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The map label for this gene is pyrE [H]

Identifier: 169833203

GI number: 169833203

Start: 738643

End: 739275

Strand: Direct

Name: pyrE [H]

Synonym: SPH_0786

Alternate gene names: 169833203

Gene position: 738643-739275 (Clockwise)

Preceding gene: 169833557

Following gene: 169833907

Centisome position: 32.89

GC content: 44.08

Gene sequence:

>633_bases
ATGACACTTGCTAAAGATATCGCTAGCCACCTCTTGAAAATCCAAGCCGTTTACCTCAAACCAGAGGAACCCTTCACTTG
GGCATCTGGTATCAAGTCACCGATTTACACTGATAATCGTGTGACACTAGCCTATCCAGAAACTCGTACCCTAATTGAAA
ATGGTTTTGTGGATGCTATCAAAGAAGCCTTTCCTGAAGTAGAAGTGATTGCAGGAACTGCAACAGCAGGGATTCCACAC
GGAGCCATTATTGCTGATAAGATGGACTTGCCTTTTGCCTACATCCGTAGCAAACCAAAAGACCATGGAGCTGGTAATCA
AATCGAAGGTCGCGTAGCTCAAGGTCAAAAAATGGTAGTGGTTGAAGACCTTATTTCAACGGGTGGTTCAGTTCTTGAAG
CTGTAGCAGCAGCCAAGCGAGAAGGAGCAGATGTGCTTGGAGTTGTAGCGATTTTCAGCTACCAATTGCCAAAAGCAGAT
AAGAACTTTGCAGATGCTGGTGTTAAACTTGTGACGCTTTCAAACTATAGCGAGCTTATCCATCTAGCCCAAGAAGAAGG
TTACATCACGCCAGAGGGCCTTGATCTTCTAAAACGCTTTAAAGAAGACCAAAAAAATTGGCAAGAAGGTTAG

Upstream 100 bases:

>100_bases
CCAAGCTGAGGATCCTGTTGCAGCTTATCATGCCATCAAGGATGAATGGACACAGGACTGGAATTAAAGAACTAGATTAG
AAAAATAAAAGGAGAATACC

Downstream 100 bases:

>100_bases
GTCAGTAAGATAAAGAGAGACGAGGCTACCGAGCCTCTTTTACCATTTTATTTAAAATATGACAATATTTTAAATAAAAT
GATTGACAACGCTTTCTTTT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLAYPETRTLIENGFVDAIKEAFPEVEVIAGTATAGIPH
GAIIADKMDLPFAYIRSKPKDHGAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKAD
KNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQKNWQEG

Sequences:

>Translated_210_residues
MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLAYPETRTLIENGFVDAIKEAFPEVEVIAGTATAGIPH
GAIIADKMDLPFAYIRSKPKDHGAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKAD
KNFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQKNWQEG
>Mature_209_residues
TLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLAYPETRTLIENGFVDAIKEAFPEVEVIAGTATAGIPHG
AIIADKMDLPFAYIRSKPKDHGAGNQIEGRVAQGQKMVVVEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKADK
NFADAGVKLVTLSNYSELIHLAQEEGYITPEGLDLLKRFKEDQKNWQEG

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=180, Percent_Identity=23.8888888888889, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17933654, Length=201, Percent_Identity=25.3731343283582, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22826; Mature: 22695

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLAYPETRTLIENGFVDAI
CCHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCCCEECCEEEEECCCHHHHHHHCHHHHH
KEAFPEVEVIAGTATAGIPHGAIIADKMDLPFAYIRSKPKDHGAGNQIEGRVAQGQKMVV
HHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCHHCCCCEEEE
VEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKADKNFADAGVKLVTLSNYSELI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHCCEEEEEECCHHHHH
HLAQEEGYITPEGLDLLKRFKEDQKNWQEG
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLAKDIASHLLKIQAVYLKPEEPFTWASGIKSPIYTDNRVTLAYPETRTLIENGFVDAI
CHHHHHHHHHHHHHHEEECCCCCCHHHHCCCCCCEECCEEEEECCCHHHHHHHCHHHHH
KEAFPEVEVIAGTATAGIPHGAIIADKMDLPFAYIRSKPKDHGAGNQIEGRVAQGQKMVV
HHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCHHCCCCEEEE
VEDLISTGGSVLEAVAAAKREGADVLGVVAIFSYQLPKADKNFADAGVKLVTLSNYSELI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHCCEEEEEECCHHHHH
HLAQEEGYITPEGLDLLKRFKEDQKNWQEG
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA