Click here to switch to the map view.

The map label for this gene is nhaB [H]

Identifier: 170024344

GI number: 170024344

Start: 2341032

End: 2342606

Strand: Direct

Name: nhaB [H]

Synonym: YPK_2110

Alternate gene names: 170024344

Gene position: 2341032-2342606 (Clockwise)

Preceding gene: 170024342

Following gene: 170024345

Centisome position: 49.92

GC content: 46.67

Gene sequence:

>1575_bases
ATGGACATTACCAACAGACAAGCTGTACTCAAGAATTTTCTTGGTAACTCTCCGGATTGGTACAAACTAGCAATTATGGG
GTTCTTGATCATTAACCCTCTAGTCTTCTTCTTTGTCAGCCCCTTTGTCGCGGGCTGGATGCTGGTTATCGAGTTTATCT
TTACCTTAGCCATGGCGCTGAAATGTTACCCGCTGCAACCGGGGGGTTTGCTCGCTATTCAAGCCGTTGCCATCGGCATG
ACCAGCCCGCATCAAGTTGCAGAAGAGATCGCCAATAACCTGGAAGTCCTCTTGCTTTTAGTATTTATGGTGGCCGGCAT
CTACTTTATGAAACAGCTGCTGCTGTTTGTATTTACGAAATTGCTGTTGAATATTCGGTCAAAAACTATCCTTTCCCTGG
CCTTTTGTCTGGCGTCAGCCTTCCTATCAGCATTTTTGGATGCCTTAACCGTAATCGCGGTAGTTATCAGCGTATCCGTT
GGTTTTTATACTATTTATCATAACGTTACTTCAAATCACAGTGACAAAGATATTACTGATGACAGCGGAATCGATAATCA
GGACAGCCATGAAACATTAGAGCAATTCCGGGCATTTTTACGCAGTCTGATGATGCATGCTGGCGTGGGTACCGCTCTGG
GGGGCGTCATGACAATGGTTGGTGAGCCTCAGAATTTGATTATTGCCAAAAGCGCGGGTTGGAATTTTGCTGACTTCTTT
ATTCGCATGTTACCCGTCACCTTACCCGTCTTTATTTGCGGGTTATTGGTCTGCTTGCTGGTCGAAAAATTTAAACTGTT
TGGTTATGGTGCCCAGTTGCCAGAACGTGTGCGTCAGGTTCTGACCGAATACGATCAGCAAGCCAGTGCGAAACGGACCA
AGCAAGAGAAGATGAAGTTAATAGTACAAGCCATTATTGGTGTCTGGTTGGTATTGGCACTGGCACTCCATTTAGCTGAA
GTCGGTTTGGTCGGGCTATCCGTTATTATTCTCGCCACCTCATTTTGTGGTATCACAAATGAGCATTCATTGGGCAAAGC
CTTTCAGGAAGCCTTGCCGTTTACCGCGCTGCTAACCGTATTTTTTGCCGTGGTCGCGGTTATTATTGAACAAAGCCTCT
TTACCCCCATTATTCAGTTTGTTTTACAAGCCTCGCCTTCCGCTCAGCTATCGCTGTTTTATCTGTTTAATGGCTTGCTC
TCATCGGTGTCAGACAATGTTTTTGTCGGTACCGTGTATATCAATGAGGCCCGTTCTGCGTTTGAGCATGGTATTGTCTC
GTTACAACAATTTGAATTGTTGGCGGTCGCCATCAATACAGGGACCAACCTCCCCTCCGTGGCGACACCAAACGGCCAGG
CCGCTTTCTTGTTCCTGCTGACTTCGGCATTGGCACCACTAATTCGCCTTTCCTATGGGCGAATGGTATATATGGCTTTG
CCTTATACTCTAGTGATGACGATTGTTGGCCTGCTGGGTGTCGAGTTTTTATTGGTACCGATGACAGAGTGGCTGACTCA
GGCTGGATGGATCAGTTTGCCACACATCACAAACGGGGTTGCCATCCCACACTGA

Upstream 100 bases:

>100_bases
CAGAGAATACGTATTGCTTTTAACTGGATTACGTAAACTAAAATGTAACCTTTCGTCGTAATCGCATCATAATAATTTAT
TAAGGGAAAAATCATTCACA

Downstream 100 bases:

>100_bases
TCACTTGCATTATGGTTGGCCAGCCTTGGGGATAAGTGCGACAACTCAAGGTGGCACGAATGGGGGCTGGCAAAACCAAC
CAACATCTCACCCAAAGTAA

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFICGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQASAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH

Sequences:

>Translated_524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFICGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQASAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH
>Mature_524_residues
MDITNRQAVLKNFLGNSPDWYKLAIMGFLIINPLVFFFVSPFVAGWMLVIEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TSPHQVAEEIANNLEVLLLLVFMVAGIYFMKQLLLFVFTKLLLNIRSKTILSLAFCLASAFLSAFLDALTVIAVVISVSV
GFYTIYHNVTSNHSDKDITDDSGIDNQDSHETLEQFRAFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKSAGWNFADFF
IRMLPVTLPVFICGLLVCLLVEKFKLFGYGAQLPERVRQVLTEYDQQASAKRTKQEKMKLIVQAIIGVWLVLALALHLAE
VGLVGLSVIILATSFCGITNEHSLGKAFQEALPFTALLTVFFAVVAVIIEQSLFTPIIQFVLQASPSAQLSLFYLFNGLL
SSVSDNVFVGTVYINEARSAFEHGIVSLQQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVYMAL
PYTLVMTIVGLLGVEFLLVPMTEWLTQAGWISLPHITNGVAIPH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=513, Percent_Identity=75.8284600389863, Blast_Score=757, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 57406; Mature: 57406

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA