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The map label for this gene is fabF [H]

Identifier: 170024861

GI number: 170024861

Start: 2891329

End: 2892603

Strand: Direct

Name: fabF [H]

Synonym: YPK_2636

Alternate gene names: 170024861

Gene position: 2891329-2892603 (Clockwise)

Preceding gene: 170024859

Following gene: 170024867

Centisome position: 61.66

GC content: 52.39

Gene sequence:

>1275_bases
ATGAGTACACGCCATGTAGTAATTACAGGTATGGGTGTCGTTTCCCCATTAGGCTGCGGTATCGAAACGGTCTGGCAACG
GCTCTTGGCAGGGCAATCAGGCATCCGTGTTCTATCGGATGAAATTGTCGGTGACTTGCCCGCTAAAATTGGTGGGCAAG
TGCCTACGTTAGCAGAAGACGCTAAAGTTGGTTTCGATCCAGATAAAGCGGTTACCCCAAAAGATCAAAAGAAAATGGAT
CGCTTTATTGAGTTTGCGATGGCGGCGGCCGATGAGGCAATTAGCCAGGCAGGCTGGCATGCGGATAACACAGAGAAACA
AGAGCGTACCGCGACAATCATAGGCGCGGGTATTGGTGGTTTTCCGGCCATTGCCCATGCAGTGCGGACTTCCGACAGCC
GTGGGCCAAAACGCCTCTCACCGTTTACTGTCCCTTCATTCTTAGTGAATTTGGCCGCTGGCCATGTTTCTATCAAACAT
CATTTTAAAGGCCCGATTGGCGCACCAGTCACTGCCTGTGCTGCCGGTGTACAGGCAATCGGTGACGCCGTGCGGATGAT
CCGCAACAATGAAGCAGATGTTGCCCTGTGCGGTGGCGCAGAAGCCGTGATCGATACCGTGAGTCTGGCCGGTTTTGCTG
CCGCTCGTGCGTTATCAACCCACTTTAATAGCACACCAGAAAAAGCCTCCCGCCCCTTCGACACTGCCCGTGACGGTTTC
GTGATGGGAGAAGGTGCTGGTTTACTGATTATTGAGGAGTTGGAGCATGCTTTAGCCAGAGGCGCGAAGCCACTAGCAGA
AATAGTCGGCTATGGTACCAGTGCCGATGCTTACCATATGACCTCTGGCGCTGAGGATGGCGACGGGGCCTATCGCGCCA
TGAAAATCGCTTTGCGTCAGGCCGGTATTACGCCCGAGCAAGTTCAGCATCTGAATGCCCACGCGACCTCAACACCGGTA
GGTGATCTCGGTGAAATTAATGCCATTAAACATTTGTTTGGCGAGAGTAATGCGTTAGCGATTACCTCAACAAAATCCGC
CACAGGGCACCTGTTGGGCGCTGCTGGTGGGCTGGAAACCATTTTCACTGTACTGGCATTGCGTGATCAAATCGTGCCCG
CAACGTTGAATCTGGAAAATCCAGATCCTGCAGCCAAGGGACTCAACATTATTGCAGGTAACGCACAACCTCATGACATG
ACGTATGCCCTTTCCAATGGTTTTGGCTTTGGTGGGGTGAACGCAAGTATCTTACTGAAACGCTGGGTGGACTAA

Upstream 100 bases:

>100_bases
CATTCATGCATAAAAACGGTCAGTAAAGATTAAATAACCGTCTTATGAAGAACGGCCTTCTAGGTTGTCTCCTGTTCAAT
CGAGTTTAAAAGGAAAAAGA

Downstream 100 bases:

>100_bases
CGCAATAAATGAAAACCTCCGCCTAATGCGGAGGTTACCCTTGATAATGACAGAGAGCCGCTTAAGCGGTCACAGCCCTG
TCTTCCATAGCCTGTCGCCA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSTRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAEDAKVGFDPDKAVTPKDQKKMD
RFIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKH
HFKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGF
VMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPV
GDLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDM
TYALSNGFGFGGVNASILLKRWVD

Sequences:

>Translated_424_residues
MSTRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAEDAKVGFDPDKAVTPKDQKKMD
RFIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKH
HFKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGF
VMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPV
GDLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDM
TYALSNGFGFGGVNASILLKRWVD
>Mature_423_residues
STRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAEDAKVGFDPDKAVTPKDQKKMDR
FIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGGFPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHH
FKGPIGAPVTACAAGVQAIGDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGFV
MGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQAGITPEQVQHLNAHATSTPVG
DLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLETIFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMT
YALSNGFGFGGVNASILLKRWVD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=45.4761904761905, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI223972627, Length=189, Percent_Identity=37.5661375661376, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=26.5588914549654, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1787337, Length=423, Percent_Identity=46.8085106382979, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1788663, Length=425, Percent_Identity=36.2352941176471, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=38.0614657210402, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=42.4812030075188, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=430, Percent_Identity=26.5116279069767, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=280, Percent_Identity=25.3571428571429, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=38.0846325167038, Blast_Score=281, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=45.0236966824645, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI221330659, Length=433, Percent_Identity=25.4041570438799, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19920632, Length=433, Percent_Identity=25.4041570438799, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24581345, Length=435, Percent_Identity=25.0574712643678, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43998; Mature: 43867

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAED
CCCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCC
AKVGFDPDKAVTPKDQKKMDRFIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCC
FPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHHFKGPIGAPVTACAAGVQAI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHH
GDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGF
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCE
VMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQ
EEECCCCEEEHHHHHHHHHCCCHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHH
AGITPEQVQHLNAHATSTPVGDLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLET
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCHHH
IFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMTYALSNGFGFGGVNASILLK
HHHHHHHHHHCCCEEEECCCCCHHHCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHH
RWVD
HHCC
>Mature Secondary Structure 
STRHVVITGMGVVSPLGCGIETVWQRLLAGQSGIRVLSDEIVGDLPAKIGGQVPTLAED
CCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCC
AKVGFDPDKAVTPKDQKKMDRFIEFAMAAADEAISQAGWHADNTEKQERTATIIGAGIGG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEECCCCC
FPAIAHAVRTSDSRGPKRLSPFTVPSFLVNLAAGHVSIKHHFKGPIGAPVTACAAGVQAI
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHH
GDAVRMIRNNEADVALCGGAEAVIDTVSLAGFAAARALSTHFNSTPEKASRPFDTARDGF
HHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCE
VMGEGAGLLIIEELEHALARGAKPLAEIVGYGTSADAYHMTSGAEDGDGAYRAMKIALRQ
EEECCCCEEEHHHHHHHHHCCCHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHH
AGITPEQVQHLNAHATSTPVGDLGEINAIKHLFGESNALAITSTKSATGHLLGAAGGLET
CCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCHHH
IFTVLALRDQIVPATLNLENPDPAAKGLNIIAGNAQPHDMTYALSNGFGFGGVNASILLK
HHHHHHHHHHCCCEEEECCCCCHHHCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHH
RWVD
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]