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The map label for this gene is mutL [H]

Identifier: 169824441

GI number: 169824441

Start: 809039

End: 810922

Strand: Direct

Name: mutL [H]

Synonym: FMG_0744

Alternate gene names: 169824441

Gene position: 809039-810922 (Clockwise)

Preceding gene: 169824440

Following gene: 169824442

Centisome position: 45.01

GC content: 26.65

Gene sequence:

>1884_bases
ATGATTAAGTTATTATCAGAAGATACAATACAAAAAATTGCAGCAGGTGAAGTTATTGAAAGGCCTGTTTCTGTTATTAA
AGAATTAGTTGAAAATTCAATAGATGCTGGCAGTGATACCATTATTGTAGAAATTAAAAATGGCGGAAAAGATTATATTT
CAGTTAGCGATAATGGGTTGGGAATTGAAAAAAATGAAATAGAATTAGCGTTTAAAAGACATTCAACTAGTAAACTTGAA
AAATTTGATGATTTATATGATATAAGGACATTGGGTTTTAGAGGAGAAGCTTTGGCTAGTATTCTAGCTGTGAGTAAACT
TATTGTAAGTACTAGAACAAAATCAGAAAAAATCGGTAAAAAAGTTGAGTTTAGAAATTCAAAAGTTATAAATGAATCAG
ATGTTGCCATGAATGTAGGAACTAAAATAGTAATAAAAGATTTGTTTTATAATGTACCTGTAAGAAAAAAGTTTATGAAG
TCAGATCAGACAGAAGCAAATCTAATAACAACAACAATGTATAAATTTGCTATTTGCAACACAGATGTTTCTATCAAATA
CATTAAAGATAACAAAACATTATTTGAGACTAAGAAGAATTCTTCAATTAAGGAGAATATTATTAATTTATTTGGCACTT
CAATGTCCAATAACTTAATAGATATTGATATAAGTTCACACGATTACAAAATTCACGGATATATTTCAAATAATAATTTG
TATAGAGCTAATAGGCAGATGCAATATATTTTCTTAAATGGTAGATTTATTAAATCGGAAGATATCAGAAATACTGTTGA
ATCTAACTATAAATCTGTAATTCCTAACGGGAGATTTACACTATTTTGGCTTTTTTTTGAAATAAATCCTAAGCTTGTAG
ATGTTAATGTCCATCCGAATAAACAAAAAGTGAAAATATCTATTTTGGATGAAATATTGGAACAACTCAATAAAAGGGTT
AGATTTTTATTAGAAAATAACGTTAAAATTACAAATATTAGTCAATCAATTCCTGATGATGATAAGTACAAAGATTTAAG
AAGAAATTATTTTGAATCTGATTCTAACTTAACTAACTATAAATATGATAAGGTATCAGAGCCAACTTATTCTTATAATC
TTTTCAACGATAATTCAAAATTAAGCAATTTAAGAAATATAAGATATAAAGATGAGTCAGAAGCATTTAATAAAAAGCCA
GAAACTAATAAATATTTTTTTAAAGAGAAAGATGTAGCGAAACAAGATAACTTCTTTCTTGACGAAAACGAACAAATTAA
AGTTGAATCTTATTTAGCAAAATATGAAAAATTTGATATACTTACAGTTTTATTCAAAACATATATTTTAGCTAAGGATG
AATATGACAGTAAAATTTATTTATTTGATCAACATGCCTGTCATGAGAGAATTAATTATGAAAAGTTAACAAAACAAATG
TTAGATAAGGAAGTAGTGTCACAAAATTTAGCATTTCCAATTAACATTTCATTAACTGATGAACTCATGGAAATATATAC
CAATAATAAGAGCATATTTGAAGAATTGGGATATGAAAGTGATGTTTTTTCTGATGATTCAGTAGTGGTTCGTGCTGTCC
CTTATCTATTCGGAAACTCAAATGCCGAGTTTTTATTTACCGATATCTTGGATACTATTGCTAAGAATTCAAATGATCCT
TTTGACGTAATTGAATCTAAAGTTATAAAAAGATCTTGCAAAATGAGTGTAAAAGCAGGTGACACTTTAAGTAACTTCGA
AATAATTAAACTTTTAGAAGATTTGTTTAAATGTGAATATCCATTAACATGTCCTCATGGAAGGCCAACTTTTATTGAAA
TGAATGAAAAAGATCTAGAAAAAATGTTTATGAGGATAAAATGA

Upstream 100 bases:

>100_bases
GATGAAATTAAAAATATTAATGTAAATGAGATTACTCCAATACAGTCTCTACAACTATTAAATGAGCTAGTTATTAAAGC
TTCAAAATTAGGTGATTAAA

Downstream 100 bases:

>100_bases
GGAAAAAATGTATTGTAATAGTTGGACCTACTGGAGTGGGGAAGACCAGGTTGAGTATTTTTTTAGCAAAAAGATTAAGT
AGTGAGATTATTTCTGCAGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MIKLLSEDTIQKIAAGEVIERPVSVIKELVENSIDAGSDTIIVEIKNGGKDYISVSDNGLGIEKNEIELAFKRHSTSKLE
KFDDLYDIRTLGFRGEALASILAVSKLIVSTRTKSEKIGKKVEFRNSKVINESDVAMNVGTKIVIKDLFYNVPVRKKFMK
SDQTEANLITTTMYKFAICNTDVSIKYIKDNKTLFETKKNSSIKENIINLFGTSMSNNLIDIDISSHDYKIHGYISNNNL
YRANRQMQYIFLNGRFIKSEDIRNTVESNYKSVIPNGRFTLFWLFFEINPKLVDVNVHPNKQKVKISILDEILEQLNKRV
RFLLENNVKITNISQSIPDDDKYKDLRRNYFESDSNLTNYKYDKVSEPTYSYNLFNDNSKLSNLRNIRYKDESEAFNKKP
ETNKYFFKEKDVAKQDNFFLDENEQIKVESYLAKYEKFDILTVLFKTYILAKDEYDSKIYLFDQHACHERINYEKLTKQM
LDKEVVSQNLAFPINISLTDELMEIYTNNKSIFEELGYESDVFSDDSVVVRAVPYLFGNSNAEFLFTDILDTIAKNSNDP
FDVIESKVIKRSCKMSVKAGDTLSNFEIIKLLEDLFKCEYPLTCPHGRPTFIEMNEKDLEKMFMRIK

Sequences:

>Translated_627_residues
MIKLLSEDTIQKIAAGEVIERPVSVIKELVENSIDAGSDTIIVEIKNGGKDYISVSDNGLGIEKNEIELAFKRHSTSKLE
KFDDLYDIRTLGFRGEALASILAVSKLIVSTRTKSEKIGKKVEFRNSKVINESDVAMNVGTKIVIKDLFYNVPVRKKFMK
SDQTEANLITTTMYKFAICNTDVSIKYIKDNKTLFETKKNSSIKENIINLFGTSMSNNLIDIDISSHDYKIHGYISNNNL
YRANRQMQYIFLNGRFIKSEDIRNTVESNYKSVIPNGRFTLFWLFFEINPKLVDVNVHPNKQKVKISILDEILEQLNKRV
RFLLENNVKITNISQSIPDDDKYKDLRRNYFESDSNLTNYKYDKVSEPTYSYNLFNDNSKLSNLRNIRYKDESEAFNKKP
ETNKYFFKEKDVAKQDNFFLDENEQIKVESYLAKYEKFDILTVLFKTYILAKDEYDSKIYLFDQHACHERINYEKLTKQM
LDKEVVSQNLAFPINISLTDELMEIYTNNKSIFEELGYESDVFSDDSVVVRAVPYLFGNSNAEFLFTDILDTIAKNSNDP
FDVIESKVIKRSCKMSVKAGDTLSNFEIIKLLEDLFKCEYPLTCPHGRPTFIEMNEKDLEKMFMRIK
>Mature_627_residues
MIKLLSEDTIQKIAAGEVIERPVSVIKELVENSIDAGSDTIIVEIKNGGKDYISVSDNGLGIEKNEIELAFKRHSTSKLE
KFDDLYDIRTLGFRGEALASILAVSKLIVSTRTKSEKIGKKVEFRNSKVINESDVAMNVGTKIVIKDLFYNVPVRKKFMK
SDQTEANLITTTMYKFAICNTDVSIKYIKDNKTLFETKKNSSIKENIINLFGTSMSNNLIDIDISSHDYKIHGYISNNNL
YRANRQMQYIFLNGRFIKSEDIRNTVESNYKSVIPNGRFTLFWLFFEINPKLVDVNVHPNKQKVKISILDEILEQLNKRV
RFLLENNVKITNISQSIPDDDKYKDLRRNYFESDSNLTNYKYDKVSEPTYSYNLFNDNSKLSNLRNIRYKDESEAFNKKP
ETNKYFFKEKDVAKQDNFFLDENEQIKVESYLAKYEKFDILTVLFKTYILAKDEYDSKIYLFDQHACHERINYEKLTKQM
LDKEVVSQNLAFPINISLTDELMEIYTNNKSIFEELGYESDVFSDDSVVVRAVPYLFGNSNAEFLFTDILDTIAKNSNDP
FDVIESKVIKRSCKMSVKAGDTLSNFEIIKLLEDLFKCEYPLTCPHGRPTFIEMNEKDLEKMFMRIK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=325, Percent_Identity=36.6153846153846, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4505913, Length=361, Percent_Identity=28.5318559556787, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI310128478, Length=361, Percent_Identity=28.5318559556787, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI4505911, Length=367, Percent_Identity=27.2479564032698, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI189458898, Length=367, Percent_Identity=27.2479564032698, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI263191589, Length=230, Percent_Identity=31.7391304347826, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI189458896, Length=360, Percent_Identity=27.7777777777778, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI310128480, Length=318, Percent_Identity=27.3584905660377, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=29.5454545454545, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=29.5454545454545, Blast_Score=107, Evalue=5e-23,
Organism=Escherichia coli, GI1790612, Length=628, Percent_Identity=28.9808917197452, Blast_Score=238, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=316, Percent_Identity=33.8607594936709, Blast_Score=193, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=340, Percent_Identity=29.4117647058824, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323819, Length=383, Percent_Identity=32.8981723237598, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324247, Length=326, Percent_Identity=32.2085889570552, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6325093, Length=732, Percent_Identity=22.5409836065574, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323063, Length=163, Percent_Identity=32.5153374233129, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136968, Length=352, Percent_Identity=34.9431818181818, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI17136970, Length=353, Percent_Identity=28.6118980169972, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 72835; Mature: 72835

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLLSEDTIQKIAAGEVIERPVSVIKELVENSIDAGSDTIIVEIKNGGKDYISVSDNGL
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCC
GIEKNEIELAFKRHSTSKLEKFDDLYDIRTLGFRGEALASILAVSKLIVSTRTKSEKIGK
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHCC
KVEFRNSKVINESDVAMNVGTKIVIKDLFYNVPVRKKFMKSDQTEANLITTTMYKFAICN
CEECCCCCCCCCCCCEEECCCEEEEEHHHHCCCHHHHHHCCCCCCCHHHHHEEEEEEEEC
TDVSIKYIKDNKTLFETKKNSSIKENIINLFGTSMSNNLIDIDISSHDYKIHGYISNNNL
CCCEEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCE
YRANRQMQYIFLNGRFIKSEDIRNTVESNYKSVIPNGRFTLFWLFFEINPKLVDVNVHPN
EECCCCEEEEEECCEEECCHHHHHHHHCCHHHHCCCCCEEEEEEEEEECCEEEEEEECCC
KQKVKISILDEILEQLNKRVRFLLENNVKITNISQSIPDDDKYKDLRRNYFESDSNLTNY
CCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCC
KYDKVSEPTYSYNLFNDNSKLSNLRNIRYKDESEAFNKKPETNKYFFKEKDVAKQDNFFL
CCCCCCCCCEEEEEECCCCHHHHHHCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCEEE
DENEQIKVESYLAKYEKFDILTVLFKTYILAKDEYDSKIYLFDQHACHERINYEKLTKQM
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEECHHHHHHCCHHHHHHHH
LDKEVVSQNLAFPINISLTDELMEIYTNNKSIFEELGYESDVFSDDSVVVRAVPYLFGNS
HHHHHHHCCCCEEEEEEHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEEEEEHHHCCCC
NAEFLFTDILDTIAKNSNDPFDVIESKVIKRSCKMSVKAGDTLSNFEIIKLLEDLFKCEY
CCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHHCCC
PLTCPHGRPTFIEMNEKDLEKMFMRIK
CCCCCCCCCCEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MIKLLSEDTIQKIAAGEVIERPVSVIKELVENSIDAGSDTIIVEIKNGGKDYISVSDNGL
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCC
GIEKNEIELAFKRHSTSKLEKFDDLYDIRTLGFRGEALASILAVSKLIVSTRTKSEKIGK
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHCC
KVEFRNSKVINESDVAMNVGTKIVIKDLFYNVPVRKKFMKSDQTEANLITTTMYKFAICN
CEECCCCCCCCCCCCEEECCCEEEEEHHHHCCCHHHHHHCCCCCCCHHHHHEEEEEEEEC
TDVSIKYIKDNKTLFETKKNSSIKENIINLFGTSMSNNLIDIDISSHDYKIHGYISNNNL
CCCEEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEECCCE
YRANRQMQYIFLNGRFIKSEDIRNTVESNYKSVIPNGRFTLFWLFFEINPKLVDVNVHPN
EECCCCEEEEEECCEEECCHHHHHHHHCCHHHHCCCCCEEEEEEEEEECCEEEEEEECCC
KQKVKISILDEILEQLNKRVRFLLENNVKITNISQSIPDDDKYKDLRRNYFESDSNLTNY
CCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCC
KYDKVSEPTYSYNLFNDNSKLSNLRNIRYKDESEAFNKKPETNKYFFKEKDVAKQDNFFL
CCCCCCCCCEEEEEECCCCHHHHHHCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCEEE
DENEQIKVESYLAKYEKFDILTVLFKTYILAKDEYDSKIYLFDQHACHERINYEKLTKQM
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEECHHHHHHCCHHHHHHHH
LDKEVVSQNLAFPINISLTDELMEIYTNNKSIFEELGYESDVFSDDSVVVRAVPYLFGNS
HHHHHHHCCCCEEEEEEHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEEEEEHHHCCCC
NAEFLFTDILDTIAKNSNDPFDVIESKVIKRSCKMSVKAGDTLSNFEIIKLLEDLFKCEY
CCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHHCCC
PLTCPHGRPTFIEMNEKDLEKMFMRIK
CCCCCCCCCCEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]