| Definition | Streptococcus pneumoniae Hungary19A-6, complete genome. |
|---|---|
| Accession | NC_010380 |
| Length | 2,245,615 |
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The map label for this gene is uvrA [H]
Identifier: 169833621
GI number: 169833621
Start: 266963
End: 269794
Strand: Direct
Name: uvrA [H]
Synonym: SPH_0305
Alternate gene names: 169833621
Gene position: 266963-269794 (Clockwise)
Preceding gene: 169833359
Following gene: 169834257
Centisome position: 11.89
GC content: 47.25
Gene sequence:
>2832_bases ATGCAAGATAAAATTGTCATTCATGGGGCGCGTGCCCATAATTTAAAAAATATTGATGTGGAGATTCCGCGAGACAAGTT GGTTGTCGTGACTGGCTTGTCAGGTTCAGGGAAGTCCAGTCTGGCTTTTGATACTCTCTATGCGGAGGGACAACGTCGCT ATGTAGAGAGTTTGTCTGCCTACGCTCGTCAGTTCTTGGGAAATATGGAAAAACCAGATGTAGATGCCATTGATGGTCTC AGCCCAGCTATTTCCATCGACCAGAAAACGACTAGTAAAAATCCTCGCTCGACGGTGGGAACGACGACTGAAATCAATGA CTATCTGCGTCTCCTCTACGCACGTGTGGGGACGCCTTACTGTATCAACGGACATGGAGCTATCAATGCTTCTTCTGTGG AGCAAATCGTTGATAAGGTTTTGGAGTTACCTGAACGCCAGCGCTTGCAGATCTTGGCTCCTGTCATCCGCAAGAAAAAA GGCCAACATAAGAGTGTTATCGAGAAGGTTCAGAAAGACGGGTATGTTCGTGTTCGTGTGGATGGGGAAGTCTATGATGT GACCGAAGTGCCAGAGTTGTCTAAGAGCAAGCAACACAATATCGATGTCGTGGTTGACCGTATTGTTATCAAGGAGGGCA TTCGTAGCCGTCTCTTTGATTCCATTGAAGCTGCCCTTCGTATCGCAGAAGGTTATGTGATTATCGACACCATGGACGAC TCTGAGTTGTTGTTCTCTGAGCATTATGCCTGTCCAGTTTGTGGATTTACTGTCCCAGAGTTAGAACCTCGTCTCTTCTC TTTCAATGCTCCCTTTGGCTCTTGTAGTGAGTGTGACGGCTTGGGGATTAAGCTGGAGGTGGATACTGATTTGGTAGTGC CAGATGCCAGCAAAACCTTACATGAGGGAGCGCTGGCACCTTGGAATCCTATCTCATCCAACTACTATCCAAACATGTTA GAGCAGGCCATGAAAGTCTTTGGAGTGGCTATGGATAAGCCTTTTGAGGACCTGTCAGAAGAAGATAAGAACTTGATTCT CTATGGGTCAGATGGTAAGGAATTCCATTTCCACTATGAGAATGAATTTGGTGGCGTGCGCGATATCGACATTCCGTTTG AGGGAGTTATCAATAATATCAAACGTCGTTACCATGAAACCAATAGCGATTACACTCGCACTCAGATGCGTCTCTACATG AATGAGCTGACCTGCGGAACCTGTCAAGGCTATCGTCTCAATGACCAGGCCTTGTCTGTCCGTGTGGGCGGCCAGCAAGG GCCACATATTGGAGAAATCTCAGACCTGTCTATCGCTGACCACTTGGACTTGGTGAGCCAGTTAACTTTGTCTGAAAATG AAGCCATCATTGCTCGTCCCATTCTCAAGGAAATCAAGGATCGTTTGACCTTCCTTAATAATGTGGGTCTTAACTATCTA ACCCTGTCACGTTCAGCAGGAACCCTTTCAGGTGGGGAAAGTCAGCGCATTCGTTTGGCAACCCAGATTGGTTCCAACCT ATCAGGCGTCCTCTATATCCTAGACGAGCCGTCAATCGGTCTTCACCAGAGAGACAATGACCGCCTGATTGCCAGTCTGA AAAAGATGCGTGACTTGGGCAATACTCTTATCGTGGTGGAACACGACGAAGATACCATGCGTGAAGCTGATTATCTGATT GACGTTGGTCCTGGTGCCGGTGTTTTTGGTGGTGAGATTGTTGCAGCAGGTACACCTAAGCAAGTGGCTCGCAACAGCAA GTCTATCACAGGTCAGTACTTGTCAGGTAAACGTGTCATCCCAGTACCAGAAGAGCGCCGTGTCGGAAATGGTCGTTTTA TTGAAGTGATAGGAGCGCGTGAGAACAACTTGCAAAATGTCACGGCTCGCTTTCCACTAGGAAAATTTATCGCAGTGACA GGTGTGTCGGGTTCAGGGAAATCGACTCTAATCAACAGCATTCTCAAAAAAGCCATTGCCCAGAAGCTCAACCGTAATTC AGACAAACCTGGTAAGTTTAAGACTATTACAGGGATTGAGCATGTCGACCGTTTGATTGATATTGACCAGAGCCCTATCG GACGGACGCCGAGGTCTAACCCAGCTACCTATACAGGAGTTTTTGACGATATACGTGACCTTTTTGCTCAGACAAATGAA GCCAAGATTCGAGGCTACAAGAAGGGGCGCTTCAGTTTCAACGTCAAGGGAGGTCGCTGTGAAGCTTGCTCAGGTGACGG GATTATCAAGATTGAGATGCACTTCTTGCCAGATGTTTATGTGGCTTGTGAAGTTTGCCACGGAACCCGCTATAACAGTG AAACCCTAGAAGTTCACTACAAGGAAAAGAATATTTCGCAGGTCTTGGATATGACGGTCAACGATGCGGTAGAATTTTTC CAACACATTCCGAAAATTCAACGCAAACTCCAGACCATCAAGGATGTAGGGCTAGGCTATGTGACCTTGGGACAGCCAGC TACCACCCTTTCTGGGGGAGAAGCCCAACGTATGAAGTTAGCTAGCGAACTCCACAAACGCTCGACAGGAAAATCTTTCT ACATTCTGGATGAGCCGACGACAGGGCTTCATACAGAGGACATTGCTCGCCTGCTCAAGGTTTTAGCTCGCTTTGTAGAC GATGGCAATACAGTCCTCGTCATCGAGCACAATCTGGATGTTATCAAGACGGCAGACCATATCATTGACTTGGGACCTGA GGGCGGTGTCGGTGGTGGAACCATCATCGTAACAGGAACTCCAGAAGAAGTAGCTGCCAACGAAGCCAGCTATACAGGAC ACTATTTGAAAGGAAAGTTACATCATGAATAA
Upstream 100 bases:
>100_bases TAAGCGATTGTTGATTATACTACAAAATCGGCCTTTTGGGTAATAGAATCTCACTTTTTTTGGTATAATGGTAAGCAATA ATGGACTAGAAAGAACAAAG
Downstream 100 bases:
>100_bases ACGCGTACAAGCATTTCTAGCTAAAATGCAAGAAAAAGAACTAGATGGTATCATCATCAACAATCTTAAAAACGTCTATT ATTTGACTGGTTTTTGGGGC
Product: excinuclease ABC subunit A
Products: NA
Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]
Number of amino acids: Translated: 943; Mature: 943
Protein sequence:
>943_residues MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGNMEKPDVDAIDGL SPAISIDQKTTSKNPRSTVGTTTEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKK GQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRLFDSIEAALRIAEGYVIIDTMDD SELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCSECDGLGIKLEVDTDLVVPDASKTLHEGALAPWNPISSNYYPNML EQAMKVFGVAMDKPFEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYTRTQMRLYM NELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTLSENEAIIARPILKEIKDRLTFLNNVGLNYL TLSRSAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLI DVGPGAGVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVIGARENNLQNVTARFPLGKFIAVT GVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHVDRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNE AKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVEFF QHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYILDEPTTGLHTEDIARLLKVLARFVD DGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGTIIVTGTPEEVAANEASYTGHYLKGKLHHE
Sequences:
>Translated_943_residues MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGNMEKPDVDAIDGL SPAISIDQKTTSKNPRSTVGTTTEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKK GQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRLFDSIEAALRIAEGYVIIDTMDD SELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCSECDGLGIKLEVDTDLVVPDASKTLHEGALAPWNPISSNYYPNML EQAMKVFGVAMDKPFEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYTRTQMRLYM NELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTLSENEAIIARPILKEIKDRLTFLNNVGLNYL TLSRSAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLI DVGPGAGVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVIGARENNLQNVTARFPLGKFIAVT GVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHVDRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNE AKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVEFF QHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYILDEPTTGLHTEDIARLLKVLARFVD DGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGTIIVTGTPEEVAANEASYTGHYLKGKLHHE >Mature_943_residues MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLGNMEKPDVDAIDGL SPAISIDQKTTSKNPRSTVGTTTEINDYLRLLYARVGTPYCINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKK GQHKSVIEKVQKDGYVRVRVDGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRLFDSIEAALRIAEGYVIIDTMDD SELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCSECDGLGIKLEVDTDLVVPDASKTLHEGALAPWNPISSNYYPNML EQAMKVFGVAMDKPFEDLSEEDKNLILYGSDGKEFHFHYENEFGGVRDIDIPFEGVINNIKRRYHETNSDYTRTQMRLYM NELTCGTCQGYRLNDQALSVRVGGQQGPHIGEISDLSIADHLDLVSQLTLSENEAIIARPILKEIKDRLTFLNNVGLNYL TLSRSAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIASLKKMRDLGNTLIVVEHDEDTMREADYLI DVGPGAGVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVIPVPEERRVGNGRFIEVIGARENNLQNVTARFPLGKFIAVT GVSGSGKSTLINSILKKAIAQKLNRNSDKPGKFKTITGIEHVDRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNE AKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHYKEKNISQVLDMTVNDAVEFF QHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSFYILDEPTTGLHTEDIARLLKVLARFVD DGNTVLVIEHNLDVIKTADHIIDLGPEGGVGGGTIIVTGTPEEVAANEASYTGHYLKGKLHHE
Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h
COG id: COG0178
COG function: function code L; Excinuclease ATPase subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ABC transporter domains [H]
Homologues:
Organism=Escherichia coli, GI2367343, Length=943, Percent_Identity=57.3700954400848, Blast_Score=1064, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003439 - InterPro: IPR017871 - InterPro: IPR013815 - InterPro: IPR003593 - InterPro: IPR004602 [H]
Pfam domain/function: PF00005 ABC_tran [H]
EC number: NA
Molecular weight: Translated: 104168; Mature: 104168
Theoretical pI: Translated: 6.33; Mature: 6.33
Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSA CCCCEEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHH YARQFLGNMEKPDVDAIDGLSPAISIDQKTTSKNPRSTVGTTTEINDYLRLLYARVGTPY HHHHHHCCCCCCCCCHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE CINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKKGQHKSVIEKVQKDGYVRVRV EECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEE DGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRLFDSIEAALRIAEGYVIIDTMDD CCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC SELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCSECDGLGIKLEVDTDLVVPDASKTL CHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCEECCCCHHHH HEGALAPWNPISSNYYPNMLEQAMKVFGVAMDKPFEDLSEEDKNLILYGSDGKEFHFHYE HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEECCCCCEEEEEEE NEFGGVRDIDIPFEGVINNIKRRYHETNSDYTRTQMRLYMNELTCGTCQGYRLNDQALSV CCCCCEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCEEEE RVGGQQGPHIGEISDLSIADHLDLVSQLTLSENEAIIARPILKEIKDRLTFLNNVGLNYL EECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCEEE TLSRSAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIASLKKMRDLG EEECCCCCCCCCCCCEEEEEEHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCC NTLIVVEHDEDTMREADYLIDVGPGAGVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVI CEEEEEECCCHHHHCCCEEEECCCCCCCCCCEEEECCCHHHHHCCCCCCCEEECCCCEEE PVPEERRVGNGRFIEVIGARENNLQNVTARFPLGKFIAVTGVSGSGKSTLINSILKKAIA CCCHHCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHH QKLNRNSDKPGKFKTITGIEHVDRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNE HHHHCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCCC AKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHY HHEEEEECCEEEEEECCCEEEECCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEE KEKNISQVLDMTVNDAVEFFQHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKL CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHH ASELHKRSTGKSFYILDEPTTGLHTEDIARLLKVLARFVDDGNTVLVIEHNLDVIKTADH HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCH IIDLGPEGGVGGGTIIVTGTPEEVAANEASYTGHYLKGKLHHE HEECCCCCCCCCCEEEEECCCHHHHCCCCCCCCCEEECEECCC >Mature Secondary Structure MQDKIVIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSA CCCCEEEEECCCCCCCCCEEECCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHH YARQFLGNMEKPDVDAIDGLSPAISIDQKTTSKNPRSTVGTTTEINDYLRLLYARVGTPY HHHHHHCCCCCCCCCHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCE CINGHGAINASSVEQIVDKVLELPERQRLQILAPVIRKKKGQHKSVIEKVQKDGYVRVRV EECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEEEE DGEVYDVTEVPELSKSKQHNIDVVVDRIVIKEGIRSRLFDSIEAALRIAEGYVIIDTMDD CCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC SELLFSEHYACPVCGFTVPELEPRLFSFNAPFGSCSECDGLGIKLEVDTDLVVPDASKTL CHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCEECCCCHHHH HEGALAPWNPISSNYYPNMLEQAMKVFGVAMDKPFEDLSEEDKNLILYGSDGKEFHFHYE HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEECCCCCEEEEEEE NEFGGVRDIDIPFEGVINNIKRRYHETNSDYTRTQMRLYMNELTCGTCQGYRLNDQALSV CCCCCEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCEEEE RVGGQQGPHIGEISDLSIADHLDLVSQLTLSENEAIIARPILKEIKDRLTFLNNVGLNYL EECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCEEE TLSRSAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIASLKKMRDLG EEECCCCCCCCCCCCEEEEEEHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCC NTLIVVEHDEDTMREADYLIDVGPGAGVFGGEIVAAGTPKQVARNSKSITGQYLSGKRVI CEEEEEECCCHHHHCCCEEEECCCCCCCCCCEEEECCCHHHHHCCCCCCCEEECCCCEEE PVPEERRVGNGRFIEVIGARENNLQNVTARFPLGKFIAVTGVSGSGKSTLINSILKKAIA CCCHHCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHH QKLNRNSDKPGKFKTITGIEHVDRLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNE HHHHCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCCC AKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVYVACEVCHGTRYNSETLEVHY HHEEEEECCEEEEEECCCEEEECCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEE KEKNISQVLDMTVNDAVEFFQHIPKIQRKLQTIKDVGLGYVTLGQPATTLSGGEAQRMKL CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHH ASELHKRSTGKSFYILDEPTTGLHTEDIARLLKVLARFVDDGNTVLVIEHNLDVIKTADH HHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCH IIDLGPEGGVGGGTIIVTGTPEEVAANEASYTGHYLKGKLHHE HEECCCCCCCCCCEEEEECCCHHHHCCCCCCCCCEEECEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: DNA [C]
Specific reaction: Protein + DNA = Protein-DNA [C]
General reaction: Hydrolase; Acting on ester bonds [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11463916 [H]