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The map label for this gene is pyrC [H]

Identifier: 169824419

GI number: 169824419

Start: 783949

End: 785145

Strand: Direct

Name: pyrC [H]

Synonym: FMG_0722

Alternate gene names: 169824419

Gene position: 783949-785145 (Clockwise)

Preceding gene: 169824418

Following gene: 169824420

Centisome position: 43.61

GC content: 27.82

Gene sequence:

>1197_bases
ATGAAATTACTGCTTAAAAATTGTCATATCATAGATAGAGATAAAGATATTTTTGCTGATATTTTAATAGAAAACGCTAA
AATAAAAGCTATAGGACAAATATTAGAAGAATACGATGAAGTCATTGATGTTAACAATAAAATAGTAATGCCAGGTTTTA
TAGATTTGCATACTCATTTCAGATATCCTGGTCAAGAAAATAAAGAAGATTTATATACTGGTAGTCTATCAGCCCTTGCT
GGAGGCTACACTAGTTGTAATTTAATGGGAAATACAAAACCAGTTGTAGATAATAACGAAATCTACAATCAAATTATAGA
TAAATCAAAAGAAATTGATTTAATAAATATATATCAATGCATGGCAACAACAAAAGACTTACAATCAAAAGAGATGATTA
ATTTTAAAAAAGCAGATAATAAAATTAAATTCTTCAGCGAAGATGGGAAAGGAATAACAGACTCTTTACTAGCTTTTAAT
ATTTTTACAGAAATAGAAAAAATAAATAAGGGTATAATGATTCACGCTGAAGATCATAATCTAACTAAAATATCTACGAG
ATATGCAGAAGATTTAGAAACAATTAGAGATTGTTACTTGAGTTTGAAAACTGGATGTAGAGTTCATTTTTGCCATGTTA
GCACTATAGATTCTCTAGAAGCAATAAAATTTTACAAAGGTAAAAAAGCGCCAATCACTTGTGAAGTTACTCCTCATCAC
ATTTACATGAAAGATAGTGAATTTAGAGTAAATCCTTCTATAAGAACTCAAGAAGATATTGATTGTATCGTAGAAATGAT
AAAAAATAATACGGTAGATGCAATTGCAACAGATCATGCTCCACATACTAAAGAAGATAAAGATAACGGTGCATGTGGAA
TGATTGGGCTAGAAACAGCATTTAATATCGCATACAAAGTTTTACACGAAAATAATAATATTTCATTAAATAAAATTTCT
GAATTAATGAGTTACAATCCAGCCAAAATATTAGGGGAAAGAAAGGGAGTTATTAACCCAACCTATGATGCAGATTTAGT
TGTTATTGATATTGAAAAAGAAATTAAAGTTGAGAAATTTAATTCTAAATCAAATAACTCTCCATTTATTGGTGAAAAGT
TTAAAGGTAGTATTGAAATGACTATTGTTAACGGTGATGTAAAATTTGAGAAAGGAGTTAAAAATGATAATAGATAA

Upstream 100 bases:

>100_bases
AATCTGAACGTAGTATTGTACAAAAATTTAGCCTAGTAGATAAGGACACTAGAACATATAAATGTGATTATTGTGATCAT
CTATATAATGTGGAGGAATA

Downstream 100 bases:

>100_bases
GCTTTCTAAAAGAATAAACGAAAGATCTATAGTATGTGTAGGCTTAGATACTAGTACAGATTATGTACCAGAGAAAATAA
AAAAAGGTAAAAAAGTTAGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKLLLKNCHIIDRDKDIFADILIENAKIKAIGQILEEYDEVIDVNNKIVMPGFIDLHTHFRYPGQENKEDLYTGSLSALA
GGYTSCNLMGNTKPVVDNNEIYNQIIDKSKEIDLINIYQCMATTKDLQSKEMINFKKADNKIKFFSEDGKGITDSLLAFN
IFTEIEKINKGIMIHAEDHNLTKISTRYAEDLETIRDCYLSLKTGCRVHFCHVSTIDSLEAIKFYKGKKAPITCEVTPHH
IYMKDSEFRVNPSIRTQEDIDCIVEMIKNNTVDAIATDHAPHTKEDKDNGACGMIGLETAFNIAYKVLHENNNISLNKIS
ELMSYNPAKILGERKGVINPTYDADLVVIDIEKEIKVEKFNSKSNNSPFIGEKFKGSIEMTIVNGDVKFEKGVKNDNR

Sequences:

>Translated_398_residues
MKLLLKNCHIIDRDKDIFADILIENAKIKAIGQILEEYDEVIDVNNKIVMPGFIDLHTHFRYPGQENKEDLYTGSLSALA
GGYTSCNLMGNTKPVVDNNEIYNQIIDKSKEIDLINIYQCMATTKDLQSKEMINFKKADNKIKFFSEDGKGITDSLLAFN
IFTEIEKINKGIMIHAEDHNLTKISTRYAEDLETIRDCYLSLKTGCRVHFCHVSTIDSLEAIKFYKGKKAPITCEVTPHH
IYMKDSEFRVNPSIRTQEDIDCIVEMIKNNTVDAIATDHAPHTKEDKDNGACGMIGLETAFNIAYKVLHENNNISLNKIS
ELMSYNPAKILGERKGVINPTYDADLVVIDIEKEIKVEKFNSKSNNSPFIGEKFKGSIEMTIVNGDVKFEKGVKNDNR
>Mature_398_residues
MKLLLKNCHIIDRDKDIFADILIENAKIKAIGQILEEYDEVIDVNNKIVMPGFIDLHTHFRYPGQENKEDLYTGSLSALA
GGYTSCNLMGNTKPVVDNNEIYNQIIDKSKEIDLINIYQCMATTKDLQSKEMINFKKADNKIKFFSEDGKGITDSLLAFN
IFTEIEKINKGIMIHAEDHNLTKISTRYAEDLETIRDCYLSLKTGCRVHFCHVSTIDSLEAIKFYKGKKAPITCEVTPHH
IYMKDSEFRVNPSIRTQEDIDCIVEMIKNNTVDAIATDHAPHTKEDKDNGACGMIGLETAFNIAYKVLHENNNISLNKIS
ELMSYNPAKILGERKGVINPTYDADLVVIDIEKEIKVEKFNSKSNNSPFIGEKFKGSIEMTIVNGDVKFEKGVKNDNR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=396, Percent_Identity=25.2525252525253, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI19923821, Length=447, Percent_Identity=24.3847874720358, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4503379, Length=446, Percent_Identity=23.0941704035874, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4503375, Length=451, Percent_Identity=22.8381374722838, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI190194363, Length=449, Percent_Identity=22.271714922049, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786722, Length=440, Percent_Identity=25.6818181818182, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI193204318, Length=355, Percent_Identity=26.7605633802817, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24642586, Length=390, Percent_Identity=26.6666666666667, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45106; Mature: 45106

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLLKNCHIIDRDKDIFADILIENAKIKAIGQILEEYDEVIDVNNKIVMPGFIDLHTHF
CCEEECCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEEE
RYPGQENKEDLYTGSLSALAGGYTSCNLMGNTKPVVDNNEIYNQIIDKSKEIDLINIYQC
CCCCCCCCCHHHCCCHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHH
MATTKDLQSKEMINFKKADNKIKFFSEDGKGITDSLLAFNIFTEIEKINKGIMIHAEDHN
HHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
LTKISTRYAEDLETIRDCYLSLKTGCRVHFCHVSTIDSLEAIKFYKGKKAPITCEVTPHH
CEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCEEEEECCCE
IYMKDSEFRVNPSIRTQEDIDCIVEMIKNNTVDAIATDHAPHTKEDKDNGACGMIGLETA
EEEECCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHH
FNIAYKVLHENNNISLNKISELMSYNPAKILGERKGVINPTYDADLVVIDIEKEIKVEKF
HHEEEEEEECCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCEEEEEC
NSKSNNSPFIGEKFKGSIEMTIVNGDVKFEKGVKNDNR
CCCCCCCCCCCCCCCCEEEEEEEECCEEEECCCCCCCC
>Mature Secondary Structure
MKLLLKNCHIIDRDKDIFADILIENAKIKAIGQILEEYDEVIDVNNKIVMPGFIDLHTHF
CCEEECCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCEEEEEEEE
RYPGQENKEDLYTGSLSALAGGYTSCNLMGNTKPVVDNNEIYNQIIDKSKEIDLINIYQC
CCCCCCCCCHHHCCCHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHH
MATTKDLQSKEMINFKKADNKIKFFSEDGKGITDSLLAFNIFTEIEKINKGIMIHAEDHN
HHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
LTKISTRYAEDLETIRDCYLSLKTGCRVHFCHVSTIDSLEAIKFYKGKKAPITCEVTPHH
CEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHCCCCCCEEEEECCCE
IYMKDSEFRVNPSIRTQEDIDCIVEMIKNNTVDAIATDHAPHTKEDKDNGACGMIGLETA
EEEECCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEHHHH
FNIAYKVLHENNNISLNKISELMSYNPAKILGERKGVINPTYDADLVVIDIEKEIKVEKF
HHEEEEEEECCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCEEEEEC
NSKSNNSPFIGEKFKGSIEMTIVNGDVKFEKGVKNDNR
CCCCCCCCCCCCCCCCEEEEEEEECCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA