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The map label for this gene is uhpB [H]

Identifier: 170022344

GI number: 170022344

Start: 94709

End: 96238

Strand: Direct

Name: uhpB [H]

Synonym: YPK_0082

Alternate gene names: 170022344

Gene position: 94709-96238 (Clockwise)

Preceding gene: 170022343

Following gene: 170022345

Centisome position: 2.02

GC content: 48.89

Gene sequence:

>1530_bases
ATGATACAGCGCTTGGTGATGCTGCTGGCGTTATTCTTTATTTATTTTACTGCGGCTTTCTGCCTGTGGGCTATAGGAAC
ACAATTAGCTGATCGGGCTTTACAGTCGCTGCTGTTGTTCCCATTTGGTCTGCGTATGGGGATTTTATTACAAAGTCCAC
GTGCTTACTGGCCTGGCATTTTACTGGGTGATGTCCTGTTGTGGTGGCTATTAGCCGATCAATTCGATGATTTATATCAG
TTGTGGGTCGCCTTGCCGCTGTTGTTATTGACCACCTTATTGGCCCTTTTTGCCTCCCCGTGGTTATTGCGCCATCAGCA
AAATGAGAGCGAATGGCAATGGCCGTTAATGCAGGGGGGCGTTATCACGGTTGCCGCGCTAATACAGGCGTTGGGGTGGC
AGATAGCCAGTGGGCAGGGCGCAATGGCGCTCTTATTAGGGTTGGTTGGTGGCTTTACCATCGCGCCTACCTGCCTGCTG
CTGTGGCACTATCTGGCACGTCAAATCTGGTTACCGCTTGAACCTGGGTTGATACATAAACCGGTTAACCTGCGGTTGCG
GCATATCCTGTGGTATCTACTGCTATTTGCCATCAGTATCTGGTTACAGTACCAAGTGACTGAAACAGATTTACGCTTAT
TTGTACCGTTCTGTTTGGCGATCCCCATTGTGTTTATGGCATATCGCTATGGCTGGCAGGGGGCGTTGGCGGCCACGTTA
CTCAATGGTGTAGTGCTGTTGATTAATACACCTGAACCCCTTGAATCTCATCGTGGCTTGCTACTTTCACTGTTGGCACA
AAGTCTAACAGGTCTGCTCTTGGGATCCGGCATTCAACGACAGCGGGAGTTGAACGATCAACTACAAATAAAATTGAACG
AAAACCGTGAGTTGGCTAAAGCATTAGTGGTTTCTGAGGAGCATACACGGCACGATGTCGCGCGTGAGCTACATGATGAA
GTGGGGCAAACCGTAACGGTTATCCGTACCCAAGCCAGTATTATTAAACGTCTGACCACCCAGCAACCGGTACTGACCAG
TGCAGAGATGATAGAAACTGCGGCATTGCGGGTTTATGATGGTGTCCATGACGTATTGGCTAAATTATGGCCAGCGGCAT
TAAATAATTTGCCGCTGTCGGCCGCCATCGCTGCATTGATGCGCGAACTCATTCCGCAAGACCAATCGGTGCTCGGTGTG
CTTAACTGGCAGGTCAATGACCATCCGATGGATGAGACGTTGAAAATTACGCTTTACCGTATATGTCAGGAGGGGGTGAC
CAATGCTTATCGGCATGGTGCCGCCAGCCGAATTGAAATTAATGCACGGCAGGATAACCAACAGATATATCTAACGATTA
GCGATAATGGTAAAGGTATCGATTTAGCCTCAATTACTCCAGGCTATGGGCTACGGGGTATTCAGTCACGGGTCAGTGCG
TTTGGGGGCAATGTGAGCCTAAGCGTTGATAACGGTACTTGCTTAAATGTGACCCTGCCCACAGTTTCTTTGTCTACAAA
AGGAAACTAA

Upstream 100 bases:

>100_bases
TCGGGCTATCGCCAAAAACGGTCCATGTGCACCGGGCTAATTTATTTGCCAAGTTGGGCATCAGCAATAATGTTGAGCTG
GCTAAGAAAGTACTGAACCT

Downstream 100 bases:

>100_bases
GAAATATTCTCGTTGGTAGCGAGAATTCCCCCGTGTGTTTTCATACACATGCAGATGATGATTATTGCACTTACAAAATA
CCCTGAGGCCCGAGATGTGG

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MIQRLVMLLALFFIYFTAAFCLWAIGTQLADRALQSLLLFPFGLRMGILLQSPRAYWPGILLGDVLLWWLLADQFDDLYQ
LWVALPLLLLTTLLALFASPWLLRHQQNESEWQWPLMQGGVITVAALIQALGWQIASGQGAMALLLGLVGGFTIAPTCLL
LWHYLARQIWLPLEPGLIHKPVNLRLRHILWYLLLFAISIWLQYQVTETDLRLFVPFCLAIPIVFMAYRYGWQGALAATL
LNGVVLLINTPEPLESHRGLLLSLLAQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDE
VGQTVTVIRTQASIIKRLTTQQPVLTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGV
LNWQVNDHPMDETLKITLYRICQEGVTNAYRHGAASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSA
FGGNVSLSVDNGTCLNVTLPTVSLSTKGN

Sequences:

>Translated_509_residues
MIQRLVMLLALFFIYFTAAFCLWAIGTQLADRALQSLLLFPFGLRMGILLQSPRAYWPGILLGDVLLWWLLADQFDDLYQ
LWVALPLLLLTTLLALFASPWLLRHQQNESEWQWPLMQGGVITVAALIQALGWQIASGQGAMALLLGLVGGFTIAPTCLL
LWHYLARQIWLPLEPGLIHKPVNLRLRHILWYLLLFAISIWLQYQVTETDLRLFVPFCLAIPIVFMAYRYGWQGALAATL
LNGVVLLINTPEPLESHRGLLLSLLAQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDE
VGQTVTVIRTQASIIKRLTTQQPVLTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGV
LNWQVNDHPMDETLKITLYRICQEGVTNAYRHGAASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSA
FGGNVSLSVDNGTCLNVTLPTVSLSTKGN
>Mature_509_residues
MIQRLVMLLALFFIYFTAAFCLWAIGTQLADRALQSLLLFPFGLRMGILLQSPRAYWPGILLGDVLLWWLLADQFDDLYQ
LWVALPLLLLTTLLALFASPWLLRHQQNESEWQWPLMQGGVITVAALIQALGWQIASGQGAMALLLGLVGGFTIAPTCLL
LWHYLARQIWLPLEPGLIHKPVNLRLRHILWYLLLFAISIWLQYQVTETDLRLFVPFCLAIPIVFMAYRYGWQGALAATL
LNGVVLLINTPEPLESHRGLLLSLLAQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAKALVVSEEHTRHDVARELHDE
VGQTVTVIRTQASIIKRLTTQQPVLTSAEMIETAALRVYDGVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGV
LNWQVNDHPMDETLKITLYRICQEGVTNAYRHGAASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSA
FGGNVSLSVDNGTCLNVTLPTVSLSTKGN

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=506, Percent_Identity=44.8616600790514, Blast_Score=357, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56745; Mature: 56745

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQRLVMLLALFFIYFTAAFCLWAIGTQLADRALQSLLLFPFGLRMGILLQSPRAYWPGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LLGDVLLWWLLADQFDDLYQLWVALPLLLLTTLLALFASPWLLRHQQNESEWQWPLMQGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHCCC
VITVAALIQALGWQIASGQGAMALLLGLVGGFTIAPTCLLLWHYLARQIWLPLEPGLIHK
HHHHHHHHHHHCCEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEC
PVNLRLRHILWYLLLFAISIWLQYQVTETDLRLFVPFCLAIPIVFMAYRYGWQGALAATL
CHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LNGVVLLINTPEPLESHRGLLLSLLAQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAK
HCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCHHHHH
ALVVSEEHTRHDVARELHDEVGQTVTVIRTQASIIKRLTTQQPVLTSAEMIETAALRVYD
HHHHCCHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHH
ICQEGVTNAYRHGAASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSA
HHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHH
FGGNVSLSVDNGTCLNVTLPTVSLSTKGN
CCCCEEEEECCCEEEEEEECEEEECCCCC
>Mature Secondary Structure
MIQRLVMLLALFFIYFTAAFCLWAIGTQLADRALQSLLLFPFGLRMGILLQSPRAYWPGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LLGDVLLWWLLADQFDDLYQLWVALPLLLLTTLLALFASPWLLRHQQNESEWQWPLMQGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHCCC
VITVAALIQALGWQIASGQGAMALLLGLVGGFTIAPTCLLLWHYLARQIWLPLEPGLIHK
HHHHHHHHHHHCCEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEC
PVNLRLRHILWYLLLFAISIWLQYQVTETDLRLFVPFCLAIPIVFMAYRYGWQGALAATL
CHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LNGVVLLINTPEPLESHRGLLLSLLAQSLTGLLLGSGIQRQRELNDQLQIKLNENRELAK
HCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCHHHHH
ALVVSEEHTRHDVARELHDEVGQTVTVIRTQASIIKRLTTQQPVLTSAEMIETAALRVYD
HHHHCCHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GVHDVLAKLWPAALNNLPLSAAIAALMRELIPQDQSVLGVLNWQVNDHPMDETLKITLYR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHH
ICQEGVTNAYRHGAASRIEINARQDNQQIYLTISDNGKGIDLASITPGYGLRGIQSRVSA
HHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHH
FGGNVSLSVDNGTCLNVTLPTVSLSTKGN
CCCCEEEEECCCEEEEEEECEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]