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The map label for this gene is bioF

Identifier: 170025152

GI number: 170025152

Start: 3228122

End: 3229273

Strand: Reverse

Name: bioF

Synonym: YPK_2930

Alternate gene names: 170025152

Gene position: 3229273-3228122 (Counterclockwise)

Preceding gene: 170025153

Following gene: 170025151

Centisome position: 68.86

GC content: 58.25

Gene sequence:

>1152_bases
ATGAGCTGGCAAGATAAAATAGCGCAAGGCTTGCAACGGCGACGTGATGCGGCGGCTTACCGTACTCGCCAGGTCAACGA
GGGGGCGAATGGGCGCTGGCTACAGTCAGGCGAGCGGCAATATCTCAACTTCTCCAGTAATGACTATCTGGGGCTAAGCC
AAAATGATGAGGTCATTGCTGCATGGCAGCAAGGCGCACGGCGCTATGGGGTAGGGAGTGGCGGTTCGGGTCATGTGACC
GGTTATAGCCAACCTCATGCCCGGTTGGAGCAGCGGTTAGCTGATTGGTTGGGCTACCCGCGCGCGCTGCTATTTATCTC
TGGTTATGCCGCGAATCAGGCAGTGCTGACGGCTCTGACCGATGCTGATGACCGGATATTGGCGGATAAACTCAGCCATG
CCTCACTATTGGAAGCCGCCGCGCATTCACCCGCGCAGTTGCGGCGTTTCCAGCATAATCAGCCCGAAGCGCTGCAAAAT
CTGCTGATCAAGCCTTGCCAGGGCCAGACGCTGGTGGTCACCGAAGGCGTATTTAGTATGGATGGCGATAGTGCGCCATT
GGCGGCGCTGCAGCAACAGACGTCAGCCGCGGGCGGCTGGTTACTGGTGGATGATGCGCACGGTATTGGGGTTCATGGTG
AAGAGGGGCGGGGCAGTTGCTGGTTACAAGGGGTTCAACCCGAGCTGTTAGTTGTCACGTTTGGCAAGGCGTTCGGCTTA
AGCGGTGCGGCGGTCTTGTGTCAGGAACCGGTTGCTGAATACTTGTTGCAGTATGCCCGCCACCTGATTTACAGCACCGC
CATGCCCCCCGCGCAAGCCTGTGCTCTACAAGCCGCCTTGCGCCAAGTGCAACAAGGTGATGCATTACGCCAACAACTTC
AGCAGCGTATCCGCCAATTTCGGACCGCGGCCGCGCATTTACCGCTGCAACTGGGGGCGTCAAAAACGGCGATCCAACCG
CTGTTGGTGGGCGATAATCAGCAAAGCCTGATCTGGGCAGAGCAACTGCGTGCTGCCGGTTTATGGGTGACGGCAATCCG
CCCCCCCACGGTGCCACCAGGAAGCGCCAGATTGCGCATTACCCTCAGCGCGGCTCACCAACCCGAGGATATCGATAGAT
TATTGGAGGTGCTTTATGGCCTCTGTCACTGA

Upstream 100 bases:

>100_bases
AGCAGACGGCAACATCACACGGTGATCGTGAACAACAACAGGCCTTGACCGAGCAGCTACTGCATGGGGATACCGCCCAG
TTTTATAATGCGGCGGTCTA

Downstream 100 bases:

>100_bases
GCACGCGCAATGGGGCGTTGGGTGTTTACCGCCACTGAACGTTGATAAACAGGCGATTGCGGCTGCATTCAGCCGGGCCG
CCGAGAGCTACGACAGCGCG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSWQDKIAQGLQRRRDAAAYRTRQVNEGANGRWLQSGERQYLNFSSNDYLGLSQNDEVIAAWQQGARRYGVGSGGSGHVT
GYSQPHARLEQRLADWLGYPRALLFISGYAANQAVLTALTDADDRILADKLSHASLLEAAAHSPAQLRRFQHNQPEALQN
LLIKPCQGQTLVVTEGVFSMDGDSAPLAALQQQTSAAGGWLLVDDAHGIGVHGEEGRGSCWLQGVQPELLVVTFGKAFGL
SGAAVLCQEPVAEYLLQYARHLIYSTAMPPAQACALQAALRQVQQGDALRQQLQQRIRQFRTAAAHLPLQLGASKTAIQP
LLVGDNQQSLIWAEQLRAAGLWVTAIRPPTVPPGSARLRITLSAAHQPEDIDRLLEVLYGLCH

Sequences:

>Translated_383_residues
MSWQDKIAQGLQRRRDAAAYRTRQVNEGANGRWLQSGERQYLNFSSNDYLGLSQNDEVIAAWQQGARRYGVGSGGSGHVT
GYSQPHARLEQRLADWLGYPRALLFISGYAANQAVLTALTDADDRILADKLSHASLLEAAAHSPAQLRRFQHNQPEALQN
LLIKPCQGQTLVVTEGVFSMDGDSAPLAALQQQTSAAGGWLLVDDAHGIGVHGEEGRGSCWLQGVQPELLVVTFGKAFGL
SGAAVLCQEPVAEYLLQYARHLIYSTAMPPAQACALQAALRQVQQGDALRQQLQQRIRQFRTAAAHLPLQLGASKTAIQP
LLVGDNQQSLIWAEQLRAAGLWVTAIRPPTVPPGSARLRITLSAAHQPEDIDRLLEVLYGLCH
>Mature_382_residues
SWQDKIAQGLQRRRDAAAYRTRQVNEGANGRWLQSGERQYLNFSSNDYLGLSQNDEVIAAWQQGARRYGVGSGGSGHVTG
YSQPHARLEQRLADWLGYPRALLFISGYAANQAVLTALTDADDRILADKLSHASLLEAAAHSPAQLRRFQHNQPEALQNL
LIKPCQGQTLVVTEGVFSMDGDSAPLAALQQQTSAAGGWLLVDDAHGIGVHGEEGRGSCWLQGVQPELLVVTFGKAFGLS
GAAVLCQEPVAEYLLQYARHLIYSTAMPPAQACALQAALRQVQQGDALRQQLQQRIRQFRTAAAHLPLQLGASKTAIQPL
LVGDNQQSLIWAEQLRAAGLWVTAIRPPTVPPGSARLRITLSAAHQPEDIDRLLEVLYGLCH

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily

Homologues:

Organism=Homo sapiens, GI7657118, Length=341, Percent_Identity=32.258064516129, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI284448556, Length=341, Percent_Identity=32.258064516129, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI83977444, Length=344, Percent_Identity=32.5581395348837, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI83977440, Length=344, Percent_Identity=32.5581395348837, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI83977442, Length=394, Percent_Identity=30.2030456852792, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4502025, Length=352, Percent_Identity=31.25, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI40316939, Length=352, Percent_Identity=31.25, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=28.808864265928, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4758668, Length=359, Percent_Identity=28.4122562674095, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI5454084, Length=279, Percent_Identity=23.2974910394265, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786993, Length=383, Percent_Identity=65.2741514360313, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1790046, Length=344, Percent_Identity=34.3023255813954, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71994529, Length=370, Percent_Identity=31.0810810810811, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI32566772, Length=362, Percent_Identity=27.3480662983425, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560914, Length=379, Percent_Identity=25.3298153034301, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=379, Percent_Identity=25.3298153034301, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=270, Percent_Identity=22.5925925925926, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982625, Length=270, Percent_Identity=22.5925925925926, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320438, Length=413, Percent_Identity=27.8450363196126, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320267, Length=356, Percent_Identity=28.0898876404494, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323954, Length=286, Percent_Identity=25.8741258741259, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24662918, Length=369, Percent_Identity=28.1842818428184, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17137420, Length=388, Percent_Identity=28.3505154639175, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=25.068870523416, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653280, Length=280, Percent_Identity=24.2857142857143, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653276, Length=280, Percent_Identity=24.2857142857143, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24653278, Length=280, Percent_Identity=24.2857142857143, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOF_YERP3 (A7FKM8)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401806.1
- ProteinModelPortal:   A7FKM8
- SMR:   A7FKM8
- STRING:   A7FKM8
- GeneID:   5384712
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2843
- NMPDR:   fig|349747.3.peg.3860
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   KDYASND
- ProtClustDB:   PRK05958
- BioCyc:   YPSE349747:YPSIP31758_2843-MONOMER
- HAMAP:   MF_01693
- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.47

Molecular weight: Translated: 41697; Mature: 41565

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 21-21 BINDING 133-133 BINDING 179-179 BINDING 350-350

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWQDKIAQGLQRRRDAAAYRTRQVNEGANGRWLQSGERQYLNFSSNDYLGLSQNDEVIA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHH
AWQQGARRYGVGSGGSGHVTGYSQPHARLEQRLADWLGYPRALLFISGYAANQAVLTALT
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHEEEEC
DADDRILADKLSHASLLEAAAHSPAQLRRFQHNQPEALQNLLIKPCQGQTLVVTEGVFSM
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCEEEC
DGDSAPLAALQQQTSAAGGWLLVDDAHGIGVHGEEGRGSCWLQGVQPELLVVTFGKAFGL
CCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCEEEEEECHHHCC
SGAAVLCQEPVAEYLLQYARHLIYSTAMPPAQACALQAALRQVQQGDALRQQLQQRIRQF
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RTAAAHLPLQLGASKTAIQPLLVGDNQQSLIWAEQLRAAGLWVTAIRPPTVPPGSARLRI
HHHHHCCCHHCCCCHHHCCEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEE
TLSAAHQPEDIDRLLEVLYGLCH
EEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SWQDKIAQGLQRRRDAAAYRTRQVNEGANGRWLQSGERQYLNFSSNDYLGLSQNDEVIA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHH
AWQQGARRYGVGSGGSGHVTGYSQPHARLEQRLADWLGYPRALLFISGYAANQAVLTALT
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHEEEEC
DADDRILADKLSHASLLEAAAHSPAQLRRFQHNQPEALQNLLIKPCQGQTLVVTEGVFSM
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCEEEC
DGDSAPLAALQQQTSAAGGWLLVDDAHGIGVHGEEGRGSCWLQGVQPELLVVTFGKAFGL
CCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCEEEEEECHHHCC
SGAAVLCQEPVAEYLLQYARHLIYSTAMPPAQACALQAALRQVQQGDALRQQLQQRIRQF
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RTAAAHLPLQLGASKTAIQPLLVGDNQQSLIWAEQLRAAGLWVTAIRPPTVPPGSARLRI
HHHHHCCCHHCCCCHHHCCEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEE
TLSAAHQPEDIDRLLEVLYGLCH
EEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA