCGA
TGAATGCAGGCTGTGAATAC

Downstream 100 bases:

>100_bases
GAAAGTCGCGGTATTGCTGGGTGGGACCTCTGCGGAGCGTGAAGTGTCATTACTGTCAGGTCAGGCGGTATTGGCAGGCT
TGAAAGAAGCCGGTATCGAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MTDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALGAQIYFHH
RPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFV
NGGLVKAAGTHARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCI
DDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVATEEGIED
EDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLY
DDFANVLSQVDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKI
ARKLAEHKLQPQLKDEEHHG

Sequences:

>Translated_500_residues
MTDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALGAQIYFHH
RPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFV
NGGLVKAAGTHARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCI
DDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVATEEGIED
EDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLY
DDFANVLSQVDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKI
ARKLAEHKLQPQLKDEEHHG
>Mature_499_residues
TDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALGAQIYFHHR
PENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVN
GGLVKAAGTHARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCID
DPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVATEEGIEDE
DILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLYD
DFANVLSQVDVLLMLDVYAAGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKIA
RKLAEHKLQPQLKDEEHHG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=490, Percent_Identity=86.1224489795918, Blast_Score=795, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=27.2916666666667, Blast_Score=138, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 54724; Mature: 54593

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDL
CCCHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCC
APNSVTQHLTALGAQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEM
CCHHHHHHHHHHHHEEEEEECCCCHHHHHEEEEEEEECCCCCCEEEECCCCCCHHHHHHH
LAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAGTHARLGSSRYL
HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHCCCCCEEE
IAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCI
EEECCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
DDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGR
CCHHHHHHHHHHCCEEEECCCCCCCCEEEEEHHCCCCCCCEEEEECCCCEEEEEECCCCC
HNALNAAAAVAVATEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDD
CCHHHHHHHEEEEHHCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEC
YGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQVDVLLMLDVYA
CCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKI
CCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHH
ARKLAEHKLQPQLKDEEHHG
HHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDKKVKRNVNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDL
CCHHHHHCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCC
APNSVTQHLTALGAQIYFHHRPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEM
CCHHHHHHHHHHHHEEEEEECCCCHHHHHEEEEEEEECCCCCCEEEECCCCCCHHHHHHH
LAELMRYRHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAGTHARLGSSRYL
HHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEECCCEEEECCCHHCCCCCEEE
IAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCI
EEECCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
DDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGPQGHFTLRRQDKPLIEVTLNAPGR
CCHHHHHHHHHHCCEEEECCCCCCCCEEEEEHHCCCCCCCEEEEECCCCEEEEEECCCCC
HNALNAAAAVAVATEEGIEDEDILRALVGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDD
CCHHHHHHHEEEEHHCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEC
YGHHPTEVDATIKAARAGWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQVDVLLMLDVYA
CCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGEPPIPGADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNIGKI
CCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHCCCCEEEEECCCCHHHH
ARKLAEHKLQPQLKDEEHHG
HHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA