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The map label for this gene is creC [H]

Identifier: 170023128

GI number: 170023128

Start: 1005158

End: 1006591

Strand: Direct

Name: creC [H]

Synonym: YPK_0879

Alternate gene names: 170023128

Gene position: 1005158-1006591 (Clockwise)

Preceding gene: 170023127

Following gene: 170023129

Centisome position: 21.43

GC content: 50.7

Gene sequence:

>1434_bases
ATGAAGATTGGTGTACGGTTGCTACTTGGCTATTTCCTGATTGTGGCTATCGCTGGCTACTTTGTTATTCGTATTTTTTT
GCAGGAAGTCAAACCCGGAGTGCGGCGCGCGACTGAAGGCACCTTAGTGGATACGGCGACCTTACTGGCGCAATTCGCCC
GGCAGGATATATTGCAGAACAAAGTGGCCGACGGGCAATTGGCGCAAGCATTTTCTTCCCTTAATCTGCGGCCTATTGGT
GCCAATATTGAAGGTATCCGTAAGGATCGCAATGAATATAGGGTCTATCTGACCGATACTGATGGGCAGGTGATTTTTGA
TTCATCAGGCCGAGCATTAGGGCAAGACTATTCACGTTGGAATGATGTCTGGTTGACGCTACGTGGTGAGTATGGCGCCC
GCAGTAGCCGCACTGACCCCGACGATGCAGAAAGTTCGGTAATGTATGTGGCGGCACCGGTCATCGTCGAAAATCGTATT
GTTGGTGTACTGAGTATAGGTAAGCCGAATCTCTCCATGGTGCCGGTGATCAAACGCAGTGAACGCAAGATCCTGTTTGC
AGGTGGGCTGCTGTTAGGCATTGCATTGCTGATTGGGTTGGGGTTTGTGTGGTGGATTAACCGGGCGATCGGCAAGTTGG
TGGACTACGCAGAACGGGTTGCCGAGGGGCAGGCGGTGGCTCTGCCAGCGATGGGGAGCAGTGAATTGAATGATTTGGCA
CTGGCGCTGGAAAGCATGCGTCTCAAATTGGATGGCAAAGCCTATATCGAACAATATGTTCACACGCTGACTCATGAATT
GAAAAGCCCGCTGGCCGCTATCTCCGGGGCGGCTGAGTTACTGCGAGAGTCTCCACCGCCAGAGACCGCACAACGTTTTC
TGATCAATATTGAGCAGCAAAGTGCACGAATCCAGCAACTGGTAGATAAAATGCTGGTGCAAGCACGGCTGGAGAGCCGG
GTAGATCTACAACTCTCCCCCTTGGAAATCAGCCATATACTCAAGCAGAGCTTTAGCGCCAAAGAAGCTCAGGCGGTTAG
CCGAGGGGTCACTCTGCGGCTAAAATCTGTAGATAACGCGATGTTGATCGGCGATGGGCTGTTGCTCAGCCAGGCCTTAA
CTAATCTGATTGATAATGCTCTGGATTTCACACCTGCGGGAGGGGAGATTAACGTGAGTGGTGAACGGCAAGATGATACC
TATCTGATCACGGTTGAAGACAGTGGCTGTGGTATTCCTGATTATGCCCAAGAGAAGATTTTTGACCGTTTTTATTCGTT
ACCACGGGCTAATAGCCCCAAAAGTACAGGGTTAGGGCTAAATTTCGTACGTGAAGTTGCTGCTATTCATCAGGGAAGTA
TTTGTTTGGAGAACCGCCTACCACAAGGGGTTAGCGCGCGTTTGACATTACCGCTGTCAAGGGTTCACCGCTAA

Upstream 100 bases:

>100_bases
ACGCACGGTTTACGCTGAAGACTCACCCATTCGCACACATCGTGGATTGGGCTATAGCCTGGGTTATCAGCCATGAGTTA
TCAGCCATGAGCCGCTATAA

Downstream 100 bases:

>100_bases
CTTCACGTTCACTTCACATAGCCTCATTCTCCTTTCACTTCACGGTCTTAAGCTGCTCTCCTGATGTTAAAAGGAGTGCA
AGTCATGTTCAAATCTGTGC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQNKVADGQLAQAFSSLNLRPIG
ANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRWNDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRI
VGVLSIGKPNLSMVPVIKRSERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQSARIQQLVDKMLVQARLESR
VDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNAMLIGDGLLLSQALTNLIDNALDFTPAGGEINVSGERQDDT
YLITVEDSGCGIPDYAQEKIFDRFYSLPRANSPKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPLSRVHR

Sequences:

>Translated_477_residues
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQNKVADGQLAQAFSSLNLRPIG
ANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRWNDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRI
VGVLSIGKPNLSMVPVIKRSERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQSARIQQLVDKMLVQARLESR
VDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNAMLIGDGLLLSQALTNLIDNALDFTPAGGEINVSGERQDDT
YLITVEDSGCGIPDYAQEKIFDRFYSLPRANSPKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPLSRVHR
>Mature_477_residues
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQNKVADGQLAQAFSSLNLRPIG
ANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRWNDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRI
VGVLSIGKPNLSMVPVIKRSERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQSARIQQLVDKMLVQARLESR
VDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNAMLIGDGLLLSQALTNLIDNALDFTPAGGEINVSGERQDDT
YLITVEDSGCGIPDYAQEKIFDRFYSLPRANSPKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPLSRVHR

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=477, Percent_Identity=58.0712788259958, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=26.7399267399267, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=26.1467889908257, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=28.0487804878049, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=212, Percent_Identity=28.3018867924528, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=293, Percent_Identity=25.5972696245734, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994928, Length=218, Percent_Identity=27.5229357798165, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=214, Percent_Identity=26.6355140186916, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=26.9076305220884, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI145693157, Length=273, Percent_Identity=26.7399267399267, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=278, Percent_Identity=26.6187050359712, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=372, Percent_Identity=27.6881720430108, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788279, Length=266, Percent_Identity=24.812030075188, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790300, Length=208, Percent_Identity=30.2884615384615, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=275, Percent_Identity=25.4545454545455, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=213, Percent_Identity=26.7605633802817, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=194, Percent_Identity=26.8041237113402, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789403, Length=219, Percent_Identity=29.2237442922374, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52379; Mature: 52379

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KVADGQLAQAFSSLNLRPIGANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRW
HCCCCHHHHHHHHCCCEEECCCHHHHHCCCCCEEEEEECCCCEEEECCCCCCHHHHHHCC
NDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRIVGVLSIGKPNLSMVPVIKRS
CCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECHHCCCCEEEEEEECCCCCCEECCEECC
ERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQ
HHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SARIQQLVDKMLVQARLESRVDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNA
HHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCE
MLIGDGLLLSQALTNLIDNALDFTPAGGEINVSGERQDDTYLITVEDSGCGIPDYAQEKI
EEEECHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHH
FDRFYSLPRANSPKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPLSRVHR
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCEEEECCHHHHCC
>Mature Secondary Structure
MKIGVRLLLGYFLIVAIAGYFVIRIFLQEVKPGVRRATEGTLVDTATLLAQFARQDILQN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KVADGQLAQAFSSLNLRPIGANIEGIRKDRNEYRVYLTDTDGQVIFDSSGRALGQDYSRW
HCCCCHHHHHHHHCCCEEECCCHHHHHCCCCCEEEEEECCCCEEEECCCCCCHHHHHHCC
NDVWLTLRGEYGARSSRTDPDDAESSVMYVAAPVIVENRIVGVLSIGKPNLSMVPVIKRS
CCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECHHCCCCEEEEEEECCCCCCEECCEECC
ERKILFAGGLLLGIALLIGLGFVWWINRAIGKLVDYAERVAEGQAVALPAMGSSELNDLA
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHH
LALESMRLKLDGKAYIEQYVHTLTHELKSPLAAISGAAELLRESPPPETAQRFLINIEQQ
HHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SARIQQLVDKMLVQARLESRVDLQLSPLEISHILKQSFSAKEAQAVSRGVTLRLKSVDNA
HHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCE
MLIGDGLLLSQALTNLIDNALDFTPAGGEINVSGERQDDTYLITVEDSGCGIPDYAQEKI
EEEECHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHH
FDRFYSLPRANSPKSTGLGLNFVREVAAIHQGSICLENRLPQGVSARLTLPLSRVHR
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]