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The map label for this gene is lytC [H]

Identifier: 169825249

GI number: 169825249

Start: 1722867

End: 1724297

Strand: Direct

Name: lytC [H]

Synonym: FMG_1552

Alternate gene names: 169825249

Gene position: 1722867-1724297 (Clockwise)

Preceding gene: 169825248

Following gene: 169825251

Centisome position: 95.84

GC content: 38.09

Gene sequence:

>1431_bases
ATGAAAAAATTGGTGGCTTTGATGCTAGCTTGTATGTTGAGTTTGCCTGTGGTGAGCGTTGCAGACAAGGATAGCACAAA
TGATAGAATTTCTGAAAAGATAGAAGCTCATACATTTGATTCTGCAACAAAATCTGATGCAGATACAAATAGCAAAAAGA
CAGATGCAAAAGACAAACAAGCTGGTGCGAAGGATCAAAAATCTGATGCAAAGGATACGTCAAATAAAAAAGATACATCT
GATAAAAAAGATGCAACGGATAAAAAAGATTCTTCCGAGAAGAAAAAAAACGAGAAAAAACAAGACCAAATCACCACTAA
CGAAGATGGTGTGTTCAAAAATGTTATTCACCAAAGATTCCAAGGTGAAAACAGGGCGAAGACTGCAGTGAATGTGCAAC
GTCATTACTTTGCGAATACAAACAAGGTAATTCTTGTCAACGACAACGCATATCCCGATGCAATCAGTGCAACGAATGTG
TCTATGGGCAAATACCCACTTTTGTACACTGGGAAAAATTCATTATCCATCGAAACCAAATCTGCGCTTGACAAGATGTT
CTTGGACGAGATTTATCTAATGGGTGGCGTGAATACTATAAGTAAAAAGGTTGAAAATAGTTTGAAAAGAAATTTCCCAC
ACGCAAAAATCACTAGAATTATGGGAAGTAATCGTTACGACACATCAGCTCAATCTGCGAGAACTCGTGCAAAAACCACT
AACTTGATATTTGCCGCAGGAACAAATTATGCAGATGCATTGTATGCTACAAGTCTTGCAGCACACCAAAATGCACCGAT
ACTACTTGTAAGTAATGATGGCATTAACCAATCTACTGCAAATTTCATCAAATCATTGGGAAATATCCACAACGTGACAA
TCGTCGGTGGAGAAATATCTGTAAATCAATCTGTGAAAAACCAAATCGAAGCCTTGACTAGAAAACCTGTCACAAGACTT
GCAGGTGTGGACAGATACGAATCCAGCGTTGAAGTCGCAAAAAGAGTGAACGCAAACCCAGCAGAAGTCATCACTACAAG
CGGTGAAGTGTTCGCCGATGCACTCGTGTCATCGACAGTTGCACAAAAAATCAAAGCGCCAATCTTGCTTGTGAAAAAAG
ACGTCCTACCACTTTCAGTTAGAGAATATTTGAAAAAAACCAACTCCATTTACAAATTAACTACAATCGGAGGATACAAC
ACAGTTACCAAAAACAATTACTCCACACAAGTAATATTAATATCGGGACTCGACATCGACAAACCACTTGTCGACAAACA
AGGAAAAGGCATAATCAAAGCCTTCACAAAAGATTACAAAAAATACTACGTACTTCCAAACAACAAATACTACAGTGCAA
TCAAAGAATACGACAAATTGTTCGTATACTTGAGAGATGCATTGGCAGAAGATTACAGACCATTGGAATAA

Upstream 100 bases:

>100_bases
GTGCGATTGGTTTTCTGATGGGTACAACTTTGTTGTTTTTCATCATTTTGAATTAGTTTTAATTAGTTGTGATGTAGTTA
GGAATTAAAAGGAGTGTTTT

Downstream 100 bases:

>100_bases
CGAAAAAATCAAAAGAGGACAATGTCCTCTTTTTTTGATGCAAAAAAATAGACGAAACCCTCGCCTATTAAAAGAACAAA
TAATTCAAAATATACATCGT

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKKLVALMLACMLSLPVVSVADKDSTNDRISEKIEAHTFDSATKSDADTNSKKTDAKDKQAGAKDQKSDAKDTSNKKDTS
DKKDATDKKDSSEKKKNEKKQDQITTNEDGVFKNVIHQRFQGENRAKTAVNVQRHYFANTNKVILVNDNAYPDAISATNV
SMGKYPLLYTGKNSLSIETKSALDKMFLDEIYLMGGVNTISKKVENSLKRNFPHAKITRIMGSNRYDTSAQSARTRAKTT
NLIFAAGTNYADALYATSLAAHQNAPILLVSNDGINQSTANFIKSLGNIHNVTIVGGEISVNQSVKNQIEALTRKPVTRL
AGVDRYESSVEVAKRVNANPAEVITTSGEVFADALVSSTVAQKIKAPILLVKKDVLPLSVREYLKKTNSIYKLTTIGGYN
TVTKNNYSTQVILISGLDIDKPLVDKQGKGIIKAFTKDYKKYYVLPNNKYYSAIKEYDKLFVYLRDALAEDYRPLE

Sequences:

>Translated_476_residues
MKKLVALMLACMLSLPVVSVADKDSTNDRISEKIEAHTFDSATKSDADTNSKKTDAKDKQAGAKDQKSDAKDTSNKKDTS
DKKDATDKKDSSEKKKNEKKQDQITTNEDGVFKNVIHQRFQGENRAKTAVNVQRHYFANTNKVILVNDNAYPDAISATNV
SMGKYPLLYTGKNSLSIETKSALDKMFLDEIYLMGGVNTISKKVENSLKRNFPHAKITRIMGSNRYDTSAQSARTRAKTT
NLIFAAGTNYADALYATSLAAHQNAPILLVSNDGINQSTANFIKSLGNIHNVTIVGGEISVNQSVKNQIEALTRKPVTRL
AGVDRYESSVEVAKRVNANPAEVITTSGEVFADALVSSTVAQKIKAPILLVKKDVLPLSVREYLKKTNSIYKLTTIGGYN
TVTKNNYSTQVILISGLDIDKPLVDKQGKGIIKAFTKDYKKYYVLPNNKYYSAIKEYDKLFVYLRDALAEDYRPLE
>Mature_476_residues
MKKLVALMLACMLSLPVVSVADKDSTNDRISEKIEAHTFDSATKSDADTNSKKTDAKDKQAGAKDQKSDAKDTSNKKDTS
DKKDATDKKDSSEKKKNEKKQDQITTNEDGVFKNVIHQRFQGENRAKTAVNVQRHYFANTNKVILVNDNAYPDAISATNV
SMGKYPLLYTGKNSLSIETKSALDKMFLDEIYLMGGVNTISKKVENSLKRNFPHAKITRIMGSNRYDTSAQSARTRAKTT
NLIFAAGTNYADALYATSLAAHQNAPILLVSNDGINQSTANFIKSLGNIHNVTIVGGEISVNQSVKNQIEALTRKPVTRL
AGVDRYESSVEVAKRVNANPAEVITTSGEVFADALVSSTVAQKIKAPILLVKKDVLPLSVREYLKKTNSIYKLTTIGGYN
TVTKNNYSTQVILISGLDIDKPLVDKQGKGIIKAFTKDYKKYYVLPNNKYYSAIKEYDKLFVYLRDALAEDYRPLE

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG2247

COG function: function code M; Putative cell wall-binding domain

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 52646; Mature: 52646

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVALMLACMLSLPVVSVADKDSTNDRISEKIEAHTFDSATKSDADTNSKKTDAKDKQ
CHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
AGAKDQKSDAKDTSNKKDTSDKKDATDKKDSSEKKKNEKKQDQITTNEDGVFKNVIHQRF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
QGENRAKTAVNVQRHYFANTNKVILVNDNAYPDAISATNVSMGKYPLLYTGKNSLSIETK
CCCCHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEHH
SALDKMFLDEIYLMGGVNTISKKVENSLKRNFPHAKITRIMGSNRYDTSAQSARTRAKTT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHC
NLIFAAGTNYADALYATSLAAHQNAPILLVSNDGINQSTANFIKSLGNIHNVTIVGGEIS
EEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEE
VNQSVKNQIEALTRKPVTRLAGVDRYESSVEVAKRVNANPAEVITTSGEVFADALVSSTV
CCHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHCCCCHHHEEECCCHHHHHHHHHHHH
AQKIKAPILLVKKDVLPLSVREYLKKTNSIYKLTTIGGYNTVTKNNYSTQVILISGLDID
HHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEECCCCCEEEEEEECCCCC
KPLVDKQGKGIIKAFTKDYKKYYVLPNNKYYSAIKEYDKLFVYLRDALAEDYRPLE
CCCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKLVALMLACMLSLPVVSVADKDSTNDRISEKIEAHTFDSATKSDADTNSKKTDAKDKQ
CHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
AGAKDQKSDAKDTSNKKDTSDKKDATDKKDSSEKKKNEKKQDQITTNEDGVFKNVIHQRF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
QGENRAKTAVNVQRHYFANTNKVILVNDNAYPDAISATNVSMGKYPLLYTGKNSLSIETK
CCCCHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEHH
SALDKMFLDEIYLMGGVNTISKKVENSLKRNFPHAKITRIMGSNRYDTSAQSARTRAKTT
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHC
NLIFAAGTNYADALYATSLAAHQNAPILLVSNDGINQSTANFIKSLGNIHNVTIVGGEIS
EEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCEEE
VNQSVKNQIEALTRKPVTRLAGVDRYESSVEVAKRVNANPAEVITTSGEVFADALVSSTV
CCHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHCCCCHHHEEECCCHHHHHHHHHHHH
AQKIKAPILLVKKDVLPLSVREYLKKTNSIYKLTTIGGYNTVTKNNYSTQVILISGLDID
HHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEECCCCCEEEEEEECCCCC
KPLVDKQGKGIIKAFTKDYKKYYVLPNNKYYSAIKEYDKLFVYLRDALAEDYRPLE
CCCCCCCCCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]