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The map label for this gene is glmS [H]

Identifier: 169834503

GI number: 169834503

Start: 330119

End: 331927

Strand: Direct

Name: glmS [H]

Synonym: SPH_0383

Alternate gene names: 169834503

Gene position: 330119-331927 (Clockwise)

Preceding gene: 169833865

Following gene: 169833705

Centisome position: 14.7

GC content: 44.89

Gene sequence:

>1809_bases
ATGTGTGGAATTGTTGGTGTTGTTGGAAACACAAATGCAACTGATATTTTGATTCAAGGGCTTGAAAAGCTTGAATACCG
TGGCTATGATTCTGCGGGAATTTTTGTCCTAGATGGTGCTGATAACCATTTGGTGAAGGCTGTTGGTCGTATTGCAGAAT
TGTCTGCCAAGACAGCTGGTGTTGAGGGAACAACTGGTATCGGACATACTCGTTGGGCTACTCACGGAAAACCAACTGAG
GACAATGCTCACCCACACCGCTCTGAGACAGAACGTTTTGTCTTGGTGCATAATGGGGTGATTGAGAACTACCTTGAAAT
CAAGGAAGAATACCTTGCAGGTCACCACTTCAAGGGGCAGACAGATACTGAAATAGCCGTTCATTTGATTGGAAAATTTG
CGGAAGAAGAAGGGCTCTCAGTTCTTGAAGCCTTCAAAAAAGCCCTTCACATCATCCGTGGTTCTTATGCCTTTGCCTTG
GTTGACTCACAAGATCCTGAAGTCATCTACGTAGCTAAAAATAAATCACCACTTTTGATTGGTCTTGGAGAAGGCTATAA
CATGGTCTGCTCAGACGCCATGGCTATGATTCGTGAAACTAACCAATACATGGAAATCCATGACCAAGAGTTGGTAATCG
TCAAGGCTGATAGTGTGGAAGTTCAAGACTATGATGGAAATCGTCGTGAGCGTGCTAGCTACACTGCTGAACTTGACTTG
TCAGATATCGGTAAGGGAACTTACCCTTACTACATGCTCAAGGAAATTGACGAGCAACCAACTGTTATGCGGAAACTCAT
CCAAGCCTACACAGATGAGGCTGGTCAAGTTGTCGTAGACCCAGATATCATTAAGGCTGTTCAAGACGCAGACCGCATCT
ACATCCTTGCAGCTGGAACATCTTACCATGCAGGATTTGCTTCTAAGAAAATGTTGGAAGAATTGACAGATACACCAGTT
GAACTTGGAATCTCATCTGAGTGGGGCTACGGTATGCCACTTCTCAGCAAGAAACCACTCTTCATCTTTATCAGCCAATC
TGGTGAAACAGCGGATAGTCGTCAAGTTTTGGTCAAGGCTAATGAAATGGGAATTCCAAGCTTAACAGTGACAAATGTTC
CAGGTTCAACCCTCTCACGTGAAGCCAACTATACCATGCTCCTTCATGCAGGTCCTGAAATTGCTGTGGCATCAACTAAA
GCCTATACAGCGCAAATCGCAGCCCTTGCCTTCCTTGCAAAAGCAGTCGGAGAAGCAAATGGTAATGCTAAAGCGCAAGT
CTTTGATCTGGTTCATGAATTGTCAATCGTAGCTCAGTCTATCGAATCAACTCTTTCAGAGAAAGAAACCATTGAAGTCA
AGGTTCGTGAACTTCTTGAAACAACTCGTAACGCCTTTTACATCGGACGTGGTCAAGATTACTACGTAGCCATGGAAGCA
AGTCTCAAACTCAAAGAGATTTCTTATATCCAGTGTGAAGGCTTTGCTGCAGGAGAACTCAAGCACGGAACCATTGCCTT
GATTGAAGAAGGAACGCCTGTTTTGGCTCTCTTGTCAGATCCAGTTCTTGCCAACCATACTCGTGGAAATATCCAAGAGG
TCGCAGCCCGTGGTGCCAAAGTCCTCACTATCGCAGAAGAGAATGTAGCCAAAGATACCGACGATATCGTCCTTACGACC
GTACATCCATACCTCTCACCAATTTCAATGGTCGTACCAACGCAATTAGTCGCTTACTTTGCAACCCTCCATCGTGGCCT
CGATGTGGACAAACCACGTAACCTTGCCAAGTCAGTAACGGTAGAATAA

Upstream 100 bases:

>100_bases
AAAGAAACAAGTATATACTGTTTTTGCTGATTCTATAAAAGATGAATTAGACTATACCAATTTTAAGGAGAAAGCACAGC
TTGCCTGTGTCGTATATACT

Downstream 100 bases:

>100_bases
GCTAAAAAAGTCTAGTTATCTAGGCTTTTTCTTGTGAGCAAATTGGTTGCTTGTACTCAAGATTCGTGTTATACTCTTCG
AAAATCTCTTCAAACCACGT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTE
DNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFAL
VDSQDPEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNRRERASYTAELDL
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDEAGQVVVDPDIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPV
ELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTK
AYTAQIAALAFLAKAVGEANGNAKAQVFDLVHELSIVAQSIESTLSEKETIEVKVRELLETTRNAFYIGRGQDYYVAMEA
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTT
VHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE

Sequences:

>Translated_602_residues
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTE
DNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFAL
VDSQDPEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNRRERASYTAELDL
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDEAGQVVVDPDIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPV
ELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTK
AYTAQIAALAFLAKAVGEANGNAKAQVFDLVHELSIVAQSIESTLSEKETIEVKVRELLETTRNAFYIGRGQDYYVAMEA
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTT
VHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE
>Mature_602_residues
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAGVEGTTGIGHTRWATHGKPTE
DNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQTDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFAL
VDSQDPEVIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNRRERASYTAELDL
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDEAGQVVVDPDIIKAVQDADRIYILAAGTSYHAGFASKKMLEELTDTPV
ELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKANEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTK
AYTAQIAALAFLAKAVGEANGNAKAQVFDLVHELSIVAQSIESTLSEKETIEVKVRELLETTRNAFYIGRGQDYYVAMEA
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAKVLTIAEENVAKDTDDIVLTT
VHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=689, Percent_Identity=32.656023222061, Blast_Score=316, Evalue=5e-86,
Organism=Homo sapiens, GI205277386, Length=691, Percent_Identity=31.6931982633864, Blast_Score=306, Evalue=4e-83,
Organism=Escherichia coli, GI1790167, Length=615, Percent_Identity=39.8373983739837, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1788651, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=32.4009324009324, Blast_Score=227, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=32.183908045977, Blast_Score=218, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=31.7865429234339, Blast_Score=218, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6322745, Length=443, Percent_Identity=33.6343115124154, Blast_Score=228, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323731, Length=414, Percent_Identity=27.536231884058, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323730, Length=210, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=32.6530612244898, Blast_Score=328, Evalue=6e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65662; Mature: 65662

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAG
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC
VEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCC
TDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFALVDSQDPEVIYVAKNKSPLLI
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCEEE
GLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNRRERASYTAELDL
ECCCCCCHHHHHHHHHHHHCCHHHEECCCEEEEEEECCEEEECCCCCCCHHCCEEEEECH
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDEAGQVVVDPDIIKAVQDADRIYILAAGT
HHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCCEEEEEEECC
SYHAGFASKKMLEELTDTPVELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKA
CCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
NEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTKAYTAQIAALAFLAKAVGEAN
CCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCC
GNAKAQVFDLVHELSIVAQSIESTLSEKETIEVKVRELLETTRNAFYIGRGQDYYVAMEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEC
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAK
CEEEEEEEEEEECCEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHCCCE
VLTIAEENVAKDTDDIVLTTVHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVT
EEEEECCCCCCCCCCEEEEEECHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
VE
CC
>Mature Secondary Structure
MCGIVGVVGNTNATDILIQGLEKLEYRGYDSAGIFVLDGADNHLVKAVGRIAELSAKTAG
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCC
VEGTTGIGHTRWATHGKPTEDNAHPHRSETERFVLVHNGVIENYLEIKEEYLAGHHFKGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCC
TDTEIAVHLIGKFAEEEGLSVLEAFKKALHIIRGSYAFALVDSQDPEVIYVAKNKSPLLI
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCEEE
GLGEGYNMVCSDAMAMIRETNQYMEIHDQELVIVKADSVEVQDYDGNRRERASYTAELDL
ECCCCCCHHHHHHHHHHHHCCHHHEECCCEEEEEEECCEEEECCCCCCCHHCCEEEEECH
SDIGKGTYPYYMLKEIDEQPTVMRKLIQAYTDEAGQVVVDPDIIKAVQDADRIYILAAGT
HHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCCEEEEEEECC
SYHAGFASKKMLEELTDTPVELGISSEWGYGMPLLSKKPLFIFISQSGETADSRQVLVKA
CCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
NEMGIPSLTVTNVPGSTLSREANYTMLLHAGPEIAVASTKAYTAQIAALAFLAKAVGEAN
CCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCC
GNAKAQVFDLVHELSIVAQSIESTLSEKETIEVKVRELLETTRNAFYIGRGQDYYVAMEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEC
SLKLKEISYIQCEGFAAGELKHGTIALIEEGTPVLALLSDPVLANHTRGNIQEVAARGAK
CEEEEEEEEEEECCEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHCCCE
VLTIAEENVAKDTDDIVLTTVHPYLSPISMVVPTQLVAYFATLHRGLDVDKPRNLAKSVT
EEEEECCCCCCCCCCEEEEEECHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
VE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]